DK0539509T3 - 4-Alkylimidazolderivater - Google Patents

4-Alkylimidazolderivater

Info

Publication number: DK0539509T3
Authority: DK; Denmark
Prior art keywords: alkylimidazole derivatives; alkylimidazole; derivatives; angiotensin; potency
Prior art date: 1990-07-13

Application number

DK91914167.1T

Other languages

Danish (da)

English (en)

Inventor

David John Carini

Original Assignee

Du Pont

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-13

Filing date

1991-07-15

Publication date

1995-07-03

1991-07-15 Application filed by Du Pont filed Critical Du Pont

1995-07-03 Application granted granted Critical

1995-07-03 Publication of DK0539509T3 publication Critical patent/DK0539509T3/da

Links

229940123413 Angiotensin II antagonist Drugs 0.000 abstract 1
239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Lubricants (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK91914167.1T 1990-07-13 1991-07-15 4-Alkylimidazolderivater DK0539509T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US55263790A	1990-07-13	1990-07-13
US07/650,258 US5137902A (en)	1990-07-13	1991-02-04	4-alkylimidazole derivatives and anti-hypertensive use thereof

Publications (1)

Publication Number	Publication Date
DK0539509T3 true DK0539509T3 (da)	1995-07-03

Family

ID=27070086

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91914167.1T DK0539509T3 (da)	1990-07-13	1991-07-15	4-Alkylimidazolderivater

Country Status (23)

Country	Link
US (1)	US5137902A (cs)
EP (1)	EP0539509B1 (cs)
JP (1)	JP2550455B2 (cs)
KR (1)	KR0162669B1 (cs)
AT (1)	ATE121087T1 (cs)
AU (1)	AU639400B2 (cs)
BG (1)	BG61341B1 (cs)
CA (1)	CA2087274C (cs)
CZ (1)	CZ280018B6 (cs)
DE (1)	DE69108913T2 (cs)
DK (1)	DK0539509T3 (cs)
ES (1)	ES2071325T3 (cs)
FI (1)	FI102752B (cs)
HU (2)	HUT63411A (cs)
IE (1)	IE69849B1 (cs)
IL (1)	IL98794A (cs)
MY (1)	MY140243A (cs)
NO (1)	NO303015B1 (cs)
NZ (1)	NZ238920A (cs)
PL (1)	PL168311B1 (cs)
RO (1)	RO111270B1 (cs)
SK (1)	SK279326B6 (cs)
WO (1)	WO1992000977A2 (cs)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5616599A (en) *	1991-02-21	1997-04-01	Sankyo Company, Limited	Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
DE4132633A1 (de) *	1991-10-01	1993-04-08	Bayer Ag	Cyclisch substituierte imidazolyl-propensaeurederivate
US5250558A (en) *	1992-01-28	1993-10-05	Merck & Co., Inc.	Substituted triazolinones, triazolinethiones, and triazolinimines as neurotensin antagonists used to treat psychosis
US5326776A (en) *	1992-03-02	1994-07-05	Abbott Laboratories	Angiotensin II receptor antagonists
GB9218449D0 (en)	1992-08-29	1992-10-14	Boots Co Plc	Therapeutic agents
US5310929A (en) *	1992-08-06	1994-05-10	E. I. Du Pont De Nemours And Company	Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
RU2109736C1 (ru) *	1992-12-17	1998-04-27	Санкио Компани Лимитед	Производные бифенила и способ их получения
US5338740A (en) *	1993-07-13	1994-08-16	Pfizer Inc.	Angiotensin II receptor antagonists
SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use
AU2001267404A1 (en) *	2000-05-04	2001-11-12	Ipf Pharmaceuticals Gmbh	Novel compounds for the treatment of inflammatory and cardiovascular diseases
DE602005025755D1 (de)	2004-06-04	2011-02-17	Teva Pharma	Irbesartan enthaltende pharmazeutische zusammensetzung
US20070054948A1 (en) *	2004-09-02	2007-03-08	Lilach Hedvati	Purification of olmesartan medoxomil
KR20090102883A (ko) *	2004-09-02	2009-09-30	테바 파마슈티컬 인더스트리즈 리미티드	올메살탄 메독소밀의 정제
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es)	2007-06-04	2018-03-21	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
ES2522968T3 (es)	2008-06-04	2014-11-19	Synergy Pharmaceuticals Inc.	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AU2009270833B2 (en)	2008-07-16	2015-02-19	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
AU2014235215A1 (en)	2013-03-15	2015-10-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
BR112015030326A2 (pt)	2013-06-05	2017-08-29	Synergy Pharmaceuticals Inc	Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4820843A (en) *	1987-05-22	1989-04-11	E. I. Du Pont De Nemours And Company	Tetrazole intermediates to antihypertensive compounds
US5015651A (en) *	1988-01-07	1991-05-14	E. I. Du Pont De Nemours And Company	Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4880804A (en) *	1988-01-07	1989-11-14	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking benzimidazoles
CA1338238C (en) *	1988-01-07	1996-04-09	David John Carini	Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US5064825A (en) *	1989-06-01	1991-11-12	Merck & Co., Inc.	Angiotensin ii antagonists
SG52709A1 (en) *	1989-06-30	1998-09-28	Du Pont	Substituted imidazoles
JP2568315B2 (ja) *	1989-06-30	1997-01-08	イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー	縮合環アリール置換イミダゾール
DE4132633A1 (de) *	1991-10-01	1993-04-08	Bayer Ag	Cyclisch substituierte imidazolyl-propensaeurederivate

1991
- 1991-02-04 US US07/650,258 patent/US5137902A/en not_active Expired - Lifetime
- 1991-07-11 NZ NZ238920A patent/NZ238920A/en not_active IP Right Cessation
- 1991-07-11 IL IL9879491A patent/IL98794A/en not_active IP Right Cessation
- 1991-07-12 IE IE243891A patent/IE69849B1/en not_active IP Right Cessation
- 1991-07-12 MY MYPI91001263A patent/MY140243A/en unknown
- 1991-07-15 CZ CS923912A patent/CZ280018B6/cs not_active IP Right Cessation
- 1991-07-15 AU AU83116/91A patent/AU639400B2/en not_active Expired
- 1991-07-15 DK DK91914167.1T patent/DK0539509T3/da active
- 1991-07-15 CA CA002087274A patent/CA2087274C/en not_active Expired - Lifetime
- 1991-07-15 JP JP3513329A patent/JP2550455B2/ja not_active Expired - Lifetime
- 1991-07-15 SK SK3912-92A patent/SK279326B6/sk not_active IP Right Cessation
- 1991-07-15 DE DE69108913T patent/DE69108913T2/de not_active Expired - Lifetime
- 1991-07-15 HU HU924058A patent/HUT63411A/hu unknown
- 1991-07-15 KR KR1019930700076A patent/KR0162669B1/ko not_active Expired - Lifetime
- 1991-07-15 EP EP91914167A patent/EP0539509B1/en not_active Expired - Lifetime
- 1991-07-15 PL PL91297616A patent/PL168311B1/pl unknown
- 1991-07-15 WO PCT/US1991/004826 patent/WO1992000977A2/en not_active Ceased
- 1991-07-15 HU HU9204058A patent/HU223530B1/hu active IP Right Grant
- 1991-07-15 AT AT91914167T patent/ATE121087T1/de not_active IP Right Cessation
- 1991-07-15 ES ES91914167T patent/ES2071325T3/es not_active Expired - Lifetime
- 1991-07-15 RO RO93-00803A patent/RO111270B1/ro unknown
1993
- 1993-01-11 NO NO930088A patent/NO303015B1/no not_active IP Right Cessation
- 1993-01-12 FI FI930109A patent/FI102752B/fi not_active IP Right Cessation
- 1993-02-11 BG BG97438A patent/BG61341B1/bg unknown

Also Published As

Publication number	Publication date
KR0162669B1 (ko)	1998-12-01
JPH05508415A (ja)	1993-11-25
IE69849B1 (en)	1996-10-02
PL297616A1 (cs)	1992-07-13
JP2550455B2 (ja)	1996-11-06
IE912438A1 (en)	1992-01-15
CZ280018B6 (cs)	1995-09-13
SK391292A3 (en)	1993-07-07
AU639400B2 (en)	1993-07-22
BG97438A (bg)	1994-03-24
HU223530B1 (hu)	2004-08-30
EP0539509A1 (en)	1993-05-05
MY140243A (en)	2009-12-31
NO303015B1 (no)	1998-05-18
DE69108913T2 (de)	1995-08-24
IL98794A (en)	1995-11-27
FI102752B1 (fi)	1999-02-15
NO930088D0 (no)	1993-01-11
RO111270B1 (ro)	1996-08-30
FI102752B (fi)	1999-02-15
FI930109A0 (fi)	1993-01-12
ES2071325T3 (es)	1995-06-16
FI930109L (fi)	1993-01-12
US5137902A (en)	1992-08-11
HU9204058D0 (en)	1993-03-29
CZ391292A3 (en)	1993-12-15
NZ238920A (en)	1993-07-27
NO930088L (no)	1993-01-11
EP0539509B1 (en)	1995-04-12
ATE121087T1 (de)	1995-04-15
BG61341B1 (en)	1997-06-30
HUT63411A (en)	1993-08-30
CA2087274C (en)	2002-02-19
WO1992000977A3 (en)	1992-02-20
WO1992000977A2 (en)	1992-01-23
PL168311B1 (pl)	1996-02-29
DE69108913D1 (de)	1995-05-18
AU8311691A (en)	1992-02-04
SK279326B6 (sk)	1998-10-07
IL98794A0 (en)	1992-07-15
CA2087274A1 (en)	1992-01-14

Publication	Publication Date	Title
DE69108913D1 (de)	1995-05-18	4-alkylimidazolderivate.
DE69620443D1 (de)	2002-05-08	Naphthyl substituierte benzimidazolderivate als antikoagulantien
LU91122I2 (fr)	2005-01-10	Efalizumab et ses dérivés pharmaceutiquement acceptables (raptiva).
LU91205I2 (fr)	2006-05-30	Ciclesonide et ses dérivés pharmaceutiquement acceptables (alvesco)
LU90219I2 (fr)	1998-05-28	Tolcapone et ses dérivés pharmaceutiquement acceptables (TASMAR)
DE69717827D1 (de)	2003-01-23	Benzofuran-4-carboxamide
LU88790I2 (fr)	1997-03-18	Moxidectin et ses dérivés pharmaceutiquement acceptables
ES2052897T3 (es)	1994-07-16	Nucleosidos didesoxidideshidrocarbociclicos.
NO952743D0 (no)	1995-07-11	Ny benzotiadiazinforbindelse, dens fremstilling og farmasöytiske preparater
DK199587D0 (da)	1987-04-15	Heterocykliske derivater af n'-substituerede-n,n'-diacylhydraziner
NO20033184D0 (no)	2003-07-11	Anvendelse av forbindelsen (+)-<alfa>-(2,3-dimetoksyfenyl)-1- [2-(4-fluorfenyl)etyl]-4-piperidinmetanol
DE69100517D1 (de)	1993-11-25	Polyethyleneiminphosphonatderivate als Dispergiermittel enthaltende Zementzusammensetzungen.
FI890185A0 (fi)	1989-01-13	Foerfarande foer framstaellning av 1-alkyl-5-nitroimidazoler.
DK199487D0 (da)	1987-04-15	Heterocykliske derivater af n'-substituerede-n,n'-diacylhydraziner
EE02942B1 (et)	1996-10-15	Metüülpiperasinoasepiini derivaadid, nende valmistamine ja kasutamine
FI912963A0 (fi)	1991-06-18	Hjaernverksamheten oekande pyrimidinylderivat.
ES2087567T3 (es)	1996-07-16	Derivados antibioticos de 7'-amino-naftazarina.
LU88789I2 (fr)	1996-11-05	Mésylate de tirilazad et ses dérivés pharmaceutiquement acceptables (Freedox (R))
FI914087A0 (fi)	1991-08-30	Foerfarande och anordning foer detektering av verktygshaverier i skaerande bearbetning.
FI970397A0 (fi)	1997-01-30	Substituoituja 1,4-dihydroksylopent(b)indol-3(2H)-onijohdannaisia
DK336088A (da)	1989-12-21	Antitumormiddel opnaaet ved mikrobiel stereoselektiv reduktion af 4'-deoxy-4'-ioddoxorubicin
IT1255093B (it)	1995-10-18	Derivati imidazolidinonici come agenti nootropici
GR1001386B (el)	1993-10-29	Ετεροκυκλικές ενώσεις.