DK0486526T3 - Bindingsligander for tumornekrosefaktor - Google Patents
Bindingsligander for tumornekrosefaktorInfo
- Publication number
- DK0486526T3 DK0486526T3 DK90911467.0T DK90911467T DK0486526T3 DK 0486526 T3 DK0486526 T3 DK 0486526T3 DK 90911467 T DK90911467 T DK 90911467T DK 0486526 T3 DK0486526 T3 DK 0486526T3
- Authority
- DK
- Denmark
- Prior art keywords
- necrosis factor
- tumor necrosis
- binding ligands
- ligands
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPJ566289 | 1989-08-07 | ||
| AUPJ757689 | 1989-11-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0486526T3 true DK0486526T3 (da) | 1996-06-24 |
Family
ID=25643730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90911467.0T DK0486526T3 (da) | 1989-08-07 | 1990-08-07 | Bindingsligander for tumornekrosefaktor |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7605233B2 (fr) |
| EP (1) | EP0486526B2 (fr) |
| JP (7) | JP3443119B2 (fr) |
| AU (1) | AU640400B2 (fr) |
| CA (1) | CA2064915C (fr) |
| DE (2) | DE10399036I1 (fr) |
| DK (1) | DK0486526T3 (fr) |
| WO (1) | WO1991002078A1 (fr) |
Families Citing this family (151)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0486526B2 (fr) | 1989-08-07 | 2001-03-07 | Peptech Limited | Ligands de liaison du facteur de necrose de tumeurs |
| US20030225254A1 (en) | 1989-08-07 | 2003-12-04 | Rathjen Deborah Ann | Tumour necrosis factor binding ligands |
| US5959087A (en) | 1989-08-07 | 1999-09-28 | Peptide Technology, Ltd. | Tumour necrosis factor binding ligands |
| US6451983B2 (en) | 1989-08-07 | 2002-09-17 | Peptech Limited | Tumor necrosis factor antibodies |
| EP0487610B1 (fr) * | 1989-08-16 | 2000-02-09 | Chiron Corporation | Anticorps prohormone pour blocage du site de clivage |
| EP1132471A3 (fr) | 1989-09-12 | 2001-11-28 | F. Hoffmann-La Roche Ag | Protéines liant le TNF |
| CA2078000C (fr) * | 1990-03-12 | 2001-10-02 | Deborah A. Rathjen | Peptides stimulateurs de neutrophile |
| US5587457A (en) * | 1990-03-12 | 1996-12-24 | Peptide Technology Limited | Neutrophil stimulating peptides |
| US6375928B1 (en) | 1990-03-12 | 2002-04-23 | Peptech Limited | Neutrophil stimulating peptides |
| EP0521918A4 (en) * | 1990-03-19 | 1993-05-05 | Peptide Technology Ltd | Anti-tumour peptides |
| DE69132470D1 (de) * | 1990-08-06 | 2000-12-21 | Chiron Corp | Verfahren zum nachweis von cytokinkonvertasehemmern |
| AU654501B2 (en) * | 1990-08-27 | 1994-11-10 | Peptide Technology Ltd. | Method of treating viral infection |
| US5919452A (en) * | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
| US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
| DE07012626T1 (de) * | 1991-03-18 | 2010-01-21 | New York University | Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor |
| US5698195A (en) * | 1991-03-18 | 1997-12-16 | New York University Medical Center | Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies |
| US5656272A (en) * | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
| US6284471B1 (en) | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| EP0593585B1 (fr) * | 1991-07-05 | 2002-05-02 | Peptech Limited | Peptide neutralisant la toxicite du facteur de necrose tumorale alpha (fnt) et la toxicite des lipopolysaccharides (lps) |
| JPH06510122A (ja) * | 1991-08-23 | 1994-11-10 | エヌチップ インコーポレイテッド | パッケージされていない集積回路のバーン・イン技術 |
| GB2260902A (en) * | 1991-09-12 | 1993-05-05 | Eurocetus Bv | Interleukin-2 and tumour necrosis factor for treating bladder cancer |
| ES2341666T3 (es) | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
| ATE270111T1 (de) * | 1993-03-18 | 2004-07-15 | Cytimmune Sciences Inc | Zusammensetzung und methode zur reduktion der toxizität von biologisch-aktiven faktoren |
| US6274552B1 (en) | 1993-03-18 | 2001-08-14 | Cytimmune Sciences, Inc. | Composition and method for delivery of biologically-active factors |
| FI955798A7 (fi) * | 1993-06-03 | 1996-02-01 | Therapeutic Antibodies Inc | Terapeuttiset vasta-ainefrangmentit |
| US5958409A (en) * | 1993-07-30 | 1999-09-28 | Kennedy Institute Of Rheumatology | Method for treating multiple sclerosis |
| US20010055581A1 (en) | 1994-03-18 | 2001-12-27 | Lawrence Tamarkin | Composition and method for delivery of biologically-active factors |
| CA2218522A1 (fr) * | 1995-04-20 | 1996-10-24 | The Kennedy Institute Of Rheumatology | Administrations multiples d'anticorps diriges contre le facteur necrosant des tumeurs (anticorps anti-tnf) |
| US7427492B1 (en) | 1995-06-05 | 2008-09-23 | Human Genome Sciences, Inc. | Polynucleotides encoding human tumor necrosis factor receptor-like2 |
| US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| DE122004000003I2 (de) | 1996-02-09 | 2007-03-29 | Abbott Biotech Ltd | Humane Antikörper welche an humanen TNFalpha Binden |
| US7229841B2 (en) | 2001-04-30 | 2007-06-12 | Cytimmune Sciences, Inc. | Colloidal metal compositions and methods |
| US6407218B1 (en) | 1997-11-10 | 2002-06-18 | Cytimmune Sciences, Inc. | Method and compositions for enhancing immune response and for the production of in vitro mabs |
| CA2365405A1 (fr) * | 1999-03-22 | 2000-09-28 | Human Genome Sciences, Inc. | Recepteur tr2 du facteur de necrose tumorale chez l'homme |
| US6579522B1 (en) * | 2000-06-27 | 2003-06-17 | Genvec, Inc. | Replication deficient adenoviral TNF vector |
| US6902734B2 (en) | 2000-08-07 | 2005-06-07 | Centocor, Inc. | Anti-IL-12 antibodies and compositions thereof |
| UA81743C2 (uk) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
| US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
| CA2817619A1 (fr) | 2001-06-08 | 2002-12-08 | Abbott Laboratories (Bermuda) Ltd. | Methodes pour administrer des anticorps anti-tnf.alpha. |
| WO2004003019A2 (fr) * | 2002-06-28 | 2004-01-08 | Domantis Limited | Ligand |
| TWI334439B (en) | 2001-08-01 | 2010-12-11 | Centocor Inc | Anti-tnf antibodies, compositions, methods and uses |
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
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| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| MY150740A (en) | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
| EP2267032A3 (fr) | 2002-11-08 | 2011-11-09 | Ablynx N.V. | Procédé d'administration de polypeptides thérapeutiques et polypeptides correspondants |
| ES2551682T3 (es) * | 2002-11-08 | 2015-11-23 | Ablynx N.V. | Anticuerpos de dominio simple dirigidos contra factor de necrosis tumoral-alfa y usos para los mismos |
| US20060034845A1 (en) | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
| JP2006520584A (ja) * | 2002-11-08 | 2006-09-14 | アブリンクス エン.ヴェー. | 安定化単一ドメイン抗体 |
| US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
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| US7892563B2 (en) | 2003-05-20 | 2011-02-22 | Wyeth Holdings Corporation | Methods for treatment of severe acute respiratory syndrome (SARS) |
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| UA89481C2 (uk) | 2003-09-30 | 2010-02-10 | Центокор, Инк. | Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування |
| US8895540B2 (en) | 2003-11-26 | 2014-11-25 | DePuy Synthes Products, LLC | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor |
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| MXPA06009805A (es) | 2004-02-27 | 2007-04-02 | Vaxconsulting | Peptidos de interleucina 1 beta y factor de necrosis tumoral alfa y metodo de tratamiento utilizando los mismos. |
| TW201705980A (zh) | 2004-04-09 | 2017-02-16 | 艾伯維生物技術有限責任公司 | 用於治療TNFα相關失調症之多重可變劑量療法 |
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| EP2043603A4 (fr) | 2006-07-11 | 2010-10-27 | Arubor Corp | Prévention de la rhinosinusite et thérapie avec des inhibiteurs de cytokine proinflammatoires |
| SI2068889T1 (sl) | 2006-08-10 | 2020-03-31 | Roy C. Levitt | Anakinra za uporabo pri zdravljenju sindroma bronchiolitisa obliteransa |
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| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US7906117B2 (en) | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
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- 1990-08-07 EP EP90911467A patent/EP0486526B2/fr not_active Expired - Lifetime
- 1990-08-07 AU AU61454/90A patent/AU640400B2/en not_active Expired
- 1990-08-07 CA CA002064915A patent/CA2064915C/fr not_active Expired - Lifetime
- 1990-08-07 DE DE2003199036 patent/DE10399036I1/de active Pending
- 1990-08-07 JP JP51078090A patent/JP3443119B2/ja not_active Expired - Lifetime
- 1990-08-07 DE DE69027121T patent/DE69027121T3/de not_active Expired - Lifetime
- 1990-08-07 WO PCT/AU1990/000337 patent/WO1991002078A1/fr not_active Ceased
- 1990-08-07 DK DK90911467.0T patent/DK0486526T3/da active
-
2002
- 2002-08-09 JP JP2002234004A patent/JP3717466B2/ja not_active Expired - Lifetime
-
2003
- 2003-01-31 JP JP2003024901A patent/JP2003231699A/ja active Pending
-
2005
- 2005-12-06 JP JP2005352530A patent/JP3977395B2/ja not_active Expired - Lifetime
-
2007
- 2007-04-19 JP JP2007110836A patent/JP2007197458A/ja not_active Withdrawn
- 2007-06-11 US US11/761,228 patent/US7605233B2/en not_active Expired - Fee Related
-
2008
- 2008-01-31 JP JP2008021278A patent/JP2008174559A/ja active Pending
-
2009
- 2009-03-04 JP JP2009051178A patent/JP4469013B2/ja not_active Expired - Lifetime
- 2009-09-10 US US12/557,309 patent/US20100125130A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0486526B2 (fr) | 2001-03-07 |
| US7605233B2 (en) | 2009-10-20 |
| JP4469013B2 (ja) | 2010-05-26 |
| EP0486526B1 (fr) | 1996-05-22 |
| JP2008174559A (ja) | 2008-07-31 |
| DE10399036I1 (de) | 2004-04-01 |
| JP2006089503A (ja) | 2006-04-06 |
| WO1991002078A1 (fr) | 1991-02-21 |
| JP2003231699A (ja) | 2003-08-19 |
| JP2007197458A (ja) | 2007-08-09 |
| US20100125130A1 (en) | 2010-05-20 |
| CA2064915C (fr) | 2001-05-29 |
| JP3977395B2 (ja) | 2007-09-19 |
| JP3443119B2 (ja) | 2003-09-02 |
| DE69027121T3 (de) | 2001-08-30 |
| DE69027121T2 (de) | 1996-11-14 |
| EP0486526A1 (fr) | 1992-05-27 |
| US20080234469A1 (en) | 2008-09-25 |
| JP2009114218A (ja) | 2009-05-28 |
| JPH04507195A (ja) | 1992-12-17 |
| DE69027121D1 (de) | 1996-06-27 |
| AU6145490A (en) | 1991-03-11 |
| CA2064915A1 (fr) | 1991-02-08 |
| EP0486526A4 (en) | 1993-05-05 |
| JP2003096096A (ja) | 2003-04-03 |
| JP3717466B2 (ja) | 2005-11-16 |
| AU640400B2 (en) | 1993-08-26 |
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