PT93313A - Processo para a preparacao do acido z(2r, 5r)-3-(2-hidroxietilideno)-7-oxo-4- -oxa-1-azabiciclo{3,2,0}heptano-2-carboxilico a partir de caldos de fermentacao de streptomyces sp. - Google Patents

Processo para a preparacao do acido z(2r, 5r)-3-(2-hidroxietilideno)-7-oxo-4- -oxa-1-azabiciclo{3,2,0}heptano-2-carboxilico a partir de caldos de fermentacao de streptomyces sp.

Info

Publication number: PT93313A
Authority: PT; Portugal
Prior art keywords: hydroxyethydidene; fermentacao; azabicyclo; streptomyces; oxa
Prior art date: 1989-03-01

Application number

PT93313A

Other languages

English (en)

Other versions

PT93313B (pt

Inventor

Maria Concepcion Graci Alvarez

Maria Pilar J De Urrie Senante

Pablo Floriano Martin

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-01

Filing date

1990-03-01

Publication date

1990-11-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8260712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT93313(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-03-01 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

1990-11-07 Publication of PT93313A publication Critical patent/PT93313A/pt

1998-06-30 Publication of PT93313B publication Critical patent/PT93313B/pt

Links

NKBWMBRPILTCRD-UHFFFAOYSA-N 2-Methylheptanoic acid Chemical compound CCCCCC(C)C(O)=O NKBWMBRPILTCRD-UHFFFAOYSA-N 0.000 title 1
241000187180 Streptomyces sp. Species 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 2
238000005189 flocculation Methods 0.000 abstract 2
230000016615 flocculation Effects 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
108020004256 Beta-lactamase Proteins 0.000 abstract 1
229930186147 Cephalosporin Natural products 0.000 abstract 1
229930182555 Penicillin Natural products 0.000 abstract 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
102000006635 beta-lactamase Human genes 0.000 abstract 1
229940124587 cephalosporin Drugs 0.000 abstract 1
150000001780 cephalosporins Chemical class 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000015271 coagulation Effects 0.000 abstract 1
238000005345 coagulation Methods 0.000 abstract 1
239000003792 electrolyte Substances 0.000 abstract 1
229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229940049954 penicillin Drugs 0.000 abstract 1
229920000867 polyelectrolyte Polymers 0.000 abstract 1
150000003141 primary amines Chemical class 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
230000002195 synergetic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT93313A 1989-03-01 1990-03-01 Processo para a preparacao do acido z(2r, 5r)-3-(2-hidroxietilideno)-7-oxo-4- -oxa-1-azabiciclo{3,2,0}heptano-2-carboxilico a partir de caldos de fermentacao de streptomyces sp. PT93313B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES8900748A ES2010143A6 (es)	1989-03-01	1989-03-01	Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.

Publications (2)

Publication Number	Publication Date
PT93313A true PT93313A (pt)	1990-11-07
PT93313B PT93313B (pt)	1998-06-30

Family

ID=8260712

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT93313A PT93313B (pt)	1989-03-01	1990-03-01	Processo para a preparacao do acido z(2r, 5r)-3-(2-hidroxietilideno)-7-oxo-4- -oxa-1-azabiciclo{3,2,0}heptano-2-carboxilico a partir de caldos de fermentacao de streptomyces sp.

Country Status (7)

Country	Link
EP (1)	EP0387178B9 (pt)
AT (1)	ATE147103T1 (pt)
DE (1)	DE69029527T3 (pt)
DK (1)	DK0387178T4 (pt)
ES (1)	ES2010143A6 (pt)
GR (1)	GR3022981T3 (pt)
PT (1)	PT93313B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2010143A6 (es) †	1989-03-01	1989-10-16	Pharma Mar S A Pharmar	Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
AT400033B (de) *	1992-03-10	1995-09-25	Biochemie Gmbh	Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) *	1992-03-26	1995-03-27	Lek Tovarna Farmacevtskih	Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
GB9222841D0 (en) *	1992-10-31	1992-12-16	Smithkline Beecham Plc	Novel process
SI9300296B (sl)	1992-06-11	1998-06-30	Smithkline Beecham P.L.C.	Postopek in intermedianti za pripravo klavulanske kisline
AT475U1 (de) *	1992-06-11	1995-11-27	Smithkline Beecham Plc	Verfahren zur herstellung von clavulansaeure
AT1447U1 (de) *	1992-06-11	1997-05-26	Smithkline Beecham Plc	Neue salze von clavulansäure
GB2282810B (en) *	1992-06-11	1997-02-26	Smithkline Beecham Plc	Preparation or purification of clavulanic acid
AT1446U1 (de) *	1992-10-31	1997-05-26	Smithkline Beecham Plc	Verfahren zur herstellung und/oder reinigung von clavulansäure
GB9305565D0 (en) *	1993-03-18	1993-05-05	Smithkline Beecham Plc	Novel compounds and processes
US5821364A (en) *	1993-03-26	1998-10-13	Gist-Brocades N.V.	Diamine salts of clavulanic acid
US5760218A (en) *	1993-03-26	1998-06-02	Gist-Brocades N.V.	Diamine salts of clavulanic acid
US5741903A (en) *	1993-03-26	1998-04-21	Gist-Brocades N.V.	Diamine salts for purification of clavulanic acid
DE69400334T2 (de) *	1993-03-26	1997-02-13	Gist Brocades Nv	Diaminsalze von clavulansäure
DE4318916A1 (de) *	1993-06-07	1994-12-08	Bayer Ag	Cyclobutylazole
GB9401969D0 (en) *	1994-02-02	1994-03-30	Smithkline Beecham Plc	Process
SI9400107A (en) *	1994-03-02	1995-10-31	Lek Tovarna Farmacevtskih	New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) *	1994-12-24	1995-02-22	Spurcourt Ltd	Clavulanic acid salts
DE69618045D1 (de) *	1995-02-25	2002-01-31	Spurcourt Ltd	Clavulansäure Salz
AT403375B (de) *	1995-11-15	1998-01-26	Biochemie Gmbh	Verfahren zur fällung von alkalisalzen der clavulansäure
AT404728B (de) *	1996-11-27	1999-02-25	Biochemie Gmbh	Verfahren zur herstellung von clavulansäure-aminsalzen
CN1312814A (zh) *	1998-07-16	2001-09-12	Dsm公司	制备棒酸盐类及其酯类的改进方法
CN105384758B (zh) *	2015-12-01	2018-05-01	国药集团威奇达药业有限公司	克拉维酸胺盐的制备方法
CN108546269B (zh) *	2018-05-22	2019-10-11	国药集团威奇达药业有限公司	从结晶母液中回收克拉维酸叔丁胺盐的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4140764A (en) *	1974-12-18	1979-02-20	Beecham Group Limited	β-Lactamase inhibitors and process for their preparation
GB1543563A (en) †	1975-02-07	1979-04-04	Glaxo Lab Ltd	Beta-lactam antibiotic in purified form
DE3063683D1 (en) †	1979-08-24	1983-07-14	Beecham Group Plc	Amine salt of clavulanic acid, its preparation and use
MX7417E (es) *	1984-10-27	1988-10-14	Antibioticos Sa	Metodo para la preparacion de acido clavulanico y sus derivados
ES2010143A6 (es) †	1989-03-01	1989-10-16	Pharma Mar S A Pharmar	Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.

1989
- 1989-03-01 ES ES8900748A patent/ES2010143A6/es not_active Expired
1990
- 1990-02-28 DE DE69029527T patent/DE69029527T3/de not_active Expired - Lifetime
- 1990-02-28 DK DK90500023T patent/DK0387178T4/da active
- 1990-02-28 AT AT90500023T patent/ATE147103T1/de not_active IP Right Cessation
- 1990-02-28 EP EP90500023A patent/EP0387178B9/en not_active Expired - Lifetime
- 1990-03-01 PT PT93313A patent/PT93313B/pt not_active IP Right Cessation
1997
- 1997-03-31 GR GR970400657T patent/GR3022981T3/el unknown

Also Published As

Publication number	Publication date
GR3022981T3 (en)	1997-06-30
PT93313B (pt)	1998-06-30
DE69029527T2 (de)	1997-07-24
DE69029527T3 (de)	2001-11-08
EP0387178B2 (en)	2001-04-18
EP0387178A1 (en)	1990-09-12
ES2010143A6 (es)	1989-10-16
DE69029527D1 (de)	1997-02-13
EP0387178B9 (en)	2002-09-25
EP0387178B1 (en)	1997-01-02
ATE147103T1 (de)	1997-01-15
DK0387178T3 (da)	1997-06-16
DK0387178T4 (da)	2001-07-30

Legal Events

Date

Code

Title

Description

1998-06-30

FG3A

Patent granted, date of granting

Effective date: 19980316

2010-09-27

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20100916

Publication	Publication Date	Title
PT93313A (pt)	1990-11-07	Processo para a preparacao do acido z(2r, 5r)-3-(2-hidroxietilideno)-7-oxo-4- -oxa-1-azabiciclo{3,2,0}heptano-2-carboxilico a partir de caldos de fermentacao de streptomyces sp.
ES2052524T3 (es)	1994-07-16	Un procedimiento para la preparacion de un compuesto de carbapenem cristalino.
EP0228893A3 (en)	1990-01-03	Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment
DZ1766A1 (fr)	2002-02-17	Inhibiteurs de vih protéase utiles pour le traitement du sida.
IE43840L (en)	1977-04-13	Clavulanic acid derivatives
RU94030236A (ru)	1996-06-20	Производные 3 бета-алкенил-пенама, способ их получения, лекарственные средства и их применение для борьбы и предупреждения болезней
SE9300758D0 (sv)	1993-03-08	Process for the production of clavulanic acid
IE891242L (en)	1989-10-19	Process for optically active 3-(methane-sulfonyloxy)thiolane¹and analogs
CA2300289A1 (en)	1999-02-04	A pharmaceutical composition active in reducing production of mcp-1 protein
PT97659A (pt)	1992-05-29	Processo biocatalitico para a preparacao de l-(-)-carnitina a partir de crotonobetaina e estirpes de proteus mirabilis para utilizacao no referido processo
BR9509889A (pt)	1997-12-30	Composto composição farmacêutica e processos para inibir beta-lactamases e para aumentar a atrividade biológica de um antibiótico do tipo beta-lactama
IE791661L (en)	1980-03-01	Penam compounds
IE800428L (en)	1980-09-05	Penicillanic acid derivatives
JPS5671092A (en)	1981-06-13	Optical active cephalosporin analogous derivative
SE7904319L (sv)	1979-11-19	Substituerade dibensyletrar samt forfarande for framstellning av dem
IE802418L (en)	1981-05-23	ANTIALLERGIC AND ANTIULCER 1-OXO-1H-THIAZOLO (3,2-a)¹PYRIMIDINE-2-CARBOXAMIDES
EP0365329A3 (en)	1990-08-29	Antibiotics active against anaerobic bacteria, their production and use, and strains of enterobacter producing the same
ES528197A0 (es)	1985-05-01	Un metodo de produccion de un antibiotico
JPS53104796A (en)	1978-09-12	Preparation of antibiotics
ES2130392T3 (es)	1999-07-01	Procedimiento para la preparacion de acido clavulanico.
MY105176A (en)	1994-08-30	Process for optically active 3-thiolanyl sulfonate esters.
PT96912A (pt)	1991-10-31	Processo para influenciar a producao de antibioticos de beta-lactama e para o isolamento de grandes quantidades de sintetase de acv
IE782539L (en)	1979-06-23	Penicillin derivatives
JPS5622787A (en)	1981-03-03	Beta-lactam compound
IE45349L (en)	1977-12-30	Antibiotic bl580 delta