ES2097774T3 - Derivados de pirimidina sustituidos, procedimiento para su preparacion y su utilizacion como reactivos. - Google Patents

Derivados de pirimidina sustituidos, procedimiento para su preparacion y su utilizacion como reactivos.

Info

Publication number
ES2097774T3
ES2097774T3 ES91113334T ES91113334T ES2097774T3 ES 2097774 T3 ES2097774 T3 ES 2097774T3 ES 91113334 T ES91113334 T ES 91113334T ES 91113334 T ES91113334 T ES 91113334T ES 2097774 T3 ES2097774 T3 ES 2097774T3
Authority
ES
Spain
Prior art keywords
reagents
preparation
substituted
procedure
pirimidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91113334T
Other languages
English (en)
Inventor
Karl Dr Geisen
Roland Dr Utz
Hildegard Dr Nimmesgern
Hans-Jochen Dr Lang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2097774T3 publication Critical patent/ES2097774T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Luminescent Compositions (AREA)

Abstract

SE DESCRIBEN DERIVADOS DE PIRIMIDINA DE FORMULA I EN LA QUE R ELEVADO 1, R (AL CUADRADO) , X E Y TIENE EL SIGNIFICADO INDICADO, SUS SALES , ASI COMO UN PROCEDIMIENTO PARA SU PREPARACION. DEBIDO A SU ACTIVIDAD ACUMULADORA DE SORBITA RESULTAN ADECUADOS PARA UTILIZARLOS COMO REACTIVOS PARA UN MODELO DE PANTALLA, VALIOSO FARMACOLOGICAMENTE, EN EL ENSAYO DE INHIBIDORES DE ALDOSA-REDUCTASA.
ES91113334T 1990-08-10 1991-08-08 Derivados de pirimidina sustituidos, procedimiento para su preparacion y su utilizacion como reactivos. Expired - Lifetime ES2097774T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4025387A DE4025387A1 (de) 1990-08-10 1990-08-10 Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als reagenzien

Publications (1)

Publication Number Publication Date
ES2097774T3 true ES2097774T3 (es) 1997-04-16

Family

ID=6412013

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91113334T Expired - Lifetime ES2097774T3 (es) 1990-08-10 1991-08-08 Derivados de pirimidina sustituidos, procedimiento para su preparacion y su utilizacion como reactivos.

Country Status (16)

Country Link
US (1) US5215990A (es)
EP (1) EP0470616B1 (es)
JP (1) JP3094535B2 (es)
KR (1) KR100191385B1 (es)
AT (1) ATE149032T1 (es)
AU (1) AU641797B2 (es)
CA (1) CA2048842C (es)
DE (2) DE4025387A1 (es)
DK (1) DK0470616T3 (es)
ES (1) ES2097774T3 (es)
GR (1) GR3022976T3 (es)
IE (1) IE912828A1 (es)
IL (1) IL99134A (es)
NZ (1) NZ239310A (es)
PT (1) PT98634B (es)
ZA (1) ZA916290B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ254550A (en) * 1992-09-28 1997-08-22 Pfizer Use of nitrogen-substituted pyrimidines to prepare medicaments useful for treatment or prevention of diabetic complications
EP0791355B1 (en) * 1996-02-29 2002-04-17 Pfizer Inc. Method of reducing tissue damage associated with ischemia
JPH09301868A (ja) * 1996-05-10 1997-11-25 Senju Pharmaceut Co Ltd 抗白内障剤
DE19710435A1 (de) * 1997-03-13 1998-09-17 Hoechst Ag Verwendung von Pyrimidinderivaten zur Prävention von Krebs allein oder in Kombination mit anderen therapeutischen Maßnahmen
ES2215570T3 (es) * 1999-04-01 2004-10-16 Pfizer Products Inc. Compuestos para tratar y prevenir complicaciones diabeticas.
CA2366858A1 (en) 1999-04-01 2000-10-12 Margaret Yuhua Chu-Moyer Sorbitol dehydrogenase inhibitors
EP1247809A3 (en) * 2001-03-30 2003-12-17 Pfizer Products Inc. Triazine compounds useful as sorbitol dehydrogenase inhibitors
AU2003245669A1 (en) * 2002-06-21 2004-01-06 Cellular Genomics, Inc. Certain aromatic monocycles as kinase modulators
US7015227B2 (en) * 2002-06-21 2006-03-21 Cgi Pharmaceuticals, Inc. Certain amino-substituted monocycles as kinase modulators
US20050261292A1 (en) * 2004-05-19 2005-11-24 Solvay Pharmaceuticals Gmbh Pharmaceutical composition containing N-sulfamoyl-N'-arylpiperazines for the treatment or inhibition of obesity and related conditions
CN1997370B (zh) 2004-05-19 2011-06-01 索尔瓦药物有限公司 N-氨磺酰-n＇-芳基哌嗪类化合物在制备用于预防或治疗肥胖和相关疾病的药物中的用途
CN115124475B (zh) * 2022-07-11 2023-11-10 贵阳学院 一种嘧啶衍生物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2362276A (en) * 1942-03-31 1944-11-07 American Cyanamid Co Beneficiation of acidic minerals
US2973362A (en) * 1959-07-24 1961-02-28 Schorsch Gerald Method of preparing monosubstituted piperazines
US3190883A (en) * 1962-10-05 1965-06-22 Geschickter Fund Med Res Aminoalkanol derivatives of piperazines
US3296261A (en) * 1965-03-09 1967-01-03 Bristol Myers Co 6-hydroxy-pyrimidine-5-acetamides
DK8600939A (es) * 1985-03-05 1986-09-06
DE3905364A1 (de) * 1989-02-22 1990-08-23 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool

Also Published As

Publication number Publication date
IE912828A1 (en) 1992-02-12
JPH04230669A (ja) 1992-08-19
DE59108549D1 (de) 1997-03-27
ATE149032T1 (de) 1997-03-15
IL99134A0 (en) 1992-07-15
PT98634A (pt) 1993-09-30
US5215990A (en) 1993-06-01
CA2048842C (en) 2002-04-09
EP0470616B1 (de) 1997-02-19
EP0470616A3 (en) 1992-03-25
AU641797B2 (en) 1993-09-30
ZA916290B (en) 1992-04-29
EP0470616A2 (de) 1992-02-12
JP3094535B2 (ja) 2000-10-03
PT98634B (pt) 1999-01-29
CA2048842A1 (en) 1992-02-11
DK0470616T3 (da) 1997-08-25
AU8256191A (en) 1992-02-13
KR100191385B1 (ko) 1999-06-15
GR3022976T3 (en) 1997-06-30
KR920004381A (ko) 1992-03-27
DE4025387A1 (de) 1992-02-13
NZ239310A (en) 1993-07-27
IL99134A (en) 1995-08-31

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