LU91071I2 - Levodopa, carbidopa, entacapone (stalevo). - Google Patents

Levodopa, carbidopa, entacapone (stalevo).

Info

Publication number
LU91071I2
LU91071I2 LU91071C LU91071C LU91071I2 LU 91071 I2 LU91071 I2 LU 91071I2 LU 91071 C LU91071 C LU 91071C LU 91071 C LU91071 C LU 91071C LU 91071 I2 LU91071 I2 LU 91071I2
Authority
LU
Luxembourg
Prior art keywords
stalevo
entacapone
carbidopa
levodopa
product
Prior art date
Application number
LU91071C
Other languages
English (en)
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10665678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU91071(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orion Corp filed Critical Orion Corp
Publication of LU91071I2 publication Critical patent/LU91071I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
LU91071C 1989-11-03 2004-04-09 Levodopa, carbidopa, entacapone (stalevo). LU91071I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8924838A GB2238047B (en) 1989-11-03 1989-11-03 Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation

Publications (1)

Publication Number Publication Date
LU91071I2 true LU91071I2 (fr) 2005-06-21

Family

ID=10665678

Family Applications (1)

Application Number Title Priority Date Filing Date
LU91071C LU91071I2 (fr) 1989-11-03 2004-04-09 Levodopa, carbidopa, entacapone (stalevo).

Country Status (13)

Country Link
US (1) US5135950A (fr)
EP (1) EP0426468B1 (fr)
JP (1) JP2823680B2 (fr)
AT (1) ATE127447T1 (fr)
BR (1) BR1100289A (fr)
DE (2) DE122004000014I1 (fr)
DK (1) DK0426468T3 (fr)
ES (1) ES2075885T3 (fr)
FI (1) FI107149B (fr)
GB (1) GB2238047B (fr)
GR (1) GR3017526T3 (fr)
LU (1) LU91071I2 (fr)
NL (1) NL300147I1 (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283352A (en) * 1986-11-28 1994-02-01 Orion-Yhtyma Oy Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
GB9113431D0 (en) * 1991-06-20 1991-08-07 Orion Yhytma Oy Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde
CA2080554A1 (fr) * 1991-10-15 1993-04-16 Mitsubishi Chemical Corporation Derives du styrene
JPH05301838A (ja) * 1991-10-15 1993-11-16 Mitsubishi Kasei Corp スチレン誘導体
US7094427B2 (en) * 2002-05-29 2006-08-22 Impax Laboratories, Inc. Combination immediate release controlled release levodopa/carbidopa dosage forms
US20060013875A1 (en) * 2002-05-29 2006-01-19 Impax Laboratories, Inc. Combination immediate release controlled release levodopa/carbidopa dosage forms
WO2005058228A2 (fr) * 2003-12-19 2005-06-30 F. Hoffmann-La Roche Ag Inhibiteurs de comt
WO2005070881A1 (fr) * 2003-12-24 2005-08-04 Wockhardt Limited Procede efficace de production de forme a polymorphe de (e)-entacapone
EP1701937A4 (fr) * 2003-12-29 2007-05-02 Wockhardt Ltd Polymorphes stables de (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide
WO2005063696A2 (fr) * 2003-12-31 2005-07-14 Cilag Ag Nouvelles formes cristallines d'entacapone et fabrication
WO2005063695A1 (fr) * 2003-12-31 2005-07-14 Cilag Ag Nouvelles formes cristallines d'entacapone et leur production
EP1577289A1 (fr) 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Inhibiteurs de selectine a petites molecules non glycosylees/glycosidiques/peptidiques pour le traitement de troubles inflammatoires
AU2005257982B8 (en) * 2004-06-16 2011-03-10 Jack Arbiser Carbazole formulations for the treatment of psoriasis and angiogenesis
US20060173074A1 (en) 2004-11-10 2006-08-03 Juha Ellmen Treatment of restless legs syndrome
EP2335696A1 (fr) 2005-06-08 2011-06-22 Orion Corporation Formule de dosage oral contenant entacapone
EP1901720A2 (fr) * 2005-06-23 2008-03-26 Spherics, Inc. Formes de dosage ameliorees pour le traitement de troubles moteurs
EP1764096A1 (fr) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Nouveaux derivés de phloroglucinol ayant activité de ligande de selectine
EP1764093A1 (fr) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Nouveaux composés aromatiques et leur application médical
EP1764095A1 (fr) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Nouveaux derivés de nitrocatéchol ayant activité de ligande de selectine
ATE445591T1 (de) * 2005-11-09 2009-10-15 Usv Ltd Verfahren zur herstellung von hochreinem (e)-n,n- diethyl-2-cyano-3-(3,4-dihydro-5- nitrophenyl)acrylamid (entacapon)
WO2007077572A1 (fr) * 2006-01-02 2007-07-12 Actavis Group Ptc Ehf Procede de preparation de la forme a de l’entacapone
HRP20120445T1 (hr) * 2006-02-06 2012-06-30 Orion Corporation Postupak proizvodnje entakapona
WO2007094007A1 (fr) * 2006-02-13 2007-08-23 Suven Life Sciences Ltd., Procede ameliore de preparation de l'entacapone
WO2007113845A1 (fr) * 2006-04-03 2007-10-11 Alembic Limited Procédé de préparation de (e)-2-cyano-3-(3, 4-dihydroxy-5-nitrophényl)-n, n-diéthyl-2-propénamide (entacapone)
GB0610207D0 (en) * 2006-05-23 2006-07-05 Pliva Istrazivanje I Razvoj D New forms of active pharmaceutical ingredient
US20080131492A1 (en) * 2006-06-23 2008-06-05 Spherics, Inc. Dosage forms for movement disorder treatment
US20080004343A1 (en) * 2006-06-29 2008-01-03 Wockhardt Limited Stable polymorphs of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide
GB0613826D0 (en) * 2006-07-12 2006-08-23 Pliva Istrazivanje I Razvoj D Process and product
ES2306587B1 (es) * 2006-11-15 2009-08-07 Quimica Sintetica, S.A. Nueva forma cristalina de entacapona y procedimiento para su obtencion.
ITMI20062450A1 (it) * 2006-12-19 2008-06-20 Dipharma Spa Procedimento per la preparazione di entacapone
CA2673511A1 (fr) * 2006-12-22 2008-07-03 Combinatorx, Incorporated Compositions pharmaceutiques pour le traitement de la maladie de parkinson et de troubles apparentes
ES2319024B1 (es) * 2007-02-13 2009-12-11 Quimica Sintetica, S.A. Procedimiento para la obtencion de entacapona sustancialmente libre de isomero z, sus intermedios de sintesis y nueva forma cristalina.
WO2009084031A2 (fr) * 2007-12-03 2009-07-09 Neuland Laboratories Ltd Procédé amélioré de préparation de la forme polymorphe a du (2e)-2-cyano-3-(3,4-dihydroxy-5-nitrophényl)-n,n-diéthyl-2-propènamide
EP2251323B1 (fr) 2009-05-14 2014-04-23 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Procédé de purification d'entacapone
JP5774610B2 (ja) 2010-03-04 2015-09-09 オリオン コーポレーション パーキンソン病の治療方法
CN103845317B (zh) 2012-11-28 2018-05-08 北京生命科学研究所 恩他卡朋在预防或治疗肥胖等代谢综合征中的应用
CN105658211A (zh) 2013-10-07 2016-06-08 怡百克制药公司 左旋多巴和/或左旋多巴的酯的粘膜粘附性、控制释放调配物和其用途
US10987313B2 (en) 2013-10-07 2021-04-27 Impax Laboratories, Llc Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
CN104402764A (zh) * 2014-11-26 2015-03-11 千辉药业（安徽）有限责任公司 一种恩他卡朋的制备方法
US12194150B2 (en) 2020-12-22 2025-01-14 Amneal Pharmaceuticals Llc Levodopa dosing regimen
US11986449B2 (en) 2020-12-22 2024-05-21 Amneal Pharmaceuticals Llc Levodopa dosing regimen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU213587A (en) * 1986-11-28 1989-06-30 Orion Yhtymae Oy Process for obtaining new pharmacologic active cateholic derivatives
DE3874257T2 (de) * 1987-03-11 1993-02-11 Kanegafuchi Chemical Ind Hydroxystyren-derivate.
DE68917357T2 (de) * 1988-04-28 1995-01-26 Suntory Ltd Derivate der Coffeinsäure und pharmazeutische Zusammensetzungen, die sie enthalten.
GB8813762D0 (en) 1988-06-10 1988-07-13 Orion Yhtymae Oy Catechol derivatives for use in cancer treatment
JP2535058B2 (ja) * 1988-07-29 1996-09-18 富士通株式会社 半導体装置の製造方法

Also Published As

Publication number Publication date
GB2238047A (en) 1991-05-22
JP2823680B2 (ja) 1998-11-11
FI905198A0 (fi) 1990-10-23
BR1100289A (pt) 1999-10-05
JPH03169844A (ja) 1991-07-23
ES2075885T3 (es) 1995-10-16
ATE127447T1 (de) 1995-09-15
GB2238047B (en) 1993-02-10
EP0426468A2 (fr) 1991-05-08
DE69022166D1 (de) 1995-10-12
FI107149B (fi) 2001-06-15
GR3017526T3 (en) 1995-12-31
DE69022166T2 (de) 1996-02-15
DE122004000014I1 (de) 2004-08-12
US5135950A (en) 1992-08-04
DK0426468T3 (da) 1995-10-23
NL300147I1 (nl) 2004-07-01
EP0426468B1 (fr) 1995-09-06
GB8924838D0 (en) 1989-12-20
EP0426468A3 (en) 1992-05-06

Similar Documents

Publication Publication Date Title
GB2238047B (en) Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation
FR2710638B1 (fr) Procédé de préparation d'isomères d'acides benzènedicarboxyliques de haute pureté.
DE69931753D1 (de) Azoverbindungen sowie verfahren zur herstellung derselben
NO912107L (no) Fortilsetning.
ATE129701T1 (de) Verfahren zur herstellung von flunixin und zwischenprodukten dafür.
DK496487A (da) Vandigt belaegningsmiddel og fremgangsmaade til belaegning af et substrat med et saadant middel
GB2291423B (en) Alkylation of amino acids
ATE96784T1 (de) Verfahren zur reinigung von tryptophan.
BR9302029A (pt) Metodo para produzir uma composicao,metodo para produzir uma solucao aquosa,composicao,e,processo para retardar o crescimento microbial
JPS5524147A (en) Peptide derivative
EP0204555A3 (en) Method of producing an amide utilizing a microorganism
DE69002362D1 (de) Zusammensetzungen zur verhinderung des zusammenbackens von duengemitteln.
DE69209210D1 (de) Verfahren zur Herstellung von Aminopolyolen
HU9602143D0 (en) Process for making hiv protease inhibitors
MY110988A (en) Enzymic process for preparing aliphatic s- cyanohydrins
TW207990B (fr)
ATE63900T1 (de) Verfahren zur herstellung von ungesaettigten, aliphatischen, langkettigen, sekundaeren aminen.
HUT60993A (en) Process for producing 2-chloro- and 2,6-dichloroaniline derivatives
CA1273643C (fr) Procede pour la production de l'acide cis-2-methyl- 2-butenoique
ATE91280T1 (de) N-hydroxylierte-alpha-aminosaeure, amide und andere derivate.
KR930019599A (ko) α,β-불포화카르복실산의 제조방법
DK680888D0 (da) Fremgangsmaade til fremstilling af dipeptider
ATE260883T1 (de) Verfahren zur herstellung von atropasäureethylester
HUT45488A (en) Process for producing betaines
DK1155138T3 (da) Fremgangsmåde til fremstilling af optisk aktive 3,3,3-trifluormethyl-2-alkylpropionsyrederivater