ES2060303T3 - Derivados de piperidiloxiisoxazol y quinuclidiniloxiisoxazol, su preparacion y su uso terapeutico. - Google Patents

Derivados de piperidiloxiisoxazol y quinuclidiniloxiisoxazol, su preparacion y su uso terapeutico.

Info

Publication number
ES2060303T3
ES2060303T3 ES91304254T ES91304254T ES2060303T3 ES 2060303 T3 ES2060303 T3 ES 2060303T3 ES 91304254 T ES91304254 T ES 91304254T ES 91304254 T ES91304254 T ES 91304254T ES 2060303 T3 ES2060303 T3 ES 2060303T3
Authority
ES
Spain
Prior art keywords
hydrogen
alkyl
quinuclidiniloxiisoxazole
piperidiloxiisoxazole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91304254T
Other languages
English (en)
Inventor
Mitsuo C O Sankyo Compa Nagano
Junichi C O Sankyo Compa Sakai
Takeo C O Sankyo Com Kobayashi
Masao C O Sankyo Compan Kozuka
Nobuyoshi C O Sankyo Com Iwata
Yoshiko C O Sankyo Compan Kubo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2060303T3 publication Critical patent/ES2060303T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

COMPUESTOS QUE TIENEN LA FORMULA (I): [EN QUE: R ELEVADO 1 ES HIDROGENO, HALOGENO O ALQUILO; R (AL CUADRADO) ES HIDROGENO, ALQUILO, FENILO OPCIONALMENTE SUSTITUIDO O UN HETEROCICLO; O R ELEVADO 1 Y R (AL CUADRADO) JUNTOS FORMAN UN GRUPO QUE TIENE LA FORMULA -CR ELEVADO 4=CR ELEVADO 5-CR ELEVADO 6=CR ELEVADO 7-, DONDE R ELEVADO 4, R ELEVADO 5, R ELEVADO 6 Y R ELEVADO 7 SON HIDROGENO, HALOGENO, UN GRUPO DE ALQUILO, ALCOXI, HALOMETILO, ALQUILAMINO, DIALQUILAMINO, HIDROXI, NITRO, ACILAMINO CARBOXILICO ALIFATICO O AMINO; Y R ELEVADO 3 ES PIPERIDILO, PIPERIDILO SUSTITUIDO O QUINUCLIDINILO] QUE SON UTILES EN EL TRATAMIENTO Y PROFILAXIS DE TRASTORNOS COGNITIVOS, DEMENCIA SENIL NOTABLE ENTRE LOS QUE CABE INCLUIR LA ENFERMEDAD DE ALZHEIMER. TAMBIEN SE PRESENTAN LOS PROCESOS PARA LA PREPARACION DE LOS COMPUESTOS.
ES91304254T 1990-05-11 1991-05-10 Derivados de piperidiloxiisoxazol y quinuclidiniloxiisoxazol, su preparacion y su uso terapeutico. Expired - Lifetime ES2060303T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11975490 1990-05-11
JP21651990 1990-08-17
JP27848990 1990-10-17

Publications (1)

Publication Number Publication Date
ES2060303T3 true ES2060303T3 (es) 1994-11-16

Family

ID=27313898

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91304254T Expired - Lifetime ES2060303T3 (es) 1990-05-11 1991-05-10 Derivados de piperidiloxiisoxazol y quinuclidiniloxiisoxazol, su preparacion y su uso terapeutico.

Country Status (14)

Country Link
US (1) US5643923A (es)
EP (1) EP0456519B1 (es)
JP (1) JPH0747585B2 (es)
KR (1) KR0178369B1 (es)
CN (1) CN1042225C (es)
AT (1) ATE108448T1 (es)
CA (1) CA2042336A1 (es)
CZ (1) CZ284343B6 (es)
DE (1) DE69102816T2 (es)
DK (1) DK0456519T3 (es)
ES (1) ES2060303T3 (es)
HU (2) HU215832B (es)
IE (1) IE65997B1 (es)
PT (1) PT97637B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0279990B1 (en) * 1986-12-17 1995-07-12 Glaxo Group Limited Use of heterocyclic derivatives in the treatment of cognitive disorders
EP0492020A1 (en) * 1990-12-21 1992-07-01 Merrell Dow Pharmaceuticals Inc. Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
DK124393D0 (da) * 1993-11-03 1993-11-03 Lundbeck & Co As H Compounds
US5646289A (en) * 1994-10-24 1997-07-08 Eli Lilly And Company Heterocyclic compounds and their preparation and use
US6040442A (en) * 1995-06-01 2000-03-21 Eli Lilly And Company Process for preparing 1,2,5-thiadiazole containing ethers
RU2165415C2 (ru) * 1996-02-27 2001-04-20 Санкио Компани Лимитед Производные изоксазола и фармацевтическая композиция на их основе
UA52698C2 (uk) 1996-10-04 2003-01-15 Х. Луннбек А/С Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі
EP1102755B1 (en) 1998-08-07 2006-01-04 Chiron Corporation Substituted isoxazole derivatives as estrogen receptor modulators
US7655657B2 (en) 2003-12-22 2010-02-02 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
US7160876B2 (en) 2003-12-22 2007-01-09 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
AR079493A1 (es) 2009-12-21 2012-02-01 Nippon Soda Co Compuesto de amina ciclica y acaricida
AR081721A1 (es) * 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
HU230649B1 (hu) 2013-01-24 2017-05-29 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Javított eljárás prasugrel gyógyszeripari hatóanyag és az 1-ciklopropil-2-(2-fluorofenil)-etanon intermedier előállítására

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3290301A (en) * 1963-12-02 1966-12-06 Shionogi & Co Certain 3-aminoalkyl-5-alkylisoxazoles
AT254868B (de) * 1964-02-13 1967-06-12 Shionogi & Co Verfahren zur Herstellung von neuen disubstituierten Isoxazolverbindungen
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
ZA879631B (en) * 1986-12-26 1989-08-30 Sankyo Co Centrally-acting muscle relaxants
US5321037A (en) * 1986-12-26 1994-06-14 Sankyo Company, Limited Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants
CA1307790C (en) * 1987-08-04 1992-09-22 Ian Anthony Cliffe Ethers
ES2057110T3 (es) * 1988-03-24 1994-10-16 Sankyo Co Utilizacion de isoxazolinonas como farmacos con accion sobre el cerebro.
IE62276B1 (en) * 1988-03-30 1995-01-25 Sankyo Co "New isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants"
US5116839A (en) * 1989-06-26 1992-05-26 Sankyo Company, Limited Use of isoxazolin-3-one derivatives as antidepressants
YU84791A (sh) * 1990-05-19 1994-06-10 Boehringer Ingelheim Kg. Biciklicni 1-aza-cikloalkalni

Also Published As

Publication number Publication date
EP0456519A1 (en) 1991-11-13
DE69102816D1 (de) 1994-08-18
IE911598A1 (en) 1991-11-20
PT97637A (pt) 1992-02-28
ATE108448T1 (de) 1994-07-15
IE65997B1 (en) 1995-11-29
EP0456519B1 (en) 1994-07-13
HU911568D0 (en) 1991-11-28
KR910019988A (ko) 1991-12-19
HUT60735A (en) 1992-10-28
US5643923A (en) 1997-07-01
PT97637B (pt) 1998-08-31
HK1005728A1 (en) 1999-01-22
HU215832B (hu) 1999-04-28
CN1042225C (zh) 1999-02-24
CN1057259A (zh) 1991-12-25
DK0456519T3 (da) 1994-11-07
KR0178369B1 (ko) 1999-03-20
HU211875A9 (en) 1995-12-28
DE69102816T2 (de) 1995-03-16
CA2042336A1 (en) 1991-11-12
JPH0747585B2 (ja) 1995-05-24
JPH04225977A (ja) 1992-08-14
CS138591A3 (en) 1992-03-18
CZ284343B6 (cs) 1998-10-14

Similar Documents

Publication Publication Date Title
ES2060303T3 (es) Derivados de piperidiloxiisoxazol y quinuclidiniloxiisoxazol, su preparacion y su uso terapeutico.
CS556587A2 (en) Process for preparing aminoderivatives
DK0658548T3 (da) Benzensylfonamidderivat og fremgangsmåde til fremstilling deraf
DE69418243D1 (de) N-Heteroaryl-N'-Phenylharnstoffderivate, ihre Herstellung und Verwendung
DK0412404T3 (da) Thiazolderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater omfattende derivaterne
ES2132284T3 (es) Derivados de carbamato de 2-(piperidin-4-il, piridin-4-il y tetrahidropiridin-4-il)-benzofurano-7, su preparacion y su uso como inhibidores de acetilcolinesterasa.
IL82395A0 (en) Process for preparation of quinolinecarboxylic acid derivatives
ZA89389B (en) Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
GR3005990T3 (es)
ZA88686B (en) Cinnoline-carboxamides and process for their preparation
IE800900L (en) Pyrrolidinyl-benzoic acid derivatives.
RU93004471A (ru) Пиперидилокси- и хинуклидинилокси-изоксазоловые производные и фармацевтическая композиция на их основе
NO905128D0 (no) Fremgangsmaate og mellomprodukter for fremstilling og anvendelse av heksahydro-1h-quino(4,3,2-ef)(1,4)benzoksazepiner samt beslektede forbindelser.
ES2060056T3 (es) Derivados de 3-isoxazolonas, su preparacion y su utilizacion en terapeutica.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 456519

Country of ref document: ES