IT1105131B - Peptidi analoghi della somatostatina dotati di piu' lunga e maggiore attivita' biologica e relativo procedimento di protezione - Google Patents

Peptidi analoghi della somatostatina dotati di piu' lunga e maggiore attivita' biologica e relativo procedimento di protezione

Info

Publication number
IT1105131B
IT1105131B IT49736/78A IT4973678A IT1105131B IT 1105131 B IT1105131 B IT 1105131B IT 49736/78 A IT49736/78 A IT 49736/78A IT 4973678 A IT4973678 A IT 4973678A IT 1105131 B IT1105131 B IT 1105131B
Authority
IT
Italy
Prior art keywords
somatostatina
analogs
long
biological activity
protection procedure
Prior art date
Application number
IT49736/78A
Other languages
English (en)
Other versions
IT7849736A0 (it
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IT7849736A0 publication Critical patent/IT7849736A0/it
Application granted granted Critical
Publication of IT1105131B publication Critical patent/IT1105131B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IT49736/78A 1977-06-08 1978-06-06 Peptidi analoghi della somatostatina dotati di piu' lunga e maggiore attivita' biologica e relativo procedimento di protezione IT1105131B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80467877A 1977-06-08 1977-06-08

Publications (2)

Publication Number Publication Date
IT7849736A0 IT7849736A0 (it) 1978-06-06
IT1105131B true IT1105131B (it) 1985-10-28

Family

ID=25189555

Family Applications (1)

Application Number Title Priority Date Filing Date
IT49736/78A IT1105131B (it) 1977-06-08 1978-06-06 Peptidi analoghi della somatostatina dotati di piu' lunga e maggiore attivita' biologica e relativo procedimento di protezione

Country Status (7)

Country Link
US (1) US4146612A (it)
EP (1) EP0000053B1 (it)
JP (1) JPS543085A (it)
DE (1) DE2860734D1 (it)
DK (1) DK252778A (it)
IE (1) IE47421B1 (it)
IT (1) IT1105131B (it)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU78191A1 (de) * 1977-09-28 1979-05-25 Ciba Geigy Ag Verfahren zur herstellung von neuen cyclopeptiden
US4190648A (en) * 1979-03-13 1980-02-26 Merck & Co., Inc. Peptides having somatostatin activity
NZ195303A (en) * 1979-10-31 1984-10-19 Merck & Co Inc Cyclic hexapeptide somatostatin analogues,and pharmaceutical compositions
US4358439A (en) * 1979-12-21 1982-11-09 Ciba-Geigy Corporation Cyclooctapeptides
US4508711A (en) * 1983-04-18 1985-04-02 American Cyanamid Company Cyclic pentapeptide displaying somatostatin antagonism and method of treatment of mammals therewith
DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
ZW11290A1 (en) * 1989-07-14 1990-10-31 Smithkline Beecham Corp Hemoregulatory peptides
JPH0745517B2 (ja) 1989-11-08 1995-05-17 ダイセル化学工業株式会社 ペプチド、および環状ペプチドの製造方法
US5965694A (en) * 1992-09-01 1999-10-12 The Trustees Of The University Of Pennsylvania Somatostatin mimics and synthetic methods therefor
US5700905A (en) * 1992-09-01 1997-12-23 The Trustees Of The University Of Pennsylvania Synthetic somatostatin mimics
US6001960A (en) * 1992-09-01 1999-12-14 The Trustees Of The University Of Pennsylvania Synthetic somatostatin mimics
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
DE4342907A1 (de) * 1993-12-16 1995-06-22 Bayer Ag Neue cyclische Depsipeptide mit 18 Ringatomen und ihre Verwendung zur Bekämpfung von Endoparasiten
WO1996014810A2 (en) * 1994-11-03 1996-05-23 The Saunders Group, Inc. Portable traction device
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
AU7655098A (en) * 1997-05-13 1998-12-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Somatostatin and somatostatin agonists for decreasing body weight
WO1998051330A1 (en) * 1997-05-13 1998-11-19 Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) Method and compositions for treating hyperlipidemia and other conditions
ES2216290T3 (es) * 1997-05-13 2004-10-16 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatina y agonistas de la somatostatina para el tratamiento de insensibilidad a la insulina y de sindrome x.
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US6171273B1 (en) 1999-08-06 2001-01-09 The Saunders Group, Inc. Self-seating occiput wedge system for applying a therapeutic traction force
BR0210915A (pt) 2001-06-08 2004-06-08 Sod Conseils Rech Applic Análogos quiméricos de somatostatina-dopamina
US7189214B1 (en) 2002-01-22 2007-03-13 The Saunders Group, Inc. Multi-axis cervical and lumbar traction table
US20040145462A1 (en) * 2003-01-29 2004-07-29 Honda Giken Kogyo Kabushiki Kaisha Variable electronic display apparatus for a vehicle, and method of using same
CN101791409A (zh) 2003-04-22 2010-08-04 研究及应用科学协会股份有限公司 肽载体
CA2727082C (en) 2008-06-12 2019-02-26 Syntaxin Limited Fusion proteins for use in suppression of acromegaly
CN102083451A (zh) 2008-06-12 2011-06-01 赛恩泰新公司 癌症的抑制
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US781610A (en) * 1904-01-11 1905-01-31 Winfield S Livengood Wagon-brake.
US3904594A (en) * 1973-07-02 1975-09-09 Salk Inst For Biological Studi Somatostatin and acylated des-(ala' 1', gly' 2') derivatives thereof
US3882098A (en) * 1974-01-03 1975-05-06 American Home Prod Synthesis of des-Ala{hu 1{b , Gly{hu 2{b , Asn{hu 5{b -SRIF and intermediates
DE2460469A1 (de) * 1974-12-20 1976-07-01 Hoechst Ag Neue peptide mit biologischer wirkung und verfahren zu ihrer herstellung
US3933784A (en) * 1975-01-27 1976-01-20 American Home Products Corporation Des-(ser13)-srif and intermediates
US4011182A (en) * 1975-03-21 1977-03-08 American Home Products Corporation Cyclic undecapeptide analogs of somatostatin and intermediates
CA1083143A (en) * 1976-01-02 1980-08-05 Nedumparambil A. Abraham Carba derivatives of somatostatin and process therefor

Also Published As

Publication number Publication date
IT7849736A0 (it) 1978-06-06
IE781151L (en) 1978-12-08
EP0000053A1 (en) 1978-12-20
EP0000053B1 (en) 1981-05-27
US4146612A (en) 1979-03-27
DE2860734D1 (en) 1981-09-03
IE47421B1 (en) 1984-03-07
JPS543085A (en) 1979-01-11
DK252778A (da) 1978-12-09

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