DK0451547T3 - 1,4,8-triazacyclotridecanderivater med prolylendopeptidase inhiberende aktivitet - Google Patents

1,4,8-triazacyclotridecanderivater med prolylendopeptidase inhiberende aktivitet

Info

Publication number: DK0451547T3
Authority: DK; Denmark
Prior art keywords: triazacyclotridecane; derivatives; inhibitory activity; prolyl endopeptidase; endopeptidase inhibitory
Prior art date: 1990-03-22

Application number

DK91104163.0T

Other languages

English (en)

Inventor

Toda Soichiro

Oki Toshikazu

Hamagishi Yasutaro

Tomita Koji

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-22

Filing date

1991-03-18

Publication date

1993-12-29

1991-03-18 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1993-12-29 Application granted granted Critical

1993-12-29 Publication of DK0451547T3 publication Critical patent/DK0451547T3/da

Links

PUPRMQSYXBJTLN-UHFFFAOYSA-N 1,4,8-triazacyclotridecane Chemical class C1CCNCCCNCCNCC1 PUPRMQSYXBJTLN-UHFFFAOYSA-N 0.000 title 1
102000056251 Prolyl Oligopeptidases Human genes 0.000 title 1
101710178372 Prolyl endopeptidase Proteins 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
LUORGXVDSLVJSV-FTDILOGSSA-N (e)-6-methyl-n-[(3s,7s,10s)-7-methyl-3-(2-methylpropyl)-2,5,6,9-tetraoxo-1,4,8-triazacyclotridec-10-yl]hept-2-enamide Chemical compound CC(C)CC\C=C\C(=O)N[C@H]1CCCNC(=O)[C@H](CC(C)C)NC(=O)C(=O)[C@H](C)NC1=O LUORGXVDSLVJSV-FTDILOGSSA-N 0.000 abstract 1
YNIGBMUXBCZRNQ-XYOKQWHBSA-N (e)-6-methyl-n-[7-methyl-3-(2-methylpropyl)-2,5,6,9-tetraoxo-1,4,8-triazacyclotridec-10-yl]oct-2-enamide Chemical compound CCC(C)CC\C=C\C(=O)NC1CCCNC(=O)C(CC(C)C)NC(=O)C(=O)C(C)NC1=O YNIGBMUXBCZRNQ-XYOKQWHBSA-N 0.000 abstract 1
241000187180 Streptomyces sp. Species 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
108010051573 eurystatin A Proteins 0.000 abstract 1
108010051571 eurystatin B Proteins 0.000 abstract 1
239000003649 prolyl endopeptidase inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Medicinal Chemistry (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK91104163.0T 1990-03-22 1991-03-18 1,4,8-triazacyclotridecanderivater med prolylendopeptidase inhiberende aktivitet DK0451547T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/497,292 US4999349A (en)	1990-03-22	1990-03-22	BU-4164E - A and B, prolyl endopeptidase inhibitors

Publications (1)

Publication Number	Publication Date
DK0451547T3 true DK0451547T3 (da)	1993-12-29

Family

ID=23976256

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91104163.0T DK0451547T3 (da)	1990-03-22	1991-03-18	1,4,8-triazacyclotridecanderivater med prolylendopeptidase inhiberende aktivitet

Country Status (7)

Country	Link
US (1)	US4999349A (da)
EP (1)	EP0451547B1 (da)
JP (1)	JPH06339390A (da)
AT (1)	ATE99298T1 (da)
CA (1)	CA2038509A1 (da)
DE (1)	DE69100865D1 (da)
DK (1)	DK0451547T3 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5073549A (en) *	1990-03-22	1991-12-17	Bristol-Myers Squibb Company	BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use
GB9024208D0 (en) *	1990-11-07	1990-12-19	Salutar Inc	Compounds
US5449750A (en) *	1991-06-20	1995-09-12	Snow Brand Milk Products Co., Ltd.	Prolyl endopeptidase inhibitors SNA-115 and SNA-115T, and process for the production and productive strain thereof
US20030072715A1 (en) *	2000-08-02	2003-04-17	Benjamin Frydman	Cyclic polyamine compounds for cancer therapy
MXPA03000905A (es) *	2000-08-02	2003-06-24	Slil Biomedical Corp	Compuestos de poliamina ciclicos como tratamiento contra el cancer.
WO2004098591A2 (en)	2003-05-05	2004-11-18	Probiodrug Ag	Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases
AU2004290499C1 (en)	2003-11-03	2011-02-24	Probiodrug Ag	Combinations useful for the treatment of neuronal disorders
CA2554809C (en)	2004-02-05	2014-04-29	Probiodrug Ag	Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
ATE554085T1 (de)	2006-11-30	2012-05-15	Probiodrug Ag	Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja)	2007-03-01	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤の新規使用
EP2142514B1 (en)	2007-04-18	2014-12-24	Probiodrug AG	Thiourea derivatives as glutaminyl cyclase inhibitors
US8524654B2 (en) *	2007-05-21	2013-09-03	The Uab Research Foundation	Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation
JP5934645B2 (ja)	2009-09-11	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
NZ602312A (en)	2010-03-10	2014-02-28	Probiodrug Ag	Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
EP2686313B1 (en)	2011-03-16	2016-02-03	Probiodrug AG	Benzimidazole derivatives as inhibitors of glutaminyl cyclase
ES2812698T3 (es)	2017-09-29	2021-03-18	Probiodrug Ag	Inhibidores de glutaminil ciclasa

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6137764A (ja) *	1984-07-31	1986-02-22	Suntory Ltd	抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPH0623190B2 (ja) *	1985-04-16	1994-03-30	サントリー株式会社	インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
EP0201743B1 (en) *	1985-04-16	1992-04-01	Suntory Limited	Dipeptide derivatives of fatty acids, process for preparing them, pharmaceutical composition and use
US4898940A (en) *	1985-08-30	1990-02-06	Bristol-Myers Company	Peptide antibiotics
JPH0764834B2 (ja) *	1985-11-29	1995-07-12	サントリー株式会社	プロリルエンドペプチダーゼ阻害活性を有する新規ピロリジンアミド誘導体およびその製法並びに用途
CA1320734C (en) *	1986-02-04	1993-07-27	Suntory Limited	Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
JPH08806B2 (ja) *	1986-11-18	1996-01-10	サントリー株式会社	プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジンアミド誘導体
DE3875361T2 (de) *	1987-02-23	1993-03-25	Ono Pharmaceutical Co	Thiazolidin-derivate.
US4857524A (en) *	1987-08-08	1989-08-15	Kissei Pharmaceutical Co., Ltd.	Thiazolidine compounds and therapeutic method

1990
- 1990-03-22 US US07/497,292 patent/US4999349A/en not_active Expired - Fee Related
1991
- 1991-03-18 EP EP91104163A patent/EP0451547B1/en not_active Expired - Lifetime
- 1991-03-18 CA CA002038509A patent/CA2038509A1/en not_active Abandoned
- 1991-03-18 AT AT91104163T patent/ATE99298T1/de not_active IP Right Cessation
- 1991-03-18 DK DK91104163.0T patent/DK0451547T3/da active
- 1991-03-18 DE DE91104163T patent/DE69100865D1/de not_active Expired - Lifetime
- 1991-03-20 JP JP3216761A patent/JPH06339390A/ja active Pending

Also Published As

Publication number	Publication date
DE69100865D1 (de)	1994-02-10
JPH06339390A (ja)	1994-12-13
EP0451547B1 (en)	1993-12-29
CA2038509A1 (en)	1991-09-23
US4999349A (en)	1991-03-12
ATE99298T1 (de)	1994-01-15
EP0451547A1 (en)	1991-10-16

Publication	Publication Date	Title
DK0451547T3 (da)	1993-12-29	1,4,8-triazacyclotridecanderivater med prolylendopeptidase inhiberende aktivitet
DK0706393T3 (da)	2000-04-03	Immun-undertrykkende og antiallergiske forbindelser, f.eks. N-(3-oxohexanoyl)homoserin-lacton
DE59510421D1 (de)	2002-11-21	Substituierte Pyridylpyrazole
ES2187660T3 (es)	2003-06-16	Derivados de rapamicina.
FI911096A7 (fi)	1991-09-07	N-(4-piperidyl) dihydrobenzofuran)karboxamid- eller n-(4-piperidyl)(dihydro-2h- benzopyran) karboxamidderivat.
EP0245518A4 (en)	1988-09-07	ISOFLAVONE DERIVATIVES, THEIR SALTS AND ONCOSTATIC AGENTS AND IMMUNOSUPPRESSANTS.
ATE338744T1 (de)	2006-09-15	Hydrazonderivate
DK0876359T3 (da)	2003-11-24	(-)-cis-6(S)-phenyl-5(R)- [4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol-D-tartrat
NO885337D0 (no)	1988-11-30	D-cykloserin og dets promedikamenter for bedring av hukommelse.
DE69211182D1 (de)	1996-07-11	Pyranylcyanoguanidinderivate
FI911980L (fi)	1991-10-25	N-(3-fluor-2-fosfonylmetoxipropyl) -derivat av heterocykliska purin- och pyrimidinbaser, deras framstaellning och anvaendning.
ES2090099T3 (es)	1996-10-16	Derivados de piranil-cianoguanidina.
DE68918681D1 (de)	1994-11-10	Glycosidasehemmer.
PT843679E (pt)	2002-04-29	Derivados da1-(piperidinil 1,2-disubstituido)-(4-imidazole fundido)-piperidina
ES2077071T3 (es)	1995-11-16	Derivados de quinolin-3-carboxamida.
DK0596929T3 (da)	1995-09-11	Amidderivater af antibiotikum A 40926
NO930520L (no)	1993-08-16	Bifenyl-substituerte kinolinderivater
LU91235I2 (fr)	2006-11-22	Palifermin et ses dérivés pharmaceutiquement acceptables (KEPIVANCE)
FI970448A7 (fi)	1997-04-03	N-substituoituja 3-atsobisyklo(3.2.0)heptaanijohdannaisia,jotka ovat k äyttökelpoisia neuroleptisina aineina
MY105128A (en)	1994-08-30	Bu-3608 derivatives.
ATE90105T1 (de)	1993-06-15	Glycosid-antibiotika bu-3608d und bu-3608e.
FI883759A0 (fi)	1988-08-12	C.12-modifierade etromycin a-derivat.
AU7879487A (en)	1988-03-08	Proteine protease inhibitors from streptomyces
FI944678A7 (fi)	1994-10-06	3,4-dihydro-2H-1-bentsopyraanien hydratsidijohdannaisia
DE58903780D1 (de)	1993-04-22	N-substituierte 3,4,5,6-tetrahydrophthalimid-derivate.