DK0387178T3 - Ny fremgangsmåde til fremstilling af Z (2R,5R)-3-(2-hydroxyethyliden)-7-oxo-4-oxa-1-azabicyclo(3,2,0)-heptan-2-carboxylsyre og farmaceutisk acceptable salte og estere deraf ud fra fermenteringsmedier med Streptomyces sp. - Google Patents

Ny fremgangsmåde til fremstilling af Z (2R,5R)-3-(2-hydroxyethyliden)-7-oxo-4-oxa-1-azabicyclo(3,2,0)-heptan-2-carboxylsyre og farmaceutisk acceptable salte og estere deraf ud fra fermenteringsmedier med Streptomyces sp.

Info

Publication number: DK0387178T3
Authority: DK; Denmark
Prior art keywords: pharmaceutically acceptable; acceptable salts; new process; hydroxyethylidene; azabicyclo
Prior art date: 1989-03-01

Application number

DK90500023.8T

Other languages

English (en)

Other versions

DK0387178T4 (da

Inventor

Alvarez Concepcion Garcia

Urries Senante Pilar J De

Martin Pablo Floriano

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-01

Filing date

1990-02-28

Publication date

1997-06-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8260712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0387178(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-02-28 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1997-06-16 Application granted granted Critical

1997-06-16 Publication of DK0387178T3 publication Critical patent/DK0387178T3/da

2001-07-30 Publication of DK0387178T4 publication Critical patent/DK0387178T4/da

Links

150000003839 salts Chemical class 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
HZZVJAQRINQKSD-RNFRBKRXSA-N (2R,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound OC(=O)[C@H]1C(=CCO)O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-RNFRBKRXSA-N 0.000 title 1
241000187180 Streptomyces sp. Species 0.000 title 1
150000002148 esters Chemical class 0.000 title 1
238000000855 fermentation Methods 0.000 title 1
230000004151 fermentation Effects 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 2
238000005189 flocculation Methods 0.000 abstract 2
230000016615 flocculation Effects 0.000 abstract 2
108020004256 Beta-lactamase Proteins 0.000 abstract 1
229930186147 Cephalosporin Natural products 0.000 abstract 1
229930182555 Penicillin Natural products 0.000 abstract 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
102000006635 beta-lactamase Human genes 0.000 abstract 1
229940124587 cephalosporin Drugs 0.000 abstract 1
150000001780 cephalosporins Chemical class 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000015271 coagulation Effects 0.000 abstract 1
238000005345 coagulation Methods 0.000 abstract 1
239000003792 electrolyte Substances 0.000 abstract 1
229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
229940049954 penicillin Drugs 0.000 abstract 1
229920000867 polyelectrolyte Polymers 0.000 abstract 1
150000003141 primary amines Chemical class 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
230000002195 synergetic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Wood Science & Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK90500023T 1989-03-01 1990-02-28 Fremgangsmåde til fremstilling af clavulansyre og farmaceutisk acceptable salte deraf ud fra fermerteringsmedier med Streptomyces sp. DK0387178T4 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES8900748A ES2010143A6 (es)	1989-03-01	1989-03-01	Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.

Publications (2)

Publication Number	Publication Date
DK0387178T3 true DK0387178T3 (da)	1997-06-16
DK0387178T4 DK0387178T4 (da)	2001-07-30

Family

ID=8260712

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90500023T DK0387178T4 (da)	1989-03-01	1990-02-28	Fremgangsmåde til fremstilling af clavulansyre og farmaceutisk acceptable salte deraf ud fra fermerteringsmedier med Streptomyces sp.

Country Status (7)

Country	Link
EP (1)	EP0387178B9 (da)
AT (1)	ATE147103T1 (da)
DE (1)	DE69029527T3 (da)
DK (1)	DK0387178T4 (da)
ES (1)	ES2010143A6 (da)
GR (1)	GR3022981T3 (da)
PT (1)	PT93313B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2010143A6 (es) †	1989-03-01	1989-10-16	Pharma Mar S A Pharmar	Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
AT400033B (de) *	1992-03-10	1995-09-25	Biochemie Gmbh	Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) *	1992-03-26	1995-03-27	Lek Tovarna Farmacevtskih	Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) *	1992-06-11	1998-06-30	Smithkline Beecham P.L.C.	Postopek in intermedianti za pripravo klavulanske kisline
AT1447U1 (de) *	1992-06-11	1997-05-26	Smithkline Beecham Plc	Neue salze von clavulansäure
GB2282810B (en) *	1992-06-11	1997-02-26	Smithkline Beecham Plc	Preparation or purification of clavulanic acid
GB9222841D0 (en) *	1992-10-31	1992-12-16	Smithkline Beecham Plc	Novel process
AT475U1 (de) *	1992-06-11	1995-11-27	Smithkline Beecham Plc	Verfahren zur herstellung von clavulansaeure
AT1446U1 (de) *	1992-10-31	1997-05-26	Smithkline Beecham Plc	Verfahren zur herstellung und/oder reinigung von clavulansäure
GB9305565D0 (en) *	1993-03-18	1993-05-05	Smithkline Beecham Plc	Novel compounds and processes
US5741903A (en) *	1993-03-26	1998-04-21	Gist-Brocades N.V.	Diamine salts for purification of clavulanic acid
US5821364A (en) *	1993-03-26	1998-10-13	Gist-Brocades N.V.	Diamine salts of clavulanic acid
FI945510L (fi) *	1993-03-26	1994-11-23	Gist Brocades Nv	Klavulaanihapon diamiinisuolat
US5760218A (en) *	1993-03-26	1998-06-02	Gist-Brocades N.V.	Diamine salts of clavulanic acid
DE4318916A1 (de) *	1993-06-07	1994-12-08	Bayer Ag	Cyclobutylazole
GB9401969D0 (en) *	1994-02-02	1994-03-30	Smithkline Beecham Plc	Process
SI9400107A (en) *	1994-03-02	1995-10-31	Lek Tovarna Farmacevtskih	New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) *	1994-12-24	1995-02-22	Spurcourt Ltd	Clavulanic acid salts
NZ301765A (en) *	1995-02-25	1999-10-28	Spurcourt Ltd	Clavulanic acid salts with a benzhydrylamine
AT403375B (de) *	1995-11-15	1998-01-26	Biochemie Gmbh	Verfahren zur fällung von alkalisalzen der clavulansäure
AT404728B (de) *	1996-11-27	1999-02-25	Biochemie Gmbh	Verfahren zur herstellung von clavulansäure-aminsalzen
WO2000004028A1 (en) *	1998-07-16	2000-01-27	Dsm N.V.	Improved process for the preparation of salts and esters of clavulanic acid
CN105384758B (zh) *	2015-12-01	2018-05-01	国药集团威奇达药业有限公司	克拉维酸胺盐的制备方法
CN108546269B (zh) *	2018-05-22	2019-10-11	国药集团威奇达药业有限公司	从结晶母液中回收克拉维酸叔丁胺盐的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4140764A (en) *	1974-12-18	1979-02-20	Beecham Group Limited	β-Lactamase inhibitors and process for their preparation
GB1543563A (en) †	1975-02-07	1979-04-04	Glaxo Lab Ltd	Beta-lactam antibiotic in purified form
DE3063683D1 (en) †	1979-08-24	1983-07-14	Beecham Group Plc	Amine salt of clavulanic acid, its preparation and use
NZ213963A (en) *	1984-10-27	1989-01-06	Antibioticos Sa	Production of clavulanic acid
ES2010143A6 (es) †	1989-03-01	1989-10-16	Pharma Mar S A Pharmar	Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.

1989
- 1989-03-01 ES ES8900748A patent/ES2010143A6/es not_active Expired
1990
- 1990-02-28 DK DK90500023T patent/DK0387178T4/da active
- 1990-02-28 DE DE69029527T patent/DE69029527T3/de not_active Expired - Lifetime
- 1990-02-28 AT AT90500023T patent/ATE147103T1/de not_active IP Right Cessation
- 1990-02-28 EP EP90500023A patent/EP0387178B9/en not_active Expired - Lifetime
- 1990-03-01 PT PT93313A patent/PT93313B/pt not_active IP Right Cessation
1997
- 1997-03-31 GR GR970400657T patent/GR3022981T3/el unknown

Also Published As

Publication number	Publication date
DK0387178T4 (da)	2001-07-30
ATE147103T1 (de)	1997-01-15
PT93313A (pt)	1990-11-07
GR3022981T3 (en)	1997-06-30
EP0387178A1 (en)	1990-09-12
DE69029527D1 (de)	1997-02-13
PT93313B (pt)	1998-06-30
DE69029527T3 (de)	2001-11-08
EP0387178B2 (en)	2001-04-18
EP0387178B9 (en)	2002-09-25
ES2010143A6 (es)	1989-10-16
DE69029527T2 (de)	1997-07-24
EP0387178B1 (en)	1997-01-02

Publication	Publication Date	Title
DK0387178T4 (da)	2001-07-30	Fremgangsmåde til fremstilling af clavulansyre og farmaceutisk acceptable salte deraf ud fra fermerteringsmedier med Streptomyces sp.
IE780642L (en)	1978-10-02	CEPHALOSPORIN DERIVATIVES AND RELATED ß-LACTAMS.
EP0228893A3 (en)	1990-01-03	Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment
DZ1766A1 (fr)	2002-02-17	Inhibiteurs de vih protéase utiles pour le traitement du sida.
DK0748387T3 (da)	1998-05-25	Fremgangsmåde til isolation af clavulansyre og farmaceutisk acceptable salte deraf fra fermenteringsvæsken af Streptomyces sp. P 6621 FERM P 2804
IE43840L (en)	1977-04-13	Clavulanic acid derivatives
ATE71086T1 (de)	1992-01-15	Verfahren zur herstellung von optischen aktiven 3-(methan-sulfonyloxy)thioland und analoge.
AU3769289A (en)	1990-01-12	Condensed pyrazole 3-oxo-propanenitrile derivatives and process for their preparation
FI103046B1 (fi)	1999-04-15	Menetelmä lääkeaineina käyttökelpoisten pyrrolidinyylitiokarbapeneemijohdannaisten valmistamiseksi
NO810758L (no)	1981-09-08	Fremgangsmaate for oekning av den orale absorpsjon av beta-lactamantibiotika
EP0453574A4 (en)	1993-03-10	Cephalosporin derivative
JPS5671092A (en)	1981-06-13	Optical active cephalosporin analogous derivative
ES2001410A6 (es)	1988-05-16	Un procedimiento para la preparacion de nuevos derivados de clavam, utiles para la preparacion de acido clavulanico, e intermedios de los mismos.
BG101996A (en)	1998-11-30	9-n-ethylenederivatives of 9(s)-erythromycylamine
GB1504426A (en)	1978-03-22	Clavulanic acid derivatives
DK0387712T3 (da)	1995-08-14	WS7622A-, B-, C- og D-stoffer, derivater deraf og fremgangsmåder til fremstilling deraf samt anvendelse deraf
AU571956B2 (en)	1988-04-28	3-azinomethyl rifamycins
IE780443L (en)	1978-09-05	Antibiotic from streptomycete
DD210709A1 (de)	1984-06-20	Verfahren zur herstellung des antibiotikums a51568 mit den faktoren a und b
SE7707366L (sv)	1977-12-29	Forfarande for framstellning av 7alfa-metoxi-cefalosporansyraderivat
JPS5394093A (en)	1978-08-17	Novel process for preparation of 7-amino-cephalosporanic acid and their derivatives
DK159320C (da)	1991-03-04	19-epi-dianemycin og salte deraf, fremgangsmaade til fremstilling af 19-epi-dianemycin og mikroorganismekultur til anvendelse ved fremgangsmaaden samt farmaceutisk praeparat indeholdende 19-epi-dianemycin
MY105176A (en)	1994-08-30	Process for optically active 3-thiolanyl sulfonate esters.
SE7809127L (sv)	1980-03-01	Allenaminer
JPS55138396A (en)	1980-10-29	Production of cephalosporin analogs