DK0436474T3 - Nye fluor-naphthacendioner, deres glycosylerede derivater og fremgangsmåder til fremstilling af sådanne - Google Patents

Nye fluor-naphthacendioner, deres glycosylerede derivater og fremgangsmåder til fremstilling af sådanne

Info

Publication number: DK0436474T3
Authority: DK; Denmark
Prior art keywords: processes; preparation; fluoro; alpha; hydrogen atom
Prior art date: 1989-11-13

Application number

DK90830507.1T

Other languages

English (en)

Inventor

Alessandro Giolitti

Antonio Guidi

Franco Pasqui

Vittorio Pestellini

Federico Arcamone

Original Assignee

Menarini Farma Ind

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-13

Filing date

1990-11-08

Publication date

1994-08-29

1989-11-13 Priority claimed from IT00956489A external-priority patent/IT1236322B/it

1990-02-20 Priority claimed from IT9321A external-priority patent/IT1239017B/it

1990-03-30 Priority claimed from IT9357A external-priority patent/IT1238673B/it

1990-11-08 Application filed by Menarini Farma Ind filed Critical Menarini Farma Ind

1994-08-29 Application granted granted Critical

1994-08-29 Publication of DK0436474T3 publication Critical patent/DK0436474T3/da

Links

AQJVULIOQZDDOP-UHFFFAOYSA-N 3-fluorotetracene-1,2-dione Chemical compound C1=CC=C2C=C(C=C3C(C=C(C(C3=O)=O)F)=C3)C3=CC2=C1 AQJVULIOQZDDOP-UHFFFAOYSA-N 0.000 title abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 1
229940045799 anthracyclines and related substance Drugs 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
230000009257 reactivity Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B35/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving a change in the type of bonding between two carbon atoms already directly linked
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
- C07D303/10—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals in which the oxirane rings are condensed with a carbocyclic ring system having three or more relevant rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

DK90830507.1T 1989-11-13 1990-11-08 Nye fluor-naphthacendioner, deres glycosylerede derivater og fremgangsmåder til fremstilling af sådanne DK0436474T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT00956489A IT1236322B (it)	1989-11-13	1989-11-13	8-fluoro-antracicline, relativi procedimenti di fabbricazione e loro uso.
IT9321A IT1239017B (it)	1990-02-20	1990-02-20	10-fluoro-antracicline, relativi procedimenti di fabbricazione e loro uso.
IT9357A IT1238673B (it)	1990-03-30	1990-03-30	8-fluoro-4-metossi-antracicline, relativi procedimenti di fabbricazione e loro uso.

Publications (1)

Publication Number	Publication Date
DK0436474T3 true DK0436474T3 (da)	1994-08-29

Family

ID=27272726

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90830507.1T DK0436474T3 (da)	1989-11-13	1990-11-08	Nye fluor-naphthacendioner, deres glycosylerede derivater og fremgangsmåder til fremstilling af sådanne

Country Status (24)

Country	Link
EP (1)	EP0436474B1 (da)
JP (1)	JPH03209343A (da)
KR (1)	KR940002983B1 (da)
CN (1)	CN1025608C (da)
AT (1)	ATE108760T1 (da)
AU (1)	AU641702B2 (da)
BR (1)	BR9005743A (da)
CA (1)	CA2029715A1 (da)
CU (1)	CU22303A3 (da)
DE (1)	DE69010874T2 (da)
DK (1)	DK0436474T3 (da)
ES (1)	ES2056433T3 (da)
HU (1)	HU208544B (da)
IE (1)	IE904002A1 (da)
IL (1)	IL96302A0 (da)
LV (1)	LV10422A (da)
MA (1)	MA21995A1 (da)
NO (1)	NO175101C (da)
NZ (1)	NZ236032A (da)
PL (1)	PL164019B1 (da)
PT (1)	PT95844B (da)
RU (1)	RU2015958C1 (da)
TN (1)	TNSN90131A1 (da)
YU (1)	YU47695B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3943029A1 (de) *	1989-12-27	1991-07-04	Behringwerke Ag	Verfahren zur herstellung von glycosyl-anthracyclinonen
CA2121929A1 (en) *	1994-04-22	1995-10-23	Pierre Doucet	Gear reducer
IT1271689B (it) *	1994-08-04	1997-06-04	Menarini Farma Ind	8-fluoro-antracicline, loro processi di preparazione e composizioni farmaceutiche che le contengono
AU3923995A (en) *	1994-11-22	1996-06-17	Novo Nordisk A/S	Active bio-compounds
WO1999058543A1 (en) *	1998-05-13	1999-11-18	Instytut Farmaceutyczny	New n-alkyloxycarbonyl derivatives of monosaccharides l-acosamine and l-daunosamine
CN1293088C (zh) *	2001-10-23	2007-01-03	住友化学工业株式会社	盐酸氨柔比星的稳定化
US7053191B2 (en)	2003-05-21	2006-05-30	Solux Corporation	Method of preparing 4-R-substituted 4-demethoxydaunorubicin
US8357785B2 (en)	2008-01-08	2013-01-22	Solux Corporation	Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en)	2011-04-29	2014-09-30	Synbias Pharma Ag	Method of producing 4-demethoxydaunorubicin
RU2766222C2 (ru) *	2017-12-26	2022-02-10	Общество с ограниченной ответственностью "НИАРМЕДИК ФАРМА"	Несимметричные производные полифенолов динафталинового ряда, способ их получения и применение
CN114230538B (zh) *	2021-12-21	2023-11-17	蚌埠医学院	一种环系蒽醌类化合物及其制备方法和应用
CN116768801B (zh) *	2022-03-07	2026-05-19	上海交通大学	稠合的醌肟咪唑及其鎓衍生物与其制备和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8321676D0 (en) *	1983-08-11	1983-09-14	Erba Farmitalia	4'-haloanthrocycline glycosides
US4697005A (en) *	1985-03-20	1987-09-29	Ohio State University Research Foundation	1-fluoro, 4-fluoro, and 1,4-difluoro anthracycline anticancer antibiotics

1990
- 1990-11-02 MA MA22269A patent/MA21995A1/fr unknown
- 1990-11-06 IE IE400290A patent/IE904002A1/en unknown
- 1990-11-08 AT AT90830507T patent/ATE108760T1/de not_active IP Right Cessation
- 1990-11-08 EP EP90830507A patent/EP0436474B1/en not_active Expired - Lifetime
- 1990-11-08 DE DE69010874T patent/DE69010874T2/de not_active Expired - Fee Related
- 1990-11-08 ES ES90830507T patent/ES2056433T3/es not_active Expired - Lifetime
- 1990-11-08 DK DK90830507.1T patent/DK0436474T3/da active
- 1990-11-09 YU YU212390A patent/YU47695B/sh unknown
- 1990-11-09 PT PT95844A patent/PT95844B/pt not_active IP Right Cessation
- 1990-11-09 CA CA002029715A patent/CA2029715A1/en not_active Abandoned
- 1990-11-09 IL IL96302A patent/IL96302A0/xx unknown
- 1990-11-12 RU SU904831619A patent/RU2015958C1/ru active
- 1990-11-12 PL PL90287728A patent/PL164019B1/pl unknown
- 1990-11-12 NO NO904907A patent/NO175101C/no unknown
- 1990-11-12 AU AU65960/90A patent/AU641702B2/en not_active Ceased
- 1990-11-12 NZ NZ236032A patent/NZ236032A/xx unknown
- 1990-11-12 HU HU907104A patent/HU208544B/hu not_active IP Right Cessation
- 1990-11-13 CU CU90175A patent/CU22303A3/es unknown
- 1990-11-13 CN CN90109104A patent/CN1025608C/zh not_active Expired - Fee Related
- 1990-11-13 KR KR1019900018328A patent/KR940002983B1/ko not_active Expired - Fee Related
- 1990-11-13 BR BR909005743A patent/BR9005743A/pt not_active Application Discontinuation
- 1990-11-13 JP JP2304175A patent/JPH03209343A/ja active Pending
- 1990-11-13 TN TNTNSN90131A patent/TNSN90131A1/fr unknown
1993
- 1993-06-22 LV LV930656A patent/LV10422A/xx unknown

Also Published As

Publication number	Publication date
NO175101B (no)	1994-05-24
LV10422A (lv)	1995-02-20
NO904907L (no)	1991-05-14
PT95844B (pt)	1997-11-28
PL287728A1 (en)	1992-11-02
DE69010874D1 (de)	1994-08-25
CN1025608C (zh)	1994-08-10
PT95844A (pt)	1991-09-13
KR940002983B1 (ko)	1994-04-09
ES2056433T3 (es)	1994-10-01
TNSN90131A1 (fr)	1991-03-05
CN1052659A (zh)	1991-07-03
NO904907D0 (no)	1990-11-12
HUT55337A (en)	1991-05-28
CU22303A3 (es)	1995-01-31
DE69010874T2 (de)	1994-11-10
YU212390A (sh)	1992-12-21
NO175101C (no)	1994-08-31
KR910009613A (ko)	1991-06-28
RU2015958C1 (ru)	1994-07-15
PL164019B1 (pl)	1994-06-30
IE904002A1 (en)	1991-05-22
AU6596090A (en)	1991-07-11
BR9005743A (pt)	1991-09-24
MA21995A1 (fr)	1991-07-01
ATE108760T1 (de)	1994-08-15
HU208544B (en)	1993-11-29
JPH03209343A (ja)	1991-09-12
EP0436474B1 (en)	1994-07-20
EP0436474A1 (en)	1991-07-10
CA2029715A1 (en)	1991-05-14
YU47695B (sh)	1996-01-08
NZ236032A (en)	1993-09-27
AU641702B2 (en)	1993-09-30
IL96302A0 (en)	1991-08-16

Publication	Publication Date	Title
DK14892D0 (da)	1992-02-06	Tigogenin-cellobiosid-heptaacetat forbindelser og fremgangsmaade til fremstilling heraf
DK353385D0 (da)	1985-08-02	Fremstilling af 3-acylamino-1-hydroxy-2-azetidinoner og herved forekommende n-hydroxybeskyttelsesgrupper
ATE168377T1 (de)	1998-08-15	Spiro(pyran)piperidine-derivate
ATE50774T1 (de)	1990-03-15	Neue fructosyltsansferase und verfahren zur herstellung von fructosyl-disacchariden, sowie eine neue halosaccharose.
DK0879236T3 (da)	2010-01-18	Derivater af camptothecin til anvendelse ved behandling af cancer
KR900700486A (ko)	1990-08-13	신규한 벤조피리도 피페리딘, 피페리딜리덴 및 피페라진 화합물, 조성물, 제조방법 및 이용방법
NO904907D0 (no)	1990-11-12	Nye fluornaftacendioner, deres glycosylerte derivater og fremgangsmaate for deres fremstilling.
ATE148501T1 (de)	1997-02-15	Durch aromaten substituiertes glykosid
NO168767C (no)	1992-04-01	Cyklopenta(d)pyrimidinderivater og fremgangsmaate til fremstilling derav
DK385681A (da)	1982-03-03	Fremgangsmaade til fremstilling af piperidylidenderivater
DK0532515T3 (da)	1997-04-21	Fremstilling af substituerede piperidiner
DK150187A (da)	1987-09-26	Fremgangsmaade til fremstilling af hydroxyaminderivater
NO872892D0 (no)	1987-07-10	Fremgangsmaate ved fremstilling av nye 6- eller 7-metylenandrosta-1,4 dien-3,17-dion-derivater.
DK89182A (da)	1982-09-03	Fremgangsmaade til fremstilling af n-naphthoylglycinderivater
AU575972B2 (en)	1988-08-11	3- aminocarbonylmethoxy - 5 - phenylpyrazole derivatives
ATE112563T1 (de)	1994-10-15	Diglycidyläther.
NO870176L (no)	1987-07-20	Nye forbindelser og fremgangsmaater.
DK0381989T3 (da)	1992-03-23	4-epi-4-amino-anthracycliner
DK0432841T3 (da)	1996-06-24	Spiro-indolin-oxazin-forbindelser med fotokromatiske og fotosensibiliserende egenskaber samt fremgangsmåde til deres fremstilling
GR3006342T3 (da)	1993-06-21
DK0431450T3 (da)	1994-05-16	1-brom-3-chlor-1,2-diaryl-2-propanoler, fremgangsmåde til stereoselektiv fremstilling af erythro-1-brom-3-chlor-1,2-diaryl-2-propanoler og deres omsætning til azolylmethyloxiraner
ES2001793A6 (es)	1988-06-16	Procedimiento para la obtencion de ciclopentanoderivados
DE69019573D1 (de)	1995-06-29	Luciferinderivate.
DK189185A (da)	1985-10-28	(6,11-dihydro-11-oxodibenz(b,e)oxepinyl)-pentanoler, deres fremstilling og anvendelse