BG61341B1 - 4- alkylimidazole derivatives - Google Patents

4- alkylimidazole derivatives Download PDF

Info

Publication number
BG61341B1
BG61341B1 BG97438A BG9743893A BG61341B1 BG 61341 B1 BG61341 B1 BG 61341B1 BG 97438 A BG97438 A BG 97438A BG 9743893 A BG9743893 A BG 9743893A BG 61341 B1 BG61341 B1 BG 61341B1
Authority
BG
Bulgaria
Prior art keywords
ethyl
solution
compounds
cho
cooh
Prior art date
Application number
BG97438A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG97438A (bg
Inventor
David J Carini
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of BG97438A publication Critical patent/BG97438A/bg
Publication of BG61341B1 publication Critical patent/BG61341B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BG97438A 1990-07-13 1993-02-11 4- alkylimidazole derivatives BG61341B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55263790A 1990-07-13 1990-07-13
US07/650,258 US5137902A (en) 1990-07-13 1991-02-04 4-alkylimidazole derivatives and anti-hypertensive use thereof
PCT/US1991/004826 WO1992000977A2 (en) 1990-07-13 1991-07-15 4-alkylimidazole derivatives

Publications (2)

Publication Number Publication Date
BG97438A BG97438A (bg) 1994-03-24
BG61341B1 true BG61341B1 (en) 1997-06-30

Family

ID=27070086

Family Applications (1)

Application Number Title Priority Date Filing Date
BG97438A BG61341B1 (en) 1990-07-13 1993-02-11 4- alkylimidazole derivatives

Country Status (23)

Country Link
US (1) US5137902A (cs)
EP (1) EP0539509B1 (cs)
JP (1) JP2550455B2 (cs)
KR (1) KR0162669B1 (cs)
AT (1) ATE121087T1 (cs)
AU (1) AU639400B2 (cs)
BG (1) BG61341B1 (cs)
CA (1) CA2087274C (cs)
CZ (1) CZ280018B6 (cs)
DE (1) DE69108913T2 (cs)
DK (1) DK0539509T3 (cs)
ES (1) ES2071325T3 (cs)
FI (1) FI102752B (cs)
HU (2) HUT63411A (cs)
IE (1) IE69849B1 (cs)
IL (1) IL98794A (cs)
MY (1) MY140243A (cs)
NO (1) NO303015B1 (cs)
NZ (1) NZ238920A (cs)
PL (1) PL168311B1 (cs)
RO (1) RO111270B1 (cs)
SK (1) SK279326B6 (cs)
WO (1) WO1992000977A2 (cs)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
DE4132633A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Cyclisch substituierte imidazolyl-propensaeurederivate
US5250558A (en) * 1992-01-28 1993-10-05 Merck & Co., Inc. Substituted triazolinones, triazolinethiones, and triazolinimines as neurotensin antagonists used to treat psychosis
US5326776A (en) * 1992-03-02 1994-07-05 Abbott Laboratories Angiotensin II receptor antagonists
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
RU2109736C1 (ru) * 1992-12-17 1998-04-27 Санкио Компани Лимитед Производные бифенила и способ их получения
US5338740A (en) * 1993-07-13 1994-08-16 Pfizer Inc. Angiotensin II receptor antagonists
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
AU2001267404A1 (en) * 2000-05-04 2001-11-12 Ipf Pharmaceuticals Gmbh Novel compounds for the treatment of inflammatory and cardiovascular diseases
DE602005025755D1 (de) 2004-06-04 2011-02-17 Teva Pharma Irbesartan enthaltende pharmazeutische zusammensetzung
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
KR20090102883A (ko) * 2004-09-02 2009-09-30 테바 파마슈티컬 인더스트리즈 리미티드 올메살탄 메독소밀의 정제
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
SG52709A1 (en) * 1989-06-30 1998-09-28 Du Pont Substituted imidazoles
JP2568315B2 (ja) * 1989-06-30 1997-01-08 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 縮合環アリール置換イミダゾール
DE4132633A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Cyclisch substituierte imidazolyl-propensaeurederivate

Also Published As

Publication number Publication date
KR0162669B1 (ko) 1998-12-01
JPH05508415A (ja) 1993-11-25
IE69849B1 (en) 1996-10-02
PL297616A1 (cs) 1992-07-13
JP2550455B2 (ja) 1996-11-06
IE912438A1 (en) 1992-01-15
CZ280018B6 (cs) 1995-09-13
SK391292A3 (en) 1993-07-07
AU639400B2 (en) 1993-07-22
BG97438A (bg) 1994-03-24
HU223530B1 (hu) 2004-08-30
EP0539509A1 (en) 1993-05-05
MY140243A (en) 2009-12-31
NO303015B1 (no) 1998-05-18
DE69108913T2 (de) 1995-08-24
IL98794A (en) 1995-11-27
FI102752B1 (fi) 1999-02-15
NO930088D0 (no) 1993-01-11
RO111270B1 (ro) 1996-08-30
FI102752B (fi) 1999-02-15
FI930109A0 (fi) 1993-01-12
ES2071325T3 (es) 1995-06-16
FI930109L (fi) 1993-01-12
US5137902A (en) 1992-08-11
HU9204058D0 (en) 1993-03-29
CZ391292A3 (en) 1993-12-15
NZ238920A (en) 1993-07-27
DK0539509T3 (da) 1995-07-03
NO930088L (no) 1993-01-11
EP0539509B1 (en) 1995-04-12
ATE121087T1 (de) 1995-04-15
HUT63411A (en) 1993-08-30
CA2087274C (en) 2002-02-19
WO1992000977A3 (en) 1992-02-20
WO1992000977A2 (en) 1992-01-23
PL168311B1 (pl) 1996-02-29
DE69108913D1 (de) 1995-05-18
AU8311691A (en) 1992-02-04
SK279326B6 (sk) 1998-10-07
IL98794A0 (en) 1992-07-15
CA2087274A1 (en) 1992-01-14

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