DK0594594T3 - Fremgangsmåder til produktion af hybride G-protein-koblede receptorer - Google Patents

Fremgangsmåder til produktion af hybride G-protein-koblede receptorer

Info

Publication number
DK0594594T3
DK0594594T3 DK91904758.9T DK91904758T DK0594594T3 DK 0594594 T3 DK0594594 T3 DK 0594594T3 DK 91904758 T DK91904758 T DK 91904758T DK 0594594 T3 DK0594594 T3 DK 0594594T3
Authority
DK
Denmark
Prior art keywords
protein
domain
coupled
methods
coupled receptors
Prior art date
Application number
DK91904758.9T
Other languages
Danish (da)
English (en)
Inventor
Andrzej Z Sledziewski
Paul O Sheppard
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of DK0594594T3 publication Critical patent/DK0594594T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK91904758.9T 1990-02-08 1991-02-08 Fremgangsmåder til produktion af hybride G-protein-koblede receptorer DK0594594T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/478,100 US5284746A (en) 1990-02-08 1990-02-08 Methods of producing hybrid G protein-coupled receptors

Publications (1)

Publication Number Publication Date
DK0594594T3 true DK0594594T3 (da) 1997-09-29

Family

ID=23898515

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91904758.9T DK0594594T3 (da) 1990-02-08 1991-02-08 Fremgangsmåder til produktion af hybride G-protein-koblede receptorer

Country Status (14)

Country Link
US (2) US5284746A (fr)
EP (1) EP0594594B1 (fr)
JP (1) JP3333506B2 (fr)
AT (1) ATE152479T1 (fr)
AU (1) AU7333691A (fr)
CA (1) CA2074837C (fr)
CS (1) CS31391A2 (fr)
DE (1) DE69125953T2 (fr)
DK (1) DK0594594T3 (fr)
ES (1) ES2100947T3 (fr)
GR (1) GR3023898T3 (fr)
IE (1) IE63987B1 (fr)
PT (1) PT96714B (fr)
WO (1) WO1991012273A2 (fr)

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CA2120518C (fr) * 1991-10-01 1998-10-13 Monika Konig Methode d'identification de ligands et d'antagonistes de ligands
DE4138621A1 (de) * 1991-11-25 1993-06-17 Boehringer Ingelheim Int Verfahren zum screenen von substanzen mit modulierender wirkung auf einen rezeptorabhaengigen zellulaeren signaluebertragungsweg
US6100042A (en) * 1993-03-31 2000-08-08 Cadus Pharmaceutical Corporation Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US7235648B1 (en) 1993-03-31 2007-06-26 Cadus Technologies, Inc. Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US6864060B1 (en) 1993-03-31 2005-03-08 Cadus Technologies, Inc. Yeast cells expressing modified G proteins and methods of use therefor
US6255059B1 (en) * 1993-03-31 2001-07-03 Cadus Pharmaceutical Corporation Methods for identifying G protein coupled receptor effectors
ATE207118T1 (de) * 1993-03-31 2001-11-15 Cadus Pharmaceutical Corp Hefe zellen so konstruiert, dass sie proteinsurrogate des pheromensystems produzieren und anwendungen dafuer
US20030054402A1 (en) * 1993-03-31 2003-03-20 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
US7416881B1 (en) * 1993-03-31 2008-08-26 Cadus Technologies, Inc. Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US5691188A (en) * 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US6806061B1 (en) 1995-01-19 2004-10-19 Children's Medical Center Corporation G protein-coupled receptor gene and methods of use therefor
US6537764B1 (en) 1995-01-19 2003-03-25 Children's Medical Center Corporation Method of identifying inhibitors of C—C chemokine receptor 3
US6881545B1 (en) 1995-12-28 2005-04-19 Takeda Chemical Industries, Ltd. Polypeptides, their production and use
AU1208497A (en) 1995-12-28 1997-07-28 Takeda Chemical Industries Ltd. Ligand polypeptides for the g-protein-coupled receptor protein, their production and use
US6528271B1 (en) 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US7541151B2 (en) 1997-06-05 2009-06-02 Duke University Single-cell biosensor for the measurement of GPCR ligands in a test sample
US6355473B1 (en) 1998-05-06 2002-03-12 Cadus Pharmaceutical Corp. Yeast cells having mutations in stp22 and uses therefor
US6692696B1 (en) * 1998-06-18 2004-02-17 ARETé ASSOCIATES Biosensor
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
US7081360B2 (en) 1998-07-28 2006-07-25 Cadus Technologies, Inc. Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties
US7273747B2 (en) 1998-08-27 2007-09-25 Cadus Technologies, Inc. Cell having amplified signal transduction pathway responses and uses therefor
US7094593B1 (en) * 1998-09-01 2006-08-22 Basf Aktiengesellschaft Method for improving the function of heterologous G protein-coupled receptors
US6251605B1 (en) 1998-10-27 2001-06-26 Cadus Pharmaceutical Corporation Yeast cells having mutations in Cav1 and uses therefor
AU2030000A (en) 1998-11-25 2000-06-13 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
US6504008B1 (en) 1999-02-01 2003-01-07 Cadus Technologies, Inc. Cell based signal generation
WO2000075660A1 (fr) * 1999-06-08 2000-12-14 The Regents Of The University Of California Methodes et compositions destinees a l'identification d'inhibiteurs de la reabsorption osseuse osteoclastique
US6555325B1 (en) 1999-06-14 2003-04-29 Cadus Technologies, Inc. System for detection of a functional interaction between a compound and a cellular signal transduction component
US7223533B2 (en) 1999-09-10 2007-05-29 Cadus Technologies, Inc. Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways
US7324236B2 (en) * 2000-02-01 2008-01-29 Canon Kabushiki Kaisha Discrepancy correction method and apparatus for correcting difference in levels of image signals obtained by an image sensor having a multiple output channels
CA2420325A1 (fr) 2000-08-25 2002-02-28 Basf Plant Science Gmbh Polynucleotides vegetaux codant de nouvelles proteases prenyle
US7163800B2 (en) * 2000-11-03 2007-01-16 Molecular Devices Corporation Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
US20050136431A1 (en) * 2000-11-03 2005-06-23 Oakley Robert H. Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
US7018812B2 (en) * 2000-11-03 2006-03-28 Duke University Modified G-protein coupled receptors
EP1326076A3 (fr) * 2001-10-26 2004-01-28 Millenium Pharmaceuticals, Inc. Méthode d'identification de ligands ou modulateurs du récepteur 2871, un récepteur couplé aux protéine g
NZ534399A (en) 2002-01-25 2008-08-29 G2 Therapies Ltd Monoclonal antibodies against extracellular loops of C5aR
US20030182669A1 (en) * 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
US7290215B2 (en) * 2002-06-03 2007-10-30 Microsoft Corporation Dynamic wizard interface system and method
US7049076B2 (en) * 2003-07-09 2006-05-23 Sentigen Biosciences, Inc. Method for assaying protein—protein interaction
JP2007521248A (ja) 2003-12-10 2007-08-02 ミレニアム ファーマシューティカルズ， インコーポレイテッド ヒト化抗ｃｃｒ２抗体および該抗体を使用する方法
US7572600B2 (en) * 2004-08-04 2009-08-11 Chemocentryx, Inc. Enzymatic activities in chemokine-mediated inflammation
US20070287160A1 (en) * 2006-04-21 2007-12-13 Chou Judy H Methods for high throughput screening of cell lines
RU2009110154A (ru) * 2006-08-22 2010-09-27 Джи2 ИНФЛЕММЕЙШН ПТИ ЛТД (AU) АНТИТЕЛА ПРОТИВ C5aR С УЛУЧШЕННЫМИ СВОЙСТВАМИ
CN104193824A (zh) * 2008-02-20 2014-12-10 G2炎症私人有限公司 人源化抗-C5aR抗体
PL2718322T3 (pl) 2011-06-06 2019-07-31 Novo Nordisk A/S Lecznicze przeciwciała
US9809862B2 (en) * 2014-08-11 2017-11-07 Georgia Tech Research Corporation G-protein coupled receptor (GPCR)-based biosensors and uses thereof
EP4051694B1 (fr) 2019-10-31 2025-07-02 Universität Bern Variantes de vecteurs aav pour l'administration oculaire de gènes

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745057A (en) * 1984-05-18 1988-05-17 Eli Lilly And Company Method, vectors and transformants for high expression of heterologous polypeptides in yeast
US4931373A (en) * 1984-05-25 1990-06-05 Zymogenetics, Inc. Stable DNA constructs for expression of α-1 antitrypsin
US4859609A (en) * 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
EP0351921A3 (fr) * 1988-07-22 1991-07-17 Merck & Co. Inc. Récepteur bêta adrénergique modifié
US5037743A (en) * 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal

Also Published As

Publication number Publication date
US5284746A (en) 1994-02-08
PT96714A (pt) 1991-10-31
ATE152479T1 (de) 1997-05-15
EP0594594B1 (fr) 1997-05-02
IE910430A1 (en) 1991-08-14
JP3333506B2 (ja) 2002-10-15
PT96714B (pt) 1998-07-31
WO1991012273A3 (fr) 1991-10-03
EP0594594A1 (fr) 1994-05-04
IE63987B1 (en) 1995-06-28
CA2074837A1 (fr) 1991-08-09
CS31391A2 (en) 1991-11-12
US5576210A (en) 1996-11-19
WO1991012273A2 (fr) 1991-08-22
AU7333691A (en) 1991-09-03
ES2100947T3 (es) 1997-07-01
DE69125953T2 (de) 1997-08-21
CA2074837C (fr) 2001-11-27
DE69125953D1 (de) 1997-06-05
GR3023898T3 (en) 1997-09-30
JPH05504258A (ja) 1993-07-08

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