DK0442850T3 - Estere af acyl L-carnitiner med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende disse til hæmning af neurondegeneration og til behandling af coma - Google Patents

Estere af acyl L-carnitiner med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende disse til hæmning af neurondegeneration og til behandling af coma

Info

Publication number: DK0442850T3
Authority: DK; Denmark
Prior art keywords: acid; carnitines; coma; esters; acyl
Prior art date: 1990-02-12

Application number

DK91830024.5T

Other languages

Danish (da)

English (en)

Inventor

Domenico Misiti

Maria Ornella Tinti

Claudio Cavazza

Nazareno Scafetta

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-12

Filing date

1991-01-28

Publication date

1994-09-05

1991-01-28 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1994-09-05 Application granted granted Critical

1994-09-05 Publication of DK0442850T3 publication Critical patent/DK0442850T3/da

Links

-1 acyl L-carnitines Chemical class 0.000 title abstract 5
SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 title abstract 2
206010010071 Coma Diseases 0.000 title abstract 2
150000002148 esters Chemical class 0.000 title abstract 2
230000002401 inhibitory effect Effects 0.000 title abstract 2
230000004770 neurodegeneration Effects 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
239000002253 acid Substances 0.000 abstract 7
150000003839 salts Chemical class 0.000 abstract 3
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 1
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
206010039966 Senile dementia Diseases 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
229940009098 aspartate Drugs 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK91830024.5T 1990-02-12 1991-01-28 Estere af acyl L-carnitiner med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende disse til hæmning af neurondegeneration og til behandling af coma DK0442850T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT47618A IT1240760B (it)	1990-02-12	1990-02-12	Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.

Publications (1)

Publication Number	Publication Date
DK0442850T3 true DK0442850T3 (da)	1994-09-05

Family

ID=11261466

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91830024.5T DK0442850T3 (da)	1990-02-12	1991-01-28	Estere af acyl L-carnitiner med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende disse til hæmning af neurondegeneration og til behandling af coma

Country Status (8)

Country	Link
US (2)	US5543556A (de)
EP (1)	EP0442850B1 (de)
JP (1)	JP2930749B2 (de)
AT (1)	ATE109128T1 (de)
DE (1)	DE69103037T2 (de)
DK (1)	DK0442850T3 (de)
ES (1)	ES2057837T3 (de)
IT (1)	IT1240760B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1242020B (it) *	1990-11-20	1994-02-02	Sigma Tau Ind Farmaceuti	Ftalidilidene derivati della carnitina e di alcanoil carnitine e composizioni farmaceutiche che li contengono.
IT1244636B (it) *	1991-01-04	1994-08-08	Sigma Tau Ind Farmaceuti	Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento.
IT1248321B (it) *	1991-05-15	1995-01-05	Sigma Tau Ind Farmaceuti	Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie
IT1263013B (it) *	1992-10-20	1996-07-23	Avantgarde Spa	Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261432B (it) *	1993-03-26	1996-05-23	Sigma Tau Ind Farmaceuti	Uso di acil l- carnitina gammaidrossibutirrato per il trattamento dell'alcolismo.
IT1261984B (it) *	1993-06-22	1996-06-11	Avantgarde Spa	Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1261828B (it) *	1993-07-14	1996-06-03	Sigma Tau Ind Farmaceuti	Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
IT1276225B1 (it) *	1995-10-17	1997-10-27	Sigma Tau Ind Farmaceuti	Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
IT1276253B1 (it)	1995-12-15	1997-10-27	Sigma Tau Ind Farmaceuti	Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi
IT1291113B1 (it) *	1997-03-20	1998-12-29	Sigma Tau Ind Farmaceuti	Composizione nutritiva terapeutica per soggetti affetti da diabete mellito
US5863940A (en)	1997-12-01	1999-01-26	Sigma-Tau Healthscience S.P.A.	Medicament and therapeutical method for treating idiopathic asthenozoospermia
US6090848A (en) *	1997-12-01	2000-07-18	Sigma-Tau Healthscience S.P.A.	Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans
DK0951909T4 (da)	1998-03-19	2011-01-24	Sigma Tau Ind Farmaceuti	Kombinationspræparat omfattende en L-carnitin eller en alkanoyl-L-carnitin, en glycosaminoglycan og/eller bestanddel deraf
ES2383673T3 (es)	2000-09-22	2012-06-25	Jpi Commercial, Llc	Composiciones de gamma-hidroxibutirato que contienen portadores de hidrato de carbonos
EP2642991A1 (de)	2010-11-22	2013-10-02	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Therapeutisches verfahren zur behandlung der leberschen optikusatrophie
KR20130140100A (ko)	2010-12-09	2013-12-23	씨그마-토 인더스트리에 파마슈티체 리유니테 에스. 피. 에이.	피부 장애 치료용 국소 사용을 위한 조성물
EP2783695A1 (de)	2013-03-28	2014-10-01	SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.	Physiologische Ergänzung oder Medikament zur ophthalmischen Verwendung mit L-Carnitin oder Alkanoyl-L-Carnitinen in Kombination mit Eledoisin
CN114292190B (zh)	2016-06-07	2025-04-11	J大卫格莱斯顿研究机构	丁二醇的中链脂肪酸酯，其组合物、口服制剂及其应用方法
MX2020000734A (es)	2017-07-21	2020-07-29	Buck Inst Res Aging	Enantiómeros s de beta-hidroxibutirato y butanodiol, y métodos para usarlos.
WO2019147503A1 (en)	2018-01-25	2019-08-01	Buck Institute For Research On Aging	Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4032641A (en) *	1976-06-09	1977-06-28	Tanabe Seiyaku Co., Ltd.	Nicotinoyl carnitine derivatives
AU518617B2 (en) *	1977-04-29	1981-10-08	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Therapeutic application of acetyl-d, 1-carnitine
IT1116037B (it) *	1979-04-23	1986-02-10	Sigma Tau Ind Farmaceuti	Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1177874B (it) *	1984-07-04	1987-08-26	Sigma Tau Ind Farmaceuti	Estere della acetil carnitina,procedimenti per la sua preparazione e composizioni farmaceutiche che lo contengono
IT1231751B (it) *	1989-04-12	1991-12-21	Sigma Tau Ind Farmaceuti	Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
IT1256705B (it) *	1992-12-21	1995-12-12	Sigma Tau Ind Farmaceuti	Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.

1990
- 1990-02-12 IT IT47618A patent/IT1240760B/it active IP Right Grant
1991
- 1991-01-28 DK DK91830024.5T patent/DK0442850T3/da active
- 1991-01-28 AT AT91830024T patent/ATE109128T1/de not_active IP Right Cessation
- 1991-01-28 EP EP91830024A patent/EP0442850B1/de not_active Expired - Lifetime
- 1991-01-28 DE DE69103037T patent/DE69103037T2/de not_active Expired - Fee Related
- 1991-01-28 ES ES91830024T patent/ES2057837T3/es not_active Expired - Lifetime
- 1991-02-08 JP JP3039174A patent/JP2930749B2/ja not_active Expired - Fee Related
1994
- 1994-10-04 US US08/317,750 patent/US5543556A/en not_active Expired - Fee Related
1995
- 1995-02-28 US US08/395,914 patent/US5534549A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5543556A (en)	1996-08-06
DE69103037T2 (de)	1994-11-17
JPH06179642A (ja)	1994-06-28
HK1005859A1 (en)	1999-01-29
ES2057837T3 (es)	1994-10-16
ATE109128T1 (de)	1994-08-15
EP0442850A1 (de)	1991-08-21
IT1240760B (it)	1993-12-17
US5534549A (en)	1996-07-09
EP0442850B1 (de)	1994-07-27
JP2930749B2 (ja)	1999-08-03
DE69103037D1 (de)	1994-09-01
IT9047618A1 (it)	1991-08-13
IT9047618A0 (it)	1990-02-12

Publication	Publication Date	Title
DK0442850T3 (da)	1994-09-05	Estere af acyl L-carnitiner med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende disse til hæmning af neurondegeneration og til behandling af coma
DK0443996T3 (da)	1994-07-25	Estere af (R)(-)-carnitin og acyl (R)(-)-carnitiner med beta-hydroxysmørsyre og farmaceutiske præparater indeholdende disse til inhibering af neurondegeneration og leverproteolyse samt til behandling af coma
DK0429403T3 (da)	1994-08-01	Ester af L-carnitin med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende denne til inhibering af neurondegeneration og til behandling af coma
DK0514359T3 (da)	1995-11-13	Alkanoyl-L-carnitin-amider med aminosyrer og farmaceutiske præparater indeholdende disse til fremme af regeneration af nervevæv, inhibering af neuronal degeneration, forøgelse af indlærings- og hukommelsesprocesserne og behandling af coma
EP0290819A3 (en)	1990-10-10	Pteridines suitable for the preparation of pharmaceutical compositions with antiamnesic activity
ATE144492T1 (de)	1996-11-15	Ester des acyl-carnitins mit langkettigen aliphatischen alkoholen und diese enthaltende pharmazeutische zusammensetzungen mit antibakterieller wirkung
DE69207479T2 (de)	1996-05-23	Verwendung der Ester von Acyl-L-Carnitin mit Gamma-Hydroxy-Buttersäure zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Lebererkrankungen
HK1005848B (en)	1999-01-29	Use of esters of acyl l-carnitines with gamma-hydroxybutyric acid for producing pharmaceutical compositions for the treatment of hepatopathies
KR940006576A (ko)	1994-04-25	에이즈 및 에이즈 관련 증후군 환자 및 무증후성 hiv혈청양성 환자치료를 위한 l-카르니틴 및 아실 l-카르니틴의 용도
FI103887B1 (fi)	1999-10-15	Menetelmä terapeuttisesti käyttökelpoisten imidatsolyylimetyyli-pyridiinien valmistamiseksi
HUT62303A (en)	1993-04-28	Process for producing n-substituted aminomethane diphosphonic acids and pharmaceutical compositions comprising same as active ingredient
ATE167056T1 (de)	1998-06-15	Verwendung von ester von acyl-l-carnitin mit gammahydroxybuttersäure zur behandlung von alkoholismus