DK0470616T3 - Substituerede pyrimidin-derivater, fremgangsmåde til fremstilling og deres anvendelse som reagenser - Google Patents

Substituerede pyrimidin-derivater, fremgangsmåde til fremstilling og deres anvendelse som reagenser

Info

Publication number
DK0470616T3
DK0470616T3 DK91113334.6T DK91113334T DK0470616T3 DK 0470616 T3 DK0470616 T3 DK 0470616T3 DK 91113334 T DK91113334 T DK 91113334T DK 0470616 T3 DK0470616 T3 DK 0470616T3
Authority
DK
Denmark
Prior art keywords
reagents
preparation
pyrimidine derivatives
substituted pyrimidine
sorbitol
Prior art date
Application number
DK91113334.6T
Other languages
English (en)
Inventor
Karl Dr Geisen
Roland Dr Utz
Hildegard Dr Nimmesgern
Hans-Jochen Dr Lang
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0470616T3 publication Critical patent/DK0470616T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK91113334.6T 1990-08-10 1991-08-08 Substituerede pyrimidin-derivater, fremgangsmåde til fremstilling og deres anvendelse som reagenser DK0470616T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4025387A DE4025387A1 (de) 1990-08-10 1990-08-10 Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als reagenzien

Publications (1)

Publication Number Publication Date
DK0470616T3 true DK0470616T3 (da) 1997-08-25

Family

ID=6412013

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91113334.6T DK0470616T3 (da) 1990-08-10 1991-08-08 Substituerede pyrimidin-derivater, fremgangsmåde til fremstilling og deres anvendelse som reagenser

Country Status (16)

Country Link
US (1) US5215990A (da)
EP (1) EP0470616B1 (da)
JP (1) JP3094535B2 (da)
KR (1) KR100191385B1 (da)
AT (1) ATE149032T1 (da)
AU (1) AU641797B2 (da)
CA (1) CA2048842C (da)
DE (2) DE4025387A1 (da)
DK (1) DK0470616T3 (da)
ES (1) ES2097774T3 (da)
GR (1) GR3022976T3 (da)
IE (1) IE912828A1 (da)
IL (1) IL99134A (da)
NZ (1) NZ239310A (da)
PT (1) PT98634B (da)
ZA (1) ZA916290B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728704A (en) * 1992-09-28 1998-03-17 Pfizer Inc. Substituted pyridmidines for control of diabetic complications
PT791355E (pt) 1996-02-29 2002-08-30 Pfizer Metodo para diminuir os daos associados com a isquemia nos tecidos
JPH09301868A (ja) * 1996-05-10 1997-11-25 Senju Pharmaceut Co Ltd 抗白内障剤
DE19710435A1 (de) * 1997-03-13 1998-09-17 Hoechst Ag Verwendung von Pyrimidinderivaten zur Prävention von Krebs allein oder in Kombination mit anderen therapeutischen Maßnahmen
PL350884A1 (en) 1999-04-01 2003-02-10 Pfizer Prod Inc Aminopyrimidines as sorbitol dehydrogenase inhibitors
PT1041068E (pt) 1999-04-01 2004-07-30 Pfizer Prod Inc Compostos para o tratamento e prevencao de complicacoes diabeticas
EP1247809A3 (en) * 2001-03-30 2003-12-17 Pfizer Products Inc. Triazine compounds useful as sorbitol dehydrogenase inhibitors
US20040082627A1 (en) * 2002-06-21 2004-04-29 Darrow James W. Certain aromatic monocycles as kinase modulators
AU2003249369A1 (en) * 2002-06-21 2004-01-06 Cellular Genomics, Inc. Certain amino-substituted monocycles as kinase modulators
CN1997370B (zh) 2004-05-19 2011-06-01 索尔瓦药物有限公司 N-氨磺酰-n'-芳基哌嗪类化合物在制备用于预防或治疗肥胖和相关疾病的药物中的用途
US20050261292A1 (en) * 2004-05-19 2005-11-24 Solvay Pharmaceuticals Gmbh Pharmaceutical composition containing N-sulfamoyl-N'-arylpiperazines for the treatment or inhibition of obesity and related conditions
CN115124475B (zh) * 2022-07-11 2023-11-10 贵阳学院 一种嘧啶衍生物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2362276A (en) * 1942-03-31 1944-11-07 American Cyanamid Co Beneficiation of acidic minerals
US2973362A (en) * 1959-07-24 1961-02-28 Schorsch Gerald Method of preparing monosubstituted piperazines
US3190883A (en) * 1962-10-05 1965-06-22 Geschickter Fund Med Res Aminoalkanol derivatives of piperazines
US3296261A (en) * 1965-03-09 1967-01-03 Bristol Myers Co 6-hydroxy-pyrimidine-5-acetamides
DK8600939A (da) * 1985-03-05 1986-09-06
DE3905364A1 (de) * 1989-02-22 1990-08-23 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool

Also Published As

Publication number Publication date
EP0470616A3 (en) 1992-03-25
JP3094535B2 (ja) 2000-10-03
KR100191385B1 (ko) 1999-06-15
ES2097774T3 (es) 1997-04-16
EP0470616B1 (de) 1997-02-19
IL99134A (en) 1995-08-31
ZA916290B (en) 1992-04-29
KR920004381A (ko) 1992-03-27
CA2048842A1 (en) 1992-02-11
US5215990A (en) 1993-06-01
IL99134A0 (en) 1992-07-15
NZ239310A (en) 1993-07-27
ATE149032T1 (de) 1997-03-15
AU641797B2 (en) 1993-09-30
JPH04230669A (ja) 1992-08-19
GR3022976T3 (en) 1997-06-30
PT98634B (pt) 1999-01-29
EP0470616A2 (de) 1992-02-12
PT98634A (pt) 1993-09-30
IE912828A1 (en) 1992-02-12
DE4025387A1 (de) 1992-02-13
AU8256191A (en) 1992-02-13
CA2048842C (en) 2002-04-09
DE59108549D1 (de) 1997-03-27

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