DK0392803T3 - Hidtil ukendte forbindelser - Google Patents

Hidtil ukendte forbindelser

Info

Publication number: DK0392803T3
Authority: DK; Denmark
Prior art keywords: group; alkyl; hitherto unknown; unknown compounds; chem
Prior art date: 1989-04-13

Application number

DK90303852T

Other languages

English (en)

Inventor

Barry Sidney Orlek

Steven Mark Bromidge

Steven Dabbs

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-13

Filing date

1990-04-10

Publication date

2004-10-18

1989-04-13 Priority claimed from GB898908365A external-priority patent/GB8908365D0/en

1989-10-16 Priority claimed from GB898923299A external-priority patent/GB8923299D0/en

1990-04-10 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

2004-10-18 Application granted granted Critical

2004-10-18 Publication of DK0392803T3 publication Critical patent/DK0392803T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
101100516563 Caenorhabditis elegans nhr-6 gene Proteins 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
-1 chloro, fluoro, bromo, cyclopropyl Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK90303852T 1989-04-13 1990-04-10 Hidtil ukendte forbindelser DK0392803T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB898908365A GB8908365D0 (en)	1989-04-13	1989-04-13	Novel compounds
GB898923299A GB8923299D0 (en)	1989-10-16	1989-10-16	Novel compounds

Publications (1)

Publication Number	Publication Date
DK0392803T3 true DK0392803T3 (da)	2004-10-18

Family

ID=26295213

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90303852T DK0392803T3 (da)	1989-04-13	1990-04-10	Hidtil ukendte forbindelser

Country Status (12)

Country	Link
US (1)	USRE35593E (da)
EP (1)	EP0392803B1 (da)
JP (3)	JP2665818B2 (da)
KR (1)	KR0185378B1 (da)
AT (1)	ATE269330T1 (da)
CA (1)	CA2014379C (da)
DE (1)	DE69034146T2 (da)
DK (1)	DK0392803T3 (da)
ES (1)	ES2219636T3 (da)
NZ (1)	NZ233290A (da)
PT (1)	PT93753B (da)
SG (1)	SG48315A1 (da)

Families Citing this family (36)

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IE912974A1 (en) *	1990-08-24	1992-02-26	Beecham Group Plc	Novel compounds
GB9019095D0 (en) *	1990-09-01	1990-10-17	Beecham Group Plc	Novel compounds
JPH06501933A (ja) *	1990-10-12	1994-03-03	ビーチャム・グループ・パブリック・リミテッド・カンパニー	１，２，５，６−テトラヒドロピリジン・オキシム誘導体
WO1992011261A1 (en) *	1990-12-21	1992-07-09	Merck Sharp & Dohme Limited	4-azatricyclo[2.2.1.02,6]heptanes and pharmaceutical compositions
MX9300875A (es) *	1992-02-20	1993-08-31	Smithkline Beecham Plc	Procedimiento para la preparacion de compuestos azabiciclicos.
GB9409718D0 (en) *	1994-05-14	1994-07-06	Smithkline Beecham Plc	Novel compounds
GB9409705D0 (en) *	1994-05-14	1994-07-06	Smithkline Beecham Plc	Novel compounds
GB9421472D0 (en) *	1994-10-25	1994-12-07	Smithkline Beecham Plc	Novel methods
AR004178A1 (es) *	1995-07-29	1998-11-04	Smithkline Beecham Plc	Procedimiento para la formulacion de un farmaco, una composicion farmaceutica obtenible mediante este procedimiento y el uso de la misma.
AU751607B2 (en) *	1995-07-29	2002-08-22	Smithkline Beecham Plc	Method of treatment of dementia
WO1997043286A1 (en) *	1996-05-13	1997-11-20	Zeneca Limited	Bicyclic amines as insecticides
GB9615628D0 (en) *	1996-07-25	1996-09-04	Smithkline Beecham Plc	Formulation
GB9619074D0 (en) *	1996-09-12	1996-10-23	Smithkline Beecham Plc	Composition
US20010003588A1 (en) *	1996-09-12	2001-06-14	Smithkline Beecham Corporation	Controlled release dosage form of [R-(Z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo[2.2.2.]oct-3-yl)acetonitrile monohydrochloride
US6284771B1 (en) *	1997-04-11	2001-09-04	Eli Lilly And Company	Method for treating schizophrenia
GB9815383D0 (en) *	1998-07-15	1998-09-16	Smithkline Beecham Plc	Novel method of treatment
KR20030021641A (ko) *	2001-09-07	2003-03-15	안병로	투명비누 자가제조용 키트 및 상기 키트를 이용한투명비누 자가제조방법
EP2258358A3 (en)	2005-08-26	2011-09-07	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
EP1928437A2 (en) *	2005-08-26	2008-06-11	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
EP1940389A2 (en)	2005-10-21	2008-07-09	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
US20070112017A1 (en)	2005-10-31	2007-05-17	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
GB0607952D0 (en) *	2006-04-21	2006-05-31	Minster Res Ltd	Novel treatment
GB0607946D0 (en) *	2006-04-21	2006-05-31	Minster Res The Ltd	Mono and combination therapy
AU2007249399A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
WO2007134077A2 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 ht receptor mediated neurogenesis
EP2068872A1 (en)	2006-09-08	2009-06-17	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
KR102287645B1 (ko)	2018-12-18	2021-08-06	한화솔루션 주식회사	실리카계 촉매를 이용한 배위-음이온 개환 중합에 의한 폴리아마이드의 제조방법 및 이에 의해 제조된 폴리아마이드
WO2026013573A1 (en) *	2024-07-09	2026-01-15	Syremis Therapeutics Ltd.	New salt forms of sabcomeline
WO2026013566A1 (en) *	2024-07-09	2026-01-15	Syremis Therapeutics Ltd.	New salt forms of sabcomeline
WO2026013570A1 (en) *	2024-07-09	2026-01-15	Syremis Therapeutics Ltd.	New salt forms of sabcomeline
WO2026013563A1 (en) *	2024-07-09	2026-01-15	Syremis Therapeutics Ltd.	New salt forms of sabcomeline
WO2026018154A1 (en)	2024-07-16	2026-01-22	Syremis Therapeutics Ltd.	Combinations of sabcomeline with non-cns penetrant muscarinic antagonists
WO2026018155A1 (en)	2024-07-16	2026-01-22	Syremis Therapeutics Ltd.	Combinations of sabcomeline with long-acting non-cns penetrant muscarinic antagonists

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ203861A (en) *	1982-04-14	1986-07-11	Beecham Group Plc	Bicyclic heterocyclic compounds and pharmaceutical compositions containing such
FR2531955A1 (fr) *	1982-08-17	1984-02-24	Pharmuka Lab	Nouveau procede de preparation de derives de la quinuclidine substitues en position 3
IL81610A (en) *	1986-02-27	1990-12-23	Roussel Uclaf	Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
GB8615785D0 (en) *	1986-06-27	1986-08-06	Beecham Group Plc	Compounds
DE3789039T2 (de) *	1986-06-27	1994-06-09	Beecham Group Plc	Verbrückte bicyclische N-heterocyclische Verbindungen.
US4710508A (en) *	1986-12-08	1987-12-01	Warner-Lambert Company	O-substituted tetrahydropyridine oxime cholinergic agents
US4786648A (en) *	1986-12-08	1988-11-22	Warner-Lambert Company	O-substituted tetrahydropyridine oxime cholinergic agents
US4798841A (en) *	1987-03-31	1989-01-17	Warner-Lambert Company	Tetrahydropyridine oxime cholinergic agents and method of treatment
EP0287356B1 (en) *	1987-04-15	1996-01-24	Beecham Group Plc	Bridgehead substituted azabicyclic derivatives
IT1203971B (it) *	1987-04-24	1989-02-23	Roussel Maestretti Spa	Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti
IT1222526B (it) *	1987-08-21	1990-09-05	Roussel Maestretti Spa	Derivati dell' ossima della 1,2,5,6-tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali
IT1222529B (it) *	1987-08-21	1990-09-05	Roussel Maestretti Spa	Derivati dell' ossima della 1,2,5,6-tetraidropirdin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali
DE3738521C1 (de) *	1987-11-13	1988-12-01	Delta Getriebe Gmbh	Planetengetriebe
IL88156A (en) *	1987-11-13	1997-02-18	Novo Nordisk As	Azacyclic compounds their preparation and pharmaceutical compositions containing them
IT1233446B (it) *	1987-12-30	1992-04-01	Roussel Maestretti Spa	Derivati della 3 piperidinocarbaldeide ossima, loro procedimento di preparazione e loro applicazione come farmaci
DK177889A (da) *	1988-04-15	1989-10-16	Beecham Group Plc	Hidtil ukendte forbindelser
IT1227436B (it) *	1988-10-28	1991-04-11	Roussel Maestretti Spa	Derivati di 1-azabicicloalcani, loro procedimento di preparazione e loro applicazione come farmaci
US4937239A (en) *	1989-02-13	1990-06-26	Warner-Lambert Company	Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents
EP0402056A3 (en) *	1989-06-06	1991-09-04	Beecham Group p.l.c.	Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them

1990
- 1990-04-10 DK DK90303852T patent/DK0392803T3/da active
- 1990-04-10 ES ES90303852T patent/ES2219636T3/es not_active Expired - Lifetime
- 1990-04-10 SG SG1996008858A patent/SG48315A1/en unknown
- 1990-04-10 AT AT90303852T patent/ATE269330T1/de not_active IP Right Cessation
- 1990-04-10 EP EP90303852A patent/EP0392803B1/en not_active Expired - Lifetime
- 1990-04-10 DE DE69034146T patent/DE69034146T2/de not_active Expired - Lifetime
- 1990-04-11 NZ NZ233290A patent/NZ233290A/en unknown
- 1990-04-11 CA CA002014379A patent/CA2014379C/en not_active Expired - Lifetime
- 1990-04-12 PT PT93753A patent/PT93753B/pt not_active IP Right Cessation
- 1990-04-13 KR KR1019900005136A patent/KR0185378B1/ko not_active Expired - Lifetime
- 1990-04-13 JP JP2096587A patent/JP2665818B2/ja not_active Expired - Lifetime
1996
- 1996-01-11 US US08/585,113 patent/USRE35593E/en not_active Expired - Lifetime
1997
- 1997-01-23 JP JP9023114A patent/JP2913467B2/ja not_active Expired - Lifetime
- 1997-01-23 JP JP9023113A patent/JP2913466B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR900016211A (ko)	1990-11-12
ATE269330T1 (de)	2004-07-15
EP0392803A1 (en)	1990-10-17
PT93753B (pt)	1996-08-30
AU619969B2 (en)	1992-02-06
KR0185378B1 (ko)	1999-05-01
JP2665818B2 (ja)	1997-10-22
AU5315990A (en)	1990-10-18
EP0392803B1 (en)	2004-06-16
HK1012365A1 (en)	1999-07-30
DE69034146D1 (de)	2004-07-22
JPH09188678A (ja)	1997-07-22
JP2913466B2 (ja)	1999-06-28
JP2913467B2 (ja)	1999-06-28
CA2014379A1 (en)	1990-10-13
CA2014379C (en)	2000-02-08
ES2219636T3 (es)	2004-12-01
PT93753A (pt)	1990-11-20
USRE35593E (en)	1997-08-19
JPH09188679A (ja)	1997-07-22
SG48315A1 (en)	1998-04-17
JPH037285A (ja)	1991-01-14
NZ233290A (en)	1992-06-25
DE69034146T2 (de)	2005-07-14

Publication	Publication Date	Title
DK0392803T3 (da)	2004-10-18	Hidtil ukendte forbindelser
DK254587A (da)	1987-11-21	Positionsspecifikke alkyleringsmidler
DE69033935D1 (de)	2002-04-18	Bis(3,4-Dialkylbenzyliden)sorbitolacetale und diese enthaltende Zusammensetzungen
ATE178599T1 (de)	1999-04-15	Substituierte 1-phenyl-oxazolidin-2-on derivate deren herstellung und der verwendung als adhäsionsrezeptor-antagonisten
DK160877C (da)	1991-10-14	Fremgangsmaade til fremstilling af 2-penemforbindelser
DK202388D0 (da)	1988-04-13	Hidtil ukendte forbindelser
PL285683A1 (en)	1991-05-20	Method of obtaining novel amines
SE8603099D0 (sv)	1986-07-11	Distamycin derivatives and process for their preparation
SE8604950D0 (sv)	1986-11-19	Dementia-improving and therapeutic agents
ATE42282T1 (de)	1989-05-15	Aromatische verbindungen.
DK0503537T3 (da)	1997-12-15	6,9-bis(substitueret amino)benzo(g)isoquinolin-5,10-dioner
DK0505778T3 (da)	1995-12-11	Derivater af imidazol-2-oner samt fremgangsmåde til fremstilling deraf
FI870090A0 (fi)	1987-01-12	Laongkedjade alkylresorcinolfosfiter.
SE7605190L (sv)	1976-11-08	Nya tiazoliner
PT87050A (pt)	1988-04-01	Process for preparing indane sulfonamides antiarrhythmic agents
NO900732L (no)	1990-08-20	Arylalkylaminforbindelser.
ATE69605T1 (de)	1991-12-15	Azolylpropenyl- und azolylmethyloxiran-derivate und diese enthaltende fungizide.
DK0543584T3 (da)	1996-07-01	Benzo(b)thiophen-2-carboxamider til behandling af forstyrrelser i centralnervesystemet
PT90815A (pt)	1989-12-29	Processo de preparacao de derivados da fenotiazina
ES2031594T3 (es)	1992-12-16	Tioeteres aromaticos.
DE3470882D1 (en)	1988-06-09	N-substituted tetrahydrothiazines, process for their preparation, and their use as pesticides
FI900796A0 (fi)	1990-02-16	Aralkylaminfoereningar.