DK0452514T3 - Peptid og fremgangsmåde til fremstilling af cyclisk peptid - Google Patents

Peptid og fremgangsmåde til fremstilling af cyclisk peptid

Info

Publication number: DK0452514T3
Authority: DK; Denmark
Prior art keywords: ser; substd; leu; protecting; asn
Prior art date: 1989-11-08

Application number

DK91909390.6T

Other languages

Danish (da)

English (en)

Inventor

Masutaka Ohsaki

Satoshi Kishida

Takashi Inoue

Original Assignee

Daicel Chem

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-08

Filing date

1990-11-07

Publication date

1995-08-21

1990-11-07 Application filed by Daicel Chem filed Critical Daicel Chem

1995-08-21 Application granted granted Critical

1995-08-21 Publication of DK0452514T3 publication Critical patent/DK0452514T3/da

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
108010069514 Cyclic Peptides Proteins 0.000 title 1
102000001189 Cyclic Peptides Human genes 0.000 title 1
125000000539 amino acid group Chemical group 0.000 abstract 3
239000011347 resin Substances 0.000 abstract 3
229920005989 resin Polymers 0.000 abstract 3
FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 2
XAKBSHICSHRJCL-UHFFFAOYSA-N [CH2]C(=O)C1=CC=CC=C1 Chemical group [CH2]C(=O)C1=CC=CC=C1 XAKBSHICSHRJCL-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
UHPQFNXOFFPHJW-UHFFFAOYSA-N (4-methylphenyl)-phenylmethanamine Chemical compound C1=CC(C)=CC=C1C(N)C1=CC=CC=C1 UHPQFNXOFFPHJW-UHFFFAOYSA-N 0.000 abstract 1
229940090248 4-hydroxybenzoic acid Drugs 0.000 abstract 1
102000055006 Calcitonin Human genes 0.000 abstract 1
108060001064 Calcitonin Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
-1 alkali metal salt Chemical class 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
229910052792 caesium Inorganic materials 0.000 abstract 1
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
229960004015 calcitonin Drugs 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
MGHPNCMVUAKAIE-UHFFFAOYSA-N diphenylmethanamine Chemical compound C=1C=CC=CC=1C(N)C1=CC=CC=C1 MGHPNCMVUAKAIE-UHFFFAOYSA-N 0.000 abstract 1
150000004820 halides Chemical class 0.000 abstract 1
125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
229910052744 lithium Inorganic materials 0.000 abstract 1
229910052700 potassium Inorganic materials 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
229910052701 rubidium Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000007790 solid phase Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK91909390.6T 1989-11-08 1990-11-07 Peptid og fremgangsmåde til fremstilling af cyclisk peptid DK0452514T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP29066089		1989-11-08

Publications (1)

Publication Number	Publication Date
DK0452514T3 true DK0452514T3 (da)	1995-08-21

Family

ID=17758846

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91909390.6T DK0452514T3 (da)	1989-11-08	1990-11-07	Peptid og fremgangsmåde til fremstilling af cyclisk peptid

Country Status (9)

Country	Link
US (2)	US5428129A (2)
EP (1)	EP0452514B1 (2)
JP (1)	JPH0745517B2 (2)
KR (1)	KR920701248A (2)
AT (1)	ATE124705T1 (2)
CA (1)	CA2045495A1 (2)
DE (1)	DE69020722T2 (2)
DK (1)	DK0452514T3 (2)
WO (1)	WO1991007433A1 (2)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69020722T2 (de) *	1989-11-08	1996-01-18	Daicel Chem	Peptide und verfahren zur herstellung von zyklischen peptiden.
JPH10501818A (ja) *	1994-06-16	1998-02-17	スミスクライン・ビーチャム・コーポレイション	鋳型指向性環化
US5661097A (en) †	1994-08-12	1997-08-26	The Dow Chemical Company	Supported olefin polymerization catalyst
WO1996029343A1 (en) *	1995-03-20	1996-09-26	Kyowa Hakko Kogyo Co., Ltd.	Novel calcitonin derivatives
US5962270A (en)	1996-02-06	1999-10-05	Bionebraska, Inc.	Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs
US6271198B1 (en) *	1996-11-06	2001-08-07	Genentech, Inc.	Constrained helical peptides and methods of making same
HUP0101629A2 (en) *	1998-04-15	2003-03-28	Aventis Pharma Inc	Process for the preparation of resin-bound cyclic peptides
CA2472956A1 (en) *	2002-02-14	2003-08-21	Bayer Pharmaceuticals Corporation	Formulation strategies in stabilizing peptides in organic solvents and in dried states
DE10325049A1 (de) *	2003-06-02	2004-12-23	Merck Patent Gmbh	Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften III
WO2008109079A2 (en) *	2007-03-01	2008-09-12	Novetide, Ltd.	High purity peptides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4043992A (en) *	1969-06-30	1977-08-23	Kyowa Hakko Kogyo Co., Ltd.	Method for preparing acylated products
JPS51128993A (en) *	1975-05-01	1976-11-10	Tanpakushitsu Kenkyu Shiyoureikai	Process for preparing new polypeptides
US4161521A (en)	1975-08-08	1979-07-17	Merck & Co., Inc.	Somatostatin analogs
JPS5359688A (en) *	1976-11-11	1978-05-29	Tanpakushitsu Kenkiyuu Shiyour	Production of novel polypeptide
IT1105131B (it)	1977-06-08	1985-10-28	Merck & Co Inc	Peptidi analoghi della somatostatina dotati di piu' lunga e maggiore attivita' biologica e relativo procedimento di protezione
JPS5850213B2 (ja) *	1977-06-20	1983-11-09	株式会社第一ラジオアイソト−プ研究所	カルチトニンの定量法
JPS62129297A (ja) *	1985-08-09	1987-06-11	Toyo Jozo Co Ltd	カルシトニン遺伝子関連ペプチド誘導体
US4658014A (en) *	1985-12-20	1987-04-14	Kempe Tomas G	Synthetic peptides with calcitonin-like activity
FR2592049B1 (fr) *	1985-12-24	1988-02-12	Milhaud Gerard	Nouveaux analogues de composes polypeptidiques hypocalcemiants epargnant le calcium de l'organisme, leur preparation et les medicaments contenant ces principes actifs
JP2777193B2 (ja) *	1988-10-24	1998-07-16	生化学工業株式会社	ペプチドの製造方法
DE69020722T2 (de) *	1989-11-08	1996-01-18	Daicel Chem	Peptide und verfahren zur herstellung von zyklischen peptiden.

1990
- 1990-11-07 DE DE69020722T patent/DE69020722T2/de not_active Expired - Fee Related
- 1990-11-07 AT AT91909390T patent/ATE124705T1/de not_active IP Right Cessation
- 1990-11-07 WO PCT/JP1990/001440 patent/WO1991007433A1/ja not_active Ceased
- 1990-11-07 KR KR1019910700711A patent/KR920701248A/ko not_active Ceased
- 1990-11-07 CA CA002045495A patent/CA2045495A1/en not_active Abandoned
- 1990-11-07 DK DK91909390.6T patent/DK0452514T3/da active
- 1990-11-07 EP EP91909390A patent/EP0452514B1/en not_active Expired - Lifetime
- 1990-11-07 JP JP2-515081A patent/JPH0745517B2/ja not_active Expired - Lifetime
1991
- 1991-07-08 US US07/726,843 patent/US5428129A/en not_active Expired - Fee Related
1993
- 1993-06-28 US US08/083,217 patent/US5508382A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0452514A4 (en)	1993-04-28
JPH0745517B1 (2)	1995-05-17
CA2045495A1 (en)	1991-05-09
DE69020722T2 (de)	1996-01-18
ATE124705T1 (de)	1995-07-15
EP0452514B1 (en)	1995-07-05
EP0452514A1 (en)	1991-10-23
KR920701248A (ko)	1992-08-11
JPH0745517B2 (ja)	1995-05-17
US5508382A (en)	1996-04-16
WO1991007433A1 (en)	1991-05-30
US5428129A (en)	1995-06-27
DE69020722D1 (de)	1995-08-10

Publication	Publication Date	Title
DK0452514T3 (da)	1995-08-21	Peptid og fremgangsmåde til fremstilling af cyclisk peptid
EP0591524A4 (2)	1994-08-03
HUT40696A (en)	1987-01-28	Process for preparing protease resistent urokinase
HUT54213A (en)	1991-01-28	Process for the enzymatic removal of n-terminal sequence of proteins
CA2168429A1 (en)	1995-02-09	Expression of fusion polypeptides transported out of cytoplasm without leader sequences
HUT63652A (en)	1993-09-28	Process for producing cd44 surface protein variants, dna sequences encoding them and antibodies against them, as well as their application in diagnosis and therapy
IL76107A (en)	1991-03-10	Method of removing n-terminal amino acid residues from eucaryotic polypeptide analogs and polypeptides produced thereby
NO164245B (no)	1990-06-05	Fremgangsmaate for fremstilling av peptidet h-arg-x-z-y-tyr-r.
DK222587D0 (da)	1987-05-01	Vaccine mod varicella zoster virus
EP0546087A4 (2)	1994-01-05
ES2009588A6 (es)	1989-10-01	Un metodo para la preparacion de un polipeptido.
EP0572737A3 (en)	1994-11-23	Gag-Env fusion antigen from HIV.
DE60037508D1 (de)	2008-01-31	Verfahren zur herstellung von rekombinantem insulin durch fusionsproteine
EP0330700A4 (en)	1990-01-08	Human prourokinase-like polypeptide.
DE69013350D1 (de)	1994-11-17	Von casein-beta ausgehendes verfahren zur herstellung von fraktionen, die mit biologisch aktiven peptiden angereichert sind sowie die so erhaltenen peptidfraktionen.
CA2025350A1 (en)	1990-07-18	Process for production of c-terminal .alpha.-amidated peptide
FR2636643B1 (fr)	1990-12-28	Peptide-signal, sequences d'adn codant pour celui-ci, vecteurs d'expression portant l'une de ces sequences et procede de production periplasmique d'un polypeptide
DE69314087D1 (de)	1997-10-30	Veränderte Signalsequenzen
NO962101L (no)	1990-12-27	Fremgangsmåte for fremstilling av peptider med modifiserte VP1/P2A i rhinovirussystemet
SKI	1987	CDMT-Mediated Peptide Synthesis
TH43867A (th)	2001-03-26	ลำดับกรดนิวคลีอิคและกรดอะมิโนที่เกี่ยวข้องกับ Helicobacter pyroli และองค์ประกอบวัคซีนของมัน
IT1077079B (it)	1985-04-27	Procedimento per la produzione di un peptide
FI961398L (fi)	1996-03-27	Menetelmä terapeuttisesti käyttökelpoisen peptidin valmistamiseksi