DK0426468T3 - Stabil polymorfisk form for (E)-N,N-diethyl-2-(3,4-dihydroxy-5-nitrophenyl)acrylamid og fremgangsmåde til fremstilling deraf - Google Patents

Stabil polymorfisk form for (E)-N,N-diethyl-2-(3,4-dihydroxy-5-nitrophenyl)acrylamid og fremgangsmåde til fremstilling deraf

Info

Publication number: DK0426468T3
Authority: DK; Denmark
Prior art keywords: dihydroxy; acrylamide; diethyl; polymorphic form; nitrophenyl
Prior art date: 1989-11-03

Application number

DK90311963.4T

Other languages

English (en)

Inventor

Aino Kyllikki Pippuri

Erkki Juhani Honkanen

Jorma Veikko Haarala

Original Assignee

Orion Yhtym Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-03

Filing date

1990-11-01

Publication date

1995-10-23

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10665678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0426468(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-11-01 Application filed by Orion Yhtym Oy filed Critical Orion Yhtym Oy

1995-10-23 Application granted granted Critical

1995-10-23 Publication of DK0426468T3 publication Critical patent/DK0426468T3/da

Links

QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
BDAGIHXWWSANSR-UHFFFAOYSA-N formic acid Substances OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
102000006378 Catechol O-methyltransferase Human genes 0.000 abstract 1
108020002739 Catechol O-methyltransferase Proteins 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000003197 catalytic effect Effects 0.000 abstract 1
JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 abstract 1
235000019253 formic acid Nutrition 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Medicinal Preparation (AREA)

DK90311963.4T 1989-11-03 1990-11-01 Stabil polymorfisk form for (E)-N,N-diethyl-2-(3,4-dihydroxy-5-nitrophenyl)acrylamid og fremgangsmåde til fremstilling deraf DK0426468T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8924838A GB2238047B (en)	1989-11-03	1989-11-03	Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation

Publications (1)

Publication Number	Publication Date
DK0426468T3 true DK0426468T3 (da)	1995-10-23

Family

ID=10665678

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90311963.4T DK0426468T3 (da)	1989-11-03	1990-11-01	Stabil polymorfisk form for (E)-N,N-diethyl-2-(3,4-dihydroxy-5-nitrophenyl)acrylamid og fremgangsmåde til fremstilling deraf

Country Status (13)

Country	Link
US (1)	US5135950A (da)
EP (1)	EP0426468B1 (da)
JP (1)	JP2823680B2 (da)
AT (1)	ATE127447T1 (da)
BR (1)	BR1100289A (da)
DE (2)	DE122004000014I1 (da)
DK (1)	DK0426468T3 (da)
ES (1)	ES2075885T3 (da)
FI (1)	FI107149B (da)
GB (1)	GB2238047B (da)
GR (1)	GR3017526T3 (da)
LU (1)	LU91071I2 (da)
NL (1)	NL300147I1 (da)

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US5283352A (en) *	1986-11-28	1994-02-01	Orion-Yhtyma Oy	Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
GB9113431D0 (en) *	1991-06-20	1991-08-07	Orion Yhytma Oy	Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde
JPH05301838A (ja) *	1991-10-15	1993-11-16	Mitsubishi Kasei Corp	スチレン誘導体
CA2080554A1 (en) *	1991-10-15	1993-04-16	Mitsubishi Chemical Corporation	Styrene derivatives
US20060013875A1 (en) *	2002-05-29	2006-01-19	Impax Laboratories, Inc.	Combination immediate release controlled release levodopa/carbidopa dosage forms
US7094427B2 (en) *	2002-05-29	2006-08-22	Impax Laboratories, Inc.	Combination immediate release controlled release levodopa/carbidopa dosage forms
CA2548300A1 (en) *	2003-12-19	2005-06-30	F. Hoffmann-La Roche Ag	Comt inhibitors
WO2005070881A1 (en) *	2003-12-24	2005-08-04	Wockhardt Limited	An efficient process for the manufacture of (e)-entacapone polymorphic form a
BR0318690A (pt) *	2003-12-29	2006-12-26	Wockhardt Ltd	polimorfos estáveis de (e)-n,n-dietil-2-ciano-3-(3,4-dihidróxi-5-nitrofenil)acril amida
EP1713768A2 (de) *	2003-12-31	2006-10-25	Cilag AG	Neue kristalline formen von entacapone und deren herstellung
WO2005063695A1 (de) *	2003-12-31	2005-07-14	Cilag Ag	Neue kristalline formen von entacapone und deren herstellung
EP1577289A1 (en)	2004-03-18	2005-09-21	Revotar Biopharmaceuticals AG	Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
CA2570884C (en) *	2004-06-16	2016-04-19	Jack Arbiser	Carbazole formulations for the treatment of psoriasis and angiogenesis
JP2008519811A (ja)	2004-11-10	2008-06-12	オリオンコーポレーション	下肢静止不能症候群の治療
ATE444746T1 (de)	2005-06-08	2009-10-15	Orion Corp	Eine herstellungsmethode von entacapon- enthaltenden granulaten für orale dosierformen
AU2006261893A1 (en) *	2005-06-23	2007-01-04	Combinatorx, Incorporated	Improved dosage forms for movement disorder treatment
EP1764096A1 (en)	2005-09-20	2007-03-21	Revotar Biopharmaceuticals AG	Novel phloroglucinol derivatives having selectin ligand activity
EP1764093A1 (en)	2005-09-20	2007-03-21	Revotar Biopharmaceuticals AG	Novel aromatic compounds and their use in medical applications
EP1764095A1 (en)	2005-09-20	2007-03-21	Revotar Biopharmaceuticals AG	Novel nitrocatechol derivatives having selectin ligand activity
US20080319226A1 (en) *	2005-11-09	2008-12-25	Usv Limited	Process For the Preparation of Highly Pure (E) N,N-Diethyl-2-Cyano-3-(3,4-Dihydroxy-5-Nitro Phenyl) Acrylamide (Entacapone)
EP1976824A1 (en) *	2006-01-02	2008-10-08	Actavis Group PTC EHF	A process for the preparation of entacapone form-a
CA2641396C (en) *	2006-02-06	2014-07-22	Orion Corporation	Process for manufacturing entacapone
WO2007094007A1 (en) *	2006-02-13	2007-08-23	Suven Life Sciences Ltd.,	An improved process for the preparation of entacapone
WO2007113845A1 (en) *	2006-04-03	2007-10-11	Alembic Limited	A process for the preparation of (e)-2-cyano-3-(3, 4-dihydroxy-5-nitrophenyl)-n, n-diethyl-2-propenamide (entacapone)
GB0610207D0 (en) *	2006-05-23	2006-07-05	Pliva Istrazivanje I Razvoj D	New forms of active pharmaceutical ingredient
US20080131492A1 (en) *	2006-06-23	2008-06-05	Spherics, Inc.	Dosage forms for movement disorder treatment
US20080004343A1 (en) *	2006-06-29	2008-01-03	Wockhardt Limited	Stable polymorphs of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide
GB0613826D0 (en) *	2006-07-12	2006-08-23	Pliva Istrazivanje I Razvoj D	Process and product
ES2306587B1 (es) *	2006-11-15	2009-08-07	Quimica Sintetica, S.A.	Nueva forma cristalina de entacapona y procedimiento para su obtencion.
ITMI20062450A1 (it) *	2006-12-19	2008-06-20	Dipharma Spa	Procedimento per la preparazione di entacapone
WO2008079404A2 (en) *	2006-12-22	2008-07-03	Combinatorx, Incorporated	Pharmaceutical compositions for treatment of parkinson's disease and related disorders
ES2319024B1 (es) *	2007-02-13	2009-12-11	Quimica Sintetica, S.A.	Procedimiento para la obtencion de entacapona sustancialmente libre de isomero z, sus intermedios de sintesis y nueva forma cristalina.
WO2009084031A2 (en) *	2007-12-03	2009-07-09	Neuland Laboratories Ltd	An improved process for preparation of (2e)-2-cyano-3-(3,4- dihydroxy-5-nitrophenyl)n,n-diethyl-2-propenamide polymorphic form a
EP2251323B1 (en)	2009-05-14	2014-04-23	F.I.S.- Fabbrica Italiana Sintetici S.p.A.	Method for the purification of entacapone
KR101868326B1 (ko)	2010-03-04	2018-06-19	오리온 코포레이션	파킨슨병의 치료를 위한 레보도파, 카르비도파 및 엔타카폰의 용도
CN103845317B (zh)	2012-11-28	2018-05-08	北京生命科学研究所	恩他卡朋在预防或治疗肥胖等代谢综合征中的应用
US10987313B2 (en)	2013-10-07	2021-04-27	Impax Laboratories, Llc	Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
PL3054929T3 (pl)	2013-10-07	2021-05-31	Impax Laboratories, Llc	Mukoadhezyjne preparaty lewodopy i / lub estrów lewodopy o kontrolowanym uwalnianiu oraz ich zastosowania
CN104402764A (zh) *	2014-11-26	2015-03-11	千辉药业（安徽）有限责任公司	一种恩他卡朋的制备方法
KR20230124622A (ko)	2020-12-22	2023-08-25	암닐 파마슈티컬스 엘엘씨	레보도파 투여 요법
US11986449B2 (en)	2020-12-22	2024-05-21	Amneal Pharmaceuticals Llc	Levodopa dosing regimen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU213587A (en) *	1986-11-28	1989-06-30	Orion Yhtymae Oy	Process for obtaining new pharmacologic active cateholic derivatives
US4971996A (en) *	1987-03-11	1990-11-20	Kanegafuchi Kagaku Kogyo Kabushiki Kaisha	Hydroxystyrene compounds which are useful as tyrosine kinase inhibitors
DE68917357T2 (de) *	1988-04-28	1995-01-26	Suntory Ltd	Derivate der Coffeinsäure und pharmazeutische Zusammensetzungen, die sie enthalten.
GB8813762D0 (en)	1988-06-10	1988-07-13	Orion Yhtymae Oy	Catechol derivatives for use in cancer treatment
JP2535058B2 (ja) *	1988-07-29	1996-09-18	富士通株式会社	半導体装置の製造方法

1989
- 1989-11-03 GB GB8924838A patent/GB2238047B/en not_active Revoked
1990
- 1990-10-23 FI FI905198A patent/FI107149B/fi not_active IP Right Cessation
- 1990-10-31 US US07/606,717 patent/US5135950A/en not_active Expired - Lifetime
- 1990-11-01 EP EP90311963A patent/EP0426468B1/en not_active Expired - Lifetime
- 1990-11-01 AT AT90311963T patent/ATE127447T1/de active
- 1990-11-01 DE DE200412000014 patent/DE122004000014I1/de active Pending
- 1990-11-01 DE DE69022166T patent/DE69022166T2/de not_active Expired - Lifetime
- 1990-11-01 DK DK90311963.4T patent/DK0426468T3/da active
- 1990-11-01 ES ES90311963T patent/ES2075885T3/es not_active Expired - Lifetime
- 1990-11-02 JP JP2298708A patent/JP2823680B2/ja not_active Expired - Lifetime
1995
- 1995-09-26 GR GR950402644T patent/GR3017526T3/el unknown
1997
- 1997-04-15 BR BR1100289-1A patent/BR1100289A/pt active IP Right Grant
2004
- 2004-04-09 LU LU91071C patent/LU91071I2/fr unknown
- 2004-04-16 NL NL300147C patent/NL300147I1/nl unknown

Also Published As

Publication number	Publication date
JP2823680B2 (ja)	1998-11-11
EP0426468A2 (en)	1991-05-08
GR3017526T3 (en)	1995-12-31
GB2238047B (en)	1993-02-10
LU91071I2 (fr)	2005-06-21
DE122004000014I1 (de)	2004-08-12
JPH03169844A (ja)	1991-07-23
BR1100289A (pt)	1999-10-05
ATE127447T1 (de)	1995-09-15
EP0426468A3 (en)	1992-05-06
FI107149B (fi)	2001-06-15
FI905198A0 (fi)	1990-10-23
DE69022166T2 (de)	1996-02-15
ES2075885T3 (es)	1995-10-16
NL300147I1 (nl)	2004-07-01
GB2238047A (en)	1991-05-22
US5135950A (en)	1992-08-04
DE69022166D1 (de)	1995-10-12
GB8924838D0 (en)	1989-12-20
EP0426468B1 (en)	1995-09-06

Publication	Publication Date	Title
GB2238047B (en)	1993-02-10	Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation
FR2710638B1 (fr)	1996-04-26	Procédé de préparation d'isomères d'acides benzènedicarboxyliques de haute pureté.
CA2174104A1 (en)	1995-04-20	Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
YU197389A (en)	1990-12-31	Process for preparing 7-substituted-hept-6-enoic and heptanoic acids and their derivatives and intermediates
FI904036A0 (fi)	1990-08-15	Menetelmä terapeuttisesti käyttökelpoisten 4-substituoitujen 17 -(syklopropyylioksi)androst-5-eenijohdannaisten valmistamiseksi, jotka ovat hyödyllisiä C17-20-lyaasi-inhibiittoreina
GR3035602T3 (en)	2001-06-29	Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1-(3-methoxyphenyl)cyclohexanol and its salts
US4321411A (en)	1982-03-23	Process for producing N-substituted acrylamide or methacrylamide
ATE115547T1 (de)	1994-12-15	Verfahren zur reinigung von tetraacetylethylendiamin (taed).
ES2148587T3 (es)	2000-10-16	Procedimiento de produccion de derivado de 2-(2-hidroximetilfenil)acetamida e intermediario utilizado para su produccion.
HU9602143D0 (en)	1996-09-30	Process for making hiv protease inhibitors
JPS6425750A (en)	1989-01-27	Manufacture of 3,3-diarylacrylic acid amide
ATE238263T1 (de)	2003-05-15	Verfahren zur herstellung von ungesättigten ketonen
DE69028938D1 (de)	1996-11-28	Verfahren zur Reinigung von 3-alpha-7-beta-Dihydroxycholansäure
GB2272218A (en)	1994-05-11	Process for the preparation of l-5-(2- - acetoxy-propionylamino)-2,4,6-triiodoisophthalic acid bis-(1,3-dihydroxy-propylamide)
Kametan et al.	1980	THE STEREOSELECTIVE REDUCTION OF a-AMINOPROPIOPHENONE DERIVATIVES WITH SODIUM BOROHYDRIDE
DK0788500T3 (da)	2004-06-07	Fremgangsmåder og mellemprodukter til fremstilling af 5,7-dihydro-3-[2-(1-benzylpiperidin-4-yl)ethyl]-6H-pyrrolo-[4,5-f],2-benzisoxazol-6-on
JPS57126462A (en)	1982-08-06	Novel carboxylic ester and its preparation
ATE319722T1 (de)	2006-03-15	Verfahren zur herstellung von vitamin-d analogen
JPS5754148A (ja)	1982-03-31	44harogenoansokukosantoransuu4 toransuu4 arukirushikurohekishiru shikurohekishiruesuteru
JPS54141764A (en)	1979-11-05	1-(4-tert-butyl)benzoyl derivative and fungicides comprising it
GR3004109T3 (da)	1993-03-31
ES8206505A1 (es)	1982-08-16	Procedimiento de obtencion de un derivado heterociclico de dimetilamina y sus sales fisiologicamente aceptables.
JPH0816090B2 (ja)	1996-02-21	Ｎ−（α−アルコキシアルキル）カルボン酸アミドの安定化方法
WO1996003401A3 (en)	1996-07-04	Process for the production of aminoazobicycloalkanes from oximes
JPS6447763A (en)	1989-02-22	Production of dichloroindoleacetic acid derivative