PT99892A - Processo para a producao de microparticulas carregadas de substancia activa a partir de polimeros que se decompoem hidroliticamente - Google Patents

Processo para a producao de microparticulas carregadas de substancia activa a partir de polimeros que se decompoem hidroliticamente

Info

Publication number
PT99892A
PT99892A PT99892A PT9989291A PT99892A PT 99892 A PT99892 A PT 99892A PT 99892 A PT99892 A PT 99892A PT 9989291 A PT9989291 A PT 9989291A PT 99892 A PT99892 A PT 99892A
Authority
PT
Portugal
Prior art keywords
pct
production
hydrolytically
active substance
loaded microparticles
Prior art date
Application number
PT99892A
Other languages
English (en)
Other versions
PT99892B (pt
Inventor
Elke Gorissen
Heike Biskup
Hannelore Schneider
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of PT99892A publication Critical patent/PT99892A/pt
Publication of PT99892B publication Critical patent/PT99892B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y10T428/2987—Addition polymer from unsaturated monomers only

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Polyamides (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
PT99892A 1990-12-22 1991-12-20 Processo para a producao de microparticulas carregadas de substancia activa a partir de polimeros que se decompoem hidroliticamente PT99892B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4041563A DE4041563A1 (de) 1990-12-22 1990-12-22 Verfahren zur herstellung wirkstoffhaltiger mikropartikel aus hydrolytisch abbaubaren polymeren

Publications (2)

Publication Number Publication Date
PT99892A true PT99892A (pt) 1992-12-31
PT99892B PT99892B (pt) 1999-06-30

Family

ID=6421280

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99892A PT99892B (pt) 1990-12-22 1991-12-20 Processo para a producao de microparticulas carregadas de substancia activa a partir de polimeros que se decompoem hidroliticamente

Country Status (15)

Country Link
US (1) US5424076A (pt)
EP (1) EP0563176B1 (pt)
JP (1) JP3496153B2 (pt)
KR (1) KR0162105B1 (pt)
AT (1) ATE116542T1 (pt)
CA (1) CA2098814C (pt)
DE (2) DE4041563A1 (pt)
DK (1) DK0563176T3 (pt)
ES (1) ES2067324T3 (pt)
FI (1) FI102811B1 (pt)
GR (1) GR3015623T3 (pt)
HU (1) HU217817B (pt)
IE (1) IE65915B1 (pt)
PT (1) PT99892B (pt)
WO (1) WO1992011000A1 (pt)

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US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
US6169763B1 (en) 1995-06-29 2001-01-02 Qualcomm Inc. Characterizing a communication system using frame aligned test signals
FR2753639B1 (fr) * 1996-09-25 1998-12-11 Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede
US5766637A (en) * 1996-10-08 1998-06-16 University Of Delaware Microencapsulation process using supercritical fluids
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
DE19711393C1 (de) * 1997-03-19 1998-08-13 Fraunhofer Ges Forschung Verfahren zum Mikroverkapseln von Partikeln
FR2776516B1 (fr) * 1998-03-25 2001-05-25 Pharma Biotech Compositions presentant une liberation prolongee et leur procede de preparation
FR2762318B1 (fr) * 1997-04-18 1999-09-17 Pharma Biotech Compositions presentant une liberation prolongee et leur procede de preparation
AR012448A1 (es) * 1997-04-18 2000-10-18 Ipsen Pharma Biotech Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
GB9810559D0 (en) * 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
GB9915975D0 (en) 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
ATE281829T1 (de) 1999-07-13 2004-11-15 Degussa Verfahren zur herstellung pulverförmiger partikelreduzierter formulierungen mit hilfe verdichteter gase
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
FR2811913B1 (fr) * 2000-07-19 2003-09-19 Separex Sa Procede d'encapsulation sous forme de micro-capsules de fines particules solides
US6521258B1 (en) * 2000-09-08 2003-02-18 Ferro Corporation Polymer matrices prepared by supercritical fluid processing techniques
US6579532B1 (en) * 2000-09-08 2003-06-17 Ferro Corporation Orthopedic mixtures prepared by supercritical fluid processing techniques
GB0027357D0 (en) * 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7582284B2 (en) * 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US6966990B2 (en) * 2002-10-11 2005-11-22 Ferro Corporation Composite particles and method for preparing
WO2004043358A2 (en) * 2002-11-08 2004-05-27 Bristol-Myers Squibb Company Formulations of low solubility bioactive agents and processes for making the same
MXPA05011343A (es) 2003-05-08 2005-12-12 Nektar Therapeutics Uk Ltd Materiales particulados.
US7507823B2 (en) * 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
EP1757361A1 (en) 2005-08-23 2007-02-28 Feyecon Development & Implementation B.V. Process for the preparation of encapsulates through precipitation
EP2077823B1 (en) * 2006-10-11 2012-06-27 Crititech, Inc. Method for precipitation of small medicament particles into use containers
DK2425820T3 (en) 2007-02-11 2015-07-13 Map Pharmaceuticals Inc A method for the therapeutic administration of DHE in order to enable quick relief of migraine, while minimizing the adverse event profile
ATE521337T1 (de) * 2007-07-18 2011-09-15 Feyecon Bv Verfahren zur herstellung einer pharmazeutischen co-kristall-zusammensetzung
US20110027172A1 (en) * 2007-12-10 2011-02-03 Zhuang Wang Drug delivery system for pharmaceuticals and radiation
MX350838B (es) 2011-02-11 2017-09-18 Grain Proc Corporation * Composicion de sal.

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US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
DE3218151A1 (de) * 1982-05-14 1983-11-17 Akzo Gmbh, 5600 Wuppertal Mikroporoese, pulverfoermige polylactide und verfahren zu deren herstellung
CA1241246A (en) * 1983-07-21 1988-08-30 Salomon Hakim Surgically-implantable device susceptible of noninvasive magnetic adjustment
CH666406A5 (de) * 1984-02-29 1988-07-29 Sandoz Ag Verfahren zur herstellung von mikrokapseln, welche bromokriptinmesylat als pharmakologischen wirkstoff enthalten.
HU192982B (en) * 1984-04-28 1987-08-28 Allatorvostudomanyi Egyetem Process for producing synergetic pharmaceutical compositions containing thiamulin and antibacterial and antiprotozoal organic acids
DE3428372A1 (de) * 1984-08-01 1986-02-13 Hoechst Ag, 6230 Frankfurt Mikrokapseln von regulatorischen peptiden mit kontrollierter freisetzung, verfahren zu ihrer herstellung und injektionszubereitungen
DE3701625A1 (de) * 1987-01-21 1988-08-04 Boehringer Ingelheim Kg Perorale arzneimittelzubereitung mit verzoegerter wirkstofffreigabe
DE3738228A1 (de) * 1987-11-11 1989-05-24 Hoechst Ag Verfahren zur herstellung von bioabbaubaren mikrokapseln wasserloeslicher peptide und proteine sowie nach diesem verfahren erhaltene mikrokapseln
DE3744329A1 (de) * 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
US5271945A (en) * 1988-07-05 1993-12-21 Takeda Chemical Industries, Ltd. Sustained release microcapsule for water soluble drug
JP2827287B2 (ja) * 1988-07-05 1998-11-25 武田薬品工業株式会社 水溶性薬物含有徐放型マイクロカプセル
JPH0739339B2 (ja) * 1989-05-01 1995-05-01 アルカーメス コントロールド セラピューティクス，インコーポレイテッド 生物活性を有する分子の小粒子の製造方法
DE3917617A1 (de) * 1989-05-31 1990-12-06 Boehringer Ingelheim Kg Mikronisierte bioabbaubare partikel, verfahren zur ihrer herstellung und ihre verwendung
CA2020755A1 (en) * 1989-07-10 1991-01-11 David M. Lokensgard Solvent extraction process
US5232707A (en) * 1989-07-10 1993-08-03 Syntex (U.S.A.) Inc. Solvent extraction process
GB8928250D0 (en) * 1989-12-14 1990-02-21 Erba Carlo Spa Use of supercritical fluids to obtain porous sponges of biodegradable polymers

Also Published As

Publication number Publication date
FI932761A0 (fi) 1993-06-16
WO1992011000A1 (de) 1992-07-09
DE4041563A1 (de) 1992-06-25
HU217817B (hu) 2000-04-28
CA2098814C (en) 1999-05-11
EP0563176B1 (de) 1995-01-04
CA2098814A1 (en) 1992-06-23
EP0563176A1 (de) 1993-10-06
HU9301812D0 (en) 1993-09-28
DE59104172D1 (de) 1995-02-16
FI932761L (fi) 1993-06-16
IE914313A1 (en) 1992-07-01
PT99892B (pt) 1999-06-30
FI102811B (fi) 1999-02-26
ATE116542T1 (de) 1995-01-15
IE65915B1 (en) 1995-11-29
ES2067324T3 (es) 1995-03-16
JPH06504531A (ja) 1994-05-26
DK0563176T3 (da) 1995-03-06
US5424076A (en) 1995-06-13
KR0162105B1 (ko) 1998-12-01
FI102811B1 (fi) 1999-02-26
GR3015623T3 (en) 1995-06-30
KR930701985A (ko) 1993-09-08
HUT63954A (en) 1993-11-29
JP3496153B2 (ja) 2004-02-09

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Legal Events

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BB1A Laying open of patent application

Effective date: 19920814

FG3A Patent granted, date of granting

Effective date: 19990305

PC3A Transfer or assignment

Free format text: INHALE THERAPEUTIC SYSTEMS, INC. PT

Effective date: 20020830

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20070905