DK0621862T3 - Organiske salte af N,N-diacetylcystin - Google Patents

Organiske salte af N,N-diacetylcystin

Info

Publication number
DK0621862T3
DK0621862T3 DK92924975.3T DK92924975T DK0621862T3 DK 0621862 T3 DK0621862 T3 DK 0621862T3 DK 92924975 T DK92924975 T DK 92924975T DK 0621862 T3 DK0621862 T3 DK 0621862T3
Authority
DK
Denmark
Prior art keywords
diacetylcystine
organic salts
salts
organic
Prior art date
Application number
DK92924975.3T
Other languages
Danish (da)
English (en)
Inventor
Edib Jakupovic
Carl-Magnus Andersson
Hakan Bergstrand
Bo-Goeran Josefsson
Magnus Lindvall
Bengt Saernstrand
Eric Teneberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Application granted granted Critical
Publication of DK0621862T3 publication Critical patent/DK0621862T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK92924975.3T 1991-11-29 1992-11-25 Organiske salte af N,N-diacetylcystin DK0621862T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9103572A SE9103572D0 (sv) 1991-11-29 1991-11-29 Organic salts of n,n'-diacetyl cystine

Publications (1)

Publication Number Publication Date
DK0621862T3 true DK0621862T3 (da) 1996-09-16

Family

ID=20384494

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92924975.3T DK0621862T3 (da) 1991-11-29 1992-11-25 Organiske salte af N,N-diacetylcystin

Country Status (38)

Country Link
US (5) US5385904A (fr)
EP (1) EP0621862B1 (fr)
JP (1) JP3302018B2 (fr)
KR (1) KR100256185B1 (fr)
CN (1) CN1039586C (fr)
AP (1) AP350A (fr)
AT (1) ATE141913T1 (fr)
AU (1) AU657827B2 (fr)
CA (1) CA2123516A1 (fr)
CZ (1) CZ282085B6 (fr)
DE (1) DE69213256T2 (fr)
DK (1) DK0621862T3 (fr)
DZ (1) DZ1637A1 (fr)
EE (1) EE03025B1 (fr)
ES (1) ES2090713T3 (fr)
FI (1) FI942504L (fr)
GR (1) GR3021546T3 (fr)
HK (1) HK62297A (fr)
HR (1) HRP921322B1 (fr)
HU (1) HU215390B (fr)
IL (1) IL103778A (fr)
IS (1) IS1645B (fr)
LV (1) LV11949B (fr)
MA (1) MA22716A1 (fr)
MX (1) MX9206851A (fr)
MY (1) MY110523A (fr)
NO (1) NO301325B1 (fr)
NZ (1) NZ245077A (fr)
PL (2) PL170787B1 (fr)
RU (1) RU2135468C1 (fr)
SE (1) SE9103572D0 (fr)
SG (1) SG73962A1 (fr)
SI (1) SI9200351A (fr)
SK (1) SK281697B6 (fr)
TN (1) TNSN92108A1 (fr)
WO (1) WO1993011104A1 (fr)
YU (1) YU48594B (fr)
ZA (1) ZA928739B (fr)

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SE9500897D0 (sv) * 1995-03-14 1995-03-14 Astra Ab The pharmacological use of certain cystine derivatives
SE9602262D0 (sv) * 1996-06-06 1996-06-06 Astra Ab New use of derivatives of cystine
US6017959A (en) * 1996-06-18 2000-01-25 Astra Aktiebolag Forms of organic salts of N,N'-diacetylcystine
SE9602416D0 (sv) * 1996-06-18 1996-06-18 Astra Ab New forms of an organic salt of N'N-diacetylcystine
AR007398A1 (es) * 1996-06-18 1999-10-27 Astrazeneca Ab Proceso para preparar sales inorganicas de n-n'-diacetilcistina
CN1059907C (zh) * 1997-05-23 2000-12-27 中国石油化工集团公司巴陵石化岳阳石油化工总厂 一种含共轭二烯轻聚合物的选择氢化方法
US20030203006A1 (en) * 1997-10-29 2003-10-30 Ajinomoto Co. Inc. Immunomodulator
US6197749B1 (en) * 1997-10-29 2001-03-06 Ajinomoto Co., Inc. Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes
SE9800932D0 (sv) 1998-03-20 1998-03-20 Astra Ab New compunds
EP1004302A3 (fr) * 1998-10-29 2003-06-04 Ajinomoto Co., Inc. Immunomodulateur
SE9900438D0 (sv) * 1999-02-10 1999-02-10 Astra Ab The pharmacological use of certian cystine derivatives
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
NO20003591L (no) * 2000-07-13 2002-01-14 Thia Medica As Fettsyreanaloger for behandling av kreft
SE518784C2 (sv) * 2000-12-27 2002-11-19 Nactilus Ab "N-Acetyl-L-cystein med kompositioner för behandling av neoplasier"
EP1374831A4 (fr) * 2001-03-13 2007-07-11 Ajinomoto Kk Produits cosmetiques ou preparations a usage externe pour la peau
RU2317299C2 (ru) * 2001-08-10 2008-02-20 Кабусики Кайся Хаясибара Сеибуцу Кагаку Ассоциат, содержащий трегалозу и хлорид кальция, в форме кристаллического моногидрата или безводного кристалла
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WO2004080956A1 (fr) * 2003-03-11 2004-09-23 Pharmacia Corporation Sel cristallin de chlorhydrate de maleate de s-[2-[(1-iminoethyl)amino]ethyl]-2-methyl-l-cysteine
DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
CN104436170B (zh) 2004-08-23 2018-02-23 曼金德公司 用于药物输送的二酮哌嗪盐
AU2006290227B2 (en) 2005-09-14 2012-08-02 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
KR20080096809A (ko) 2006-02-22 2008-11-03 맨카인드 코포레이션 디케토피페라진 및 활성제를 포함하는 마이크로입자의 약학특성의 개선 방법
US8438729B2 (en) * 2006-03-09 2013-05-14 Canon Kabushiki Kaisha Method of producing liquid discharge head
SG10201507036TA (en) 2008-06-13 2015-10-29 Mannkind Corp A dry powder inhaler and system for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP2609954B1 (fr) 2008-06-20 2021-12-29 MannKind Corporation Appareil interactif pour l'établissement en temps réel d'un profil des efforts d'inhalation
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
MX2011009512A (es) 2009-03-11 2011-11-29 Mannkind Corp Aparato, sistema y metodo para medir la resistencia de un inhalador.
MY157166A (en) 2009-06-12 2016-05-13 Mankind Corp Diketopiperazine microparticles with defined specific surface areas
CA2778698A1 (fr) 2009-11-03 2011-05-12 Mannkind Corporation Appareil et methode de simulation d'efforts d'inhalation
IL223742A (en) 2010-06-21 2016-06-30 Mannkind Corp A dry powder inhaler and preparation for it
EP2694402B1 (fr) 2011-04-01 2017-03-22 MannKind Corporation Emballage coque pour cartouches pharmaceutiques
WO2012174472A1 (fr) 2011-06-17 2012-12-20 Mannkind Corporation Microparticules de dicétopipérazine de capacité élevée
HK1200318A1 (en) 2011-10-24 2015-08-07 曼金德公司 Methods and compositions for treating pain
CN102491926B (zh) * 2011-12-15 2013-09-25 青岛市药品检验所 一种硫普罗宁二硫化物的制备和纯化方法
EP2872205B1 (fr) 2012-07-12 2017-02-08 MannKind Corporation Systèmes de libération de médicament en poudre sèche
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
WO2014144895A1 (fr) 2013-03-15 2014-09-18 Mannkind Corporation Compositions de dicétopipérazine microcristallines et procédés
KR102465025B1 (ko) 2013-07-18 2022-11-09 맨카인드 코포레이션 열-안정성 건조 분말 약제학적 조성물 및 방법
EP3030294B1 (fr) 2013-08-05 2020-10-07 MannKind Corporation Appareil d'insufflation
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
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Also Published As

Publication number Publication date
MY110523A (en) 1998-07-31
FI942504A0 (fi) 1994-05-27
ATE141913T1 (de) 1996-09-15
ZA928739B (en) 1993-06-09
EP0621862B1 (fr) 1996-08-28
IS1645B (is) 1997-03-25
LV11949B (en) 1998-07-20
KR100256185B1 (ko) 2000-05-15
MX9206851A (es) 1993-05-01
HU9401473D0 (en) 1994-08-29
NO941968L (no) 1994-05-26
HRP921322B1 (en) 1998-12-31
FI942504A7 (fi) 1994-05-27
WO1993011104A1 (fr) 1993-06-10
AU3099692A (en) 1993-06-28
JP3302018B2 (ja) 2002-07-15
ES2090713T3 (es) 1996-10-16
US5693858A (en) 1997-12-02
CZ282085B6 (cs) 1997-05-14
DE69213256D1 (de) 1996-10-02
EE03025B1 (et) 1997-08-15
IL103778A0 (en) 1993-04-04
SE9103572D0 (sv) 1991-11-29
CA2123516A1 (fr) 1993-06-10
HK62297A (en) 1997-05-16
FI942504L (fi) 1994-05-27
AU657827B2 (en) 1995-03-23
PL171336B1 (en) 1997-04-30
US5824681A (en) 1998-10-20
AP350A (en) 1994-08-09
LV11949A (lv) 1998-01-20
HUT70851A (en) 1995-11-28
NO941968D0 (no) 1994-05-26
TNSN92108A1 (fr) 1993-06-08
SK63294A3 (en) 1995-02-08
SK281697B6 (sk) 2001-06-11
IS3949A (is) 1993-05-30
CN1039586C (zh) 1998-08-26
HRP921322A2 (en) 1996-10-31
NZ245077A (en) 1995-04-27
SI9200351A (en) 1993-06-30
AP9200448A0 (en) 1993-01-31
PL170787B1 (en) 1997-01-31
US5650538A (en) 1997-07-22
SG73962A1 (en) 2000-07-18
MA22716A1 (fr) 1993-07-01
CN1073683A (zh) 1993-06-30
RU2135468C1 (ru) 1999-08-27
HU215390B (hu) 1998-12-28
US5804582A (en) 1998-09-08
US5385904A (en) 1995-01-31
DZ1637A1 (fr) 2002-02-17
YU99092A (sh) 1995-12-04
GR3021546T3 (en) 1997-02-28
YU48594B (sh) 1998-12-23
CZ129794A3 (en) 1995-01-18
JPH07501539A (ja) 1995-02-16
DE69213256T2 (de) 1997-01-23
IL103778A (en) 1997-08-14
EP0621862A1 (fr) 1994-11-02
NO301325B1 (no) 1997-10-13

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