DK0563176T3 - Fremgangsmåde til fremstilling af mikropartikler af hydrolytisk nedbrydelige polymerer og indeholdende aktive forbindelser - Google Patents

Fremgangsmåde til fremstilling af mikropartikler af hydrolytisk nedbrydelige polymerer og indeholdende aktive forbindelser

Info

Publication number
DK0563176T3
DK0563176T3 DK92901683.0T DK92901683T DK0563176T3 DK 0563176 T3 DK0563176 T3 DK 0563176T3 DK 92901683 T DK92901683 T DK 92901683T DK 0563176 T3 DK0563176 T3 DK 0563176T3
Authority
DK
Denmark
Prior art keywords
pct
containing active
microparticles
preparation
active compounds
Prior art date
Application number
DK92901683.0T
Other languages
English (en)
Inventor
Heike Biskup
Elke Gorissen
Hannelore Schneider
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Application granted granted Critical
Publication of DK0563176T3 publication Critical patent/DK0563176T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y10T428/2987—Addition polymer from unsaturated monomers only

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Saccharide Compounds (AREA)
  • Polyamides (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DK92901683.0T 1990-12-22 1991-12-18 Fremgangsmåde til fremstilling af mikropartikler af hydrolytisk nedbrydelige polymerer og indeholdende aktive forbindelser DK0563176T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4041563A DE4041563A1 (de) 1990-12-22 1990-12-22 Verfahren zur herstellung wirkstoffhaltiger mikropartikel aus hydrolytisch abbaubaren polymeren

Publications (1)

Publication Number Publication Date
DK0563176T3 true DK0563176T3 (da) 1995-03-06

Family

ID=6421280

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92901683.0T DK0563176T3 (da) 1990-12-22 1991-12-18 Fremgangsmåde til fremstilling af mikropartikler af hydrolytisk nedbrydelige polymerer og indeholdende aktive forbindelser

Country Status (15)

Country Link
US (1) US5424076A (da)
EP (1) EP0563176B1 (da)
JP (1) JP3496153B2 (da)
KR (1) KR0162105B1 (da)
AT (1) ATE116542T1 (da)
CA (1) CA2098814C (da)
DE (2) DE4041563A1 (da)
DK (1) DK0563176T3 (da)
ES (1) ES2067324T3 (da)
FI (1) FI102811B (da)
GR (1) GR3015623T3 (da)
HU (1) HU217817B (da)
IE (1) IE65915B1 (da)
PT (1) PT99892B (da)
WO (1) WO1992011000A1 (da)

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US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
US6169763B1 (en) 1995-06-29 2001-01-02 Qualcomm Inc. Characterizing a communication system using frame aligned test signals
FR2753639B1 (fr) 1996-09-25 1998-12-11 Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede
US5766637A (en) * 1996-10-08 1998-06-16 University Of Delaware Microencapsulation process using supercritical fluids
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
DE19711393C1 (de) * 1997-03-19 1998-08-13 Fraunhofer Ges Forschung Verfahren zum Mikroverkapseln von Partikeln
FR2762318B1 (fr) * 1997-04-18 1999-09-17 Pharma Biotech Compositions presentant une liberation prolongee et leur procede de preparation
AR012448A1 (es) * 1997-04-18 2000-10-18 Ipsen Pharma Biotech Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada
FR2776516B1 (fr) * 1998-03-25 2001-05-25 Pharma Biotech Compositions presentant une liberation prolongee et leur procede de preparation
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
GB9810559D0 (en) * 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
GB9915975D0 (en) 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
ATE281829T1 (de) * 1999-07-13 2004-11-15 Degussa Verfahren zur herstellung pulverförmiger partikelreduzierter formulierungen mit hilfe verdichteter gase
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
FR2811913B1 (fr) * 2000-07-19 2003-09-19 Separex Sa Procede d'encapsulation sous forme de micro-capsules de fines particules solides
US6521258B1 (en) * 2000-09-08 2003-02-18 Ferro Corporation Polymer matrices prepared by supercritical fluid processing techniques
US6579532B1 (en) * 2000-09-08 2003-06-17 Ferro Corporation Orthopedic mixtures prepared by supercritical fluid processing techniques
GB0027357D0 (en) * 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7582284B2 (en) * 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US6966990B2 (en) * 2002-10-11 2005-11-22 Ferro Corporation Composite particles and method for preparing
AU2003291757A1 (en) * 2002-11-08 2004-06-03 Bristol-Myers Squibb Company Formulations of low solubility bioactive agents and processes for making the same
WO2004098561A2 (en) 2003-05-08 2004-11-18 Nektar Therapeutics Uk Ltd Particulate materials
US7507823B2 (en) * 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
EP1757361A1 (en) * 2005-08-23 2007-02-28 Feyecon Development & Implementation B.V. Process for the preparation of encapsulates through precipitation
JP4705691B2 (ja) * 2006-10-11 2011-06-22 クリティテック・インコーポレイテッド 使用のための容器に小さい医薬粒子を沈殿させるための方法
DK2425820T3 (da) 2007-02-11 2015-07-13 Map Pharmaceuticals Inc Fremgangsmåde til terapeutisk administration af dhe for at muliggøre hurtig lindring af migræne, mens bivirkningsprofilen minimeres
US20100184744A1 (en) * 2007-07-18 2010-07-22 Feyecon Development & Implementation B.V. Method of preparing a pharmaceutical co-crystal composition
WO2009110939A2 (en) * 2007-12-10 2009-09-11 Massachusetts Institute Of Technology Drug delivery system for pharmaceuticals and radiation
US9808030B2 (en) 2011-02-11 2017-11-07 Grain Processing Corporation Salt composition

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HU192982B (en) * 1984-04-28 1987-08-28 Allatorvostudomanyi Egyetem Process for producing synergetic pharmaceutical compositions containing thiamulin and antibacterial and antiprotozoal organic acids
DE3428372A1 (de) * 1984-08-01 1986-02-13 Hoechst Ag, 6230 Frankfurt Mikrokapseln von regulatorischen peptiden mit kontrollierter freisetzung, verfahren zu ihrer herstellung und injektionszubereitungen
DE3701625A1 (de) * 1987-01-21 1988-08-04 Boehringer Ingelheim Kg Perorale arzneimittelzubereitung mit verzoegerter wirkstofffreigabe
DE3738228A1 (de) * 1987-11-11 1989-05-24 Hoechst Ag Verfahren zur herstellung von bioabbaubaren mikrokapseln wasserloeslicher peptide und proteine sowie nach diesem verfahren erhaltene mikrokapseln
DE3744329A1 (de) * 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
US5271945A (en) * 1988-07-05 1993-12-21 Takeda Chemical Industries, Ltd. Sustained release microcapsule for water soluble drug
JP2827287B2 (ja) * 1988-07-05 1998-11-25 武田薬品工業株式会社 水溶性薬物含有徐放型マイクロカプセル
DK0432232T3 (da) * 1989-05-01 1994-01-31 Alkermes Inc Fremgangsmåde til fremstilling af små partikler af biologisk aktive molekyler
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Also Published As

Publication number Publication date
HUT63954A (en) 1993-11-29
IE65915B1 (en) 1995-11-29
EP0563176A1 (de) 1993-10-06
ATE116542T1 (de) 1995-01-15
EP0563176B1 (de) 1995-01-04
PT99892B (pt) 1999-06-30
FI932761L (fi) 1993-06-16
FI102811B1 (fi) 1999-02-26
ES2067324T3 (es) 1995-03-16
JP3496153B2 (ja) 2004-02-09
DE4041563A1 (de) 1992-06-25
GR3015623T3 (en) 1995-06-30
CA2098814C (en) 1999-05-11
HU217817B (hu) 2000-04-28
HU9301812D0 (en) 1993-09-28
WO1992011000A1 (de) 1992-07-09
IE914313A1 (en) 1992-07-01
KR0162105B1 (ko) 1998-12-01
JPH06504531A (ja) 1994-05-26
FI932761A0 (fi) 1993-06-16
FI102811B (fi) 1999-02-26
DE59104172D1 (de) 1995-02-16
US5424076A (en) 1995-06-13
PT99892A (pt) 1992-12-31
KR930701985A (ko) 1993-09-08
CA2098814A1 (en) 1992-06-23

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