DK0408295T3 - Fremgangsmåder til opformering af nukleinsyresekvenser - Google Patents

Fremgangsmåder til opformering af nukleinsyresekvenser

Info

Publication number
DK0408295T3
DK0408295T3 DK90307503.4T DK90307503T DK0408295T3 DK 0408295 T3 DK0408295 T3 DK 0408295T3 DK 90307503 T DK90307503 T DK 90307503T DK 0408295 T3 DK0408295 T3 DK 0408295T3
Authority
DK
Denmark
Prior art keywords
nucleic acid
methods
copies
acid sequences
disclosed
Prior art date
Application number
DK90307503.4T
Other languages
Danish (da)
English (en)
Inventor
Daniel Louis Kacian
Timothy J Fultz
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Application granted granted Critical
Publication of DK0408295T3 publication Critical patent/DK0408295T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK90307503.4T 1989-07-11 1990-07-10 Fremgangsmåder til opformering af nukleinsyresekvenser DK0408295T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37950189A 1989-07-11 1989-07-11

Publications (1)

Publication Number Publication Date
DK0408295T3 true DK0408295T3 (da) 1996-09-16

Family

ID=23497522

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90307503.4T DK0408295T3 (da) 1989-07-11 1990-07-10 Fremgangsmåder til opformering af nukleinsyresekvenser

Country Status (15)

Country Link
US (1) US5480784A (fr)
EP (3) EP0731175A3 (fr)
JP (4) JP3241717B2 (fr)
KR (1) KR100242252B1 (fr)
AT (2) ATE141956T1 (fr)
AU (2) AU650622B2 (fr)
DE (2) DE69034177T2 (fr)
DK (1) DK0408295T3 (fr)
ES (1) ES2091225T3 (fr)
FI (1) FI911152A7 (fr)
GR (1) GR3021704T3 (fr)
IE (1) IE902539A1 (fr)
NO (1) NO910902D0 (fr)
PT (1) PT94662A (fr)
WO (1) WO1991001384A1 (fr)

Families Citing this family (295)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817797A (en) * 1988-06-01 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services Sequencing DNA; a modification of the polymerase chain reaction
US5856088A (en) * 1989-07-11 1999-01-05 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
US6589734B1 (en) * 1989-07-11 2003-07-08 Gen-Probe Incorporated Detection of HIV
US5780219A (en) * 1989-07-11 1998-07-14 Gen-Probe Incorporated Nucleic acid amplification oligonucleotides and probes to human hepatitis B virus
US7009041B1 (en) 1989-07-11 2006-03-07 Gen-Probe Incorporated Oligonucleotides for nucleic acid amplification and for the detection of Mycobacterium tuberculosis
US5766849A (en) * 1989-07-11 1998-06-16 Gen-Probe Incorporated Methods of amplifying nucleic acids using promoter-containing primer sequence
CA2020958C (fr) * 1989-07-11 2005-01-11 Daniel L. Kacian Methodes d'amplification de sequences d'acide nucleique
ZA918965B (en) * 1990-11-13 1992-08-26 Siska Diagnostics Inc Nucleic acid amplification by two-enzyme,self-sustained sequence replication
KR100231383B1 (ko) 1990-12-31 1999-11-15 랜들 엘. 다이어몬드 Rna 레플리카제의 dna-의존성 rna 폴리머라제 활성을 이용한 핵산 증폭
DE4106473C2 (de) * 1991-03-01 1994-03-10 Boehringer Mannheim Gmbh Verfahren zur Herstellung in vitro replizierbarer Nukleinsäuren
AU2663292A (en) * 1991-09-10 1993-04-05 Jack D. Love Dna/rna target and signal amplification
DE4213029A1 (de) * 1991-09-26 1993-04-01 Boehringer Mannheim Gmbh Verfahren zur spezifischen vervielfaeltigung von nukleins aeuresequenzen
US6100099A (en) 1994-09-06 2000-08-08 Abbott Laboratories Test strip having a diagonal array of capture spots
US6093538A (en) * 1992-05-06 2000-07-25 Gen-Probe Incorporated Nucleic acid probes to ureaplasma
JPH07506254A (ja) * 1992-05-06 1995-07-13 ジェン−プローブ・インコーポレイテッド ヒトｂ型肝炎ウイルスに対する核酸増幅オリゴヌクレオチドおよびプローブ
JP4137996B2 (ja) * 1992-05-06 2008-08-20 ジェン−プローブ・インコーポレイテッド 核酸配列増幅方法，組成物及びキット
WO1993025710A1 (fr) * 1992-06-08 1993-12-23 Gen-Probe Incorporated Preparation d'acide nucleique a partir de cellules mononucleaires
US5612200A (en) * 1992-06-24 1997-03-18 Gen-Probe Incorporated Method and kit for destroying ability of nucleic acid to be amplified
CA2141430C (fr) * 1992-08-04 2009-05-12 Sherrol H. Mcdonough Amplification d'une sequence d'acide nucleique
DE4238699A1 (de) * 1992-11-17 1994-05-19 Boehringer Mannheim Gmbh Einfaches Nukleinsäurevermehrungsverfahren
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
WO1994023069A1 (fr) 1993-03-26 1994-10-13 Gen-Probe Incorporated Detection du virus de type 1 de l'immunodeficience humaine
WO1995003430A1 (fr) * 1993-07-23 1995-02-02 Gen-Probe Incorporated Procede d'amelioration de l'amplification de l'acide nucleique
FR2708288B1 (fr) * 1993-07-26 1995-09-01 Bio Merieux Procédé d'amplification d'acides nucléiques par transcription utilisant le déplacement, réactifs et nécessaire pour la mise en Óoeuvre de ce procédé.
US5459037A (en) * 1993-11-12 1995-10-17 The Scripps Research Institute Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations
EP1251182A3 (fr) * 1993-12-01 2002-11-27 Toyo Boseki Kabushiki Kaisha Procédé d'amplification et de détection d'une séquence nucléotidique au moyen d'enzymes thermostables
WO1995025180A1 (fr) * 1994-03-16 1995-09-21 Gen-Probe Incorporated Amplification d'acide nucleique par deplacement de la souche isotherme
DE69524105T2 (de) * 1994-07-15 2002-07-18 Organon Teknika B.V., Boxtel Verwendung von rna-polymerase zur verbesserung von nukeinsaeure-amplifikationsverfahren
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
EP0709466B1 (fr) * 1994-10-28 2006-09-27 Gen-Probe Incorporated Compositions et procédés pour la détection et quantification simultanée de plusieurs séquences d'acide nucléique
DE4441602A1 (de) * 1994-11-23 1996-05-30 Boehringer Mannheim Gmbh Verbessertes Transkriptionsverfahren
US5652126A (en) * 1995-06-07 1997-07-29 Gen-Probe Incorporated Use of restriction endonuclease sequences for cleaving phosphorothioate oligonucleotides
US5932450A (en) * 1995-06-07 1999-08-03 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using digestible templates
US5739311A (en) * 1995-06-07 1998-04-14 Gen-Probe Incorporated Enzymatic synthesis of phosphorothioate oligonucleotides using restriction endonucleases
US5916777A (en) * 1995-06-07 1999-06-29 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers
JP2000505312A (ja) * 1996-03-18 2000-05-09 モレキュラー バイオロジー リソーシーズ，インコーポレイテッド 標的核酸配列増幅
WO1997044488A2 (fr) 1996-05-22 1997-11-27 Gen-Probe Incorporated Compositions et procedes de detection de mycobacterium kansasii
AU3276497A (en) 1996-06-28 1998-01-21 Chugai Seiyaku Kabushiki Kaisha Method for detecting telomerase activity
JPH1028585A (ja) * 1996-07-16 1998-02-03 Toyobo Co Ltd 耐熱性リボヌクレアーゼｈを用いる核酸増幅法
US6537783B1 (en) 1996-08-02 2003-03-25 Bio Merieux Prefunctionalized nucleotide and process for amplifying a sequence using a prefunctionalized nucleotide
DE69738206T2 (de) * 1996-11-06 2008-07-17 Sequenom, Inc., San Diego DNA-Diagnostik mittels Massenspektrometrie
US5962665A (en) 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
US6849400B1 (en) 1997-07-23 2005-02-01 Gen-Probe Incorporated Methods for detecting and measuring spliced nucleic acids
US7098025B1 (en) 1997-07-25 2006-08-29 Ligand Pharmaceuticals Incorporated Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor
ES2479065T3 (es) 1997-08-08 2014-07-23 Biomérieux Bv Métodos de uso de secuencias de ácido nucleico como cebadores y sondas en la amplificación y detección de todos los subtipos de VIH-1
AU741141B2 (en) 1997-11-04 2001-11-22 Roche Diagnostics Gmbh Specific and sensitive method for detecting nucleic acids
JP3736617B2 (ja) * 1997-12-12 2006-01-18 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 細胞型の決定方法
US20040002079A1 (en) * 1998-02-11 2004-01-01 Gunn Robert B. Sodium-phosphate cotransporter in lithium therapy for the treatment of mental illness
DE69900592T2 (de) * 1998-02-27 2002-08-22 Pamgene B.V., Den Bosch Verfahren zur unspezifischen amplifizierung einer nukleinsäure
DE10011529T1 (de) * 1998-05-01 2011-09-01 Gen-Probe Incorporated Automatisches Diagnoseanalysegerät und Verfahren
ATE269417T1 (de) * 1998-07-23 2004-07-15 Gen Probe Inc Verfahren zur erkennung und messung von gespleisten nukleinsäuren
ATE330031T1 (de) 1998-07-31 2006-07-15 Gen Probe Inc Reversibel inhibierende sonden
US20030049657A1 (en) * 1998-11-13 2003-03-13 Cherry Joshua L. Use of primers containing non-replicatable residues for improved cycle-sequencing of nucleic acids
AU781570B2 (en) 1999-07-23 2005-06-02 Gen-Probe Incorporated Polynucleotide amplification method
GB9917816D0 (en) * 1999-07-29 1999-09-29 Cytocell Ltd Chemically modified probes used to regulate nucleic acid amplification assays
US6692918B2 (en) * 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
MXPA02002656A (es) 1999-09-13 2003-10-14 Nugen Technologies Inc Metodos y composiciones para la ampliacion lineal isotermica de secuencias de polinucleotidos.
US6582938B1 (en) 2001-05-11 2003-06-24 Affymetrix, Inc. Amplification of nucleic acids
AU2001254670A1 (en) * 2000-03-02 2001-09-12 Akzo Nobel N.V. Detection of hepatitis b virus rna
US7220832B2 (en) 2000-03-31 2007-05-22 Merck & Co., Inc Dermacentor variabilis GABA-gated chloride channels
US6534292B1 (en) 2000-05-08 2003-03-18 Genencor International, Inc. Methods for forming recombined nucleic acids
EP1356094B1 (fr) * 2000-06-26 2010-01-13 Nugen Technologies, Inc. Procedes et compositions permettant l'amplification d'acide nucleique fondee sur la transcription
US7846733B2 (en) * 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
DE60045932D1 (de) 2000-09-01 2011-06-16 Gen Probe Inc HIV-1-Sequenzverstärkung zur Erkennung von Sequenzen in Zusammenhang mit Wirkstoffresistenz-Mutationen
CA2423729A1 (fr) 2000-10-06 2002-04-11 Nugen Technologies, Inc. Procedes et sondes pour la detection et/ou la quantification de sequences d'acides nucleiques
WO2002048402A2 (fr) 2000-12-13 2002-06-20 Nugen Technologies, Inc. Methodes et compositions de generation de copies multiples de sequences d'acides nucleiques et methodes de detection correspondantes
US6794141B2 (en) 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
US6770752B2 (en) 2001-01-09 2004-08-03 Becton, Dickinson And Company Sequences for detection of HIV-1
CA2439795A1 (fr) * 2001-03-07 2002-09-12 Biomerieux B.V. Procede d'amplification et de detection d'adn au moyen d'une amplification fondee sur la transcription
WO2002072773A2 (fr) * 2001-03-09 2002-09-19 Nugen Technologies, Inc. Methodes et compositions pour amplification de sequences d'arn
JP4542312B2 (ja) 2001-03-09 2010-09-15 ニューゲン テクノロジーズ， インコーポレイテッド Ｒｎａ配列の増幅のための方法および組成物
US7208282B2 (en) * 2001-05-31 2007-04-24 Merck & Co., Inc. Rhesus monkey, dog and ferret melanin-concentrating hormone type 2 receptor
US7074558B2 (en) * 2001-06-07 2006-07-11 Pbi Technology, Inc. Nucleic acid amplification using an RNA polymerase and DNA/RNA mixed polymer intermediate products
TWI335938B (en) * 2001-08-15 2011-01-11 Rna replication and amplification
US20050042629A1 (en) 2002-09-13 2005-02-24 Applera Corporation Thermus scotoductus nucleic acid polymerases
WO2003048309A2 (fr) 2001-11-30 2003-06-12 Applera Corporation Polymerases d'acides nucleiques provenant de thermus thermophilus
US7052877B2 (en) 2001-11-30 2006-05-30 Applera Corporation Thermus brockianus nucleic acid polymerases
KR100446621B1 (ko) * 2001-12-18 2004-09-07 삼성전자주식회사 다중 중합효소 연쇄반응에 의한 ｍｏｄｙ３유전자의 증폭을 위한 프라이머 세트
WO2003064679A2 (fr) * 2002-01-30 2003-08-07 Id Biomedical Corporation Procedes pour detecter des microorganismes resistant a la vancomycine et composition pour la mise en oeuvre dudit procede
WO2003078645A2 (fr) * 2002-03-11 2003-09-25 Nugen Technologies, Inc. Procedes d'obtention d'adn a double brin comprenant une portion 3' a simple brin, et utilisation de ces complexes a des fins de recombinaison
EP1485503A4 (fr) * 2002-03-15 2005-12-28 Arcturus Bioscience Inc Amplification amelioree d'acides nucleiques
CA2486283A1 (fr) * 2002-05-17 2004-02-05 Nugen Technologies, Inc. Procedes de fragmentation, d'etiquetage et d'immobilisation d'acides nucleiques
EP1513958B1 (fr) 2002-06-14 2011-08-10 Gen-Probe Incorporated Compositions de detection du virus de l'hepatite b
US7074561B2 (en) 2002-10-22 2006-07-11 Biomerieux, Inc. Isothermal amplification based assay for the detection and quantitation of alpha-fetoprotein mRNA
US6852494B2 (en) * 2003-01-10 2005-02-08 Linden Technologies, Inc. Nucleic acid amplification
JP2006523465A (ja) 2003-04-14 2006-10-19 ニューゲン テクノロジーズ， インコーポレイテッド ランダムにプライミングされる複合プライマーを用いる大規模増幅
ATE542917T1 (de) 2003-05-19 2012-02-15 Gen Probe Inc Zusammensetzungen, verfahren und kits zur bestimmung des vorhandenseins von trichomonas vaginalis in einer testprobe
US20050176125A1 (en) * 2003-12-23 2005-08-11 Rosetta Inpharmatics Llc Alternatively spliced isoform of CDC25A phosphatase and methods of use
WO2005065321A2 (fr) 2003-12-29 2005-07-21 Nugen Technologies, Inc. Methodes permettant d'analyser l'etat de methylation d'acides nucleiques et methodes permettant de fragmenter, de marquer et d'immobiliser des acides nucleiques
EP2383350B1 (fr) 2004-05-07 2018-07-11 Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Procédés de diagnostic ou traitement du cancer de la prostate au moyen du gène erg, seul ou en combinaison avec d'autres gènes sur ou sous-exprimés dans le cancer de la prostate
US20050266469A1 (en) * 2004-05-25 2005-12-01 Raymond Christopher K Alternatively spliced isoforms of checkpoint kinase 1 (CHK1)
US20060030036A1 (en) 2004-05-28 2006-02-09 Victor Joseph Chips for multiplex analyses
US7150969B2 (en) * 2004-06-04 2006-12-19 Rosetta Inpharmatics Llc Alternatively spliced isoform of acetyl-CoA carboxylase 2 (ACC2)
US20050277121A1 (en) 2004-06-11 2005-12-15 Ambion, Inc. Crude biological derivatives competent for nucleic acid detection
JP4658660B2 (ja) 2005-03-30 2011-03-23 株式会社日立ハイテクノロジーズ 核酸検出法
WO2006121773A2 (fr) 2005-05-06 2006-11-16 Gen-Probe Incorporated Compositions et analyses permettant de detecter des acides nucleiques des virus a et b de la grippe
KR101931899B1 (ko) 2005-05-09 2018-12-21 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
ES2357902T3 (es) 2005-05-13 2011-05-03 Wako Pure Chemical Industries, Ltd. Cebadores, sondas, procedimientos y usos de los mismos para la detección de mycobacteriium kansasii.
US7550264B2 (en) * 2005-06-10 2009-06-23 Datascope Investment Corporation Methods and kits for sense RNA synthesis
WO2007030759A2 (fr) * 2005-09-07 2007-03-15 Nugen Technologies, Inc. Procedure d'amplication d'acide nucleique amelioree
US9957569B2 (en) * 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
CA2814598A1 (fr) 2005-09-12 2007-03-22 The Regents Of The University Of Michigan Fusion geniques recurrentes dans le cancer de la prostate
EP1992689B1 (fr) 2006-02-15 2015-03-18 Tosoh Corporation Procédé d'extraction d'acide nucléique à partir d'un matériau biologique
ATE553220T1 (de) 2006-03-13 2012-04-15 Wako Pure Chem Ind Ltd Verfahren zur erkennung eines mutierten gens
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US8188256B2 (en) 2006-05-02 2012-05-29 Wako Pure Chemical Industries, Ltd. Primer and probe for detection of Mycobacterium intracellulare
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
EP1945821B1 (fr) 2006-06-06 2011-01-19 Gen-Probe Incorporated Oligonucléotides marqués et leur utilisation pour des procédés d'amplification d'acides nucléiques
US20100022403A1 (en) * 2006-06-30 2010-01-28 Nurith Kurn Methods for fragmentation and labeling of nucleic acids
US7501254B2 (en) 2006-07-20 2009-03-10 Ghc Technologies, Inc. Methods and compositions for amplification and capture of nucleic acid sequences
WO2008014485A2 (fr) 2006-07-28 2008-01-31 California Institute Of Technology Ensembles de pcr-q multiplex
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
EP2520935A3 (fr) 2006-08-09 2013-02-13 Homestead Clinical Corporation Protéines spécifiques d'organes et leurs procédés d'utilisation
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
EP1921156A1 (fr) * 2006-11-10 2008-05-14 bioMerieux B.V. Amplification multiplexe améliorée d'acides nucléiques au moyen d' amorces bloquées
EP2479273A3 (fr) 2006-12-18 2012-10-10 Wako Pure Chemical Industries, Ltd. Amorce et sonde pour la détection de Mycobacterium avium et procédé pour la détection de Mycobacterium avium les utilisant
EP3121286B1 (fr) 2006-12-21 2019-11-20 Gen-Probe Incorporated Procédés et compositions pour amplification d'acide nucléique
EP2108048A1 (fr) * 2007-01-17 2009-10-14 Meridian Bioscience, Inc. Reactifs stables et necessaires intervenant dans l'amplification isotherme induite par la boucle (lamp)
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
JP4340298B2 (ja) 2007-03-01 2009-10-07 株式会社日立ハイテクノロジーズ 核酸回収方法及び核酸回収装置
EP1978111B1 (fr) 2007-04-02 2013-03-27 Gen-Probe Incorporated Compositions, kits et procédés associés pour la détection et/ou la surveillance de Pseudomonas aeruginosa
JP2009000044A (ja) 2007-06-21 2009-01-08 Hitachi High-Technologies Corp 核酸増幅法
JP2009000063A (ja) 2007-06-22 2009-01-08 Tosoh Corp 改良されたノロウイルスｒｎａ検出方法
ES2376509T3 (es) * 2007-07-06 2012-03-14 The Regents Of The University Of Michigan Reordenamientos de genes mipol 1-etv1.
WO2009009432A2 (fr) 2007-07-06 2009-01-15 The Regents Of The University Of Michigan Fusions géniques récurrentes dans le cancer de la prostate
ES2447875T3 (es) 2007-10-02 2014-03-13 Theranos, Inc. Dispositivos modulares para punto de cuidados y usos de los mismos
EP2202305A4 (fr) 2007-10-04 2011-01-19 Tosoh Corp Amorce pour l'amplification de l'arnr d'une bactérie appartenant à l'espèce<i>legionella</i>, procédé de détection et coffret de détection
JP5299986B2 (ja) * 2007-11-01 2013-09-25 国立大学法人山口大学 核酸の定量方法
EP2657351B1 (fr) 2007-12-21 2018-06-20 Biomerieux Sa Détection de Staphylococcus aureus résistant à la méthicilline
US20100323365A1 (en) 2008-02-08 2010-12-23 Tomokazu Ishikawa Primer and probe for detecting chlamydophila caviae, as well as a chlamydophila caviae detection method using the same
US20090203531A1 (en) * 2008-02-12 2009-08-13 Nurith Kurn Method for Archiving and Clonal Expansion
GB2470672B (en) 2008-03-21 2012-09-12 Nugen Technologies Inc Methods of RNA amplification in the presence of DNA
US20090304714A1 (en) * 2008-03-25 2009-12-10 The Regents Of The University Of Michigan IKKi Inhibitor Therapies and Screening Methods, and Related IKKi Diagnostics
AU2009246363B2 (en) 2008-05-13 2013-10-24 Gen-Probe Incorporated Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
US10359424B2 (en) 2008-05-28 2019-07-23 Fujifilm Wako Pure Chemical Corporation Primer and probe for detection of Mycobacterium intracellulare, and method for detection of Mycobacterium intracellulare using the primer or the probe
EP2806054A1 (fr) 2008-05-28 2014-11-26 Genomedx Biosciences Inc. Systèmes et procédés de discrimination basés sur l'expression d'états pathologiques cliniques distincts dans le cancer de la prostate
AU2009262870B2 (en) 2008-05-30 2014-03-20 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Salmonella
EP2326957B1 (fr) * 2008-09-03 2013-06-12 Abbott Molecular Inc. Dosages et kits pour déterminer un tropisme du vih-1
EP2331703A2 (fr) * 2008-09-12 2011-06-15 Promega Corporation Determiner l'expression des genes endogenes et exogenes
JP5428272B2 (ja) 2008-10-06 2014-02-26 東ソー株式会社 サバイビンｍＲＮＡの測定方法
US8748133B2 (en) 2008-12-30 2014-06-10 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Listeria
EP2382328A2 (fr) 2009-01-09 2011-11-02 The Regents of the University of Michigan Fusions de gène récurrent dans le cancer
WO2010114842A1 (fr) 2009-03-30 2010-10-07 Ibis Biosciences, Inc. Systèmes, dispositifs et procédés de détection d'agent biologique
CA2768768C (fr) 2009-06-23 2021-08-24 Gen-Probe Incorporated Compositions et procedes pour detecter un acide nucleique a partir de mollicutes
EP2449132B1 (fr) 2009-07-01 2015-05-13 Gen-Probe Incorporated Procédés et compositions pour l'amplification d'acide nucléique
US20110059453A1 (en) * 2009-08-23 2011-03-10 Affymetrix, Inc. Poly(A) Tail Length Measurement by PCR
EP2473624B1 (fr) 2009-08-31 2019-05-01 Gen-Probe Incorporated Essai du virus de la dengue
CN102712953A (zh) * 2009-09-17 2012-10-03 密歇根大学董事会 前列腺癌中的复发性基因融合物
IN2012DN05145A (fr) 2009-11-19 2015-10-23 Solis Biodyne
EP2531515B1 (fr) 2010-01-22 2015-10-21 Gen-Probe Incorporated Sondes pour détecter la présence de trichomonas vaginalis dans un échantillon
CN102918155B (zh) 2010-03-23 2015-12-16 和光纯药工业株式会社 沙眼衣原体检测用引物和探针、以及使用该引物和探针的沙眼衣原体的检测方法
EP2561094B1 (fr) 2010-04-21 2017-03-29 Gen-Probe Incorporated Compositions, méthodes et kits permettant de détecter l'acide nucléique du virus de l'herpès simplex
US8980253B2 (en) 2010-04-26 2015-03-17 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
CA2797362C (fr) 2010-04-27 2020-12-08 Atyr Pharma, Inc. Decouverte innovante de compositions therapeutiques, de diagnostic et d'anticorps se rapportant a des fragments proteiques d'isoleucyl arnt synthetases
WO2011139853A2 (fr) 2010-04-28 2011-11-10 Atyr Pharma, Inc. Compositions thérapeutiques, diagnostiques et d'anticorps à base de fragments de protéines d'aminoacyl-arnt synthétases
CA2797374C (fr) 2010-04-29 2021-02-16 Pangu Biopharma Limited Decouverte innovante de compositions therapeutiques, diagnostiques et a based' anticorps associees a des fragments proteiques d'asparaginyl-arnt-synthetases
CA2797393C (fr) 2010-04-29 2020-03-10 Pangu Biopharma Limited Decouverte innovatrice de compositions therapeutiques, diagnostiques, et d'anticorps associees aux fragments proteiques des valyle arnt synthesases
US8961961B2 (en) 2010-05-03 2015-02-24 a Tyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases
CN103140233B (zh) 2010-05-03 2017-04-05 Atyr 医药公司 与甲硫氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
CN103096912A (zh) 2010-05-03 2013-05-08 Atyr医药公司 与苯丙氨酰-α-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
JP6008844B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ， インコーポレイテッド ｐ３８ＭＵＬＴＩ−ｔＲＮＡ合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
EP2568996B1 (fr) 2010-05-14 2017-10-04 aTyr Pharma, Inc. Compositions thérapeutique, diagnostique et à base d'anticorps contenant des fragments protéiques de phénylalanyl-bêta-arnt synthétases
CA2800375C (fr) 2010-05-27 2021-03-09 Atyr Pharma, Inc. Decouverte innovante de compositions therapeutiques, de diagnostic et d'anticorps liees a fragments proteiques de glutaminyl-arnt synthetases
EP2575857B1 (fr) 2010-06-01 2018-01-24 aTyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, diagnostiques, et d'anticorps associés à des fragments de protéine de lysyl-tarn synthétases
AU2011272868B2 (en) 2010-06-30 2015-09-17 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
EP2591363B1 (fr) 2010-07-07 2017-09-20 The Regents Of The University Of Michigan Diagnostic et traitement du cancer du sein
US9234249B2 (en) 2010-07-12 2016-01-12 Gen-Probe Incorporated Compositions and assays to detect swine H1N1 influenza A virus, seasonal H1 influenza A virus and seasonal H3 influenza A virus nucleic acids
EP2593125B1 (fr) 2010-07-12 2017-11-01 aTyr Pharma, Inc. DÉCOUVERTE INNOVANTE DE COMPOSITIONS THÉRAPEUTIQUES, DE DIAGNOSTIC ET D'ANTICORPS SE RAPPORTANT À DES FRAGMENTS PROTÉIQUES DE GLYCYL-ARNt SYNTHÉTASES
KR20130029128A (ko) 2010-07-23 2013-03-21 베크만 컬터, 인코포레이티드 실시간 pcr용 용기
AU2011293294B2 (en) 2010-08-25 2016-03-24 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases
EP3438289A1 (fr) 2010-10-04 2019-02-06 Gen-Probe Prodesse, Inc. Compositions, procédés et kits de détection d'acides nucléiques de l'adénovirus
EP2640854B1 (fr) 2010-11-19 2018-02-21 The Regents Of The University Of Michigan ARNnc PCAT1 ET UTILISATIONS DE CELUI-CI
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
US20130267443A1 (en) 2010-11-19 2013-10-10 The Regents Of The University Of Michigan ncRNA AND USES THEREOF
EP4024029A3 (fr) 2011-01-21 2022-09-14 Labrador Diagnostics LLC Systèmes et procédés de maximisation d'utilisation d'échantillon
US10245255B2 (en) 2011-02-14 2019-04-02 The Regents Of The University Of Michigan Compositions and methods for the treatment of obesity and related disorders
AU2012249751B2 (en) 2011-04-25 2016-11-03 Gen-Probe Incorporated Compositions and methods for detecting BV-associated bacterial nucleic acid
JP6040227B2 (ja) 2011-05-19 2016-12-07 アジーナ バイオサイエンス， インコーポレイテッド マルチプレックス核酸同定のための製品およびプロセス
EP3620533B1 (fr) 2011-09-06 2023-01-18 Gen-Probe Incorporated Structures d'acide nucléique fermée
EP2753714B1 (fr) 2011-09-06 2017-04-12 Gen-Probe Incorporated Gabarits mis sous forme circulaire pour séquençage
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
WO2013044097A1 (fr) 2011-09-21 2013-03-28 Gen-Probe Incorporated Procédés d'amplification d'acide nucléique à l'aide d'un déplacement à médiation par étiquette
EP2758510A4 (fr) 2011-09-25 2015-05-06 Theranos Inc Systèmes et procédés pour multi-analyse
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
FR2981088B1 (fr) 2011-10-06 2013-11-29 Biomerieux Sa Arn polymerases mutees
SG10201510189WA (en) 2011-10-19 2016-01-28 Nugen Technologies Inc Compositions And Methods For Directional Nucleic Acid Amplification And Sequencing
EP3848474A1 (fr) 2011-11-04 2021-07-14 Gen-Probe Incorporated Réactifs et procédés de dosage moléculaire
JP2014533100A (ja) 2011-11-04 2014-12-11 オスロ ウニヴェルスィテーツスィーケフース ハーエフＯｓｌｏ Ｕｎｉｖｅｒｓｉｔｅｔｓｓｙｋｅｈｕｓ Ｈｆ 結腸直腸癌の分析のための方法およびバイオマーカー
JP6062449B2 (ja) 2011-11-07 2017-01-18 ベックマン コールター， インコーポレイテッド 標本コンテナ検出
BR112014011044A2 (pt) 2011-11-07 2017-04-25 Beckman Coulter Inc amortecimento magnético para sistema de transporte de espécime
KR102040996B1 (ko) 2011-11-07 2019-11-05 베크만 컬터, 인코포레이티드 로봇식 아암
KR20140092375A (ko) 2011-11-07 2014-07-23 베크만 컬터, 인코포레이티드 원심분리기 시스템 및 작업 흐름
EP2776846B1 (fr) 2011-11-07 2019-08-21 Beckman Coulter, Inc. Système d'aliquote et flux de travail
BR112014010955A2 (pt) 2011-11-07 2017-06-06 Beckman Coulter Inc sistema e método para processar amostras
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
EP2795333A4 (fr) 2011-12-20 2016-02-17 Univ Michigan Pseudogènes et leurs applications
US9803188B2 (en) 2011-12-22 2017-10-31 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids
WO2013096799A1 (fr) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Systèmes et procédés d'isolement d'acides nucléiques à partir d'échantillons cellulaires
IN2014DN05831A (fr) 2011-12-23 2015-06-26 Biomerieux Sa
WO2013101935A1 (fr) 2011-12-27 2013-07-04 Ibis Biosciences, Inc. Oligonucléotides pour la détection d'agent biologique
AU2013208757A1 (en) 2012-01-09 2014-07-24 Oslo Universitetssykehus Hf Methods and biomarkers for analysis of colorectal cancer
EP4372084A3 (fr) 2012-01-26 2024-08-14 Tecan Genomics, Inc. Compositions et procédés pour l'enrichissement ciblé de séquences d'acides nucléiques et la génération de bibliothèques à haute efficacité
MX356107B (es) 2012-02-16 2018-05-15 Atyr Pharma Inc Histidil-arnt sintetasas para tratar enfermedades autoinmunes e inflamatorias.
US9506117B2 (en) 2012-02-21 2016-11-29 Oslo Universitetssykehus Hf Methods and biomarkers for detection and prognosis of cervical cancer
US20150111758A1 (en) 2012-03-06 2015-04-23 Oslo Universitetssykehus Hf Gene signatures associated with efficacy of postmastectomy radiotherapy in breast cancer
ES2716995T3 (es) 2012-04-03 2019-06-18 Univ Michigan Regents Biomarcadores asociados con el síndrome del intestino irritable y la enfermedad de Crohn
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
WO2013191775A2 (fr) 2012-06-18 2013-12-27 Nugen Technologies, Inc. Compositions et procédés pour la sélection négative de séquences d'acide nucléique indésirable
WO2014005076A2 (fr) 2012-06-29 2014-01-03 The Regents Of The University Of Michigan Procédés et biomarqueurs pour la détection de troubles rénaux
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
DK3435084T3 (da) 2012-08-16 2023-05-30 Mayo Found Medical Education & Res Prostatakræftprognose under anvendelse af biomarkører
SG11201501820TA (en) 2012-09-11 2015-04-29 Theranos Inc Information management systems and methods using a biological signature
WO2014051076A1 (fr) 2012-09-28 2014-04-03 株式会社Ｂｎａ Procédé de blocage d'acide nucléique ponté (bna - bridged nucleic acid)
MY167603A (en) 2012-10-04 2018-09-20 The Board Of Trustees Of Leland Stanford Junior Univ Method and reagents for detection, quantitation, and serotyping of dengue viruses
US20160046997A1 (en) 2012-10-18 2016-02-18 Oslo Universitetssykehus Hf Biomarkers for cervical cancer
US10260103B2 (en) 2012-11-27 2019-04-16 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
MX390142B (es) 2013-02-18 2025-03-20 Theranos Inc Sistemas y metodos para recolectar y transmitir resultados de ensayos
US20140272967A1 (en) 2013-03-13 2014-09-18 Abbott Molecular Inc. Systems and methods for isolating nucleic acids
EP2971175B1 (fr) 2013-03-14 2019-04-17 Abbott Molecular Inc. Minimisation d'erreurs utilisant de l'uracil-adn-n-glycosylase
EP2971171A4 (fr) 2013-03-14 2016-11-02 Abbott Molecular Inc Systèmes et procédés d'amplification multiplexe spécifiques de la méthylation
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
CA2905410A1 (fr) 2013-03-15 2014-09-25 Abbott Molecular Inc. Systemes et procedes pour la detection de changements de nombre de copie de genome
EP3533884A1 (fr) 2013-03-15 2019-09-04 Ibis Biosciences, Inc. Séquences d'adn pour évaluer la contamination dans le séquençage de l'adn
US9822408B2 (en) 2013-03-15 2017-11-21 Nugen Technologies, Inc. Sequential sequencing
AU2014241191A1 (en) 2013-03-27 2015-10-22 Sample Technologies, Inc. Recombinant phage and bacterial detection methods
CA2910553A1 (fr) 2013-04-30 2014-11-06 Universite De Montreal Nouveaux biomarqueurs pour la leucemie myeloide aigue
WO2014179734A1 (fr) 2013-05-02 2014-11-06 The Regents Of The University Of Michigan Amléxanox deutéré
CN105531382A (zh) 2013-06-19 2016-04-27 六品科技公司 基于噬菌体的细菌检测法
WO2015013465A2 (fr) 2013-07-25 2015-01-29 Dch Molecular Diagnostics, Inc. Méthodes et compositions de détection d'une contamination bactérienne
US11545241B1 (en) 2013-09-07 2023-01-03 Labrador Diagnostics Llc Systems and methods for analyte testing and data management
CA2929596C (fr) 2013-11-13 2022-07-05 Nugen Technologies, Inc. Compositions et procedes pour l'identification d'une lecture de sequencage en double
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
CN104946737B (zh) 2013-12-11 2019-02-22 安可济控股有限公司 用于检测罕见序列变体的组合物和方法
CN113388664A (zh) * 2014-01-27 2021-09-14 阿谢尔德克斯有限公司 用于制备核酸的等温方法及相关组合物
WO2015131107A1 (fr) 2014-02-28 2015-09-03 Nugen Technologies, Inc. Séquençage au bisulfite de représentation réduite avec adaptateurs de diversité
WO2015188178A1 (fr) 2014-06-06 2015-12-10 The Regents Of The University Of Michigan Compositions et méthodes de caractérisation et de diagnostic d'une maladie parodontale
WO2016077426A1 (fr) 2014-11-11 2016-05-19 Abbott Molecular Inc. Sondes d'hybridation et procédés associés
JP6620160B2 (ja) 2015-02-20 2019-12-11 タカラ バイオ ユーエスエー， インコーポレイテッド 単一細胞の迅速かつ正確な分注、視覚化及び解析のための方法
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
EP3283512A4 (fr) 2015-04-17 2018-10-03 Distributed Bio Inc Procédé pour l'humanisation de masse d'anticorps non humains
WO2016172571A1 (fr) 2015-04-24 2016-10-27 Agena Bioscience, Inc. Procédé multiplexé d'identification et de quantification d'allèles mineurs et de polymorphismes
AU2016252998B2 (en) 2015-04-24 2021-11-04 Atila Biosystems Incorporated Amplification with primers of limited nucleotide composition
US10640817B2 (en) 2015-04-24 2020-05-05 Agena Bioscience, Inc. Multiplex methods for detection and quantification of minor variants
CN108026593A (zh) * 2015-05-18 2018-05-11 卡琳缪恩股份有限公司 区分hiv-1与慢病毒载体的方法
US10392665B2 (en) 2015-06-19 2019-08-27 Sera Prognostics, Inc. Biomarker pairs for predicting preterm birth
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
AU2016334233B2 (en) 2015-10-09 2023-01-05 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
CN108699505A (zh) 2015-12-03 2018-10-23 安可济控股有限公司 用于形成连接产物的方法和组合物
US10214536B2 (en) 2016-01-29 2019-02-26 The Regents Of The University Of Michigan Amlexanox analogs
WO2017155858A1 (fr) 2016-03-07 2017-09-14 Insilixa, Inc. Identification de séquence d'acide nucléique à l'aide d'une extension de base unique cyclique en phase solide
CA3024630A1 (fr) 2016-05-16 2017-11-23 Accuragen Holdings Limited Procede de sequencage ameliore par identification de brin
WO2018013509A1 (fr) 2016-07-11 2018-01-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions et méthodes pour diagnostiquer et traiter des arythmies
CA3020629A1 (fr) 2016-07-21 2018-01-25 Takara Bio Usa, Inc. Imagerie multi-z et distribution a l'aide de dispositifs multipuits
CA3033749C (fr) 2016-08-15 2026-03-24 Accuragen Holdings Limited Compositions et procedes permettant de detecter des variants de sequences rares
EP3504348B1 (fr) 2016-08-24 2022-12-14 Decipher Biosciences, Inc. Utilisation de signatures génomiques en vue d'une prédiction de la réactivité de patients atteints d'un cancer de la prostate à une radiothérapie postopératoire
WO2018053362A1 (fr) 2016-09-15 2018-03-22 ArcherDX, Inc. Procédés de préparation d'échantillon d'acide nucléique
CA3037190A1 (fr) 2016-09-15 2018-03-22 ArcherDX, Inc. Procedes de preparation d'echantillon d'acide nucleique pour l'analyse d'adn acellulaire
JP6767833B2 (ja) 2016-09-29 2020-10-14 日本特殊陶業株式会社 加熱装置
EP3736324A1 (fr) 2016-09-30 2020-11-11 The Governing Council Of The University Of Toronto Système d'identification et de ciblage de cellules individuelles à l'intérieur d'une population hétérogène pour l'extraction sélective d'un contenu cellulaire
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
WO2018127786A1 (fr) 2017-01-06 2018-07-12 Oslo Universitetssykehus Hf Compositions et méthodes permettant de déterminer un plan d'action thérapeutique
EP3571322B9 (fr) 2017-01-20 2023-10-04 VERACYTE SD, Inc. Sous-typage moléculaire, pronostic et traitement du cancer de la vessie
EP3593140A4 (fr) 2017-03-09 2021-01-06 Decipher Biosciences, Inc. Sous-typage du cancer de la prostate pour prédire la réponse à une thérapie hormonale
AU2018240553B2 (en) 2017-03-24 2023-03-02 Gen-Probe Incorporated Cover assembly and related methods of use
US12492430B2 (en) 2017-04-11 2025-12-09 Tecan Genomics, Inc. Library quantitation and qualification
CA3062716A1 (fr) 2017-05-12 2018-11-15 Decipher Biosciences, Inc. Signatures genetiques pour predire une metastase du cancer de la prostate et identifier la virulence d'une tumeur
WO2019028285A2 (fr) 2017-08-04 2019-02-07 Genomedx, Inc. Utilisation d'une expression génique spécifique des cellules immunitaires pour le pronostic du cancer de la prostate et la prédiction de la sensibilité à la radiothérapie
EP4530633A3 (fr) 2017-08-18 2026-03-25 Sera Prognostics, Inc. Proteines d'horloge de grossesse pour predire la date et le temps de naissance
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
US12049665B2 (en) 2018-06-12 2024-07-30 Accuragen Holdings Limited Methods and compositions for forming ligation products
US12460254B2 (en) 2018-08-08 2025-11-04 Gen-Probe Incorporated Compositions, methods and kits for detecting Mycoplasma genitalium
EP3937780A4 (fr) 2019-03-14 2022-12-07 InSilixa, Inc. Procédés et systèmes pour une détection à base de fluorescence résolue en temps
US20220298548A1 (en) 2019-08-23 2022-09-22 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
JP7556945B2 (ja) 2019-09-05 2024-09-26 ジェン－プローブ・インコーポレーテッド Ｃｈｌａｍｙｄｉａ ｔｒａｃｈｏｍａｔｉｓ変異体の核酸の検出
EP3851542A1 (fr) 2020-01-20 2021-07-21 Tecan Genomics, Inc. Épuisement de séquences non informatives abondantes
US12059674B2 (en) 2020-02-03 2024-08-13 Tecan Genomics, Inc. Reagent storage system
WO2021252574A1 (fr) 2020-06-10 2021-12-16 Sera Prognostics, Inc. Biomarqueurs d'acide nucléique pour un dysfonctionnement placentaire
US20240271186A1 (en) 2021-08-03 2024-08-15 Wageningen Universiteit Argonaute-based nucleic acid detection system
WO2023021330A1 (fr) 2021-08-16 2023-02-23 University Of Oslo Compositions et méthodes permettant de déterminer un plan d'action thérapeutique
AU2023209322A1 (en) 2022-01-20 2024-08-08 Wageningen Universiteit Thermostable rna polymerase
WO2023152568A2 (fr) 2022-02-10 2023-08-17 Oslo Universitetssykehus Hf Compositions et méthodes de caractérisation du cancer du poumon
CA3254118A1 (fr) 2022-03-15 2023-09-21 Diagenode S.A. Détection de l'état de méthylation d'un échantillon d'adn

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA559709A (fr) * 1958-07-01 International Standard Electric Corporation Lampes a ondes progressives
US4562159A (en) 1981-03-31 1985-12-31 Albert Einstein College Of Medicine, A Division Of Yeshiva Univ. Diagnostic test for hepatitis B virus
US4957858A (en) * 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
ES8706823A1 (es) * 1985-03-28 1987-06-16 Cetus Corp Un procedimiento para detectar la presencia o ausencia de al menos una secuencia especifica de acidos nucleicos en una muestra
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
AU606043B2 (en) * 1985-03-28 1991-01-31 F. Hoffmann-La Roche Ag Detection of viruses by amplification and hybridization
US5075211A (en) * 1986-03-26 1991-12-24 Genetic Systems Corporation Synthetic antigen for the detection of AIDS-related disease
CA1338457C (fr) * 1986-08-22 1996-07-16 Henry A. Erlich Enzyme thermostable purifiee
IL86724A (en) * 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
US4994368A (en) * 1987-07-23 1991-02-19 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
CA1340843C (fr) * 1987-07-31 1999-12-07 J. Lawrence Burg Amplification selective de sequences polynucleotidiques cibles
CA1340807C (fr) * 1988-02-24 1999-11-02 Lawrence T. Malek Procede d'amplification d'une sequence d'acide nucleique
WO1990001068A1 (fr) * 1988-07-22 1990-02-08 Life Technologies, Inc. Analyse specifique a une sequence, pour la detection d'une molecule d'acide nucleique
CA2005589C (fr) * 1988-12-16 2001-02-06 Akzo Nobel Nv Systeme de replication de sequences auto-entretenu
US5112734A (en) * 1989-05-26 1992-05-12 Gene-Trak Systems Target-dependent synthesis of an artificial gene for the synthesis of a replicatable rna
CA2020958C (fr) * 1989-07-11 2005-01-11 Daniel L. Kacian Methodes d'amplification de sequences d'acide nucleique
US5194370A (en) * 1990-05-16 1993-03-16 Life Technologies, Inc. Promoter ligation activated transcription amplification of nucleic acid sequences

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JP2002355099A (ja) 2002-12-10
FI911152A0 (fi) 1991-03-07
EP0408295A2 (fr) 1991-01-16
WO1991001384A1 (fr) 1991-02-07
DE69034177D1 (de) 2004-12-23
JP3241717B2 (ja) 2001-12-25
AU650622B2 (en) 1994-06-30
JP3350511B2 (ja) 2002-11-25
NO910902D0 (no) 1991-03-07
AU6166390A (en) 1991-02-22
EP0731174A3 (fr) 1998-03-25
EP0731174A2 (fr) 1996-09-11
US5480784A (en) 1996-01-02
JP2000350592A (ja) 2000-12-19
EP0731175A2 (fr) 1996-09-11
AU7415694A (en) 1994-11-24
EP0731174B1 (fr) 2004-11-17
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JP3445131B2 (ja) 2003-09-08
DE69028257D1 (de) 1996-10-02
ES2091225T3 (es) 1996-11-01
PT94662A (pt) 1991-03-20
AU677418B2 (en) 1997-04-24
JPH04500759A (ja) 1992-02-13
ATE282716T1 (de) 2004-12-15
DE69028257T2 (de) 1997-01-09
IE902539A1 (en) 1991-02-27
EP0731175A3 (fr) 2004-05-26
KR920701478A (ko) 1992-08-11
JPH1146778A (ja) 1999-02-23
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ATE141956T1 (de) 1996-09-15
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