DK0456519T3 - Piperidyloxy- og quinuclidinyloxyisoxazolderivater, deres fremstilling og deres terapeutiske anvendelse - Google Patents

Piperidyloxy- og quinuclidinyloxyisoxazolderivater, deres fremstilling og deres terapeutiske anvendelse

Info

Publication number: DK0456519T3
Authority: DK; Denmark
Prior art keywords: hydrogen; quinuclidinyloxyisoxazole; piperidyloxy; derivatives; preparation
Prior art date: 1990-05-11

Application number

DK91304254.5T

Other languages

English (en)

Inventor

Mitsuo Nagano

Junichi Sakai

Takeo Kobayashi

Masao Kozuka

Nobuyoshi Iwata

Yoshiko Kubo

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-11

Filing date

1991-05-10

Publication date

1994-11-07

1991-05-10 Application filed by Sankyo Co filed Critical Sankyo Co

1994-11-07 Application granted granted Critical

1994-11-07 Publication of DK0456519T3 publication Critical patent/DK0456519T3/da

Links

TYKDAIZLVDFALU-UHFFFAOYSA-N 3-(1-azabicyclo[2.2.2]octan-2-yloxy)-1,2-oxazole Chemical class C1CN2CCC1CC2OC=1C=CON=1 TYKDAIZLVDFALU-UHFFFAOYSA-N 0.000 title 1
-1 Piperidyloxy Chemical group 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
208000024827 Alzheimer disease Diseases 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000005936 piperidyl group Chemical group 0.000 abstract 2
206010039966 Senile dementia Diseases 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
208000010877 cognitive disease Diseases 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000004970 halomethyl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK91304254.5T 1990-05-11 1991-05-10 Piperidyloxy- og quinuclidinyloxyisoxazolderivater, deres fremstilling og deres terapeutiske anvendelse DK0456519T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP11975490		1990-05-11
JP21651990		1990-08-17
JP27848990		1990-10-17

Publications (1)

Publication Number	Publication Date
DK0456519T3 true DK0456519T3 (da)	1994-11-07

Family

ID=27313898

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91304254.5T DK0456519T3 (da)	1990-05-11	1991-05-10	Piperidyloxy- og quinuclidinyloxyisoxazolderivater, deres fremstilling og deres terapeutiske anvendelse

Country Status (15)

Country	Link
US (1)	US5643923A (da)
EP (1)	EP0456519B1 (da)
JP (1)	JPH0747585B2 (da)
KR (1)	KR0178369B1 (da)
CN (1)	CN1042225C (da)
AT (1)	ATE108448T1 (da)
CA (1)	CA2042336A1 (da)
CZ (1)	CZ284343B6 (da)
DE (1)	DE69102816T2 (da)
DK (1)	DK0456519T3 (da)
ES (1)	ES2060303T3 (da)
HK (1)	HK1005728A1 (da)
HU (2)	HU215832B (da)
IE (1)	IE65997B1 (da)
PT (1)	PT97637B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3752062T2 (de) *	1986-12-17	1997-09-11	Glaxo Group Ltd	Verwendung von heterozyklischen Derivaten zur Herstellung von Arzneimitteln
EP0492020A1 (en) *	1990-12-21	1992-07-01	Merrell Dow Pharmaceuticals Inc.	Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
GB9226573D0 (en) *	1992-12-21	1993-02-17	Ici Plc	Heterocyclic compounds
DK124393D0 (da) *	1993-11-03	1993-11-03	Lundbeck & Co As H	Compounds
US5821371A (en) *	1994-10-24	1998-10-13	Eli Lilly And Comany	Heterocyclic compounds and their preparation and use
US6040442A (en) *	1995-06-01	2000-03-21	Eli Lilly And Company	Process for preparing 1,2,5-thiadiazole containing ethers
WO1997031906A1 (en) *	1996-02-27	1997-09-04	Sankyo Company, Limited	Isoxazole derivatives
UA52698C2 (uk)	1996-10-04	2003-01-15	Х. Луннбек А/С	Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі
ATE315033T1 (de)	1998-08-07	2006-02-15	Chiron Corp	Subtituierte isoxazole derivate als estrogen rezeptor modulatore
US7655657B2 (en)	2003-12-22	2010-02-02	Abbott Laboratories	Fused bicycloheterocycle substituted quinuclidine derivatives
US7160876B2 (en)	2003-12-22	2007-01-09	Abbott Laboratories	Fused bicycloheterocycle substituted quinuclidine derivatives
TWI471095B (zh)	2009-12-21	2015-02-01	Nippon Soda Co	環胺化合物及殺蟎劑
AR081721A1 (es) *	2010-02-25	2012-10-17	Nippon Soda Co	Compuesto de amina ciclica y acaricida
HU230649B1 (hu)	2013-01-24	2017-05-29	Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság	Javított eljárás prasugrel gyógyszeripari hatóanyag és az 1-ciklopropil-2-(2-fluorofenil)-etanon intermedier előállítására

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3290301A (en) *	1963-12-02	1966-12-06	Shionogi & Co	Certain 3-aminoalkyl-5-alkylisoxazoles
AT254868B (de) *	1964-02-13	1967-06-12	Shionogi & Co	Verfahren zur Herstellung von neuen disubstituierten Isoxazolverbindungen
NZ219646A (en) *	1986-03-27	1990-10-26	Merck Sharp & Dohme	Oxadiazole derivatives of azacyclics for treating cns disorders
IE60267B1 (en) *	1986-12-26	1994-06-29	Sankyo Co	Centrally-acting muscle relaxants
US5321037A (en) *	1986-12-26	1994-06-14	Sankyo Company, Limited	Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants
CA1307790C (en) *	1987-08-04	1992-09-22	Ian Anthony Cliffe	Ethers
CA1329128C (en) *	1988-03-24	1994-05-03	Nobuyoshi Iwata	Isoxazolinones as cerebro-active drugs
IE62276B1 (en) *	1988-03-30	1995-01-25	Sankyo Co	"New isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants"
US5116839A (en) *	1989-06-26	1992-05-26	Sankyo Company, Limited	Use of isoxazolin-3-one derivatives as antidepressants
YU84791A (sh) *	1990-05-19	1994-06-10	Boehringer Ingelheim Kg.	Biciklicni 1-aza-cikloalkalni

1991
- 1991-05-10 DE DE69102816T patent/DE69102816T2/de not_active Expired - Fee Related
- 1991-05-10 CA CA002042336A patent/CA2042336A1/en not_active Abandoned
- 1991-05-10 HU HU1568/91A patent/HU215832B/hu not_active IP Right Cessation
- 1991-05-10 JP JP3105741A patent/JPH0747585B2/ja not_active Expired - Lifetime
- 1991-05-10 EP EP91304254A patent/EP0456519B1/en not_active Expired - Lifetime
- 1991-05-10 AT AT91304254T patent/ATE108448T1/de not_active IP Right Cessation
- 1991-05-10 IE IE159891A patent/IE65997B1/en unknown
- 1991-05-10 CZ CS911385A patent/CZ284343B6/cs not_active IP Right Cessation
- 1991-05-10 ES ES91304254T patent/ES2060303T3/es not_active Expired - Lifetime
- 1991-05-10 PT PT97637A patent/PT97637B/pt not_active IP Right Cessation
- 1991-05-10 DK DK91304254.5T patent/DK0456519T3/da active
- 1991-05-11 CN CN91103768A patent/CN1042225C/zh not_active Expired - Fee Related
- 1991-05-11 KR KR1019910007621A patent/KR0178369B1/ko not_active Expired - Fee Related
1992
- 1992-08-27 US US07/937,445 patent/US5643923A/en not_active Expired - Fee Related
1995
- 1995-06-29 HU HU95P/P00539P patent/HU211875A9/hu unknown
1998
- 1998-06-03 HK HK98104828A patent/HK1005728A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
IE911598A1 (en)	1991-11-20
JPH0747585B2 (ja)	1995-05-24
EP0456519B1 (en)	1994-07-13
HU911568D0 (en)	1991-11-28
KR0178369B1 (ko)	1999-03-20
DE69102816T2 (de)	1995-03-16
US5643923A (en)	1997-07-01
CN1042225C (zh)	1999-02-24
CZ284343B6 (cs)	1998-10-14
EP0456519A1 (en)	1991-11-13
IE65997B1 (en)	1995-11-29
ATE108448T1 (de)	1994-07-15
KR910019988A (ko)	1991-12-19
HUT60735A (en)	1992-10-28
PT97637A (pt)	1992-02-28
PT97637B (pt)	1998-08-31
CA2042336A1 (en)	1991-11-12
CS138591A3 (en)	1992-03-18
JPH04225977A (ja)	1992-08-14
CN1057259A (zh)	1991-12-25
HU215832B (hu)	1999-04-28
ES2060303T3 (es)	1994-11-16
HK1005728A1 (en)	1999-01-22
HU211875A9 (en)	1995-12-28
DE69102816D1 (de)	1994-08-18

Publication	Publication Date	Title
DK0456519T3 (da)	1994-11-07	Piperidyloxy- og quinuclidinyloxyisoxazolderivater, deres fremstilling og deres terapeutiske anvendelse
CS556587A2 (en)	1988-08-16	Process for preparing aminoderivatives
NO179246C (no)	1996-09-04	Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
DK359289A (da)	1990-01-21	4-oxoquinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf samt deres anvendelse
DK0637586T3 (da)	1999-12-06	2-(Piperidin-4-yl, pyridin-4-yl og tetrahydropyridin-4-yl)-benzofuran-7-carbamatderivater, deres fremstilling og anvendelse
IE890177L (en)	1989-07-21	Piperidinyl derivatives
ZA88686B (en)	1989-10-25	Cinnoline-carboxamides and process for their preparation
DK0471297T3 (da)	1996-03-04	3-(1,2-Benzisoxazol-3-yl)-4-pyridinaminer og derivater
ZA917141B (en)	1992-04-29	3-(1h-indazol-3-yl)-4-pyridinamines,a process and intermediates for their preparation and their use as medicaments
RU93004471A (ru)	1995-10-27	Пиперидилокси- и хинуклидинилокси-изоксазоловые производные и фармацевтическая композиция на их основе
NO905128D0 (no)	1990-11-27	Fremgangsmaate og mellomprodukter for fremstilling og anvendelse av heksahydro-1h-quino(4,3,2-ef)(1,4)benzoksazepiner samt beslektede forbindelser.