DK0473564T3 - Antikoagulant kombination af LACI og sulfatiserede polysaccharider - Google Patents

Antikoagulant kombination af LACI og sulfatiserede polysaccharider

Info

Publication number: DK0473564T3
Authority: DK; Denmark
Prior art keywords: laci; sulfated polysaccharides; combination; anticoagulant; anticoagulant combination
Prior art date: 1990-08-27

Application number

DK91870132.7T

Other languages

English (en)

Inventor

Tze-Chein Wun

Original Assignee

Monsanto Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-27

Filing date

1991-08-26

Publication date

1996-04-15

1991-08-26 Application filed by Monsanto Co filed Critical Monsanto Co

1996-04-15 Application granted granted Critical

1996-04-15 Publication of DK0473564T3 publication Critical patent/DK0473564T3/da

Links

150000004676 glycans Chemical class 0.000 title abstract 2
229920001282 polysaccharide Polymers 0.000 title abstract 2
239000005017 polysaccharide Substances 0.000 title abstract 2
102100030951 Tissue factor pathway inhibitor Human genes 0.000 title 1
101710139626 Tissue factor pathway inhibitor Proteins 0.000 title 1
239000003146 anticoagulant agent Substances 0.000 title 1
229940127219 anticoagulant drug Drugs 0.000 title 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
102000004895 Lipoproteins Human genes 0.000 abstract 1
108090001030 Lipoproteins Proteins 0.000 abstract 1
230000002429 anti-coagulating effect Effects 0.000 abstract 1
230000015271 coagulation Effects 0.000 abstract 1
238000005345 coagulation Methods 0.000 abstract 1
-1 heparin Chemical class 0.000 abstract 1
229920000669 heparin Polymers 0.000 abstract 1
229960002897 heparin Drugs 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000002195 synergetic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK91870132.7T 1990-08-27 1991-08-26 Antikoagulant kombination af LACI og sulfatiserede polysaccharider DK0473564T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US57308390A	1990-08-27	1990-08-27

Publications (1)

Publication Number	Publication Date
DK0473564T3 true DK0473564T3 (da)	1996-04-15

Family

ID=24290576

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91870132.7T DK0473564T3 (da)	1990-08-27	1991-08-26	Antikoagulant kombination af LACI og sulfatiserede polysaccharider

Country Status (10)

Country	Link
EP (1)	EP0473564B1 (da)
JP (1)	JPH0733336B2 (da)
AT (1)	ATE135585T1 (da)
CA (1)	CA2049873C (da)
DE (1)	DE69118056T2 (da)
DK (1)	DK0473564T3 (da)
ES (1)	ES2085462T3 (da)
GR (1)	GR3020312T3 (da)
IE (1)	IE913004A1 (da)
PT (1)	PT98779B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5610148A (en) *	1991-01-18	1997-03-11	University College London	Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) *	1991-01-18	1997-05-13	University College London	Depot formulations
US5276015A (en) *	1992-03-18	1994-01-04	Washington University	Method of inhibiting microvascular thrombosis
US20030171292A1 (en)	1992-06-01	2003-09-11	Creasey Abla A.	Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US6063764A (en) *	1992-06-01	2000-05-16	Washington University & Chiron Corp.	Method for using lipoprotein associated coagulation inhibitor to treat sepsis
ITPD940054A1 (it)	1994-03-23	1995-09-23	Fidia Advanced Biopolymers Srl	Polisaccaridi solfatati
PT769962E (pt) *	1994-07-07	2003-07-31	Univ Washington	Metodo de atenuacao da estenose arterial
US5589359A (en)	1994-08-05	1996-12-31	Chiron Corporation	Chimeric proteins
DE69528591T2 (de) *	1994-08-05	2003-02-20	Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville	Herstellung des inhibitors fuer die komplexbildung des gewebefaktors
AU759412B2 (en) *	1995-06-07	2003-04-17	G.D. Searle & Co.	Method of solubilizing, purifying and refolding protein and compositions comprising proteins and solubilizing agents
CA2223745C (en) *	1995-06-07	2004-03-16	Chiron Corporation	Method of solubilizing, purifying, and refolding protein
AU2003200506B2 (en) *	1995-06-07	2007-01-18	G.D. Searle Llc	Method of solubilizing, purifying and refolding protein and compositions comprising proteins and solubilizing agents
US5772629A (en) *	1995-10-23	1998-06-30	Localmed, Inc.	Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels
EP0868191A1 (en) *	1995-12-18	1998-10-07	Stichting Sanquin Bloedvoorziening	Potentiation of complement and coagulation inhibitory properties of c1-inhibitor.
EA200400548A1 (ru)	2001-10-15	2005-06-30	Чирон Корпорейшн	Лечение тяжёлой пневмонии путём введения ингибитора пути тканевого фактора (tfpi)
WO2005019265A1 (en)	2003-08-13	2005-03-03	Chiron Corporation	Improved method of purifying tfpi and tfpi analogs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL87172A (en) *	1987-07-23	1994-12-29	Univ Washington	Method of isolating highly purified tissue factor inhibitor
IL87171A (en) *	1987-11-23	1995-08-31	Monsanto Co	cDNA of human tissue factor inhibitor
DE69117545T2 (de) *	1990-01-25	1996-10-31	Univ Washington	Faktor X-LACI-Hybridprotein

1991
- 1991-08-26 CA CA002049873A patent/CA2049873C/en not_active Expired - Lifetime
- 1991-08-26 ES ES91870132T patent/ES2085462T3/es not_active Expired - Lifetime
- 1991-08-26 DE DE69118056T patent/DE69118056T2/de not_active Expired - Lifetime
- 1991-08-26 JP JP3213844A patent/JPH0733336B2/ja not_active Expired - Fee Related
- 1991-08-26 DK DK91870132.7T patent/DK0473564T3/da active
- 1991-08-26 AT AT91870132T patent/ATE135585T1/de not_active IP Right Cessation
- 1991-08-26 IE IE300491A patent/IE913004A1/en not_active IP Right Cessation
- 1991-08-26 EP EP91870132A patent/EP0473564B1/en not_active Expired - Lifetime
- 1991-08-26 PT PT98779A patent/PT98779B/pt not_active IP Right Cessation
1996
- 1996-06-20 GR GR960401682T patent/GR3020312T3/el unknown

Also Published As

Publication number	Publication date
IE913004A1 (en)	1992-03-11
JPH04257524A (ja)	1992-09-11
ES2085462T3 (es)	1996-06-01
PT98779A (pt)	1992-07-31
CA2049873A1 (en)	1992-02-28
ATE135585T1 (de)	1996-04-15
EP0473564A1 (en)	1992-03-04
JPH0733336B2 (ja)	1995-04-12
GR3020312T3 (en)	1996-09-30
CA2049873C (en)	2001-12-04
PT98779B (pt)	1999-06-30
DE69118056D1 (de)	1996-04-25
DE69118056T2 (de)	1996-10-24
EP0473564B1 (en)	1996-03-20

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