DK0468063T3 - En-beholder fremgangsmåde til fremstilling af -L-asparatyl-L-phenylalanin-methylester, hydrochlorid - Google Patents

En-beholder fremgangsmåde til fremstilling af -L-asparatyl-L-phenylalanin-methylester, hydrochlorid

Info

Publication number: DK0468063T3
Authority: DK; Denmark
Prior art keywords: methyl ester; hydrochloride; asparatyl; preparing; phenylalanine methyl
Prior art date: 1988-02-12

Application number

DK90114007.9T

Other languages

English (en)

Inventor

John B Hill

Robert A Erickson

Yefim Gelman

Kuang Hsu

Hugh L Dryden Jr

Mark R Johnson

Original Assignee

Nutrasweet Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-12

Filing date

1990-07-21

Publication date

1996-08-19

1990-07-03 Priority claimed from US07/547,429 external-priority patent/US5053532A/en

1990-07-21 Application filed by Nutrasweet Co filed Critical Nutrasweet Co

1996-08-19 Application granted granted Critical

1996-08-19 Publication of DK0468063T3 publication Critical patent/DK0468063T3/da

Links

VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000002360 preparation method Methods 0.000 abstract 2
AAQFSZFQCXLMNT-ACMTZBLWSA-N (3s)-3-amino-4-[[(2s)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid;hydrochloride Chemical compound Cl.OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 AAQFSZFQCXLMNT-ACMTZBLWSA-N 0.000 abstract 1
108010011485 Aspartame Proteins 0.000 abstract 1
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 abstract 1
229960003438 aspartame Drugs 0.000 abstract 1
235000010357 aspartame Nutrition 0.000 abstract 1
239000000605 aspartame Substances 0.000 abstract 1
238000005580 one pot reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
- B—PERFORMING OPERATIONS; TRANSPORTING
- B42—BOOKBINDING; ALBUMS; FILES; SPECIAL PRINTED MATTER
- B42D—BOOKS; BOOK COVERS; LOOSE LEAVES; PRINTED MATTER CHARACTERISED BY IDENTIFICATION OR SECURITY FEATURES; PRINTED MATTER OF SPECIAL FORMAT OR STYLE NOT OTHERWISE PROVIDED FOR; DEVICES FOR USE THEREWITH AND NOT OTHERWISE PROVIDED FOR; MOVABLE-STRIP WRITING OR READING APPARATUS
- B42D25/00—Information-bearing cards or sheet-like structures characterised by identification or security features; Manufacture thereof
- B42D25/20—Information-bearing cards or sheet-like structures characterised by identification or security features; Manufacture thereof characterised by a particular use or purpose
- B42D25/29—Securities; Bank notes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Finance (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Business, Economics & Management (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Accounting & Taxation (AREA)
Peptides Or Proteins (AREA)
Seasonings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Duplication Or Marking (AREA)
Facsimile Image Signal Circuits (AREA)
Credit Cards Or The Like (AREA)
Printing Methods (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK90114007.9T 1988-02-12 1990-07-21 En-beholder fremgangsmåde til fremstilling af -L-asparatyl-L-phenylalanin-methylester, hydrochlorid DK0468063T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US15626788A	1988-02-12	1988-02-12
US07/547,429 US5053532A (en)	1988-02-12	1990-07-03	One-pot process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride
PCT/US1990/003967 WO1992000953A1 (en)	1988-02-12	1990-07-11	A one-pot process for the preparation of alpha-l-aspartyl-l-phenylalanine methyl ester hydrochloride
US71989791A	1991-06-24	1991-06-24

Publications (1)

Publication Number	Publication Date
DK0468063T3 true DK0468063T3 (da)	1996-08-19

Family

ID=40139216

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90114007.9T DK0468063T3 (da)	1988-02-12	1990-07-21	En-beholder fremgangsmåde til fremstilling af -L-asparatyl-L-phenylalanin-methylester, hydrochlorid

Country Status (11)

Country	Link
US (1)	US5476961A (da)
EP (1)	EP0468063B1 (da)
JP (2)	JPH089584B2 (da)
AT (1)	ATE138933T1 (da)
AU (1)	AU648291B2 (da)
BR (1)	BR9007646A (da)
DE (1)	DE69027318T2 (da)
DK (1)	DK0468063T3 (da)
ES (1)	ES2087100T3 (da)
GR (1)	GR3020162T3 (da)
WO (1)	WO1992000953A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9101160B2 (en)	2005-11-23	2015-08-11	The Coca-Cola Company	Condiments with high-potency sweetener
US8017168B2 (en)	2006-11-02	2011-09-13	The Coca-Cola Company	High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3833553A (en) *	1970-01-31	1974-09-03	Ajinomoto Kk	Method of producing alpha-l-aspartyl-l-phenylalanine alkyl esters
US3933781A (en) *	1973-11-05	1976-01-20	Monsanto Company	Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS5113737A (en) *	1974-07-23	1976-02-03	Ajinomoto Kk	Arufua ll asuparuchiru ll fueniruaraninteikyuarukiruesuteruno seizoho
FR2295015A1 (fr) *	1974-12-18	1976-07-16	Ajinomoto Kk	Procede de preparation d'esters alkyliques inferieurs d'a-l-aspartyl l-phenylalanine
JPS55167268A (en) *	1979-06-16	1980-12-26	Toyo Soda Mfg Co Ltd	Purification of alpha-l-aspartyl-l-phenylalanine lower alkyl ester
JPH07636B2 (ja) *	1984-12-17	1995-01-11	三井東圧化学株式会社	Ｎ−ホルミル−α−アスパルチルフエニルアラニンの製造法
JPH0647600B2 (ja) *	1985-06-04	1994-06-22	味の素株式会社	β−アスパルチルフエニルアラニン誘導体のα−アスパルチルフエニルアラニン誘導体への変換法
JPH0680075B2 (ja) *	1985-12-24	1994-10-12	味の素株式会社	Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法
DE3600731A1 (de) *	1986-01-13	1987-07-16	Green Cross Korea	Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
JPH085912B2 (ja) *	1986-09-04	1996-01-24	味の素株式会社	Ｎ−ホルミルアスパルチル−フエニルアラニンまたはそのメチルエステルの製造方法
JP2503592B2 (ja) *	1988-02-05	1996-06-05	味の素株式会社	α−アスパルチルフェニルアラニン誘導体の製造法
AU649623B2 (en) *	1988-02-12	1994-06-02	Nutrasweet Company, The	Process for the preparation of N-formyl-L-aspartic anhydride
US4946988A (en) *	1988-07-14	1990-08-07	The Nutrasweet Company	Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride

1990
- 1990-07-11 JP JP3504315A patent/JPH089584B2/ja not_active Expired - Lifetime
- 1990-07-11 JP JP91504315A patent/JPH05500371A/ja active Pending
- 1990-07-11 AU AU72422/91A patent/AU648291B2/en not_active Ceased
- 1990-07-11 BR BR909007646A patent/BR9007646A/pt not_active Application Discontinuation
- 1990-07-11 WO PCT/US1990/003967 patent/WO1992000953A1/en not_active Ceased
- 1990-07-21 DE DE69027318T patent/DE69027318T2/de not_active Expired - Fee Related
- 1990-07-21 DK DK90114007.9T patent/DK0468063T3/da active
- 1990-07-21 AT AT90114007T patent/ATE138933T1/de not_active IP Right Cessation
- 1990-07-21 EP EP90114007A patent/EP0468063B1/en not_active Expired - Lifetime
- 1990-07-21 ES ES90114007T patent/ES2087100T3/es not_active Expired - Lifetime
1993
- 1993-06-21 US US08/080,445 patent/US5476961A/en not_active Expired - Fee Related
1996
- 1996-06-06 GR GR960401464T patent/GR3020162T3/el unknown

Also Published As

Publication number	Publication date
DE69027318T2 (de)	1997-01-23
DE69027318D1 (de)	1996-07-11
BR9007646A (pt)	1992-09-15
JPH05500371A (ja)	1993-01-28
AU648291B2 (en)	1994-04-21
ES2087100T3 (es)	1996-07-16
AU7242291A (en)	1992-02-04
WO1992000953A1 (en)	1992-01-23
JPH04504543A (ja)	1992-08-13
EP0468063B1 (en)	1996-06-05
ATE138933T1 (de)	1996-06-15
JPH089584B2 (ja)	1996-01-31
EP0468063A1 (en)	1992-01-29
GR3020162T3 (en)	1996-09-30
US5476961A (en)	1995-12-19

Similar Documents

Publication	Publication Date	Title
FI892881A7 (fi)	1989-12-14	Menetelmä terapeuttisesti käyttökelpoisten aminohappojohdannaisten va lmistamiseksi
FI890282L (fi)	1989-07-21	Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi
FI901490A7 (fi)	1990-09-29	Aminohappojohdannaiset
DE59008394D1 (de)	1995-03-16	Aminosäureamid-Derivate.
FI906204L (fi)	1991-06-23	Menetelmä farmaseuttisesti vaikuttavien peptidiyhdisteiden valmistamiseksi
FI892682L (fi)	1989-12-03	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-deoksinojirimysiinijohdannaisten valmistamiseksi
FI901129A7 (fi)	1990-09-07	Aminohappojohdannaisia
PT91631A (pt)	1990-03-30	A process for the preparation of cyclic graf-analogs ii
FI890245A7 (fi)	1989-07-22	Menetelmä uusien terapeuttisesti käyttökelpoisten 1,4-disubstituoitujen piperidinyylijohdannaisten valmistamiseksi
FI895389A7 (fi)	1990-05-16	Menetelmä 3,5-dimetyyli-4-metoksipyridiinijohdosten valmistamiseksi sekä uusi välituote näitä varten
CS387490A3 (en)	1992-02-19	Process for preparing hydrochloride of alpha-l-asparagyl-l-phenylalanine methyl ester
FI893003L (fi)	1989-12-21	Menetelmä uusien terapeuttisesti käyttökelpoisten neplanosiinijohdannaisten valmistamiseksi
FR2646774B1 (fr)	1992-02-14	Compositions therapeutiques a base de nouveaux derives de thieno-triazolo-diazepine
DE69030155D1 (de)	1997-04-17	Zeitbasis-Korrekturanordnung
FR2656221B1 (fr)	1992-09-18	Compositions therapeutiques a base de derives du glycerol.
FI904393A7 (fi)	1990-09-06	Parannettu menetelmä amidoksiimijohdannaisten valmistamiseksi
FI901730A7 (fi)	1990-10-06	Aminohappojohdannaisia
DE3862072D1 (de)	1991-04-25	Verstellvorrichtung eines verdichters.
FI95913C (fi)	1996-04-10	Menetelmä terapeuttisesti käyttökelpoisen syklisen neurokiniini A -peptidin valmistamiseksi
FI903232A7 (fi)	1990-12-30	Muramyylidipeptidijohdannaisia
FI892946A7 (fi)	1989-12-16	Menetelmä uusien terapeuttisesti käyttökelpoisten 2,3,4,5-tetrahydro-1H-3-bentsoatsepiinijohdannaisten valmistamiseksi
FI905655A7 (fi)	1991-05-17	Menetelmä valmistaa farmaseuttisesti aktiivinen tetrahydronaftaliinijohdannainen
FI916036A0 (fi)	1991-12-20	Menetelmä valmistaa farmaseuttisesti käyttökelpoista spirofuraanijohdosta
GR3020162T3 (en)	1996-09-30	A one-pot process for the preparation of alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride
FI894812L (fi)	1990-04-12	Menetelmä valmistaa farmakologisesti arvokkaita 2-karbonyylisubstituoituja N,N'-di(trimetoksibentsoyyli)piperatsiineja