DK0479960T3 - Fremgangsmåde til syntese af foscarnet - Google Patents

Fremgangsmåde til syntese af foscarnet

Info

Publication number: DK0479960T3
Authority: DK; Denmark
Prior art keywords: foscarnet; synthesis; heating; reaction mixture; sodium hydroxide
Prior art date: 1990-03-12

Application number

DK91905856.0T

Other languages

Danish (da)

English (en)

Inventor

Edib Jakupovic

Urban Stenhede

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-12

Filing date

1991-03-06

Publication date

1996-03-04

1991-03-06 Application filed by Astra Ab filed Critical Astra Ab

1996-03-04 Application granted granted Critical

1996-03-04 Publication of DK0479960T3 publication Critical patent/DK0479960T3/da

Links

HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 6
238000010438 heat treatment Methods 0.000 abstract 2
ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 abstract 2
239000011541 reaction mixture Substances 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
238000001816 cooling Methods 0.000 abstract 1
NOJFJZZMRDSOLM-UHFFFAOYSA-N ethyl diethoxyphosphorylformate Chemical compound CCOC(=O)P(=O)(OCC)OCC NOJFJZZMRDSOLM-UHFFFAOYSA-N 0.000 abstract 1
229960005102 foscarnet Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000010992 reflux Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
JTFHKOYORZAXSV-UHFFFAOYSA-K trisodium phosphonoformate hexahydrate Chemical compound O.O.O.O.O.O.[Na+].[Na+].[Na+].OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O JTFHKOYORZAXSV-UHFFFAOYSA-K 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Crystallography & Structural Chemistry (AREA)
Catalysts (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Glass Compositions (AREA)
Saccharide Compounds (AREA)
Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Inorganic Compounds Of Heavy Metals (AREA)
Treating Waste Gases (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Steroid Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

DK91905856.0T 1990-03-12 1991-03-06 Fremgangsmåde til syntese af foscarnet DK0479960T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB9005534A GB2241954A (en)	1990-03-12	1990-03-12	Preparation of trisodium phosphonoformate hexahydrate

Publications (1)

Publication Number	Publication Date
DK0479960T3 true DK0479960T3 (da)	1996-03-04

Family

ID=10672476

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91905856.0T DK0479960T3 (da)	1990-03-12	1991-03-06	Fremgangsmåde til syntese af foscarnet

Country Status (29)

Country	Link
EP (1)	EP0479960B1 (id)
JP (1)	JP2568341B2 (id)
KR (1)	KR920701214A (id)
AT (1)	ATE129249T1 (id)
AU (1)	AU635413B2 (id)
BG (1)	BG61650B1 (id)
CA (1)	CA2053270C (id)
DE (2)	DE479960T1 (id)
DK (1)	DK0479960T3 (id)
ES (1)	ES2055681T3 (id)
FI (1)	FI101540B (id)
GB (1)	GB2241954A (id)
GR (2)	GR920300063T1 (id)
HK (1)	HK7297A (id)
HU (1)	HU212621B (id)
ID (1)	ID853B (id)
IE (1)	IE71021B1 (id)
IS (1)	IS1635B (id)
LT (1)	LT3585B (id)
LV (1)	LV10869B (id)
MY (1)	MY135300A (id)
NO (1)	NO179793C (id)
NZ (1)	NZ237386A (id)
PL (1)	PL166798B1 (id)
PT (1)	PT97009B (id)
RO (1)	RO111574B1 (id)
RU (1)	RU2043993C1 (id)
UA (1)	UA25900A1 (id)
WO (1)	WO1991013894A1 (id)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3590579B2 (ja) *	2000-12-11	2004-11-17	オーエスジー株式会社	ダイヤモンド被覆部材およびその製造方法
RU2228336C1 (ru) *	2002-12-23	2004-05-10	Бондаренко Наталья Александровна	Способ получения тринатриевой соли фосфонмуравьиной кислоты гексагидрата

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4018854A (en) *	1973-07-23	1977-04-19	E. I. Du Pont De Nemours And Company	Carboxyphosphonates
DD243500A1 (de) *	1985-12-17	1987-03-04	Univ Halle Wittenberg	Verfahren zur herstellung von phosphonoformiaten
DE3607445A1 (de) *	1986-03-07	1987-09-10	Hoechst Ag	Verfahren zur herstellung von alkali-phosphonoformiaten
CS253848B1 (cs) *	1986-07-18	1987-12-17	Viktor Zikan	Způsob výroby hexahydrátu trojsodné soli kyseliny fosfonomravenčí

1990
- 1990-03-12 GB GB9005534A patent/GB2241954A/en not_active Withdrawn
1991
- 1991-03-06 DK DK91905856.0T patent/DK0479960T3/da active
- 1991-03-06 AU AU74921/91A patent/AU635413B2/en not_active Expired
- 1991-03-06 ES ES91905856T patent/ES2055681T3/es not_active Expired - Lifetime
- 1991-03-06 HU HU913521A patent/HU212621B/hu unknown
- 1991-03-06 PL PL91293014A patent/PL166798B1/pl unknown
- 1991-03-06 KR KR1019910701581A patent/KR920701214A/ko not_active Ceased
- 1991-03-06 AT AT91905856T patent/ATE129249T1/de not_active IP Right Cessation
- 1991-03-06 WO PCT/SE1991/000172 patent/WO1991013894A1/en not_active Ceased
- 1991-03-06 RO RO148727A patent/RO111574B1/ro unknown
- 1991-03-06 UA UA5010100A patent/UA25900A1/uk unknown
- 1991-03-06 DE DE199191905856T patent/DE479960T1/de active Pending
- 1991-03-06 DE DE69113949T patent/DE69113949T2/de not_active Expired - Lifetime
- 1991-03-06 CA CA002053270A patent/CA2053270C/en not_active Expired - Lifetime
- 1991-03-06 JP JP3505894A patent/JP2568341B2/ja not_active Expired - Lifetime
- 1991-03-06 EP EP91905856A patent/EP0479960B1/en not_active Expired - Lifetime
- 1991-03-11 PT PT97009A patent/PT97009B/pt not_active IP Right Cessation
- 1991-03-11 IE IE78891A patent/IE71021B1/en not_active IP Right Cessation
- 1991-03-11 NZ NZ237386A patent/NZ237386A/en unknown
- 1991-03-11 IS IS3682A patent/IS1635B/is unknown
- 1991-03-12 MY MYPI91000403A patent/MY135300A/en unknown
- 1991-11-01 NO NO914291A patent/NO179793C/no not_active IP Right Cessation
- 1991-11-11 FI FI915313A patent/FI101540B/sv active
- 1991-11-11 RU SU915010100A patent/RU2043993C1/ru active
- 1991-11-12 BG BG95452A patent/BG61650B1/bg unknown
1992
- 1992-01-27 ID IDP174892A patent/ID853B/id unknown
- 1992-08-31 GR GR92300063T patent/GR920300063T1/el unknown
1993
- 1993-06-30 LV LVP-93-817A patent/LV10869B/en unknown
- 1993-12-30 LT LTIP1737A patent/LT3585B/lt not_active IP Right Cessation
1995
- 1995-12-15 GR GR950403569T patent/GR3018439T3/el unknown
1997
- 1997-01-16 HK HK7297A patent/HK7297A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2055681T3 (es)	1995-12-16
EP0479960A1 (en)	1992-04-15
HUT58750A (en)	1992-03-30
GB2241954A (en)	1991-09-18
BG61650B1 (bg)	1998-02-27
DE479960T1 (de)	1992-08-13
NO914291L (no)	1991-11-01
IS3682A7 (is)	1991-09-13
HU212621B (en)	1996-09-30
RU2043993C1 (ru)	1995-09-20
LV10869B (en)	1996-08-20
JP2568341B2 (ja)	1997-01-08
PL166798B1 (pl)	1995-06-30
ES2055681T1 (es)	1994-09-01
MY135300A (en)	2008-03-31
IE910788A1 (en)	1991-09-25
AU635413B2 (en)	1993-03-18
BG95452A (bg)	1993-12-24
DE69113949T2 (de)	1996-03-21
NO179793C (no)	1996-12-18
FI101540B1 (fi)	1998-07-15
GR3018439T3 (en)	1996-03-31
ATE129249T1 (de)	1995-11-15
RO111574B1 (ro)	1996-11-29
NO179793B (no)	1996-09-09
GR920300063T1 (en)	1992-08-31
IE71021B1 (en)	1997-01-15
AU7492191A (en)	1991-10-10
JPH04503822A (ja)	1992-07-09
LTIP1737A (en)	1995-07-25
NZ237386A (en)	1992-03-26
PT97009B (pt)	1998-07-31
IS1635B (is)	1996-09-20
FI101540B (sv)	1998-07-15
EP0479960B1 (en)	1995-10-18
WO1991013894A1 (en)	1991-09-19
UA25900A1 (uk)	1999-02-26
PT97009A (pt)	1991-10-31
NO914291D0 (no)	1991-11-01
FI915313A0 (fi)	1991-11-11
DE69113949D1 (de)	1995-11-23
CA2053270C (en)	1995-10-03
GB9005534D0 (en)	1990-05-09
ID853B (id)	1996-08-02
PL293014A1 (en)	1992-06-15
CA2053270A1 (en)	1991-09-13
LV10869A (lv)	1995-10-20
KR920701214A (ko)	1992-08-11
HK7297A (en)	1997-01-24
LT3585B (en)	1995-12-27
HU913521D0 (en)	1992-01-28

Publication	Publication Date	Title
ES8201947A1 (es)	1982-01-01	Un procedimiento para preparar 9-aminoalquilfluorenos
DK0479960T3 (da)	1996-03-04	Fremgangsmåde til syntese af foscarnet
ES532278A0 (es)	1985-08-01	Un procedimiento para la preparacion de nuevos indonaftoles.
DK434989A (da)	1990-03-04	Fremgangsmaade til kontinuerlig fremstilling af 2-phosphonobutan-1,2,4-tricarboxylsyre eller dennes alkalimetalsalte
KR940018357A (ko)	1994-08-16	방향족 니트릴의 제조 방법
GR3033271T3 (en)	2000-09-29	Polymerization process with anti-scaling agents
FR2514006B1 (id)	1984-12-28
KR950032110A (ko)	1995-12-20	3- 메르캅토프로피오니트릴 및 3- 메르캅토프로피온산의 제조방법
Inokawa et al.	1983	A NEW SYNTHETIC APPROACH TO α, β-UNSATURATED PHOSPHONATES (1-METHYLENEALKANE-PHOSPHONATES)
MX9300983A (es)	1993-09-01	Metodo para producir ariletanoles.
DK0491240T3 (da)	1995-08-21	Fremgangsmåde til fremstilling af vandopløselige sulfonerede diphosphaner
ES483898A1 (es)	1980-09-01	Procedimiento para la preparacion de aminoalcohilguanidinas sustituidas
AR016040A1 (es)	2001-05-30	Procedimiento para la preparacion de r- o bien s-norbenzomorfanos
GB1067782A (en)	1967-05-03	Aldimines
ATE92481T1 (de)	1993-08-15	Verfahren zur herstellung von n,n'-bis-(2hydroxyethyl)-piperazin.
ATE297376T1 (de)	2005-06-15	Verfahren zur herstellung von alkyl-n- alkylanthranilate
MX9606563A (es)	1997-09-30	Procedimiento para preaparar compuestos de hidrocarburo aromatico sustituidos con bromoalquilo.
JPS543059A (en)	1979-01-11	Preparation of tryptophane
KR940000470A (ko)	1994-01-03	N-포스포노메틸글리신의 합성방법
YU5693A (sh)	1996-05-20	Postupak za sintezu 3-alfa-fenil-beta-acetiletil-4-hidroksikumarina i dobijanje njegove natrijumove soli
DE69409427D1 (de)	1998-05-14	Verfahren zur Herstellung von Hydroxyphenylessigsäuren
ES8100658A1 (es)	1980-10-01	Un procedimiento de preparacion de un inhibidor del enzima covertidor de la angiotensina