ES2139744T3 - Sintesis estereoselectiva de analogos de nucleosidos empleando un intermediario biciclico. - Google Patents

Sintesis estereoselectiva de analogos de nucleosidos empleando un intermediario biciclico.

Info

Publication number
ES2139744T3
ES2139744T3 ES94918252T ES94918252T ES2139744T3 ES 2139744 T3 ES2139744 T3 ES 2139744T3 ES 94918252 T ES94918252 T ES 94918252T ES 94918252 T ES94918252 T ES 94918252T ES 2139744 T3 ES2139744 T3 ES 2139744T3
Authority
ES
Spain
Prior art keywords
bicycle
intermediary
stereoselective synthesis
nucleosid
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94918252T
Other languages
English (en)
Inventor
Tarek S Mansour
Colleen A Evans
Haolun Jin
Arshad M Siddiqui
Allan H L Tse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Canada Inc
Original Assignee
IAF BioChem International Inc
Biochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IAF BioChem International Inc, Biochem Pharma Inc filed Critical IAF BioChem International Inc
Application granted granted Critical
Publication of ES2139744T3 publication Critical patent/ES2139744T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCESO PARA PRODUCIR ANALOGOS DE NUCLEOSIDOS CIS PREDOMINANTEMENTE PUROS UTILIZANDO UN NUEVO COMPUESTO INTERMEDIO BICICLICO DE LA FORMULA (III), EN LA X ES S, U O; Y ES S, CH2, O O CH(R); EN DONDE R ES AZIDO O HALOGENO, Y Z ES S U O.
ES94918252T 1993-06-07 1994-06-07 Sintesis estereoselectiva de analogos de nucleosidos empleando un intermediario biciclico. Expired - Lifetime ES2139744T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939311709A GB9311709D0 (en) 1993-06-07 1993-06-07 Stereoselective synthesis of nucleoside analogues using bicycle intermediate

Publications (1)

Publication Number Publication Date
ES2139744T3 true ES2139744T3 (es) 2000-02-16

Family

ID=10736757

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94918252T Expired - Lifetime ES2139744T3 (es) 1993-06-07 1994-06-07 Sintesis estereoselectiva de analogos de nucleosidos empleando un intermediario biciclico.

Country Status (21)

Country Link
US (1) US5763606A (es)
EP (1) EP0654031B1 (es)
JP (1) JP3110461B2 (es)
KR (1) KR100304072B1 (es)
CN (1) CN1046720C (es)
AT (1) ATE188215T1 (es)
AU (1) AU668829B2 (es)
BR (1) BR9405423A (es)
CA (1) CA2141029C (es)
DE (1) DE69422374T2 (es)
DK (1) DK0654031T3 (es)
ES (1) ES2139744T3 (es)
FI (1) FI112078B (es)
GB (1) GB9311709D0 (es)
HU (1) HU219199B (es)
NO (1) NO303449B1 (es)
NZ (1) NZ267379A (es)
OA (1) OA10349A (es)
PL (1) PL180870B1 (es)
RU (1) RU2139870C1 (es)
WO (1) WO1994029301A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6175008B1 (en) * 1988-04-11 2001-01-16 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
US6034087A (en) * 1994-10-22 2000-03-07 Chong Kun Dang Corp. Nucleoside derivatives and process for preparing thereof
JP4249393B2 (ja) 1998-08-12 2009-04-02 トライアングル・ファーマシューティカルズ，インコーポレイテッド １，３−オキサチオランヌクレオチドの製造方法
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
CA2308559C (en) 2000-05-16 2005-07-26 Brantford Chemicals Inc. 1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues
PT1574512E (pt) 2001-03-01 2008-03-05 Abbott Lab Formas polimórficas e outras formas cristalinas de cis-ftc
EA015145B1 (ru) 2003-01-14 2011-06-30 Джилид Сайэнс, Инк. Фармацевтическая композиция и пероральная фармацевтическая дозированная форма (варианты), проявляющие активность в отношении вич-инфекций, лечебный набор и таблетка и способ лечения или предотвращения симптомов или эффектов вич-инфекции
CN101044122A (zh) * 2004-02-03 2007-09-26 埃莫里大学 制备1,3－二氧戊环核苷的方法
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
GB9009861D0 (en) * 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
AU9125991A (en) * 1990-12-05 1992-07-08 University Of Georgia Research Foundation, Inc., The Enantiomerically pure beta -l-(-)-1,3-oxathiolane nucleosides
ZA923641B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
US5332814A (en) * 1991-11-12 1994-07-26 Ciba-Geigy Corporation Process for the preparation of carbacyclic nucleosides, and intermediates

Also Published As

Publication number Publication date
CA2141029C (en) 2000-07-25
NO950432L (no) 1995-03-13
PL180870B1 (pl) 2001-04-30
NO950432D0 (no) 1995-02-06
RU2139870C1 (ru) 1999-10-20
DE69422374D1 (de) 2000-02-03
CN1110479A (zh) 1995-10-18
FI950535L (fi) 1995-02-07
BR9405423A (pt) 1999-05-25
DE69422374T2 (de) 2000-06-29
DK0654031T3 (da) 2000-06-13
OA10349A (en) 2001-10-18
GB9311709D0 (en) 1993-07-21
WO1994029301A1 (en) 1994-12-22
JP3110461B2 (ja) 2000-11-20
EP0654031A1 (en) 1995-05-24
HU219199B (en) 2001-03-28
CN1046720C (zh) 1999-11-24
PL307350A1 (en) 1995-05-15
CA2141029A1 (en) 1994-12-22
NO303449B1 (no) 1998-07-13
RU95108553A (ru) 1996-11-20
HK1008673A1 (en) 1999-05-14
KR100304072B1 (ko) 2001-11-22
AU6966794A (en) 1995-01-03
AU668829B2 (en) 1996-05-16
FI950535A0 (fi) 1995-02-07
HU9500364D0 (en) 1995-05-29
FI112078B (fi) 2003-10-31
ATE188215T1 (de) 2000-01-15
US5763606A (en) 1998-06-09
NZ267379A (en) 1997-04-24
JPH08505643A (ja) 1996-06-18
HUT73630A (en) 1996-08-28
EP0654031B1 (en) 1999-12-29

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