DK0464638T3 - Oligonukleotidanaloge med terminale 3-3- eller 5-5-internukleotidbindinger. - Google Patents

Oligonukleotidanaloge med terminale 3-3- eller 5-5-internukleotidbindinger.

Info

Publication number: DK0464638T3
Authority: DK; Denmark
Prior art keywords: terminal; oligonucleotide analogs; internucleotide bonds; internucleotide; bonds
Prior art date: 1990-07-02

Application number

DK91110570.8T

Other languages

English (en)

Inventor

Hannelore Roesch

Anja Froehlich

Jose Flavio Ramalho-Ortigao

Matthias Prof Dr Montenarh

Hartmut Prof Dr Seliger

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-02

Filing date

1991-06-26

Publication date

1997-10-13

1991-06-26 Application filed by Hoechst Ag filed Critical Hoechst Ag

1997-10-13 Application granted granted Critical

1997-10-13 Publication of DK0464638T3 publication Critical patent/DK0464638T3/da

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 2
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
230000008827 biological function Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
150000007523 nucleic acids Chemical class 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R15/00—Details of measuring arrangements of the types provided for in groups G01R17/00 - G01R29/00, G01R33/00 - G01R33/26 or G01R35/00
- G01R15/14—Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks
- G01R15/18—Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using inductive devices, e.g. transformers
- G01R15/186—Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using inductive devices, e.g. transformers using current transformers with a core consisting of two or more parts, e.g. clamp-on type

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Power Engineering (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Physics & Mathematics (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Polyesters Or Polycarbonates (AREA)
Peptides Or Proteins (AREA)

DK91110570.8T 1990-07-02 1991-06-26 Oligonukleotidanaloge med terminale 3-3- eller 5-5-internukleotidbindinger. DK0464638T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4021019		1990-07-02

Publications (1)

Publication Number	Publication Date
DK0464638T3 true DK0464638T3 (da)	1997-10-13

Family

ID=6409497

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91110570.8T DK0464638T3 (da)	1990-07-02	1991-06-26	Oligonukleotidanaloge med terminale 3-3- eller 5-5-internukleotidbindinger.

Country Status (22)

Country	Link
US (1)	US5750669A (da)
EP (1)	EP0464638B1 (da)
JP (1)	JP3186795B2 (da)
KR (1)	KR100200400B1 (da)
AT (1)	ATE151076T1 (da)
AU (1)	AU647143B2 (da)
CA (1)	CA2045891C (da)
CZ (1)	CZ285408B6 (da)
DE (1)	DE59108644D1 (da)
DK (1)	DK0464638T3 (da)
ES (1)	ES2099718T3 (da)
FI (1)	FI104177B1 (da)
GR (1)	GR3023432T3 (da)
HU (1)	HU215147B (da)
IE (1)	IE912309A1 (da)
IL (1)	IL98672A (da)
NO (1)	NO303018B1 (da)
NZ (1)	NZ238769A (da)
PT (1)	PT98169B (da)
SK (1)	SK279544B6 (da)
TW (1)	TW206232B (da)
ZA (1)	ZA915056B (da)

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DK0593901T3 (da) *	1992-09-24	1997-10-27	Hoechst Ag	Oligoribonucleotid- og ribozym-analoge med terminale 3-3- og 5-5-bindinger.
HU9501974D0 (en) *	1993-03-31	1995-09-28	Sterling Winthrop Inc	Oligonucleotides with amide linkages replacing phosphodiester linkages
US6015886A (en) *	1993-05-24	2000-01-18	Chemgenes Corporation	Oligonucleotide phosphate esters
US6605708B1 (en)	1993-07-28	2003-08-12	Hybridon, Inc.	Building blocks with carbamate internucleoside linkages and oligonucleotides derived therefrom
US5855911A (en) *	1995-08-29	1999-01-05	Board Of Regents, The University Of Texas System	Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
US20080119427A1 (en) *	1996-06-06	2008-05-22	Isis Pharmaceuticals, Inc.	Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
US9096636B2 (en) *	1996-06-06	2015-08-04	Isis Pharmaceuticals, Inc.	Chimeric oligomeric compounds and their use in gene modulation
US5898031A (en)	1996-06-06	1999-04-27	Isis Pharmaceuticals, Inc.	Oligoribonucleotides for cleaving RNA
US7812149B2 (en)	1996-06-06	2010-10-12	Isis Pharmaceuticals, Inc.	2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US7309692B1 (en) *	1996-07-08	2007-12-18	Board Of Regents, The University Of Texas System	Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1
US6977244B2 (en)	1996-10-04	2005-12-20	Board Of Regents, The University Of Texas Systems	Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
CN1060177C (zh) *	1997-06-28	2001-01-03	中国科学院上海生物化学研究所	3′－单磷酸化寡核苷酸
US7704962B1 (en)	1997-10-03	2010-04-27	Board Of Regents, The University Of Texas System	Small oligonucleotides with anti-tumor activity
US7285288B1 (en)	1997-10-03	2007-10-23	Board Of Regents, The University Of Texas System	Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US20030180789A1 (en) *	1998-12-30	2003-09-25	Dale Roderic M.K.	Arrays with modified oligonucleotide and polynucleotide compositions
US6087112A (en) *	1998-12-30	2000-07-11	Oligos Etc. Inc.	Arrays with modified oligonucleotide and polynucleotide compositions
DE19935756A1 (de) *	1999-07-27	2001-02-08	Mologen Forschungs Entwicklung	Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation
DE19935303A1 (de)	1999-07-28	2001-02-08	Aventis Pharma Gmbh	Oligonukleotide zur Inhibierung der Expression von humanem eg5
US6271360B1 (en)	1999-08-27	2001-08-07	Valigen (Us), Inc.	Single-stranded oligodeoxynucleotide mutational vectors
EP1702983A3 (en)	2000-04-13	2007-01-10	Medical University of South Carolina	Tissue-specific and pathogen-specific toxic agents, ribozymes, DNAzymes and antisense oligonucleotides and methods of use thereof
EP1289911A2 (en) *	2000-06-13	2003-03-12	Proligo LLC	Universal solid supports for solid phase oligosynthesis and methods for their preparation and use
EP2292632A3 (en) *	2000-09-26	2012-07-25	Idera Pharmaceuticals, Inc.	Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
GB0114007D0 (en) *	2001-06-08	2001-08-01	Isis Innovation	Oilgonucleotides
US7070933B2 (en) *	2001-09-28	2006-07-04	Gen-Probe Incorporated	Inversion probes
CA2471967A1 (en) *	2002-01-03	2003-07-31	Board Of Regents, The University Of Texas System	Wt1 antisense oligos for the inhibition of breast cancer
AU2003203079B9 (en) *	2002-02-04	2009-01-15	Oncothyreon Inc.	Immunostimulatory, covalently lipidated oligonucleotides
WO2004044138A2 (en)	2002-11-05	2004-05-27	Isis Pharmaceuticals, Inc.	Chimeric oligomeric compounds and their use in gene modulation
US8604183B2 (en)	2002-11-05	2013-12-10	Isis Pharmaceuticals, Inc.	Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
US8569474B2 (en)	2004-03-09	2013-10-29	Isis Pharmaceuticals, Inc.	Double stranded constructs comprising one or more short strands hybridized to a longer strand
US8394947B2 (en)	2004-06-03	2013-03-12	Isis Pharmaceuticals, Inc.	Positionally modified siRNA constructs
US7884086B2 (en)	2004-09-08	2011-02-08	Isis Pharmaceuticals, Inc.	Conjugates for use in hepatocyte free uptake assays
CA2679750A1 (en)	2008-09-23	2010-03-23	Nexus Dx, Inc.	Methods for detecting nucleic acids in a sample
EP2781523A1 (en)	2013-03-18	2014-09-24	Miltenyi Biotec GmbH	Lipophilic oligonucleotide analogs
KR101323476B1 (ko) *	2013-06-12	2013-10-31	조선미	건물용 층간소음 방지재와 이를 이용한 층간소음 방지구조 및 그 시공 방법
LU92821B1 (en)	2015-09-09	2017-03-20	Mologen Ag	Combination comprising immunostimulatory oligonucleotides
GB2542425A (en)	2015-09-21	2017-03-22	Mologen Ag	Means for the treatment of HIV
AU2017248189B2 (en) *	2016-04-08	2021-04-29	Translate Bio, Inc.	Multimeric coding nucleic acid and uses thereof
US11603532B2 (en)	2017-06-02	2023-03-14	Wave Life Sciences Ltd.	Oligonucleotide compositions and methods of use thereof
EP3775264A4 (en)	2018-04-05	2022-03-23	Tsinghua University	METHODS FOR SEQUENCING AND PRODUCTION OF NUCLEIC ACID SEQUENCES
JP2021521140A (ja) *	2018-04-12	2021-08-26	ウェイブライフサイエンシズリミテッドＷａｖｅＬｉｆｅＳｃｉｅｎｃｅｓＬｔｄ．	オリゴヌクレオチド組成物及びその使用方法
CA3098624A1 (en)	2018-05-11	2019-11-14	Wave Life Sciences Ltd.	Oligonucleotide compositions and methods of use thereof

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US4123610A (en) *	1977-03-09	1978-10-31	The United States Government	Nucleic acid crosslinking agent and affinity inactivation of nucleic acids therewith
US4711955A (en) *	1981-04-17	1987-12-08	Yale University	Modified nucleotides and methods of preparing and using same
FR2540122B1 (fr) *	1983-01-27	1985-11-29	Centre Nat Rech Scient	Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
DE3332068A1 (de) *	1983-09-06	1985-03-21	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten
US4795700A (en) *	1985-01-25	1989-01-03	California Institute Of Technology	Nucleic acid probes and methods of using same
US5276019A (en) *	1987-03-25	1994-01-04	The United States Of America As Represented By The Department Of Health And Human Services	Inhibitors for replication of retroviruses and for the expression of oncogene products
EP0406309A4 (en) *	1988-03-25	1992-08-19	The University Of Virginia Alumni Patents Foundation	Oligonucleotide n-alkylphosphoramidates
WO1990012022A1 (en) *	1989-03-31	1990-10-18	University Patents, Inc.	Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections

1991
- 1991-06-26 EP EP91110570A patent/EP0464638B1/de not_active Expired - Lifetime
- 1991-06-26 DK DK91110570.8T patent/DK0464638T3/da active
- 1991-06-26 AT AT91110570T patent/ATE151076T1/de not_active IP Right Cessation
- 1991-06-26 DE DE59108644T patent/DE59108644D1/de not_active Expired - Lifetime
- 1991-06-26 ES ES91110570T patent/ES2099718T3/es not_active Expired - Lifetime
- 1991-06-28 CA CA002045891A patent/CA2045891C/en not_active Expired - Lifetime
- 1991-06-28 NZ NZ238769A patent/NZ238769A/en not_active IP Right Cessation
- 1991-06-28 FI FI913169A patent/FI104177B1/fi not_active IP Right Cessation
- 1991-06-30 IL IL9867291A patent/IL98672A/en not_active IP Right Cessation
- 1991-07-01 HU HU215/91A patent/HU215147B/hu unknown
- 1991-07-01 NO NO912585A patent/NO303018B1/no not_active IP Right Cessation
- 1991-07-01 KR KR1019910011064A patent/KR100200400B1/ko not_active Expired - Lifetime
- 1991-07-01 CZ CS912014A patent/CZ285408B6/cs not_active IP Right Cessation
- 1991-07-01 IE IE230991A patent/IE912309A1/en not_active IP Right Cessation
- 1991-07-01 SK SK2014-91A patent/SK279544B6/sk not_active IP Right Cessation
- 1991-07-01 AU AU79475/91A patent/AU647143B2/en not_active Expired
- 1991-07-01 PT PT98169A patent/PT98169B/pt not_active IP Right Cessation
- 1991-07-01 ZA ZA915056A patent/ZA915056B/xx unknown
- 1991-07-02 JP JP18820291A patent/JP3186795B2/ja not_active Expired - Lifetime
- 1991-07-27 TW TW080105851A patent/TW206232B/zh not_active IP Right Cessation
1994
- 1994-08-01 US US08/282,503 patent/US5750669A/en not_active Expired - Lifetime
1997
- 1997-05-15 GR GR970401081T patent/GR3023432T3/el unknown

Also Published As

Publication number	Publication date
CZ285408B6 (cs)	1999-08-11
HU912215D0 (en)	1991-12-30
DE59108644D1 (de)	1997-05-07
FI913169L (fi)	1992-01-03
CS201491A3 (en)	1992-01-15
EP0464638A3 (en)	1992-09-02
ES2099718T3 (es)	1997-06-01
SK279544B6 (sk)	1998-12-02
TW206232B (da)	1993-05-21
IL98672A (en)	1995-12-08
IL98672A0 (en)	1992-07-15
IE912309A1 (en)	1992-01-15
NO912585L (no)	1992-01-03
PT98169B (pt)	1998-12-31
CA2045891A1 (en)	1992-01-03
ATE151076T1 (de)	1997-04-15
KR100200400B1 (ko)	1999-06-15
KR920002625A (ko)	1992-02-28
ZA915056B (en)	1992-03-25
GR3023432T3 (en)	1997-08-29
PT98169A (pt)	1993-09-30
FI104177B (fi)	1999-11-30
FI104177B1 (fi)	1999-11-30
HUT62010A (en)	1993-03-29
AU647143B2 (en)	1994-03-17
EP0464638A2 (de)	1992-01-08
NZ238769A (en)	1993-11-25
US5750669A (en)	1998-05-12
HU215147B (hu)	2000-03-28
NO303018B1 (no)	1998-05-18
AU7947591A (en)	1992-01-02
CA2045891C (en)	2003-07-22
EP0464638B1 (de)	1997-04-02
FI913169A0 (fi)	1991-06-28
NO912585D0 (no)	1991-07-01
JP3186795B2 (ja)	2001-07-11
JPH05222088A (ja)	1993-08-31

Publication	Publication Date	Title
DE59108644D1 (de)	1997-05-07	Oligonucleotid-analoge mit terminalen 3'-3'-bzw. 5'-5'-Internucleotidverknüpfungen
DE3889091D1 (de)	1994-05-19	Härtbare Zusammensetzung von Oxyalkylenpolymeren.
DE3884453D1 (de)	1993-11-04	Homogene additionscopolymere von ethylen und cycloolefinmonomeren und deren herstellung.
MA22905A1 (fr)	1993-12-31	Nouvelles sequences d'adn .
AR242987A1 (es)	1993-06-30	Secuencias de adn no codificada y genes quimicamente regulables.
BG85409A (bg)	1993-12-24	Т7 днк полимераза
DE69004712D1 (de)	1994-01-05	Verfahren zur Herstellung von Polybutadien mit verbesserter Verarbeitkeit.
FI893526A0 (fi)	1989-07-21	Material och metod foer oekning av nukleinsyrahybridisering.
PT88275A (pt)	1989-06-30	Processo para a preparacao de composicoes farmaceuticas contendo 5-amino ou amino substituido-1,2,3-triazois uteis como agentes antiproliferativos
DE3673203D1 (de)	1990-09-13	Silylgruppen enthaltende vinylharze und haertungszusammensetzung.
IL75963A0 (en)	1985-12-31	Interferon derivatives,their preparation and pharmaceutical compositions containing them
ES2080736T3 (es)	1996-02-16	Uso de 2,3,4,5-tetrahidro-1h-3-benzazepinas en el tratamiento de trastornos neurologicos.
DK656488D0 (da)	1988-11-24	Praeparat med langvarig frigivelse indeholdende 1,4-dihydropyridinforbindelser
FR2645157B1 (fr)	1994-02-04	Inhibition selective de l'adn polymerase
ES2102772T3 (es)	1997-08-01	Compuesto citotoxico y antiviral.
FI881526L (fi)	1988-10-03	Tvaerbundbar silylpolymerkomposition.
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