PT93979A - Processo para a preparacao de guanidinas heterociclicas - Google Patents

Processo para a preparacao de guanidinas heterociclicas

Info

Publication number: PT93979A
Authority: PT; Portugal
Prior art keywords: methyl; carbon atoms; indol; hydrogen; guanidins
Prior art date: 1989-05-19

Application number

PT199093979A

Other languages

English (en)

Other versions

PT93979B (pt

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-19

Filing date

1990-05-08

Publication date

1991-01-08

1990-05-08 Application filed filed Critical

1991-01-08 Publication of PT93979A publication Critical patent/PT93979A/pt

1996-11-29 Publication of PT93979B publication Critical patent/PT93979B/pt

Links

-1 2-methyl-indol-3-yl Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
206010028813 Nausea Diseases 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 abstract 1
125000000842 isoxazolyl group Chemical group 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
230000008693 nausea Effects 0.000 abstract 1
230000036407 pain Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Pyridine Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT93979A 1989-05-19 1990-05-08 Processo para a preparacao de guanidinas heterociclicas PT93979B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/349,189 US4963689A (en)	1989-05-19	1989-05-19	Heterocyclicguanidines as 5HT3 antagonists

Publications (2)

Publication Number	Publication Date
PT93979A true PT93979A (pt)	1991-01-08
PT93979B PT93979B (pt)	1996-11-29

Family

ID=23371270

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT93979A PT93979B (pt)	1989-05-19	1990-05-08	Processo para a preparacao de guanidinas heterociclicas

Country Status (19)

Country	Link
US (1)	US4963689A (pt)
EP (1)	EP0397364B1 (pt)
JP (1)	JPH0635454B2 (pt)
KR (1)	KR920003927B1 (pt)
AT (1)	ATE92062T1 (pt)
AU (1)	AU615385B2 (pt)
CA (1)	CA2016182C (pt)
DE (1)	DE69002384T2 (pt)
DK (1)	DK0397364T3 (pt)
ES (1)	ES2058795T3 (pt)
FI (1)	FI902291A7 (pt)
HU (1)	HUT58063A (pt)
IE (1)	IE62935B1 (pt)
IL (1)	IL94254A (pt)
MY (1)	MY105555A (pt)
NO (1)	NO902029L (pt)
NZ (1)	NZ233576A (pt)
PT (1)	PT93979B (pt)
ZA (1)	ZA903478B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5140034A (en) *	1989-03-14	1992-08-18	Merck Sharp & Dohme Ltd.	Five-membered ring systems with bonded imidazolyl ring substituents
JP2776984B2 (ja) *	1992-09-14	1998-07-16	山之内製薬株式会社	新規な縮合チアゾール誘導体，その製造法及びその医薬組成物
MX9603998A (es) *	1994-03-11	1997-12-31	Yamanouchi Pharma Co Ltd	Agonista receptor de 5-ht3, derivado de tiazol novedoso e intermediario del mismo.
GB9406857D0 (en) *	1994-04-07	1994-06-01	Sandoz Ltd	Improvements in or relating to organic compounds
US5887415A (en) *	1995-05-11	1999-03-30	Bernard Matthews Plc	Cooked, extruded meat product comprising additive
US5811425A (en) *	1997-03-04	1998-09-22	Abbott Laboratories	Heterocyclic compounds as COX-2 inhibitors
DE102005027193A1 (de) *	2005-06-06	2006-12-07	Wilhelm Stahlecker Gmbh	Zwillingseinheit mit zwei Streckwerken für eine Spinnmaschine
EP2253316B1 (en)	2009-05-20	2013-08-14	INSERM (Institut National de la Santé et de la Recherche Médicale)	Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
ES2664599T3 (es)	2009-05-20	2018-04-20	INSERM (Institut National de la Santé et de la Recherche Médicale)	Antagonistas del receptor 5-HT3 de serotonina para uso en el tratamiento de trastornos vestibulares lesionales
WO2014078568A1 (en)	2012-11-14	2014-05-22	The Johns Hopkins University	Methods and compositions for treating schizophrenia

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1031165A (en) *	1965-08-18	1966-05-25	Wellcome Found	Guanidines, isoureas and isothioureas
GB1305549A (pt) *	1969-10-29	1973-02-07
DE2739723A1 (de) *	1977-09-03	1979-03-08	Merck Patent Gmbh	2-guanidinomethyl-indoline und verfahren zu ihrer herstellung
US4220654A (en) *	1979-06-04	1980-09-02	Merck & Co., Inc.	Cyclic imidazole cyanoguanidines
US4563527A (en) *	1984-07-19	1986-01-07	Torii & Co., Ltd.	Amidine compounds

1989
- 1989-05-19 US US07/349,189 patent/US4963689A/en not_active Expired - Lifetime
1990
- 1990-04-30 EP EP90304684A patent/EP0397364B1/en not_active Expired - Lifetime
- 1990-04-30 ES ES90304684T patent/ES2058795T3/es not_active Expired - Lifetime
- 1990-04-30 DK DK90304684.5T patent/DK0397364T3/da active
- 1990-04-30 DE DE90304684T patent/DE69002384T2/de not_active Expired - Fee Related
- 1990-04-30 AT AT90304684T patent/ATE92062T1/de not_active IP Right Cessation
- 1990-05-02 IL IL9425490A patent/IL94254A/en not_active IP Right Cessation
- 1990-05-07 MY MYPI90000733A patent/MY105555A/en unknown
- 1990-05-07 NZ NZ233576A patent/NZ233576A/en unknown
- 1990-05-07 CA CA002016182A patent/CA2016182C/en not_active Expired - Fee Related
- 1990-05-07 AU AU54767/90A patent/AU615385B2/en not_active Ceased
- 1990-05-08 FI FI902291A patent/FI902291A7/fi not_active IP Right Cessation
- 1990-05-08 ZA ZA903478A patent/ZA903478B/xx unknown
- 1990-05-08 IE IE166490A patent/IE62935B1/en not_active IP Right Cessation
- 1990-05-08 NO NO90902029A patent/NO902029L/no unknown
- 1990-05-08 KR KR1019900006421A patent/KR920003927B1/ko not_active Expired
- 1990-05-08 PT PT93979A patent/PT93979B/pt not_active IP Right Cessation
- 1990-05-09 JP JP2119635A patent/JPH0635454B2/ja not_active Expired - Lifetime
- 1990-05-09 HU HU902976A patent/HUT58063A/hu unknown

Also Published As

Publication number	Publication date
IL94254A (en)	1994-05-30
US4963689A (en)	1990-10-16
KR900018054A (ko)	1990-12-20
HU902976D0 (en)	1990-09-28
PT93979B (pt)	1996-11-29
NO902029L (no)	1990-11-12
IE901664L (en)	1990-11-09
DE69002384D1 (de)	1993-09-02
ZA903478B (en)	1991-12-24
EP0397364A1 (en)	1990-11-14
DE69002384T2 (de)	1993-11-18
KR920003927B1 (ko)	1992-05-18
CA2016182A1 (en)	1990-11-09
DK0397364T3 (da)	1993-09-27
CA2016182C (en)	1996-03-12
NZ233576A (en)	1991-06-25
FI902291A0 (fi)	1990-05-08
AU615385B2 (en)	1991-09-26
HUT58063A (en)	1992-01-28
JPH0635454B2 (ja)	1994-05-11
MY105555A (en)	1994-10-31
NO902029D0 (no)	1990-05-08
ATE92062T1 (de)	1993-08-15
IE62935B1 (en)	1995-03-08
JPH0311070A (ja)	1991-01-18
EP0397364B1 (en)	1993-07-28
ES2058795T3 (es)	1994-11-01
FI902291A7 (fi)	1990-11-10
AU5476790A (en)	1990-11-15

Legal Events

Date

Code

Title

Description

1996-11-29

FG3A

Patent granted, date of granting

Effective date: 19960829

2000-06-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20000229

Publication	Publication Date	Title
CA2084193A1 (en)	1991-12-02	3-amino-2-aryl quinuclidines
ATE282614T1 (de)	2004-12-15	Phenylharnstoff und phenylthioharnstoffderivate
CA2124206A1 (en)	1993-06-10	Indole derivatives
ATE88182T1 (de)	1993-04-15	Antidepressive n-substitierte nikotinamidverbindungen.
IL190780A0 (en)	2008-11-03	Heterocyclic substituted aminoazacycles useful as central nervous system agents
ECSP045359A (es)	2005-01-03	Isoxazolinas 5 metiloximetil sustituidas por 3-heteroarilo utilizadas con herbicidas
FI902292A0 (fi)	1990-05-08	Menetelmä terapeuttisesti käyttökelpoisten aryylitiatsolyylimetyyli-imidatsolien valmistamiseksi
DK0397364T3 (da)	1993-09-27	Heterocycliske guandiner som 5HT3-antagonister
SE0201937D0 (sv)	2002-06-20	Therapeutic agents
DK152090D0 (da)	1990-06-22	Piperidylsubstituerede indolderivater
FR2683819B1 (fr)	1994-02-11	Derives de quinoleine, leur procede de preparation et leur application en therapeutique.
ATE13885T1 (de)	1985-07-15	Phenylpiperazinderivate von hetarylphenolen und hetarylanilinen, ihre herstellung und diese enthaltende therapeutische mittel.
ES2088567T3 (es)	1996-08-16	Empleo de derivados de la 2-iminotioazolidin-4-ona como nuevos productos activos para medicamentos.
KR940009186A (ko)	1994-05-20	이미다조피리딘
NO903230D0 (no)	1990-07-19	Fremgangsmaate for fremstilling av benzoksazolon-derivater.
KR910016694A (ko)	1991-11-05	티오카르바모일아세토니트릴 화합물