DK0397364T3 - Heterocycliske guandiner som 5HT3-antagonister - Google Patents

Heterocycliske guandiner som 5HT3-antagonister

Info

Publication number
DK0397364T3
DK0397364T3 DK90304684.5T DK90304684T DK0397364T3 DK 0397364 T3 DK0397364 T3 DK 0397364T3 DK 90304684 T DK90304684 T DK 90304684T DK 0397364 T3 DK0397364 T3 DK 0397364T3
Authority
DK
Denmark
Prior art keywords
methyl
carbon atoms
indol
hydrogen
antagonists
Prior art date
Application number
DK90304684.5T
Other languages
English (en)
Inventor
Arthur Adam Nagel
James Patrick Rizzi
Terry Jay Rosen
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0397364T3 publication Critical patent/DK0397364T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK90304684.5T 1989-05-19 1990-04-30 Heterocycliske guandiner som 5HT3-antagonister DK0397364T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/349,189 US4963689A (en) 1989-05-19 1989-05-19 Heterocyclicguanidines as 5HT3 antagonists

Publications (1)

Publication Number Publication Date
DK0397364T3 true DK0397364T3 (da) 1993-09-27

Family

ID=23371270

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90304684.5T DK0397364T3 (da) 1989-05-19 1990-04-30 Heterocycliske guandiner som 5HT3-antagonister

Country Status (19)

Country Link
US (1) US4963689A (da)
EP (1) EP0397364B1 (da)
JP (1) JPH0635454B2 (da)
KR (1) KR920003927B1 (da)
AT (1) ATE92062T1 (da)
AU (1) AU615385B2 (da)
CA (1) CA2016182C (da)
DE (1) DE69002384T2 (da)
DK (1) DK0397364T3 (da)
ES (1) ES2058795T3 (da)
FI (1) FI902291A7 (da)
HU (1) HUT58063A (da)
IE (1) IE62935B1 (da)
IL (1) IL94254A (da)
MY (1) MY105555A (da)
NO (1) NO902029L (da)
NZ (1) NZ233576A (da)
PT (1) PT93979B (da)
ZA (1) ZA903478B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140034A (en) * 1989-03-14 1992-08-18 Merck Sharp & Dohme Ltd. Five-membered ring systems with bonded imidazolyl ring substituents
JP2776984B2 (ja) * 1992-09-14 1998-07-16 山之内製薬株式会社 新規な縮合チアゾール誘導体，その製造法及びその医薬組成物
MX9603998A (es) * 1994-03-11 1997-12-31 Yamanouchi Pharma Co Ltd Agonista receptor de 5-ht3, derivado de tiazol novedoso e intermediario del mismo.
GB9406857D0 (en) * 1994-04-07 1994-06-01 Sandoz Ltd Improvements in or relating to organic compounds
US5887415A (en) * 1995-05-11 1999-03-30 Bernard Matthews Plc Cooked, extruded meat product comprising additive
US5811425A (en) * 1997-03-04 1998-09-22 Abbott Laboratories Heterocyclic compounds as COX-2 inhibitors
DE102005027193A1 (de) * 2005-06-06 2006-12-07 Wilhelm Stahlecker Gmbh Zwillingseinheit mit zwei Streckwerken für eine Spinnmaschine
EP2253316B1 (en) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
ES2664599T3 (es) 2009-05-20 2018-04-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonistas del receptor 5-HT3 de serotonina para uso en el tratamiento de trastornos vestibulares lesionales
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1031165A (en) * 1965-08-18 1966-05-25 Wellcome Found Guanidines, isoureas and isothioureas
GB1305549A (da) * 1969-10-29 1973-02-07
DE2739723A1 (de) * 1977-09-03 1979-03-08 Merck Patent Gmbh 2-guanidinomethyl-indoline und verfahren zu ihrer herstellung
US4220654A (en) * 1979-06-04 1980-09-02 Merck & Co., Inc. Cyclic imidazole cyanoguanidines
US4563527A (en) * 1984-07-19 1986-01-07 Torii & Co., Ltd. Amidine compounds

Also Published As

Publication number Publication date
IL94254A (en) 1994-05-30
US4963689A (en) 1990-10-16
KR900018054A (ko) 1990-12-20
HU902976D0 (en) 1990-09-28
PT93979B (pt) 1996-11-29
NO902029L (no) 1990-11-12
IE901664L (en) 1990-11-09
DE69002384D1 (de) 1993-09-02
ZA903478B (en) 1991-12-24
EP0397364A1 (en) 1990-11-14
DE69002384T2 (de) 1993-11-18
KR920003927B1 (ko) 1992-05-18
CA2016182A1 (en) 1990-11-09
CA2016182C (en) 1996-03-12
PT93979A (pt) 1991-01-08
NZ233576A (en) 1991-06-25
FI902291A0 (fi) 1990-05-08
AU615385B2 (en) 1991-09-26
HUT58063A (en) 1992-01-28
JPH0635454B2 (ja) 1994-05-11
MY105555A (en) 1994-10-31
NO902029D0 (no) 1990-05-08
ATE92062T1 (de) 1993-08-15
IE62935B1 (en) 1995-03-08
JPH0311070A (ja) 1991-01-18
EP0397364B1 (en) 1993-07-28
ES2058795T3 (es) 1994-11-01
FI902291A7 (fi) 1990-11-10
AU5476790A (en) 1990-11-15

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