DK0443449T3 - Fremgangsmåde til fremstilling af oxetanoner - Google Patents
Fremgangsmåde til fremstilling af oxetanonerInfo
- Publication number
- DK0443449T3 DK0443449T3 DK91102150.9T DK91102150T DK0443449T3 DK 0443449 T3 DK0443449 T3 DK 0443449T3 DK 91102150 T DK91102150 T DK 91102150T DK 0443449 T3 DK0443449 T3 DK 0443449T3
- Authority
- DK
- Denmark
- Prior art keywords
- oxetanones
- production
- beta
- novel
- lactones
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heat Treatment Of Steel (AREA)
- Examining Or Testing Airtightness (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH58990 | 1990-02-23 | ||
| CH392590 | 1990-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0443449T3 true DK0443449T3 (da) | 1997-11-24 |
Family
ID=25685045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91102150.9T DK0443449T3 (da) | 1990-02-23 | 1991-02-15 | Fremgangsmåde til fremstilling af oxetanoner |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US5245056A (pt) |
| EP (1) | EP0443449B1 (pt) |
| JP (1) | JP2912463B2 (pt) |
| KR (2) | KR0183034B1 (pt) |
| AT (1) | ATE153332T1 (pt) |
| AU (1) | AU644846B2 (pt) |
| CA (1) | CA2035972C (pt) |
| DE (1) | DE59108707D1 (pt) |
| DK (1) | DK0443449T3 (pt) |
| ES (1) | ES2103751T3 (pt) |
| FI (1) | FI115458B (pt) |
| GR (1) | GR3024420T3 (pt) |
| HU (1) | HU208686B (pt) |
| IE (1) | IE910608A1 (pt) |
| NO (1) | NO178764C (pt) |
| NZ (1) | NZ237132A (pt) |
| PT (1) | PT96857B (pt) |
| ZA (1) | ZA911153B (pt) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5274143A (en) * | 1991-07-23 | 1993-12-28 | Hoffmann-La Roche Inc. | Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione |
| AT398579B (de) * | 1992-07-06 | 1994-12-27 | Chemie Linz Gmbh | Enzymatisches verfahren zur trennung racemischer gemische von delta-valerolactonen |
| DE4225817A1 (de) * | 1992-08-05 | 1994-02-10 | Chemie Linz Deutschland | Enzymatisches Verfahren zur Trennung racemischer Gemische von delta-Valerolactonen |
| US5481008A (en) * | 1993-09-13 | 1996-01-02 | Hoffmann-La Roche Inc. | Process for the preparation of optically active compounds |
| IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
| DE19703713A1 (de) * | 1997-01-23 | 1998-07-30 | Hans Prof Dr Schick | Verfahren für die Herstellung von Oxetan-2-onen und Zwischenprodukte |
| CN1154505C (zh) * | 1997-02-05 | 2004-06-23 | 弗·哈夫曼-拉罗切有限公司 | 胃肠道脂酶抑制剂的用途 |
| WO1999014210A1 (en) * | 1997-09-15 | 1999-03-25 | Warner-Lambert Company | Process for the preparation of substituted 5,6-dihydro-2h-pyran-2-ones |
| US7124221B1 (en) | 1999-10-19 | 2006-10-17 | Rambus Inc. | Low latency multi-level communication interface |
| US6545165B1 (en) | 2000-02-04 | 2003-04-08 | Roche Colorado Corporation | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one |
| US6552204B1 (en) * | 2000-02-04 | 2003-04-22 | Roche Colorado Corporation | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one |
| EP1132389A1 (en) | 2000-03-06 | 2001-09-12 | Vernalis Research Limited | New aza-indolyl derivatives for the treatment of obesity |
| EP1307263B1 (en) | 2000-07-28 | 2005-04-20 | F. Hoffmann-La Roche Ag | New use of lipase inhibitors |
| CN1323661C (zh) | 2000-08-09 | 2007-07-04 | 霍夫曼-拉罗奇有限公司 | 脂酶抑制剂的用途 |
| US6900226B2 (en) | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
| WO2002044152A1 (en) | 2000-10-16 | 2002-06-06 | F. Hoffmann-La Roche Ag | Indoline derivatives and their use as 5-ht2 receptor ligands |
| GB0030710D0 (en) * | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
| WO2002051844A1 (en) | 2000-12-27 | 2002-07-04 | F. Hoffmann-La Roche Ag | Indole derivatives and their use as 5-ht2b and 5-ht2c receptor ligands |
| GB0106177D0 (en) | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| US20030027786A1 (en) | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
| US6730319B2 (en) | 2001-06-06 | 2004-05-04 | Hoffmann-La Roche Inc. | Pharmaceutical compositions having depressed melting points |
| US6787558B2 (en) | 2001-09-28 | 2004-09-07 | Hoffmann-La Roche Inc. | Quinoline derivatives |
| AU2002347539A1 (en) * | 2001-12-13 | 2003-06-23 | Ranbaxy Laboratories Limited | Crystalline cefdinir potassium dihydrate |
| GB0202015D0 (en) * | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| BR0307441A (pt) | 2002-02-04 | 2005-01-04 | Hoffmann La Roche | Compostos, processo para a preparação de um composto, composição farmacêutica, utilização desses compostos, método para o tratamento e profilaxia de enfermidades e método para o tratamento de obesidade |
| KR100611854B1 (ko) | 2002-02-28 | 2006-08-11 | 에프. 호프만-라 로슈 아게 | 신경 펩타이드 ｙ(ｎｐｙ) 수용체 길항제로서의 티아졸유도체 |
| WO2003088975A1 (en) * | 2002-04-17 | 2003-10-30 | The Burnham Institute | Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation |
| US7728153B2 (en) | 2002-04-17 | 2010-06-01 | The Burnham Institute For Medical Research | Method for the asymmetric synthesis of beta-lactone compounds |
| MXPA05000131A (es) | 2002-07-05 | 2005-04-11 | Hoffmann La Roche | Derivados de quinazolina. |
| US8861667B1 (en) | 2002-07-12 | 2014-10-14 | Rambus Inc. | Clock data recovery circuit with equalizer clock calibration |
| CA2493712A1 (en) | 2002-08-07 | 2004-02-19 | F. Hoffmann-La Roche Ag | Aminothiazole derivatives as npy5 receptor inhibitors |
| NZ537979A (en) | 2002-09-12 | 2007-08-31 | Hoffmann La Roche | N-substituted-1H-indol-5-propionic acid compounds as PPAR agonists useful for the treatment of diabetes |
| US20040092735A1 (en) * | 2002-11-08 | 2004-05-13 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of cefuroxime sodium |
| ATE405560T1 (de) | 2002-11-25 | 2008-09-15 | Hoffmann La Roche | Indolderivaten |
| GB0314967D0 (en) * | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
| CN100393718C (zh) * | 2003-08-12 | 2008-06-11 | 霍夫曼-拉罗奇有限公司 | 作为npy拮抗剂的噻唑衍生物 |
| RU2006107444A (ru) * | 2003-08-12 | 2007-09-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | 2-амино-5-бензоилтиазолы в качестве антагонистов npy |
| US7074822B2 (en) | 2004-02-23 | 2006-07-11 | Solvay Pharmaceuticals Gmbh | Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them |
| ATE514698T1 (de) * | 2005-05-03 | 2011-07-15 | Hoffmann La Roche | Tetracyclische azapyrazinoindoline als 5-ht2- liganden |
| MX2008002061A (es) | 2005-08-18 | 2008-04-16 | Hoffmann La Roche | Derivados de tiazolil piperidina utiles como moduladores del receptor h3. |
| DE602006014022D1 (de) | 2005-11-30 | 2010-06-10 | Hoffmann La Roche | 5-substituierte indol-2-carbonsäureamidderivate |
| ATE507222T1 (de) | 2005-11-30 | 2011-05-15 | Hoffmann La Roche | 1,1-dioxo-thiomorpholinyl-indolyl-methanon- derivate zur verwendung als h3-modulatoren |
| RU2008126391A (ru) | 2005-11-30 | 2010-01-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные 1,5-замещенного индол-2-иламида |
| JP2009518351A (ja) | 2005-12-09 | 2009-05-07 | エフ．ホフマン−ラ ロシュ アーゲー | 肥満症の処置に有用な三環性アミド誘導体 |
| ATE449776T1 (de) | 2005-12-15 | 2009-12-15 | Hoffmann La Roche | Pyrroloä2,3-cüpyridinderivate |
| BRPI0619985A2 (pt) | 2005-12-16 | 2011-10-25 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas, métodos para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, de obesidade e de diabetes do tipo ii em um ser humano ou animal e usos dos compostos |
| AU2007204426A1 (en) * | 2006-01-13 | 2007-07-19 | F. Hoffmann-La Roche Ag | Cyclohexyl piperazinyl methanone derivatives and their use as histamine H3 receptor modulators |
| AU2007206997B2 (en) * | 2006-01-23 | 2011-11-24 | F. Hoffmann-La Roche Ag | Cyclohexyl sulfonamide derivatives having H3 receptor activity |
| US7432255B2 (en) | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
| BRPI0711740A2 (pt) | 2006-05-30 | 2011-12-06 | Hoffmann La Roche | compostos, processo para a sua manufatura,composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, método para o tratamento ou prevenção de obesidade, de diabetes do tipo ii, e uso dos compostos na manufatura de medicamentos |
| US7514433B2 (en) | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
| US20080146559A1 (en) | 2006-12-08 | 2008-06-19 | Li Chen | 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives |
| CN101348475B (zh) * | 2007-07-20 | 2011-03-30 | 重庆人本药物研究院 | 一种奥利司他合成方法、中间体化合物及其制备方法 |
| EP2183237A1 (en) * | 2007-07-25 | 2010-05-12 | F. Hoffmann-Roche AG | Benzofuran- and benzo[b]thiophene-2-carboxylic acid amide derivatives and use thereof as histamine 3 receptor modulators |
| KR101076680B1 (ko) * | 2007-11-01 | 2011-10-26 | 한미홀딩스 주식회사 | (6ｒ)-3-헥실-4-히드록시-6-운데실-5,6-다이히드로피란-2-온의 제조방법 및 이에 사용되는 중간체 |
| KR101126084B1 (ko) * | 2008-11-04 | 2012-03-29 | 한미홀딩스 주식회사 | (3ｓ,4ｓ)-4-((ｒ)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체 |
| WO2012075147A2 (en) | 2010-11-30 | 2012-06-07 | Board Of Trustees Of The University Of Illinois | Stable helical ionic polypeptides |
| CN103588735A (zh) * | 2013-11-13 | 2014-02-19 | 大连九信生物化工科技有限公司 | 一种奥利司他的结晶提纯方法 |
| FR3017878B1 (fr) * | 2014-02-27 | 2017-12-08 | Charabot | Procede de production de lactones a partir d'une souche d'aureobasidium pullulans |
| WO2018140613A1 (en) | 2017-01-25 | 2018-08-02 | The Board Of Trustees Of The University Of Illinois | Conformation switchable antimicrobial peptides and methods of using the same |
| CN112625009A (zh) * | 2020-12-18 | 2021-04-09 | 植恩生物技术股份有限公司 | 一种奥利司他关键中间体的精制方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3457193A (en) * | 1965-06-30 | 1969-07-22 | Union Carbide Corp | Epoxyoxacyclobutanes and polymers thereof |
| DE2400429A1 (de) * | 1974-01-05 | 1975-07-17 | Basf Ag | Verfahren zur herstellung von 4-ketotetrahydro-alpha-pyronen |
| US4395561A (en) * | 1982-05-14 | 1983-07-26 | The United States Of America As Represented By The Secretary Of The Navy | Synthesis of 3-hydroxyoxetane |
| CA1328881C (en) * | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
| CA1270837A (en) * | 1984-12-21 | 1990-06-26 | Hoffmann-La Roche Limited | Oxetanones |
| WO1988010258A1 (en) * | 1987-06-17 | 1988-12-29 | La Trobe University | Human leucocyte elastase inhibitor compounds |
| HU202851B (en) * | 1988-04-04 | 1991-04-29 | Sandoz Ag | Herbicidal or acaricidal compositions and process for producing the active ingredient aryldione derivatives |
| US5149835A (en) * | 1989-04-27 | 1992-09-22 | University Of New Mexico | Substituted mevalonolactones, and methods for stereoselective preparation thereof and desmethyl homologues thereof |
| US5036008A (en) * | 1989-07-12 | 1991-07-30 | Bristol-Myers Company | Antitumor antibiotic BU-3285T |
| US5110825A (en) * | 1989-12-28 | 1992-05-05 | Shionogi & Co., Ltd. | Benzofuran derivative |
| IL97148A (en) * | 1990-02-26 | 1996-11-14 | Hoffmann La Roche | Oxetanones a process for their manufacture and pharmaceutical compositions containing them |
-
1991
- 1991-02-07 CA CA002035972A patent/CA2035972C/en not_active Expired - Lifetime
- 1991-02-11 US US07/653,846 patent/US5245056A/en not_active Expired - Lifetime
- 1991-02-15 ES ES91102150T patent/ES2103751T3/es not_active Expired - Lifetime
- 1991-02-15 DK DK91102150.9T patent/DK0443449T3/da active
- 1991-02-15 DE DE59108707T patent/DE59108707D1/de not_active Expired - Lifetime
- 1991-02-15 ZA ZA911153A patent/ZA911153B/xx unknown
- 1991-02-15 NZ NZ237132A patent/NZ237132A/xx unknown
- 1991-02-15 EP EP91102150A patent/EP0443449B1/de not_active Expired - Lifetime
- 1991-02-15 AT AT91102150T patent/ATE153332T1/de not_active IP Right Cessation
- 1991-02-18 AU AU71166/91A patent/AU644846B2/en not_active Expired
- 1991-02-20 HU HU91559A patent/HU208686B/hu unknown
- 1991-02-20 JP JP3045629A patent/JP2912463B2/ja not_active Expired - Lifetime
- 1991-02-22 NO NO910712A patent/NO178764C/no not_active IP Right Cessation
- 1991-02-22 KR KR1019910002903A patent/KR0183034B1/ko not_active Expired - Lifetime
- 1991-02-22 PT PT96857A patent/PT96857B/pt not_active IP Right Cessation
- 1991-02-22 FI FI910857A patent/FI115458B/fi active IP Right Grant
- 1991-02-22 IE IE060891A patent/IE910608A1/en not_active IP Right Cessation
-
1993
- 1993-06-15 US US08/077,475 patent/US5399720A/en not_active Expired - Lifetime
-
1997
- 1997-08-13 GR GR970402063T patent/GR3024420T3/el unknown
-
1998
- 1998-09-16 KR KR1019980038144A patent/KR100191365B1/ko not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU7116691A (en) | 1991-08-29 |
| US5399720A (en) | 1995-03-21 |
| EP0443449B1 (de) | 1997-05-21 |
| JP2912463B2 (ja) | 1999-06-28 |
| FI115458B (fi) | 2005-05-13 |
| HU208686B (en) | 1993-12-28 |
| PT96857A (pt) | 1991-10-31 |
| IE910608A1 (en) | 1991-08-28 |
| KR910021393A (ko) | 1991-12-20 |
| ES2103751T3 (es) | 1997-10-01 |
| FI910857A0 (fi) | 1991-02-22 |
| NO910712D0 (no) | 1991-02-22 |
| DE59108707D1 (de) | 1997-06-26 |
| NO910712L (no) | 1991-08-26 |
| ATE153332T1 (de) | 1997-06-15 |
| PT96857B (pt) | 1998-07-31 |
| EP0443449A2 (de) | 1991-08-28 |
| NO178764C (no) | 1996-05-29 |
| CA2035972A1 (en) | 1991-08-24 |
| HUT56558A (en) | 1991-09-30 |
| FI910857L (fi) | 1991-08-24 |
| JPH04211675A (ja) | 1992-08-03 |
| KR0183034B1 (ko) | 1999-05-01 |
| AU644846B2 (en) | 1993-12-23 |
| ZA911153B (en) | 1991-11-27 |
| NZ237132A (en) | 1993-04-28 |
| US5245056A (en) | 1993-09-14 |
| GR3024420T3 (en) | 1997-11-28 |
| CA2035972C (en) | 2006-07-11 |
| KR100191365B1 (ko) | 1999-06-15 |
| EP0443449A3 (en) | 1991-12-04 |
| NO178764B (no) | 1996-02-19 |
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