DK0405370T4 - Riboflavinoverproducerende bakteriestammer - Google Patents

Riboflavinoverproducerende bakteriestammer

Info

Publication number: DK0405370T4
Authority: DK; Denmark
Prior art keywords: riboflavin; bacteria; rib operon; bacterial strains; deregulated
Prior art date: 1989-06-22

Application number

DK90111916T

Other languages

English (en)

Other versions

DK0405370T3 (da

Inventor

John B Perkins

Janice G Pero

Alan Sloma

Original Assignee

Dsm Ip Assets Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-22

Filing date

1990-06-22

Publication date

2008-04-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23459380&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0405370(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-06-22 Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv

2000-12-27 Application granted granted Critical

2000-12-27 Publication of DK0405370T3 publication Critical patent/DK0405370T3/da

2008-04-28 Publication of DK0405370T4 publication Critical patent/DK0405370T4/da

Links

AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 title abstract 8
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 title abstract 4
229960002477 riboflavin Drugs 0.000 title abstract 4
235000019192 riboflavin Nutrition 0.000 title abstract 4
239000002151 riboflavin Substances 0.000 title abstract 4
230000001580 bacterial effect Effects 0.000 title 1
241000894006 Bacteria Species 0.000 abstract 4
230000002074 deregulated effect Effects 0.000 abstract 2
108700026244 Open Reading Frames Proteins 0.000 abstract 1
239000013611 chromosomal DNA Substances 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
150000003212 purines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

DK90111916T 1989-06-22 1990-06-22 Riboflavinoverproducerende bakteriestammer DK0405370T4 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US37037889A	1989-06-22	1989-06-22

Publications (2)

Publication Number	Publication Date
DK0405370T3 DK0405370T3 (da)	2000-12-27
DK0405370T4 true DK0405370T4 (da)	2008-04-28

Family

ID=23459380

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90111916T DK0405370T4 (da)	1989-06-22	1990-06-22	Riboflavinoverproducerende bakteriestammer

Country Status (6)

Country	Link
EP (2)	EP0405370B2 (da)
JP (2)	JP3149175B2 (da)
CN (1)	CN1066486C (da)
AT (1)	ATE195971T1 (da)
DE (1)	DE69033616T3 (da)
DK (1)	DK0405370T4 (da)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE59310239D1 (de) *	1992-05-11	2002-01-10	Basf Ag	DNA-Verbindungen und rekombinante, die Ribloflavinsynthetaseaktivität von S. cerevisiae codierende DNA-Expressionsvektoren
DE4238904A1 (de) *	1992-11-19	1994-05-26	Basf Ag	Riboflavin-Synthese in Hefen
JPH06225776A (ja) *	1992-12-07	1994-08-16	Kyowa Hakko Kogyo Co Ltd	リボフラビンの製造法
DK0751995T3 (da) *	1994-03-25	2004-03-08	Basf Ag	Riboflavin-biosyntese i svampe
ES2160829T3 (es) *	1995-07-13	2001-11-16	Basf Ag	Procedimiento para la obtencion de riboflavina por medio de microorganismos con actividad de isocitratoliasa modificada.
DE19545468A1 (de) *	1995-12-06	1997-08-21	Forschungszentrum Juelich Gmbh	Verfahren zur Herstellung von Riboflavin mittels Mikroorganismen mit erhöhter Isocitratlyase-Aktivität
US5925354A (en) *	1995-11-30	1999-07-20	Michigan State University	Riboflavin mutants as vaccines against Actinobacillus pleuropneumoniae
US6448036B1 (en)	1996-02-20	2002-09-10	Smithkline Beecham Corporation	ribB
US5976840A (en) *	1997-04-18	1999-11-02	Smithkline Beecham Corporation	Polynucleotides encoding gluS polypeptides of streptococcal pneumoniae
JPH1084978A (ja)	1996-07-24	1998-04-07	F Hoffmann La Roche Ag	改良されたリボフラビン生産
WO1998006734A1 (en) *	1996-08-16	1998-02-19	Smithkline Beecham Corporation	Novel prokaryotic polynucleotides, polypeptides and their uses
US6252044B1 (en) *	1996-08-16	2001-06-26	Smithkline Beecham Corporation	Ribb
US6335424B1 (en) *	1996-08-16	2002-01-01	Smithkline Beecham Corporation	ribG
ES2227759T3 (es) *	1997-12-04	2005-04-01	Dsm Ip Assets B.V.	Glucosidos de roboflavina.
DE19840709A1 (de) *	1997-12-22	1999-06-24	Forschungszentrum Juelich Gmbh	Ein- oder mehrzellige Organismen zur Herstellung von Riboflavin
EP0927761A3 (de)	1997-12-23	2001-09-05	Basf Aktiengesellschaft	Gene der Purinbiosyntese aus Ashbya gossypii und deren Verwendung in der mikrobiellen Riboflavinsynthese
DE19823834A1 (de) *	1998-05-28	1999-12-02	Basf Ag	Genetisches Verfahren zur Herstellung von Riboflavin
US6720174B1 (en)	1999-01-28	2004-04-13	Novozymes A/S	Phytases
DE19937548A1 (de) *	1999-08-09	2001-03-29	Forschungszentrum Juelich Gmbh	Ein- oder mehrzellige Organismen zur Herstellung von Riboflavin
US6656721B1 (en) *	2000-08-08	2003-12-02	Roche Vitamins, Inc.	Polynucleotide portions of the biotin operon from B. subtilis for use in enhanced fermentation
DE10159396A1 (de) *	2001-12-04	2003-06-12	Basf Ag	Genetische Stammoptimierung zur verbesserten Herstellung von Riboflavin
DE60336712D1 (de)	2002-02-27	2011-05-26	Dsm Ip Assets Bv	Fermentationsverfahren
KR100422305B1 (ko) *	2002-12-05	2004-03-10	씨제이 주식회사	리보플라빈을 생산하는 미생물 및 이를 이용한리보플라빈의 생산방법
KR100422307B1 (ko)	2002-12-05	2004-03-10	씨제이 주식회사	리보플라빈을 생산하는 미생물 및 이를 이용한리보플라빈의 생산방법
EP2186880A1 (en) *	2008-11-07	2010-05-19	DSM IP Assets B.V.	Improved production of riboflavin
DE102008063234B4 (de)	2008-12-15	2011-06-22	Insilico Biotechnology AG, 70569	Biotechnologische Herstellung von Riboflavin mit hoher Ausbeute
KR101335853B1 (ko) *	2011-12-01	2013-12-02	씨제이제일제당 (주)	Ｌ-아미노산 및 리보플라빈을 동시에 생산하는 미생물 및 이를 이용한 ｌ-아미노산 및 리보플라빈을 생산하는 방법
CN103865944B (zh) *	2014-02-20	2016-01-20	天津大学	一种生产核黄素的大肠杆菌菌株及构建方法及用途
KR102561864B1 (ko) *	2014-11-19	2023-08-01	바스프 에스이	Rib７ 프로모터를 사용하여 유전자 발현을 하향조절하기 위한 에레모테시움의 유전적 변형
CN108277189A (zh) *	2017-01-05	2018-07-13	上海创诺医药集团有限公司	一种生产核黄素的工程菌株及其应用
JP7497348B2 (ja)	2018-11-15	2024-06-10	ディーエスエムアイピーアセッツビー．ブイ．	リボフラビンの改善された産生
US20230235375A1 (en)	2020-06-23	2023-07-27	Dsm Ip Assets B.V.	Fermentation process
CN113462704B (zh) *	2021-06-22	2022-07-05	武汉大学	一种植物细胞分裂素狭霉素的生物合成基因簇及其生物材料以及在合成狭霉素中的应用
CN113801910A (zh) *	2021-08-30	2021-12-17	湖北广济药业股份有限公司	一种纯天然核黄素的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH668081A5 (de) *	1983-06-02	1988-11-30	Vnii Genetiki Selek	Verfahren zur herstellung von riboflavin.
DE3483599D1 (de) *	1983-09-09	1990-12-20	Daicel Chem	Verfahren zur herstellung von riboflavin.
FR2556408B1 (fr) *	1983-12-07	1986-09-05	Schlumberger Cie Dowell	Nouvelles applications du scleroglucane dans le domaine du traitement des puits d'hydrocarbures comme fluide de fracturation
EP0190921A3 (en) *	1985-02-04	1988-01-13	Engenics, Inc.	Method for the overproduction of amino acids
FI870103A7 (fi) *	1986-01-13	1987-08-01	Genex Corp	Ihmisen seerumin albumiinin tuottaminen Bacillus-kannassa.
EP0273040B1 (en) *	1986-03-26	1994-06-22	GX BioSystems A/S	Biological containment

1990
- 1990-06-21 CN CN90104934A patent/CN1066486C/zh not_active Expired - Lifetime
- 1990-06-22 DE DE69033616T patent/DE69033616T3/de not_active Expired - Fee Related
- 1990-06-22 DK DK90111916T patent/DK0405370T4/da active
- 1990-06-22 JP JP16546990A patent/JP3149175B2/ja not_active Expired - Fee Related
- 1990-06-22 EP EP90111916A patent/EP0405370B2/en not_active Expired - Lifetime
- 1990-06-22 AT AT90111916T patent/ATE195971T1/de not_active IP Right Cessation
- 1990-06-22 EP EP99124888A patent/EP1001026A3/en not_active Withdrawn
1997
- 1997-07-17 JP JP9192766A patent/JPH1066562A/ja active Pending

Also Published As

Publication number	Publication date
DE69033616T2 (de)	2001-04-26
JPH03117489A (ja)	1991-05-20
EP1001026A3 (en)	2000-06-14
CN1066486C (zh)	2001-05-30
JP3149175B2 (ja)	2001-03-26
DE69033616T3 (de)	2008-07-03
DE69033616D1 (de)	2000-10-05
EP0405370A1 (en)	1991-01-02
EP1001026A2 (en)	2000-05-17
JPH1066562A (ja)	1998-03-10
EP0405370B2 (en)	2007-12-19
ATE195971T1 (de)	2000-09-15
CN1049185A (zh)	1991-02-13
DK0405370T3 (da)	2000-12-27
EP0405370B1 (en)	2000-08-30

Publication	Publication Date	Title
DK0405370T4 (da)	2008-04-28	Riboflavinoverproducerende bakteriestammer
ATE293165T1 (de)	2005-04-15	Mikroorganismen und verfahren zur fermentativen herstellung von l-cystein, l-cystin, n-acetyl- serin oder thiazolindinderivaten
HUP9702361A2 (hu)	1999-06-28	Eljárás L-lizin előállítására
KR930018036A (ko)	1993-09-21	발효에 의한 아미노산 제조방법
GB9107846D0 (en)	1991-05-29	Polypeptides
DK0563169T3 (da)	1998-05-18	Enzymmutanter med lille variation i molekylær ladning i et pH område
ATE247167T1 (de)	2003-08-15	Methode zur kontrollierten herstellung von polypeptiden in bakterien
IL78197A (en)	1991-07-18	Nucleic acid encoding tgf-beta and its uses
NO964754L (no)	1997-01-08	DNA-kjede anvendelig i ökning av karotenoid utbytte
DE3268340D1 (en)	1986-02-20	A process for cloning the gene coding for a thermostable alpha-amylase into escherichia coli and bacillus subtilis
DE3789766D1 (de)	1994-06-09	Verwendung von bakteriellen luciferase strukturellen genen zum klonieren und zur steuerung der genexpression in mikroorganismen, sowie zur etikettierung und identifizierung von genetisch gebildeten organismen.
HU0004877D0 (da)	2001-02-28
KR850005494A (ko)	1985-08-26	L-세린 디아미나아제 활동도가 결여된 돌연변이체 속
ATE161880T1 (de)	1998-01-15	Biokontrolle von mikrobiellen pathogenen
EP0529653A3 (en)	1994-07-06	Microbiological process for the preparation of 6-hydroxy pyrazinoic acid
DK251385A (da)	1985-12-07	Kultur af bacillus subtilis mutant og fremgangsmaade til fremstilling deraf samt fremgangsmaade til anvendelse deraf
DE69231145D1 (de)	2000-07-13	Für eine Esterase kodierendes Gen und dieses Gen enthaltender Mikroorganismus
ATE243256T1 (de)	2003-07-15	Fermentative herstellung von biotin
GB1085588A (en)	1967-10-04	The production of diaminopimelic acid by fermentation
ATE105337T1 (de)	1994-05-15	Verwendung von bakteriellen luciferase strukturellen genen zum klonieren und zur steuerung der genexpression in mikroorganismen, sowie zur etikettierung und identifizierung von genetisch gebildeten organismen.
KR870005087A (ko)	1987-06-04	코리네형균, 대장균, 고초균간의 셔틀벡터의 제조방법
JPS6460393A (en)	1989-03-07	Production of l-threonine by fermentation
IT1258351B (it)	1996-02-26	Nuovi costrutti di dna modulati dalla temperatura per la produzione controllata di proteine ricombinati, microorganismi modificati che li contengono e procedimenti che usano questi microorganismi.
ES441307A1 (es)	1976-08-16	Procedimiento para la produccion a escala industrial de l- lisina.