DK0608336T3 - Azabicycloarylacetylen- og -arylenynoximer som cholinerge midler og fremgangsmåde til behandling - Google Patents
Azabicycloarylacetylen- og -arylenynoximer som cholinerge midler og fremgangsmåde til behandlingInfo
- Publication number
- DK0608336T3 DK0608336T3 DK92921974T DK92921974T DK0608336T3 DK 0608336 T3 DK0608336 T3 DK 0608336T3 DK 92921974 T DK92921974 T DK 92921974T DK 92921974 T DK92921974 T DK 92921974T DK 0608336 T3 DK0608336 T3 DK 0608336T3
- Authority
- DK
- Denmark
- Prior art keywords
- nynoxymes
- azabicycloaryl
- arylene
- acetylene
- treatment
- Prior art date
Links
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 title 1
- 125000000732 arylene group Chemical group 0.000 title 1
- 230000001713 cholinergic effect Effects 0.000 title 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 title 1
- 150000001412 amines Chemical group 0.000 abstract 2
- -1 nitrogen containing cyclic oxime Chemical group 0.000 abstract 2
- 150000002923 oximes Chemical class 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Carbon And Carbon Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/778,412 US5306718A (en) | 1990-03-06 | 1991-10-16 | Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment |
| PCT/US1992/008642 WO1993008192A1 (en) | 1991-10-16 | 1992-10-09 | Azabicyclo arylacetylene and arylenyne oximes as cholinergic agents and methods of treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0608336T3 true DK0608336T3 (da) | 1999-01-18 |
Family
ID=25113261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92921974T DK0608336T3 (da) | 1991-10-16 | 1992-10-09 | Azabicycloarylacetylen- og -arylenynoximer som cholinerge midler og fremgangsmåde til behandling |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5306718A (da) |
| EP (1) | EP0608336B1 (da) |
| JP (1) | JP3367670B2 (da) |
| KR (1) | KR100241479B1 (da) |
| AT (1) | ATE166354T1 (da) |
| AU (1) | AU658685B2 (da) |
| CA (1) | CA2115443C (da) |
| DE (1) | DE69225601T2 (da) |
| DK (1) | DK0608336T3 (da) |
| ES (1) | ES2119823T3 (da) |
| FI (1) | FI106797B (da) |
| NO (1) | NO302072B1 (da) |
| NZ (1) | NZ244726A (da) |
| PH (1) | PH31431A (da) |
| PT (1) | PT100961B (da) |
| WO (1) | WO1993008192A1 (da) |
| ZA (1) | ZA927973B (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5346911A (en) * | 1990-03-06 | 1994-09-13 | Warner-Lambert Company | Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment |
| US5514812A (en) * | 1994-06-10 | 1996-05-07 | Warner-Lambert Company | Preparation of stereochemically pure oximes with muscarinic activity |
| AUPM910994A0 (en) * | 1994-10-28 | 1994-11-24 | Commonwealth Scientific And Industrial Research Organisation | Bisallyloxyimides |
| US5534522A (en) * | 1995-06-07 | 1996-07-09 | Warner-Lambert Company | (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent |
| US6168912B1 (en) | 1996-01-23 | 2001-01-02 | Martek Biosciences Corporation | Method and kit for making a multidimensional combinatorial chemical library |
| EP1021446A1 (en) * | 1997-01-27 | 2000-07-26 | Warner-Lambert Company | Single pot process for producing (z)-azabicyclo oxime ethers |
| US6924313B1 (en) | 1999-09-23 | 2005-08-02 | Pfizer Inc. | Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
| US6521607B1 (en) * | 1999-09-23 | 2003-02-18 | Pharmacia Corporation | (R)-chiral halogenated substituted N-phenoxy N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity |
| JP4202250B2 (ja) | 2001-07-25 | 2008-12-24 | バイオマリン ファーマシューティカル インコーポレイテッド | 血液脳関門輸送を調節するための組成物および方法 |
| KR100465277B1 (ko) * | 2002-01-24 | 2005-01-13 | 한국과학기술연구원 | 신규한 옥심계 아자 두 고리 화합물 및 그 제조방법 |
| EP2671507A3 (en) | 2005-04-28 | 2014-02-19 | Proteus Digital Health, Inc. | Pharma-informatics system |
| MX2009002893A (es) | 2006-09-18 | 2009-07-10 | Raptor Pharmaceutical Inc | Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap). |
| CA2752373C (en) | 2009-02-20 | 2017-10-10 | To-Bbb Holding B.V. | Glutathione-based drug delivery system |
| IL255113B (en) | 2009-05-06 | 2022-09-01 | Laboratory Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3371094A (en) * | 1961-08-08 | 1968-02-27 | Sterling Drug Inc | N-(amidoximino-lower-alkyl)-and n-amidino-n-[(1-piperidyl)-lower-alkyl]amines |
| US3502692A (en) * | 1962-06-13 | 1970-03-24 | American Cyanamid Co | Cyclic nitroxides and process for preparing same |
| DE2019536A1 (de) * | 1970-04-23 | 1971-11-11 | Basf Ag | Oximcarbamate |
| DE2552176A1 (de) * | 1975-11-21 | 1977-06-02 | Hoechst Ag | Neue piperidin-derivate, ihre herstellung und verwendung |
| US4341795A (en) * | 1975-12-01 | 1982-07-27 | Union Carbide Corporation | Asymmetrical bis-carbamate compounds |
| US4710508A (en) * | 1986-12-08 | 1987-12-01 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
| NZ226000A (en) * | 1987-09-10 | 1991-06-25 | Merck Sharp & Dohme | Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions |
| US4937239A (en) * | 1989-02-13 | 1990-06-26 | Warner-Lambert Company | Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents |
| IL97266A0 (en) * | 1990-03-06 | 1992-05-25 | Warner Lambert Co | Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them |
-
1991
- 1991-10-16 US US07/778,412 patent/US5306718A/en not_active Expired - Fee Related
-
1992
- 1992-10-09 ES ES92921974T patent/ES2119823T3/es not_active Expired - Lifetime
- 1992-10-09 DK DK92921974T patent/DK0608336T3/da active
- 1992-10-09 WO PCT/US1992/008642 patent/WO1993008192A1/en not_active Ceased
- 1992-10-09 EP EP92921974A patent/EP0608336B1/en not_active Expired - Lifetime
- 1992-10-09 AU AU27835/92A patent/AU658685B2/en not_active Ceased
- 1992-10-09 DE DE69225601T patent/DE69225601T2/de not_active Expired - Fee Related
- 1992-10-09 KR KR1019940701231A patent/KR100241479B1/ko not_active Expired - Fee Related
- 1992-10-09 JP JP50773793A patent/JP3367670B2/ja not_active Expired - Fee Related
- 1992-10-09 CA CA002115443A patent/CA2115443C/en not_active Expired - Fee Related
- 1992-10-09 AT AT92921974T patent/ATE166354T1/de not_active IP Right Cessation
- 1992-10-14 NZ NZ244726A patent/NZ244726A/en unknown
- 1992-10-14 PH PH45704A patent/PH31431A/en unknown
- 1992-10-15 ZA ZA927973A patent/ZA927973B/xx unknown
- 1992-10-15 PT PT100961A patent/PT100961B/pt active IP Right Grant
-
1994
- 1994-02-01 US US08/189,620 patent/US5482938A/en not_active Expired - Fee Related
- 1994-04-13 FI FI941699A patent/FI106797B/fi active
- 1994-04-15 NO NO941365A patent/NO302072B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2115443A1 (en) | 1993-04-29 |
| US5482938A (en) | 1996-01-09 |
| US5306718A (en) | 1994-04-26 |
| AU2783592A (en) | 1993-05-21 |
| ES2119823T3 (es) | 1998-10-16 |
| JPH07500337A (ja) | 1995-01-12 |
| DE69225601D1 (de) | 1998-06-25 |
| AU658685B2 (en) | 1995-04-27 |
| DE69225601T2 (de) | 1998-12-17 |
| PT100961A (pt) | 1993-11-30 |
| EP0608336B1 (en) | 1998-05-20 |
| NO941365D0 (no) | 1994-04-15 |
| FI941699L (fi) | 1994-04-13 |
| EP0608336A1 (en) | 1994-08-03 |
| WO1993008192A1 (en) | 1993-04-29 |
| ZA927973B (en) | 1994-04-15 |
| NO941365L (no) | 1994-04-15 |
| ATE166354T1 (de) | 1998-06-15 |
| PH31431A (en) | 1998-11-03 |
| NZ244726A (en) | 1995-09-26 |
| KR100241479B1 (ko) | 2000-03-02 |
| FI106797B (fi) | 2001-04-12 |
| NO302072B1 (no) | 1998-01-19 |
| FI941699A0 (fi) | 1994-04-13 |
| CA2115443C (en) | 2003-05-13 |
| PT100961B (pt) | 1999-07-30 |
| JP3367670B2 (ja) | 2003-01-14 |
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