ATE147103T1 - Verfahren zur gewinnung von klavulinsäure und deren pharmazeutisch annehmbare salze aus fermentationskulturen von streptomyces sp. - Google Patents

Verfahren zur gewinnung von klavulinsäure und deren pharmazeutisch annehmbare salze aus fermentationskulturen von streptomyces sp.

Info

Publication number: ATE147103T1
Authority: AT; Austria
Prior art keywords: pharmaceutically acceptable; acceptable salts; clavulic; streptomyces; obtaining
Prior art date: 1989-03-01

Application number

AT90500023T

Other languages

English (en)

Inventor

Urries Senante Pilar J De

Alvarez Concepcion Garcia

Martin Pablo Floriano

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-01

Filing date

1990-02-28

Publication date

1997-01-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8260712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE147103(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-02-28 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1997-01-15 Application granted granted Critical

1997-01-15 Publication of ATE147103T1 publication Critical patent/ATE147103T1/de

Links

150000003839 salts Chemical class 0.000 title abstract 3
239000002253 acid Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
241000187180 Streptomyces sp. Species 0.000 title 1
238000000855 fermentation Methods 0.000 title 1
230000004151 fermentation Effects 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 2
238000005189 flocculation Methods 0.000 abstract 2
230000016615 flocculation Effects 0.000 abstract 2
108020004256 Beta-lactamase Proteins 0.000 abstract 1
229930186147 Cephalosporin Natural products 0.000 abstract 1
229930182555 Penicillin Natural products 0.000 abstract 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
102000006635 beta-lactamase Human genes 0.000 abstract 1
229940124587 cephalosporin Drugs 0.000 abstract 1
150000001780 cephalosporins Chemical class 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000015271 coagulation Effects 0.000 abstract 1
238000005345 coagulation Methods 0.000 abstract 1
239000003792 electrolyte Substances 0.000 abstract 1
229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
229940049954 penicillin Drugs 0.000 abstract 1
229920000867 polyelectrolyte Polymers 0.000 abstract 1
150000003141 primary amines Chemical class 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
230000002195 synergetic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT90500023T 1989-03-01 1990-02-28 Verfahren zur gewinnung von klavulinsäure und deren pharmazeutisch annehmbare salze aus fermentationskulturen von streptomyces sp. ATE147103T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES8900748A ES2010143A6 (es)	1989-03-01	1989-03-01	Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.

Publications (1)

Publication Number	Publication Date
ATE147103T1 true ATE147103T1 (de)	1997-01-15

Family

ID=8260712

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90500023T ATE147103T1 (de)	1989-03-01	1990-02-28	Verfahren zur gewinnung von klavulinsäure und deren pharmazeutisch annehmbare salze aus fermentationskulturen von streptomyces sp.

Country Status (7)

Country	Link
EP (1)	EP0387178B9 (de)
AT (1)	ATE147103T1 (de)
DE (1)	DE69029527T3 (de)
DK (1)	DK0387178T4 (de)
ES (1)	ES2010143A6 (de)
GR (1)	GR3022981T3 (de)
PT (1)	PT93313B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2010143A6 (es) †	1989-03-01	1989-10-16	Pharma Mar S A Pharmar	Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
AT400033B (de) *	1992-03-10	1995-09-25	Biochemie Gmbh	Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) *	1992-03-26	1995-03-27	Lek Tovarna Farmacevtskih	Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
GB9222841D0 (en) *	1992-10-31	1992-12-16	Smithkline Beecham Plc	Novel process
SI9300296B (sl)	1992-06-11	1998-06-30	Smithkline Beecham P.L.C.	Postopek in intermedianti za pripravo klavulanske kisline
AT475U1 (de) *	1992-06-11	1995-11-27	Smithkline Beecham Plc	Verfahren zur herstellung von clavulansaeure
AT1447U1 (de) *	1992-06-11	1997-05-26	Smithkline Beecham Plc	Neue salze von clavulansäure
GB2282810B (en) *	1992-06-11	1997-02-26	Smithkline Beecham Plc	Preparation or purification of clavulanic acid
AT1446U1 (de) *	1992-10-31	1997-05-26	Smithkline Beecham Plc	Verfahren zur herstellung und/oder reinigung von clavulansäure
GB9305565D0 (en) *	1993-03-18	1993-05-05	Smithkline Beecham Plc	Novel compounds and processes
US5821364A (en) *	1993-03-26	1998-10-13	Gist-Brocades N.V.	Diamine salts of clavulanic acid
US5760218A (en) *	1993-03-26	1998-06-02	Gist-Brocades N.V.	Diamine salts of clavulanic acid
US5741903A (en) *	1993-03-26	1998-04-21	Gist-Brocades N.V.	Diamine salts for purification of clavulanic acid
DE69400334T2 (de) *	1993-03-26	1997-02-13	Gist Brocades Nv	Diaminsalze von clavulansäure
DE4318916A1 (de) *	1993-06-07	1994-12-08	Bayer Ag	Cyclobutylazole
GB9401969D0 (en) *	1994-02-02	1994-03-30	Smithkline Beecham Plc	Process
SI9400107A (en) *	1994-03-02	1995-10-31	Lek Tovarna Farmacevtskih	New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) *	1994-12-24	1995-02-22	Spurcourt Ltd	Clavulanic acid salts
DE69618045D1 (de) *	1995-02-25	2002-01-31	Spurcourt Ltd	Clavulansäure Salz
AT403375B (de) *	1995-11-15	1998-01-26	Biochemie Gmbh	Verfahren zur fällung von alkalisalzen der clavulansäure
AT404728B (de) *	1996-11-27	1999-02-25	Biochemie Gmbh	Verfahren zur herstellung von clavulansäure-aminsalzen
CN1312814A (zh) *	1998-07-16	2001-09-12	Dsm公司	制备棒酸盐类及其酯类的改进方法
CN105384758B (zh) *	2015-12-01	2018-05-01	国药集团威奇达药业有限公司	克拉维酸胺盐的制备方法
CN108546269B (zh) *	2018-05-22	2019-10-11	国药集团威奇达药业有限公司	从结晶母液中回收克拉维酸叔丁胺盐的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4140764A (en) *	1974-12-18	1979-02-20	Beecham Group Limited	β-Lactamase inhibitors and process for their preparation
GB1543563A (en) †	1975-02-07	1979-04-04	Glaxo Lab Ltd	Beta-lactam antibiotic in purified form
DE3063683D1 (en) †	1979-08-24	1983-07-14	Beecham Group Plc	Amine salt of clavulanic acid, its preparation and use
MX7417E (es) *	1984-10-27	1988-10-14	Antibioticos Sa	Metodo para la preparacion de acido clavulanico y sus derivados
ES2010143A6 (es) †	1989-03-01	1989-10-16	Pharma Mar S A Pharmar	Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.

1989
- 1989-03-01 ES ES8900748A patent/ES2010143A6/es not_active Expired
1990
- 1990-02-28 DE DE69029527T patent/DE69029527T3/de not_active Expired - Lifetime
- 1990-02-28 DK DK90500023T patent/DK0387178T4/da active
- 1990-02-28 AT AT90500023T patent/ATE147103T1/de not_active IP Right Cessation
- 1990-02-28 EP EP90500023A patent/EP0387178B9/de not_active Expired - Lifetime
- 1990-03-01 PT PT93313A patent/PT93313B/pt not_active IP Right Cessation
1997
- 1997-03-31 GR GR970400657T patent/GR3022981T3/el unknown

Also Published As

Publication number	Publication date
GR3022981T3 (en)	1997-06-30
PT93313B (pt)	1998-06-30
DE69029527T2 (de)	1997-07-24
DE69029527T3 (de)	2001-11-08
EP0387178B2 (de)	2001-04-18
PT93313A (pt)	1990-11-07
EP0387178A1 (de)	1990-09-12
ES2010143A6 (es)	1989-10-16
DE69029527D1 (de)	1997-02-13
EP0387178B9 (de)	2002-09-25
EP0387178B1 (de)	1997-01-02
DK0387178T3 (da)	1997-06-16
DK0387178T4 (da)	2001-07-30

Legal Events

Date	Code	Title
1997-08-15	UEP	Publication of translation of european patent specification
2001-07-15	UEP	Publication of translation of european patent specification
2010-05-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE147103T1 (de)	1997-01-15	Verfahren zur gewinnung von klavulinsäure und deren pharmazeutisch annehmbare salze aus fermentationskulturen von streptomyces sp.
ATE210728T1 (de)	2001-12-15	Herstellungsverfahren einer substanz
ATE432344T1 (de)	2009-06-15	Verfahren zur bestimmung der neigung von bakterien zum gelöstem sauerstofinstabilität
DE69119216D1 (de)	1996-06-05	Enzymatisches Verfahren zur Herstellung von 7-Aminocephalosporinsäure und Derivate
ATE159549T1 (de)	1997-11-15	Verfahren zur isolation von clavulansäure und von pharmazeutisch verträgliche salze aus fermentationsbrühe von streptomyces sp.p6621 ferm p2804
RU94030236A (ru)	1996-06-20	Производные 3 бета-алкенил-пенама, способ их получения, лекарственные средства и их применение для борьбы и предупреждения болезней
SE9300758D0 (sv)	1993-03-08	Process for the production of clavulanic acid
DE68906200D1 (de)	1993-06-03	Kondensierte pyrazol-3-oxo-propannitril-derivate und verfahren zu deren herstellung.
FI103046B1 (fi)	1999-04-15	Menetelmä lääkeaineina käyttökelpoisten pyrrolidinyylitiokarbapeneemijohdannaisten valmistamiseksi
BR9509889A (pt)	1997-12-30	Composto composição farmacêutica e processos para inibir beta-lactamases e para aumentar a atrividade biológica de um antibiótico do tipo beta-lactama
DE59711536D1 (de)	2004-05-27	Osmokontrolliertes Fermentationsverfahren zur Herstellung von Acarbose
IE791661L (en)	1980-03-01	Penam compounds
JPS5671092A (en)	1981-06-13	Optical active cephalosporin analogous derivative
DE3578423D1 (de)	1990-08-02	Neue cephalosporine und verfahren zu ihrer herstellung.
ATE81341T1 (de)	1992-10-15	Verfahren zur herstellung von antibiotica 10381b.
IE802418L (en)	1981-05-23	ANTIALLERGIC AND ANTIULCER 1-OXO-1H-THIAZOLO (3,2-a)¹PYRIMIDINE-2-CARBOXAMIDES
GB1479179A (en)	1977-07-06	Antibiotics designated xk-88 series and process for production thereof
JPS5394093A (en)	1978-08-17	Novel process for preparation of 7-amino-cephalosporanic acid and their derivatives
EP0365329A3 (en)	1990-08-29	Antibiotics active against anaerobic bacteria, their production and use, and strains of enterobacter producing the same
JPS5537136A (en)	1980-03-15	Preparation of cephalosporin antibiotic
GB1499710A (en)	1978-02-01	Fluidized bed waste incineration process
ES8605861A1 (es)	1986-04-01	Un procedimiento para la produccion de un nuevo antibiotico de eter policiclico acido
JPS5574795A (en)	1980-06-05	Preparation of bacteriohemagglutinin mha no.101
DE3574675D1 (de)	1990-01-18	Verfahren zum sterilisieren von rekombinantem mikroorganismus.
JPS55118396A (en)	1980-09-11	Preparation of mitomycin derivative