DK0539960T3 - Hermatoporphyrinderivatkomplekssalte og deres anvendelse ved detektering og behandling af neoplasmer - Google Patents

Hermatoporphyrinderivatkomplekssalte og deres anvendelse ved detektering og behandling af neoplasmer

Info

Publication number
DK0539960T3
DK0539960T3 DK92118447.9T DK92118447T DK0539960T3 DK 0539960 T3 DK0539960 T3 DK 0539960T3 DK 92118447 T DK92118447 T DK 92118447T DK 0539960 T3 DK0539960 T3 DK 0539960T3
Authority
DK
Denmark
Prior art keywords
hermatoporphyrin
neoplasms
detection
treatment
complex salts
Prior art date
Application number
DK92118447.9T
Other languages
English (en)
Inventor
Alfreda Asst Prof Dr C Graczyk
Jerzy Dr Chem Konarski
Original Assignee
Wojskowa Akad Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wojskowa Akad Tech filed Critical Wojskowa Akad Tech
Application granted granted Critical
Publication of DK0539960T3 publication Critical patent/DK0539960T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK92118447.9T 1991-10-29 1992-10-28 Hermatoporphyrinderivatkomplekssalte og deres anvendelse ved detektering og behandling af neoplasmer DK0539960T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL91292220A PL165249B1 (pl) 1991-10-29 1991-10-29 Sposób otrzymywania soli kompleksowych hematoporfiryny i jej pochodnych PL PL PL PL PL PL PL

Publications (1)

Publication Number Publication Date
DK0539960T3 true DK0539960T3 (da) 1997-09-15

Family

ID=20055985

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92118447.9T DK0539960T3 (da) 1991-10-29 1992-10-28 Hermatoporphyrinderivatkomplekssalte og deres anvendelse ved detektering og behandling af neoplasmer

Country Status (18)

Country Link
US (1) US5451599A (da)
EP (1) EP0539960B1 (da)
JP (1) JP3020759B2 (da)
CN (1) CN1040328C (da)
BG (1) BG61648B1 (da)
CA (1) CA2081605C (da)
CZ (1) CZ281694B6 (da)
DE (1) DE69217819T2 (da)
DK (1) DK0539960T3 (da)
FI (1) FI100243B (da)
HR (1) HRP921337B1 (da)
LV (1) LV11952B (da)
NO (1) NO300499B1 (da)
PL (1) PL165249B1 (da)
RU (1) RU2122003C1 (da)
SI (1) SI9200286B (da)
UA (1) UA40568C2 (da)
YU (1) YU48961B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO180167C (no) 1994-09-08 1997-02-26 Photocure As Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
US5948771A (en) * 1996-01-31 1999-09-07 The Trustees Of Columbia University In The City Of New York Method for treating heart failure using tetrapyrroles and metallotetrapyrroles
GB9606293D0 (en) * 1996-03-26 1996-05-29 William Harvey Research Limite Treatment of cancers and other tumours
RU2164136C2 (ru) * 1998-09-09 2001-03-20 Государственный научный центр РФ "НИОПИК" Фотосенсибилизатор для фотодинамической терапии
HU229805B1 (en) 2000-11-29 2014-07-28 Pci Biotech As Photochemical internalization for delivery of molecules into the cytosol
EP1339862B1 (en) 2000-11-29 2014-01-08 PCI Biotech AS Photochemical internalization for virus-mediated molecule delivery into the cytosol
RU2236411C2 (ru) * 2002-06-06 2004-09-20 Московская государственная академия тонкой химической технологии им. М.В. Ломоносова Металлокомплексы карборанилпорфиринов, обладающие противоопухолевой активностью
RU2278119C1 (ru) * 2004-12-06 2006-06-20 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" Тетраазахлорины как фотосенсибилизаторы для фотодинамической терапии
RU2282646C1 (ru) * 2005-05-31 2006-08-27 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Фотосенсибилизаторы для фотодинамической терапии
RU2282647C1 (ru) * 2005-05-31 2006-08-27 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Фотосенсибилизаторы для антимикробной фотодинамической терапии
CN104130266A (zh) * 2013-05-02 2014-11-05 中国医学科学院生物医学工程研究所 一种新型原卟啉衍生物及制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2912M (fr) * 1963-07-24 1964-11-09 Rech S Pharma E R P H A R Soc Dichlorhydrate d'hématoporphyrinate de procaine.
US4649151A (en) * 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
JPS60152487A (ja) * 1984-01-18 1985-08-10 Sato Yakugaku Kenkyusho:Kk デユウテロポルフイリン誘導体及びその塩
US4675338A (en) * 1984-07-18 1987-06-23 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
GB8429845D0 (en) * 1984-11-26 1985-01-03 Efamol Ltd Porphyrins & cancer treatment
AU589957B2 (en) * 1985-04-30 1989-10-26 Nippon Petrochemicals Company Limited New tetrapyrrole therapeutic agents
US4977177A (en) * 1985-04-30 1990-12-11 Nippon Petrochemicals Company, Ltd. Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents
DE3687399T2 (de) * 1985-10-23 1993-04-29 Nihon Mediphysics Co Ltd Porphyrinderivate, ihre herstellung und verwendung.
US4882234A (en) * 1986-11-12 1989-11-21 Healux, Inc. Storage-stable porphin compositions and a method for their manufacture
US4861876A (en) * 1986-11-26 1989-08-29 Wayne State University Hematoporphyrin derivative and method of preparation and purification
JPH0786109B2 (ja) * 1987-12-21 1995-09-20 浜理薬品工業株式会社 フェオフォルバイド誘導体
GB8805849D0 (en) * 1988-03-11 1988-04-13 Efamol Holdings Porphyrins & cancer treatment
US5190966A (en) * 1988-07-06 1993-03-02 Health Research, Inc. Purified hematoporphyrin dimers and trimers useful in photodynamic therapy
US4968715A (en) * 1988-07-06 1990-11-06 Health Research, Inc. Use of purified hematoporphyrin trimers in photodynamic therapy
US4961920A (en) * 1988-12-08 1990-10-09 Luminis Pty, Ltd. Phototherapeutic monovinyl and divinyl ether-linked dimers
US5059619A (en) * 1989-06-14 1991-10-22 Quadra Logic Technologies, Inc. Stable freeze-dried polyhematoporphyrin ether/ester
US4965054A (en) * 1989-08-01 1990-10-23 Henkel Corporation Process of extraction of gallium from aqueous solutions thereof
CN102565846B (zh) * 2011-12-30 2014-05-14 清华大学 蜂窝型热中子探测器

Also Published As

Publication number Publication date
US5451599A (en) 1995-09-19
CZ281694B6 (cs) 1996-12-11
NO300499B1 (no) 1997-06-09
PL165249B1 (pl) 1994-11-30
DE69217819D1 (de) 1997-04-10
CN1040328C (zh) 1998-10-21
FI924856A0 (fi) 1992-10-26
BG97030A (bg) 1994-03-24
EP0539960B1 (en) 1997-03-05
DE69217819T2 (de) 1997-09-04
SI9200286B (en) 2001-06-30
BG61648B1 (bg) 1998-02-27
RU2122003C1 (ru) 1998-11-20
NO924151D0 (no) 1992-10-28
UA40568C2 (uk) 2001-08-15
PL292220A1 (en) 1993-09-20
CZ325292A3 (en) 1993-09-15
NO924151L (no) 1993-04-30
FI924856A7 (fi) 1993-04-30
YU48961B (sh) 2003-01-31
YU94592A (sh) 1995-12-04
JP3020759B2 (ja) 2000-03-15
HRP921337B1 (en) 2000-02-29
CA2081605A1 (en) 1993-04-30
EP0539960A2 (en) 1993-05-05
LV11952A (lv) 1998-01-20
LV11952B (en) 1998-06-20
CA2081605C (en) 2002-02-26
FI100243B (fi) 1997-10-31
CN1071914A (zh) 1993-05-12
SI9200286A (en) 1993-06-30
EP0539960A3 (en) 1993-06-16
JPH05262775A (ja) 1993-10-12
HRP921337A2 (en) 1994-10-31

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