DK0433846T3 - Fremgangsmåde til fremstilling af 2-acylamino-6-halogen-purin ud fra 2,9-diacylguanin - Google Patents
Fremgangsmåde til fremstilling af 2-acylamino-6-halogen-purin ud fra 2,9-diacylguaninInfo
- Publication number
- DK0433846T3 DK0433846T3 DK90123794T DK90123794T DK0433846T3 DK 0433846 T3 DK0433846 T3 DK 0433846T3 DK 90123794 T DK90123794 T DK 90123794T DK 90123794 T DK90123794 T DK 90123794T DK 0433846 T3 DK0433846 T3 DK 0433846T3
- Authority
- DK
- Denmark
- Prior art keywords
- acylamino
- diacylguanine
- purine
- halo
- preparation
- Prior art date
Links
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- UXCDUFKZSUBXGM-UHFFFAOYSA-N phosphoric tribromide Chemical compound BrP(Br)(Br)=O UXCDUFKZSUBXGM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3941657A DE3941657A1 (de) | 1989-12-16 | 1989-12-16 | Verfahren zur herstellung von 2-acylamino-6-halogen-purin aus 2,9-diacylguanin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0433846T3 true DK0433846T3 (da) | 1998-12-07 |
Family
ID=6395642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90123794T DK0433846T3 (da) | 1989-12-16 | 1990-12-11 | Fremgangsmåde til fremstilling af 2-acylamino-6-halogen-purin ud fra 2,9-diacylguanin |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5434263A (da) |
| EP (1) | EP0433846B1 (da) |
| JP (1) | JPH04234883A (da) |
| AT (1) | ATE164160T1 (da) |
| DE (2) | DE3941657A1 (da) |
| DK (1) | DK0433846T3 (da) |
| ES (1) | ES2114855T3 (da) |
| GR (1) | GR3026624T3 (da) |
| IE (1) | IE904518A1 (da) |
| PT (1) | PT96211B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9102127D0 (en) * | 1991-01-31 | 1991-03-13 | Smithkline Beecham Plc | Pharmaceuticals |
| CA2076886C (en) * | 1991-11-22 | 2002-06-11 | Masami Igi | Method for production of 2-amino-6-halogenopurine and synthesis intermediate therefor |
| GB9201961D0 (en) | 1992-01-30 | 1992-03-18 | Smithkline Beecham Plc | Pharmaceuticals |
| DE4231036A1 (de) * | 1992-09-17 | 1994-03-24 | Basf Ag | Verfahren zur Herstellung von 2-Amino-6-halogenpurinen |
| JPH07133276A (ja) * | 1993-09-17 | 1995-05-23 | Jiyuuzen Kagaku Kk | 2−アセチルアミノ−6−クロロプリンの製造方法 |
| DE4415196C1 (de) * | 1994-04-30 | 1995-04-27 | Boehringer Ingelheim Kg | Verbessertes Verfahren zur Herstellung von 2-Amino-6-chlorpurin und 2-Acylamino-6-chlorpurinen |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4405781A (en) * | 1981-03-02 | 1983-09-20 | Polaroid Corporation | Method for preparing salts of 6-chloropurine |
| GB8507606D0 (en) * | 1985-03-23 | 1985-05-01 | Beecham Group Plc | Process |
-
1989
- 1989-12-16 DE DE3941657A patent/DE3941657A1/de not_active Withdrawn
-
1990
- 1990-10-26 US US07/604,218 patent/US5434263A/en not_active Expired - Fee Related
- 1990-12-11 AT AT90123794T patent/ATE164160T1/de not_active IP Right Cessation
- 1990-12-11 EP EP90123794A patent/EP0433846B1/de not_active Expired - Lifetime
- 1990-12-11 DK DK90123794T patent/DK0433846T3/da active
- 1990-12-11 DE DE59010812T patent/DE59010812D1/de not_active Expired - Fee Related
- 1990-12-11 ES ES90123794T patent/ES2114855T3/es not_active Expired - Lifetime
- 1990-12-14 JP JP2419201A patent/JPH04234883A/ja active Pending
- 1990-12-14 IE IE451890A patent/IE904518A1/en unknown
- 1990-12-14 PT PT96211A patent/PT96211B/pt not_active IP Right Cessation
-
1998
- 1998-04-14 GR GR980400820T patent/GR3026624T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT96211B (pt) | 1998-05-29 |
| EP0433846A1 (de) | 1991-06-26 |
| GR3026624T3 (en) | 1998-07-31 |
| ATE164160T1 (de) | 1998-04-15 |
| DE59010812D1 (de) | 1998-04-23 |
| EP0433846B1 (de) | 1998-03-18 |
| PT96211A (pt) | 1991-09-30 |
| US5434263A (en) | 1995-07-18 |
| DE3941657A1 (de) | 1991-06-20 |
| JPH04234883A (ja) | 1992-08-24 |
| IE904518A1 (en) | 1991-06-19 |
| ES2114855T3 (es) | 1998-06-16 |
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