DK2311432T3 - Modificerede Kunitz-domæne-polypeptider og deres anvendelse til reduktion af iskæmi eller indtræden af en systemisk inflammatorisk reaktion i forbindelse med en kirurgisk procedure - Google Patents
Modificerede Kunitz-domæne-polypeptider og deres anvendelse til reduktion af iskæmi eller indtræden af en systemisk inflammatorisk reaktion i forbindelse med en kirurgisk procedure Download PDFInfo
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- DK2311432T3 DK2311432T3 DK10180484.7T DK10180484T DK2311432T3 DK 2311432 T3 DK2311432 T3 DK 2311432T3 DK 10180484 T DK10180484 T DK 10180484T DK 2311432 T3 DK2311432 T3 DK 2311432T3
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Claims (11)
1. Et polypeptid bestående ag aminosyresekvensen: Xaal Xaa2 Xaa3 Xaa4 Cys Xaa6 Xaa7 Xaa8 Xaa9 XaalO Xaal 1 Gly Xaal 3 Cys Xaal 5 Xaal 6 Xaal 7 Xaal 8 Xaal 9 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 Xaa25 Xaa26 Xaa27 Xaa28 Xaa29 Cys Xaa31 Xaa32 Phe Xaa34 Xaa35 Gly Gly Cys Xaa39 Xaa40 Xaa41 Xaa42 Xaa43 Xaa44 Xaa45 Xaa46 Xaa47 Xaa48 Xaa49 Xaa50 Cys Xaa52 Xaa53 Xaa54 Cys Xaa56 Xaa57 Xaa58 (SEQ ID NO:l), hvori Xaal, Xaa2, Xaa3, Xaa4, Xaa56, Xaa57 eller Xaa58 er individuel, en aminosyre eller fraværende; Xaal 0 er Asp; Xaall er Asp; Xaal 3 er Pro; Xaal 5 er Arg; Xaal 6 er Ala; Xaal 7 er Ala; Xaal 8 er His; Xaal 9 er Pro; Xaa21 erTrp; Xaa22 er en aminosyre valgt fra gruppen bestående af Tyr og Phe; Xaa23 er en aminosyre valgt lfa gruppen bestående af Tyr og Phe; Xaa31 er Glu; Xaa32 er Glu; Xaa34 er Ile; Xaa35 er Tyr; Xaa39 er Glu; Xaa40 er en aminosyre valgt fra gruppen bestående af Gly og Ala; Xaa43 er en aminosyre valgt fra gruppen bestående af Asn og Gly; Xaa45 er en aminosyre valgt fra gruppen bestående af Phe og Tyr; og hvori polypeptidet inhiberer kallikrein.
2. Polypeptidet i henhold til patentkrav 1, hvor polypeptidet består af aminosyresekvensen: Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Arg Ala Ala His Pro Arg Trp Phe Phe Asn Ile Phe Thr Arg Gin Cys Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gin Asn Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp (aminosyre 5-60 af SEQ ID NO:2).
3. Polypeptidet i henhold til patentkrav 1, hvor aminosyresekvensen er mindst 95% identitisk med SEQ ID NO: 2.
4. Et polypeptid bestående af en del af aminosyresekvensen, der er angivet i et hvilket som helst af kravene 1 til 3, hvor nævnte del binder kallikrein.
5. Polypeptidet i henhold til hvilket som helst af kravene 1 til 4 til brug ved forebyggelse eller reduktion af iskæmi i en patient, eller til brug ved forebyggelse eller begrænsning af indtræden af en systemisk inflammatorisk reaktion i forbindelse med en kirurgisk procedure i en patient.
6. Et nukleinsyremolekyle bestående af en nukleinsyresekvens, der koder for polypeptidet i henhold et hvilket som helst af kravene 1 til 4.
7. En ekspressionsvektor bestående af nukleinsyren i henhold til krav 6.
8. Polypeptid i henhold til krav 5, hvor den kirurgiske procedure er hjerte-thoraxkirurgi.
9. Polypeptid i henhold til krav 5, hvor den kirurgiske procedure er koronararterie bypassoperation.
10. Polypeptid i henhold til krav 5, hvor den kirurgiske procedure er kardiopulmonal bypassoperation.
11. Polypeptid i henhold til krav 5, hvor den kirurgiske procedure er en hofteudskiftning eller en stemalsplitting.
Applications Claiming Priority (3)
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| EP07023364A EP1941867B1 (en) | 2002-06-07 | 2003-06-06 | Modified kunitz domain polypeptide |
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| DK07023364.8T DK1941867T3 (da) | 2002-06-07 | 2003-06-06 | Polypeptid med modificeret Kunitz domæne |
| DK10180486.2T DK2298278T3 (da) | 2002-06-07 | 2003-06-06 | Forebyggelse og reduktion af blodtab og inflammatorisk respons |
| DK03757339.1T DK1531791T3 (da) | 2002-06-07 | 2003-06-06 | Forebyggelse og begrænsning af iskæmi |
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| DK07023364.8T DK1941867T3 (da) | 2002-06-07 | 2003-06-06 | Polypeptid med modificeret Kunitz domæne |
| DK10180486.2T DK2298278T3 (da) | 2002-06-07 | 2003-06-06 | Forebyggelse og reduktion af blodtab og inflammatorisk respons |
| DK03757339.1T DK1531791T3 (da) | 2002-06-07 | 2003-06-06 | Forebyggelse og begrænsning af iskæmi |
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| EP (4) | EP2298278B1 (da) |
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| AU (3) | AU2003243394B2 (da) |
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| ES (4) | ES2372978T3 (da) |
| PT (4) | PT2298278E (da) |
| WO (1) | WO2003103475A2 (da) |
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