DK0458861T3 - Middel til reparation og forebyggelse af fibrotiske læsioner - Google Patents

Middel til reparation og forebyggelse af fibrotiske læsioner

Info

Publication number: DK0458861T3
Authority: DK; Denmark
Prior art keywords: prevention; repair; fibrotic lesions; fibrotic; pyridone
Prior art date: 1989-02-15

Application number

DK90903464.7T

Other languages

Danish (da)

English (en)

Inventor

Solomon B Margolin

Original Assignee

Solomon B Margolin

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-15

Filing date

1990-01-26

Publication date

1996-08-12

1990-01-26 Application filed by Solomon B Margolin filed Critical Solomon B Margolin

1996-08-12 Application granted granted Critical

1996-08-12 Publication of DK0458861T3 publication Critical patent/DK0458861T3/da

Links

230000003176 fibrotic effect Effects 0.000 title abstract 2
230000003902 lesion Effects 0.000 title abstract 2
230000002265 prevention Effects 0.000 title abstract 2
SOHMZGMHXUQHGE-UHFFFAOYSA-N 5-methyl-1h-pyridin-2-one Chemical compound CC1=CC=C(O)N=C1 SOHMZGMHXUQHGE-UHFFFAOYSA-N 0.000 abstract 1
208000033116 Asbestos intoxication Diseases 0.000 abstract 1
230000003510 anti-fibrotic effect Effects 0.000 abstract 1
206010003441 asbestosis Diseases 0.000 abstract 1
230000003480 fibrinolytic effect Effects 0.000 abstract 1
ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Hematology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Medicines Containing Plant Substances (AREA)

DK90903464.7T 1989-02-15 1990-01-26 Middel til reparation og forebyggelse af fibrotiske læsioner DK0458861T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP1035436A JPH02215719A (ja)	1989-02-15	1989-02-15	線維化病変組織の修復並びに線維化病変の阻止剤

Publications (1)

Publication Number	Publication Date
DK0458861T3 true DK0458861T3 (da)	1996-08-12

Family

ID=12441800

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90903464.7T DK0458861T3 (da)	1989-02-15	1990-01-26	Middel til reparation og forebyggelse af fibrotiske læsioner

Country Status (9)

Country	Link
EP (3)	EP0458861B1 (mo)
JP (1)	JPH02215719A (mo)
AT (1)	ATE136215T1 (mo)
AU (1)	AU633541B2 (mo)
CA (1)	CA2010017C (mo)
DE (2)	DE69033863T2 (mo)
DK (1)	DK0458861T3 (mo)
ES (2)	ES2220612T3 (mo)
WO (1)	WO1990009176A1 (mo)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH02215719A (ja) *	1989-02-15	1990-08-28	Yamauchi Akitomo	線維化病変組織の修復並びに線維化病変の阻止剤
US5716632A (en) *	1989-11-22	1998-02-10	Margolin; Solomon B.	Compositions and methods for reparation and prevention of fibrotic lesions
JPH08510251A (ja) *	1993-05-07	1996-10-29	ビーマーゴリン、ソロモン	線維症の病変の修復と予防のための組成物および方法
AU697742B2 (en) *	1995-03-03	1998-10-15	Intermune, Inc.	Treatment of cytokine growth factor caused disorders
US6492395B1 (en)	1998-09-18	2002-12-10	Mepha Ag	Topical formulation of alkyl-, phenyl-pyridone
EP1356816B1 (en) *	2001-01-29	2009-12-23	Shionogi & Co., Ltd.	Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient
JP4542743B2 (ja)	2002-12-26	2010-09-15	Ｋｄｌ株式会社	ピリドン誘導体の溶液状医薬組成物
WO2004073680A1 (ja) *	2003-02-21	2004-09-02	Shionogi & Co., Ltd.	液滴分散型軟膏剤
TW200501952A (en) *	2003-02-21	2005-01-16	Shionogi & Co	Pirfenidone gel formulations
WO2005047256A1 (en) *	2003-11-14	2005-05-26	Shanghai Genomics, Inc.	The derivatives of pyridone and the use of them
CN1846699A (zh) *	2005-04-13	2006-10-18	中南大学湘雅医院	1－(取代苯基)－5－甲基－2－(1h) 吡啶酮(i)化合物用于制备抗除肾间质纤维化外其他器官纤维化或组织纤维化药物的应用
NZ591443A (en) *	2005-09-22	2013-04-26	Intermune Inc	Granule formation of pirfenidone and pharmaceutically acceptable excipients
JP5213852B2 (ja)	2006-06-15	2013-06-19	シャンハイゲノミックスインク	放射線肺障害の予防及び治療のためのピリドン系誘導体の使用
MX2007006347A (es) *	2007-05-29	2009-02-18	Cell Therapy And Technology S	Nuevo uso de 5-metil-1-fenil-2-(1h)-piridona para el tratamiento y prevencion de cicatrices hipertroficas, y composicion conteniendo la misma.
NZ599643A (en)	2007-06-20	2013-11-29	Auspex Pharmaceuticals Inc	Substituted N-aryl pyridinones as fibrotic inhibitors
US20100099719A1 (en) *	2008-10-21	2010-04-22	Dierepharma, Inc.	Composition and method for treating proteinuria
US7635707B1 (en)	2008-11-10	2009-12-22	Intermune, Inc.	Pirfenidone treatment for patients with atypical liver function
US7816383B1 (en) *	2009-12-04	2010-10-19	Intermune, Inc.	Methods of administering pirfenidone therapy
US8084475B2 (en)	2009-12-04	2011-12-27	Intermune, Inc.	Pirfenidone therapy and inducers of cytochrome P450
DK2670242T3 (da) *	2011-01-31	2022-05-02	Avalyn Pharma Inc	Aerosolpirfenidon- og pyridonanalogforbindelser og anvendelser deraf
JP2014507474A (ja)	2011-03-08	2014-03-27	オースペックス・ファーマシューティカルズ・インコーポレイテッド	置換ｎ−アリールピリジノン
JP5872564B2 (ja) *	2011-09-14	2016-03-01	塩野義製薬株式会社	吸入用医薬組成物
JP6186434B2 (ja)	2012-07-18	2017-08-23	サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅＬａｋｅＰｈａｒｍａＣｏ．，Ｌｔｄ．	窒素複素環誘導体及びその医薬品への応用
US12226407B2 (en)	2012-07-24	2025-02-18	Avalyn Pharma Inc.	Aerosol pirfenidone and pyridone analog compounds and uses thereof
CA2819967C (en)	2012-08-31	2016-03-22	Intermune, Inc.	Use of pirfenidone concomitantly with ciprofloxacin
JP6454348B2 (ja) *	2013-12-19	2019-01-16	サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅＬａｋｅＰｈａｒｍａＣｏ．，Ｌｔｄ．	窒素複素環誘導体およびその医薬品への応用
EP3307714A1 (en)	2015-01-26	2018-04-18	Ulkar Kimya Sanayii Ve Ticaret A. S.	An improved method for the synthesis and purification of pirfenidone
CA2937365C (en)	2016-03-29	2018-09-18	F. Hoffmann-La Roche Ag	Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
TWI745396B (zh)	2016-07-12	2021-11-11	日商鹽野義製藥股份有限公司	吸入用醫藥組成物
CN109223723B (zh) *	2017-07-11	2021-08-27	南京华威医药科技集团有限公司	吡非尼酮片剂及其制备方法和用途
MX368750B (es)	2018-08-31	2019-10-15	Cell Therapy And Tech S A De C V	Composiciones farmaceuticas semisolidas de base oleosa conteniendo pirfenidona para su aplicacion en la reparacion tisular.
MX2020005775A (es) *	2020-07-13	2022-01-14	Centro De Retina Medica Y Quirurgica S C	Uso farmaceutico de pirfenidona para la reduccion de fibrosis cardiaca en pacientes con cardiomiopatia y/o esteatosis cardiaca y/o covid-19.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL6816241A (mo) *	1967-12-01	1969-06-03
US3721676A (en) *	1969-11-12	1973-03-20	Merck & Co Inc	Certain 3-amino-2(1h)pyridones
US3644626A (en) *	1969-11-25	1972-02-22	Merck & Co Inc	Novel pyridones in compositions and methods for treating inflammation pain and fever
US3655897A (en) *	1971-01-25	1972-04-11	Merck & Co Inc	Anti-inflammatory agents
US4052509A (en) *	1972-12-18	1977-10-04	Affiliated Medical Research, Inc.	Method for reducing serum uric acid levels
CA1049411A (en) *	1972-12-18	1979-02-27	Affiliated Medical Research	N-substituted pyridone and general method for preparing pyridones
US4042699A (en) *	1972-12-18	1977-08-16	Affiliated Medical Research, Inc.	Method for reducing serum glucose levels
ZA757570B (en) *	1974-12-09	1977-07-27	Affiliated Med Res	A useful n-substituted pyridone
JPH02215719A (ja) *	1989-02-15	1990-08-28	Yamauchi Akitomo	線維化病変組織の修復並びに線維化病変の阻止剤

1989
- 1989-02-15 JP JP1035436A patent/JPH02215719A/ja active Granted
1990
- 1990-01-26 AT AT90903464T patent/ATE136215T1/de not_active IP Right Cessation
- 1990-01-26 WO PCT/US1990/000449 patent/WO1990009176A1/en not_active Ceased
- 1990-01-26 DK DK90903464.7T patent/DK0458861T3/da active
- 1990-01-26 EP EP90903464A patent/EP0458861B1/en not_active Expired - Lifetime
- 1990-02-14 CA CA002010017A patent/CA2010017C/en not_active Expired - Lifetime
- 1990-02-15 EP EP90301607A patent/EP0383591B1/en not_active Expired - Lifetime
- 1990-02-15 DE DE69033863T patent/DE69033863T2/de not_active Expired - Lifetime
- 1990-02-15 EP EP01107235A patent/EP1138329B8/en not_active Expired - Lifetime
- 1990-02-15 ES ES01107235T patent/ES2220612T3/es not_active Expired - Lifetime
- 1990-02-15 AU AU49812/90A patent/AU633541B2/en not_active Expired
- 1990-02-15 DE DE69034143T patent/DE69034143T2/de not_active Expired - Lifetime
- 1990-02-15 ES ES90301607T patent/ES2163389T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH02215719A (ja)	1990-08-28
ES2220612T3 (es)	2004-12-16
DE69033863D1 (de)	2002-01-03
EP0458861A1 (en)	1991-12-04
EP0458861B1 (en)	1996-04-03
JPH0552814B2 (mo)	1993-08-06
EP0383591B1 (en)	2001-11-21
EP1138329A2 (en)	2001-10-04
EP0458861A4 (en)	1992-07-08
EP1138329B1 (en)	2004-06-02
EP0383591A3 (en)	1992-01-15
EP0383591A2 (en)	1990-08-22
WO1990009176A1 (en)	1990-08-23
CA2010017A1 (en)	1990-08-15
EP1138329B8 (en)	2006-05-17
DE69034143T2 (de)	2005-06-30
DE69034143D1 (de)	2004-07-08
AU633541B2 (en)	1993-02-04
AU4981290A (en)	1990-08-23
EP1138329A3 (en)	2002-04-17
ES2163389T3 (es)	2002-02-01
DE69033863T2 (de)	2002-06-13
CA2010017C (en)	1995-09-05
ATE136215T1 (de)	1996-04-15

Publication	Publication Date	Title
DK0458861T3 (da)	1996-08-12	Middel til reparation og forebyggelse af fibrotiske læsioner
NO811841L (no)	1981-12-03	Substituerte imidazolinyl-pyridiner og -kinoliner og anvendelse derav som herbicide midler
NO960811D0 (no)	1996-02-28	Karbosykliske og heterosykliske kinolinkarboksylsyrer med kondenserte ringer som kan anvendes som immunresponsundertrykkende midler
DK0731088T3 (da)	2000-10-16	Retrovirale proteaseinhibitorer
DK407483A (da)	1984-03-10	Antibakterielle naphthyridin-, quinolin- og benzoxazincarboxylsyrer, fremgangsmaader til deres fremstilling, deres anvendelse og mellemprodukter anvendelige ved forbindelsernes fremstilling
FI944217A7 (fi)	1994-09-13	Substituoidut pipekoliinihappojohdannaiset HIV-proteaasin estäjinä
FI853220A7 (fi)	1986-03-20	Aminoalkoksibentsopyranonit antipsykoottisina ja anksiolyyttisinä aineina.
BG37376A3 (en)	1985-05-15	Method for preparing salts of benzothiazine dioxide
MX9101861A (es)	1992-07-08	Novedosos 2-sacarinilmetil ari carboxilatos utiles como inhibidores de enzima proteolitica y composiciones y metodo para usarlos
DE69307050D1 (de)	1997-02-13	Reihe von Elementen zum Gebrauch im belüfteten Fassadenbau
FI911269A7 (fi)	1991-09-16	Menetelmä ja koostumus aktiivisten aineiden lisääntyneen pitoisuuden aikaansaamiseksi iholla iontoforeesin avulla
IT7851874A0 (it)	1978-11-13	Ti attrezzo e procedimento per giuntare assialmente due oggetti allunga
EE9600044A (et)	1996-10-15	Püranooni derivaadid kui proteaasi inhibiitorid ja viirusevastased toimeained
NO862412D0 (no)	1986-06-17	Koblingslist med arbeidskontakter.
AT388949B (de)	1989-09-25	Fahrbare gleisbearbeitungsmaschine fuer den weichen- und kreuzungsbereich
DK100087D0 (da)	1987-02-26	Transdermale 3-phenoxypyridin-praeparater
DK574178A (da)	1979-06-22	Indretning til rengoering af gulve trapper og lignende flader
DK475480A (da)	1981-05-09	S 2-(thio) oxo-1,3,2-oxazaphospholander fremgangsmaade til dere fremstilling og deres anvendelse som synergister i midler til bekaempelse af skadelige organismer
ID817B (id)	1996-07-19	Alat penutup yang dapat dilepaskan
IT1184696B (it)	1987-10-28	Impalcatura semovente per lavori di restauro,imbiancatura e simili
ES292804Y (es)	1987-03-01	Estructuracion perfeccionada para frontis de armarios y muebles similares
FI960489A7 (fi)	1996-02-02	Menetelmiä proteolyyttisen entsyymin inhibiittoreina käyttökelpoisten sakkariinijohdannaisten ja niiden välituotteiden valmistamiseksi
MX9203685A (es)	1992-08-01	Nuevos derivados de mercaptoacetil-amida utiles como inhibidores de encefalinasa y ace.
BR6401935U (pt)	1986-06-17	Carrinho de chopp ambulantes
NO156674C (no)	1987-11-04	Regulerbart arbeidsbord og lignende for sengeliggende.