DK0469742T3 - Fremstilling af acetaminophen - Google Patents

Fremstilling af acetaminophen

Info

Publication number: DK0469742T3
Authority: DK; Denmark
Prior art keywords: oxime; hydroxyacetophenone; beckmann rearrangement; solvent; aminophenol
Prior art date: 1990-07-20

Application number

DK91306423.4T

Other languages

Danish (da)

English (en)

Inventor

John R Fritch

Daniel A Aguila

Theodore Horlenko

O Stanley Fruchey

Original Assignee

Hoechst Celanese Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-20

Filing date

1991-07-15

Publication date

1997-07-14

1991-07-15 Application filed by Hoechst Celanese Corp filed Critical Hoechst Celanese Corp

1997-07-14 Application granted granted Critical

1997-07-14 Publication of DK0469742T3 publication Critical patent/DK0469742T3/da

Links

RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title abstract 6
229960005489 paracetamol Drugs 0.000 title 1
238000006237 Beckmann rearrangement reaction Methods 0.000 abstract 3
239000003054 catalyst Substances 0.000 abstract 3
TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 abstract 2
BVZSQTRWIYKUSF-TWGQIWQCSA-N 4-[(Z)-N-hydroxy-C-methylcarbonimidoyl]phenol Chemical compound C1=C(C=CC(=C1)O)/C(=N\O)/C BVZSQTRWIYKUSF-TWGQIWQCSA-N 0.000 abstract 2
150000002923 oximes Chemical class 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
229940073735 4-hydroxy acetophenone Drugs 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000006227 byproduct Substances 0.000 abstract 1
239000007810 chemical reaction solvent Substances 0.000 abstract 1
JBTWLSYIZRCDFO-UHFFFAOYSA-N ethyl methyl carbonate Chemical compound CCOC(=O)OC JBTWLSYIZRCDFO-UHFFFAOYSA-N 0.000 abstract 1
150000002443 hydroxylamines Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/74—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Cephalosporin Compounds (AREA)
Catalysts (AREA)
Solid State Image Pick-Up Elements (AREA)
Light Receiving Elements (AREA)

DK91306423.4T 1990-07-20 1991-07-15 Fremstilling af acetaminophen DK0469742T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/556,589 US5155273A (en)	1988-07-12	1990-07-20	Production of acetaminophen

Publications (1)

Publication Number	Publication Date
DK0469742T3 true DK0469742T3 (da)	1997-07-14

Family

ID=24221981

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91306423.4T DK0469742T3 (da)	1990-07-20	1991-07-15	Fremstilling af acetaminophen

Country Status (20)

Country	Link
US (1)	US5155273A (de)
EP (1)	EP0469742B1 (de)
JP (3)	JPH04253944A (de)
KR (1)	KR920002519A (de)
CN (1)	CN1058391A (de)
AT (1)	ATE148096T1 (de)
AU (1)	AU8118591A (de)
BR (1)	BR9103122A (de)
CA (1)	CA2046763A1 (de)
DE (1)	DE69124306T2 (de)
DK (1)	DK0469742T3 (de)
ES (1)	ES2097794T3 (de)
FI (1)	FI913498A7 (de)
GR (1)	GR3022362T3 (de)
HU (1)	HU912322D0 (de)
IE (1)	IE912543A1 (de)
IL (1)	IL98891A0 (de)
MX (1)	MX9100279A (de)
NO (1)	NO912836L (de)
SG (1)	SG49089A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2607981B2 (ja) *	1991-05-21	1997-05-07	有亮泉	環状オキシムのラクタム類への転位反応触媒およびこれを用いるラクタム類の製造方法
WO1994001394A1 (en) *	1992-07-02	1994-01-20	Commonwealth Scientific And Industrial Research Organisation	Preparation of n-aryl amides
US5344979A (en) *	1993-04-29	1994-09-06	Hoechst Celanese Corporation	Process for preparing color-stabilized acetaminophen
US5510389A (en) *	1994-03-02	1996-04-23	The Procter & Gamble Company	Concentrated acetaminophen solution compositions
KR100355532B1 (ko) *	1999-10-27	2002-10-09	서울대학교 공과대학 교육연구재단	수소가 치환된 다공질 결정성 규산 알루미늄 촉매를 이용하여 아세트아미노펜을 합성하는 방법
CN100500646C (zh) *	2007-02-07	2009-06-17	浙江工业大学	一种酰胺类物质的化学合成方法
CN106380418B (zh) *	2016-09-07	2018-07-31	上饶师范学院	一种用N-甲基吡咯烷酮/SOCl2高效实现酮肟Beckmann重排的方法
US11667202B2 (en) *	2017-03-08	2023-06-06	A3 Labs LLC	Energy source supply systems, energy source supply devices, and related methods
CN113173829A (zh) *	2021-04-19	2021-07-27	清华大学	一种酮肟贝克曼重排反应制备酰胺的催化方法
CN113185424A (zh) *	2021-05-21	2021-07-30	安徽金禾实业股份有限公司	一种去除DMF中微量DMAc的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU4195185A (en) *	1984-06-04	1985-12-12	Celanese Corporation	Producing n-acyl-hydroxy and n-acyl acyloxy aromatic amines
US4524217A (en) *	1984-06-08	1985-06-18	Celanese Corporation	Process for producing N-acyl-hydroxy aromatic amines
US4568763A (en) *	1984-07-03	1986-02-04	Celanese Corporation	Process for producing N-acyl-acyloxy aromatic amines
US4560789A (en) *	1984-07-03	1985-12-24	Celanese Corporation	Process for producing 4-acetoxyacetanilide
US4665216A (en) *	1985-03-12	1987-05-12	Celanese Corporation	Process for producing n-acyl-acyloxy aromatic amines
US5157142A (en) *	1986-06-17	1992-10-20	Hoechst Celanese Corporation	Thiocarbamates and their derivatives
US4855499A (en) *	1987-11-06	1989-08-08	Hoechst Celanese Corporation	Novel process to prevent formation of chlorinated by-products in APAP production
US4954652A (en) *	1988-07-12	1990-09-04	Hoechst Celanese Corporation	Production of acetaminophen

1990
- 1990-07-20 US US07/556,589 patent/US5155273A/en not_active Expired - Fee Related
1991
- 1991-07-10 HU HU912322A patent/HU912322D0/hu unknown
- 1991-07-11 CA CA002046763A patent/CA2046763A1/en not_active Abandoned
- 1991-07-15 DE DE69124306T patent/DE69124306T2/de not_active Expired - Fee Related
- 1991-07-15 ES ES91306423T patent/ES2097794T3/es not_active Expired - Lifetime
- 1991-07-15 DK DK91306423.4T patent/DK0469742T3/da active
- 1991-07-15 AT AT91306423T patent/ATE148096T1/de not_active IP Right Cessation
- 1991-07-15 SG SG1996005951A patent/SG49089A1/en unknown
- 1991-07-15 EP EP91306423A patent/EP0469742B1/de not_active Expired - Lifetime
- 1991-07-18 MX MX9100279A patent/MX9100279A/es not_active IP Right Cessation
- 1991-07-18 IL IL98891A patent/IL98891A0/xx unknown
- 1991-07-19 KR KR1019910012417A patent/KR920002519A/ko not_active Withdrawn
- 1991-07-19 AU AU81185/91A patent/AU8118591A/en not_active Abandoned
- 1991-07-19 IE IE254391A patent/IE912543A1/en not_active IP Right Cessation
- 1991-07-19 FI FI913498A patent/FI913498A7/fi not_active Application Discontinuation
- 1991-07-19 NO NO91912836A patent/NO912836L/no unknown
- 1991-07-20 CN CN91104889A patent/CN1058391A/zh active Pending
- 1991-07-20 JP JP3271718A patent/JPH04253944A/ja active Pending
- 1991-07-22 BR BR919103122A patent/BR9103122A/pt unknown
1997
- 1997-01-23 GR GR970400006T patent/GR3022362T3/el unknown
2001
- 2001-07-23 JP JP2001221199A patent/JP2002030055A/ja active Pending
- 2001-07-23 JP JP2001221188A patent/JP2002030054A/ja active Pending

Also Published As

Publication number	Publication date
MX9100279A (es)	1992-02-28
ES2097794T3 (es)	1997-04-16
EP0469742B1 (de)	1997-01-22
CA2046763A1 (en)	1992-01-21
GR3022362T3 (en)	1997-04-30
HU912322D0 (en)	1991-12-30
DE69124306D1 (de)	1997-03-06
SG49089A1 (en)	1998-05-18
IL98891A0 (en)	1992-07-15
FI913498L (fi)	1992-01-21
KR920002519A (ko)	1992-02-28
EP0469742A3 (en)	1992-05-20
NO912836D0 (no)	1991-07-19
DE69124306T2 (de)	1997-06-12
EP0469742A2 (de)	1992-02-05
IE912543A1 (en)	1992-01-29
US5155273A (en)	1992-10-13
BR9103122A (pt)	1992-04-28
FI913498A0 (fi)	1991-07-19
CN1058391A (zh)	1992-02-05
JP2002030055A (ja)	2002-01-29
JP2002030054A (ja)	2002-01-29
JPH04253944A (ja)	1992-09-09
NO912836L (no)	1992-01-21
FI913498A7 (fi)	1992-01-21
ATE148096T1 (de)	1997-02-15
AU8118591A (en)	1992-01-23

Publication	Publication Date	Title
DE69108600D1 (de)	1995-05-11	Verfahren zur Herstellung von e-Caprolacton.
DE69124306D1 (de)	1997-03-06	Herstellung von Acetaminophen
ATE107941T1 (de)	1994-07-15	Verfahren für die herstellung von n-(polyoxyalkyl-n-alcylaminen.
GB1070322A (en)	1967-06-01	Process for the preparation of 6-formyloxy caproic acids and derivatives thereof
SE9300583D0 (sv)	1993-02-22	A process for the producton of ketene dimers
BG60314B2 (en)	1994-07-25	Method for producing ceramic and composition ceramic articles
ES2079877T3 (es)	1996-01-16	Procedimiento para la fabricacion de nitrilo.
DK0414262T3 (da)	1995-05-15	Fremgangsmåde til fremstilling af antikonvulsive cycliske aminosyreforbindelser
ATE175967T1 (de)	1999-02-15	Verfahren zur herstellung von 2-amino-6- halogenopurin und synthese einer zwischenverbindung
ATE82955T1 (de)	1992-12-15	Verfahren zur herstellung von o-substituierten hydroxylaminen.
ATE292617T1 (de)	2005-04-15	Herstellung von hydroxypropionitril
GB1259747A (en)	1972-01-12	Process for the preparation of aliphatic tertiary amides
JPH029851A (ja)	1990-01-12	第２ホルムアミドの合成方法
ES8703400A1 (es)	1987-02-16	Procedimiento para preparar cloroformatos de lactatos de alquilo.
US4048210A (en)	1977-09-13	Transcyanohydrination
FR2386551A1 (fr)	1978-11-03	Procede de production d'amidines phosphorylees
KR890003289B1 (ko)	1989-09-06	α-시아노-3-페녹시벤질-S-(+)-2-(4-클로로페닐)-3-메틸부틸레이트의 제조방법
ATE56016T1 (de)	1990-09-15	Verfahren zur herstellung von bicyclischen amidacetalen.
ATE144767T1 (de)	1996-11-15	Verfahren zur herstellung o-substituierter oxime
SU745893A1 (ru)	1980-07-07	Способ получени низших алифатических эфиров 2,2-дихлорпропионовой кислоты
ES2018661B3 (es)	1991-05-01	Procedimiento mejorado para la obtencion de dihidro-1h-pirrolizin-3,5-(2h,6h)-diona.
ATE165814T1 (de)	1998-05-15	Verfahren zur herstellung von 5-oxohexannitrilen und die verbindung 2,4-dimethyl-5-oxo- hexannitrile
JPS5746951A (en)	1982-03-17	Production of 2-amino-4-cyanobutyric derivative
SU588222A1 (ru)	1978-01-15	Способ получени -нитроалкилнитратов
JPS54125654A (en)	1979-09-29	Preparation of amino-schiff base