ATE127447T1 - Stabile polymorphe form von (e)-n,n-diethyl-2- cyano-3-(3,4-dihydroxy-5-nitrophenyl)-acrylamid und verfahren zu ihrer herstellung. - Google Patents

Stabile polymorphe form von (e)-n,n-diethyl-2- cyano-3-(3,4-dihydroxy-5-nitrophenyl)-acrylamid und verfahren zu ihrer herstellung.

Info

Publication number: ATE127447T1
Authority: AT; Austria
Prior art keywords: dihydroxy; acrylamide; cyano; diethyl; nitrophenyl
Prior art date: 1989-11-03

Application number

AT90311963T

Other languages

English (en)

Inventor

Aino Kyllikki Pippuri

Erkki Juhani Honkanen

Jorma Veikko Haarala

Original Assignee

Orion Yhtymae Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-03

Filing date

1990-11-01

Publication date

1995-09-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10665678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE127447(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-11-01 Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy

1995-09-15 Application granted granted Critical

1995-09-15 Publication of ATE127447T1 publication Critical patent/ATE127447T1/de

Links

JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 title abstract 2
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
BDAGIHXWWSANSR-UHFFFAOYSA-N formic acid Substances OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
102000006378 Catechol O-methyltransferase Human genes 0.000 abstract 1
108020002739 Catechol O-methyltransferase Proteins 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000003197 catalytic effect Effects 0.000 abstract 1
235000019253 formic acid Nutrition 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

AT90311963T 1989-11-03 1990-11-01 Stabile polymorphe form von (e)-n,n-diethyl-2- cyano-3-(3,4-dihydroxy-5-nitrophenyl)-acrylamid und verfahren zu ihrer herstellung. ATE127447T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8924838A GB2238047B (en)	1989-11-03	1989-11-03	Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation

Publications (1)

Publication Number	Publication Date
ATE127447T1 true ATE127447T1 (de)	1995-09-15

Family

ID=10665678

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90311963T ATE127447T1 (de)	1989-11-03	1990-11-01	Stabile polymorphe form von (e)-n,n-diethyl-2- cyano-3-(3,4-dihydroxy-5-nitrophenyl)-acrylamid und verfahren zu ihrer herstellung.

Country Status (13)

Country	Link
US (1)	US5135950A (de)
EP (1)	EP0426468B1 (de)
JP (1)	JP2823680B2 (de)
AT (1)	ATE127447T1 (de)
BR (1)	BR1100289A (de)
DE (2)	DE122004000014I1 (de)
DK (1)	DK0426468T3 (de)
ES (1)	ES2075885T3 (de)
FI (1)	FI107149B (de)
GB (1)	GB2238047B (de)
GR (1)	GR3017526T3 (de)
LU (1)	LU91071I2 (de)
NL (1)	NL300147I1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
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US5283352A (en) *	1986-11-28	1994-02-01	Orion-Yhtyma Oy	Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
GB9113431D0 (en) *	1991-06-20	1991-08-07	Orion Yhytma Oy	Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde
CA2080554A1 (en) *	1991-10-15	1993-04-16	Mitsubishi Chemical Corporation	Styrene derivatives
JPH05301838A (ja) *	1991-10-15	1993-11-16	Mitsubishi Kasei Corp	スチレン誘導体
US7094427B2 (en) *	2002-05-29	2006-08-22	Impax Laboratories, Inc.	Combination immediate release controlled release levodopa/carbidopa dosage forms
US20060013875A1 (en) *	2002-05-29	2006-01-19	Impax Laboratories, Inc.	Combination immediate release controlled release levodopa/carbidopa dosage forms
WO2005058228A2 (en) *	2003-12-19	2005-06-30	F. Hoffmann-La Roche Ag	Comt inhibitors
WO2005070881A1 (en) *	2003-12-24	2005-08-04	Wockhardt Limited	An efficient process for the manufacture of (e)-entacapone polymorphic form a
EP1701937A4 (de) *	2003-12-29	2007-05-02	Wockhardt Ltd	Stabile polymorphe von (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamid
WO2005063696A2 (de) *	2003-12-31	2005-07-14	Cilag Ag	Neue kristalline formen von entacapone und deren herstellung
WO2005063695A1 (de) *	2003-12-31	2005-07-14	Cilag Ag	Neue kristalline formen von entacapone und deren herstellung
EP1577289A1 (de)	2004-03-18	2005-09-21	Revotar Biopharmaceuticals AG	Nicht-glykosylierte/-glykosidische/-peptidische keine Moleküle als Selektininhibitoren für die Behandlung entzündlicher Erkrankungen.
AU2005257982B8 (en) *	2004-06-16	2011-03-10	Jack Arbiser	Carbazole formulations for the treatment of psoriasis and angiogenesis
US20060173074A1 (en)	2004-11-10	2006-08-03	Juha Ellmen	Treatment of restless legs syndrome
EP2335696A1 (de)	2005-06-08	2011-06-22	Orion Corporation	Orale Dosierungsform enthaltend Entacapon
EP1901720A2 (de) *	2005-06-23	2008-03-26	Spherics, Inc.	Verbesserte dosierformen zur behandlung von bewegungsstörungen
EP1764096A1 (de)	2005-09-20	2007-03-21	Revotar Biopharmaceuticals AG	Neue Phloroglucinolderivate mit Selectin-Ligand-Aktivität
EP1764093A1 (de)	2005-09-20	2007-03-21	Revotar Biopharmaceuticals AG	Neue aromatische Verbindungen und deren medizinische Verwendung
EP1764095A1 (de)	2005-09-20	2007-03-21	Revotar Biopharmaceuticals AG	Neue Nitrocatecholderivate mit Selectin-Ligand-Activität
ATE445591T1 (de) *	2005-11-09	2009-10-15	Usv Ltd	Verfahren zur herstellung von hochreinem (e)-n,n- diethyl-2-cyano-3-(3,4-dihydro-5- nitrophenyl)acrylamid (entacapon)
WO2007077572A1 (en) *	2006-01-02	2007-07-12	Actavis Group Ptc Ehf	A process for the preparation of entacapone form-a
HRP20120445T1 (hr) *	2006-02-06	2012-06-30	Orion Corporation	Postupak proizvodnje entakapona
WO2007094007A1 (en) *	2006-02-13	2007-08-23	Suven Life Sciences Ltd.,	An improved process for the preparation of entacapone
WO2007113845A1 (en) *	2006-04-03	2007-10-11	Alembic Limited	A process for the preparation of (e)-2-cyano-3-(3, 4-dihydroxy-5-nitrophenyl)-n, n-diethyl-2-propenamide (entacapone)
GB0610207D0 (en) *	2006-05-23	2006-07-05	Pliva Istrazivanje I Razvoj D	New forms of active pharmaceutical ingredient
US20080131492A1 (en) *	2006-06-23	2008-06-05	Spherics, Inc.	Dosage forms for movement disorder treatment
US20080004343A1 (en) *	2006-06-29	2008-01-03	Wockhardt Limited	Stable polymorphs of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide
GB0613826D0 (en) *	2006-07-12	2006-08-23	Pliva Istrazivanje I Razvoj D	Process and product
ES2306587B1 (es) *	2006-11-15	2009-08-07	Quimica Sintetica, S.A.	Nueva forma cristalina de entacapona y procedimiento para su obtencion.
ITMI20062450A1 (it) *	2006-12-19	2008-06-20	Dipharma Spa	Procedimento per la preparazione di entacapone
CA2673511A1 (en) *	2006-12-22	2008-07-03	Combinatorx, Incorporated	Pharmaceutical compositions for treatment of parkinson's disease and related disorders
ES2319024B1 (es) *	2007-02-13	2009-12-11	Quimica Sintetica, S.A.	Procedimiento para la obtencion de entacapona sustancialmente libre de isomero z, sus intermedios de sintesis y nueva forma cristalina.
WO2009084031A2 (en) *	2007-12-03	2009-07-09	Neuland Laboratories Ltd	An improved process for preparation of (2e)-2-cyano-3-(3,4- dihydroxy-5-nitrophenyl)n,n-diethyl-2-propenamide polymorphic form a
EP2251323B1 (de)	2009-05-14	2014-04-23	F.I.S.- Fabbrica Italiana Sintetici S.p.A.	Verfahren zur Reinigung von Entacapon
JP5774610B2 (ja)	2010-03-04	2015-09-09	オリオンコーポレーション	パーキンソン病の治療方法
CN103845317B (zh)	2012-11-28	2018-05-08	北京生命科学研究所	恩他卡朋在预防或治疗肥胖等代谢综合征中的应用
CN105658211A (zh)	2013-10-07	2016-06-08	怡百克制药公司	左旋多巴和/或左旋多巴的酯的粘膜粘附性、控制释放调配物和其用途
US10987313B2 (en)	2013-10-07	2021-04-27	Impax Laboratories, Llc	Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof
CN104402764A (zh) *	2014-11-26	2015-03-11	千辉药业（安徽）有限责任公司	一种恩他卡朋的制备方法
US12194150B2 (en)	2020-12-22	2025-01-14	Amneal Pharmaceuticals Llc	Levodopa dosing regimen
US11986449B2 (en)	2020-12-22	2024-05-21	Amneal Pharmaceuticals Llc	Levodopa dosing regimen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU213587A (en) *	1986-11-28	1989-06-30	Orion Yhtymae Oy	Process for obtaining new pharmacologic active cateholic derivatives
DE3874257T2 (de) *	1987-03-11	1993-02-11	Kanegafuchi Chemical Ind	Hydroxystyren-derivate.
DE68917357T2 (de) *	1988-04-28	1995-01-26	Suntory Ltd	Derivate der Coffeinsäure und pharmazeutische Zusammensetzungen, die sie enthalten.
GB8813762D0 (en)	1988-06-10	1988-07-13	Orion Yhtymae Oy	Catechol derivatives for use in cancer treatment
JP2535058B2 (ja) *	1988-07-29	1996-09-18	富士通株式会社	半導体装置の製造方法

1989
- 1989-11-03 GB GB8924838A patent/GB2238047B/en not_active Revoked
1990
- 1990-10-23 FI FI905198A patent/FI107149B/fi not_active IP Right Cessation
- 1990-10-31 US US07/606,717 patent/US5135950A/en not_active Expired - Lifetime
- 1990-11-01 EP EP90311963A patent/EP0426468B1/de not_active Expired - Lifetime
- 1990-11-01 DE DE200412000014 patent/DE122004000014I1/de active Pending
- 1990-11-01 DE DE69022166T patent/DE69022166T2/de not_active Expired - Lifetime
- 1990-11-01 ES ES90311963T patent/ES2075885T3/es not_active Expired - Lifetime
- 1990-11-01 AT AT90311963T patent/ATE127447T1/de active
- 1990-11-01 DK DK90311963.4T patent/DK0426468T3/da active
- 1990-11-02 JP JP2298708A patent/JP2823680B2/ja not_active Expired - Lifetime
1995
- 1995-09-26 GR GR950402644T patent/GR3017526T3/el unknown
1997
- 1997-04-15 BR BR1100289-1A patent/BR1100289A/pt active IP Right Grant
2004
- 2004-04-09 LU LU91071C patent/LU91071I2/fr unknown
- 2004-04-16 NL NL300147C patent/NL300147I1/nl unknown

Also Published As

Publication number	Publication date
GB2238047A (en)	1991-05-22
JP2823680B2 (ja)	1998-11-11
FI905198A0 (fi)	1990-10-23
BR1100289A (pt)	1999-10-05
JPH03169844A (ja)	1991-07-23
ES2075885T3 (es)	1995-10-16
GB2238047B (en)	1993-02-10
LU91071I2 (fr)	2005-06-21
EP0426468A2 (de)	1991-05-08
DE69022166D1 (de)	1995-10-12
FI107149B (fi)	2001-06-15
GR3017526T3 (en)	1995-12-31
DE69022166T2 (de)	1996-02-15
DE122004000014I1 (de)	2004-08-12
US5135950A (en)	1992-08-04
DK0426468T3 (da)	1995-10-23
NL300147I1 (nl)	2004-07-01
EP0426468B1 (de)	1995-09-06
GB8924838D0 (en)	1989-12-20
EP0426468A3 (en)	1992-05-06

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