IL103778A - Organic salts of N,N'-diacetyl cystine process for their preparation and pharmaceutical compositions containing them - Google Patents

Organic salts of N,N'-diacetyl cystine process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL103778A
IL103778A IL10377892A IL10377892A IL103778A IL 103778 A IL103778 A IL 103778A IL 10377892 A IL10377892 A IL 10377892A IL 10377892 A IL10377892 A IL 10377892A IL 103778 A IL103778 A IL 103778A
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
organic salts
diacetyl cystine
Prior art date
Application number
IL10377892A
Other languages
English (en)
Other versions
IL103778A0 (en
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of IL103778A0 publication Critical patent/IL103778A0/xx
Publication of IL103778A publication Critical patent/IL103778A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL10377892A 1991-11-29 1992-11-17 Organic salts of N,N'-diacetyl cystine process for their preparation and pharmaceutical compositions containing them IL103778A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9103572A SE9103572D0 (sv) 1991-11-29 1991-11-29 Organic salts of n,n'-diacetyl cystine

Publications (2)

Publication Number Publication Date
IL103778A0 IL103778A0 (en) 1993-04-04
IL103778A true IL103778A (en) 1997-08-14

Family

ID=20384494

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10377892A IL103778A (en) 1991-11-29 1992-11-17 Organic salts of N,N'-diacetyl cystine process for their preparation and pharmaceutical compositions containing them

Country Status (38)

Country Link
US (5) US5385904A (fr)
EP (1) EP0621862B1 (fr)
JP (1) JP3302018B2 (fr)
KR (1) KR100256185B1 (fr)
CN (1) CN1039586C (fr)
AP (1) AP350A (fr)
AT (1) ATE141913T1 (fr)
AU (1) AU657827B2 (fr)
CA (1) CA2123516A1 (fr)
CZ (1) CZ282085B6 (fr)
DE (1) DE69213256T2 (fr)
DK (1) DK0621862T3 (fr)
DZ (1) DZ1637A1 (fr)
EE (1) EE03025B1 (fr)
ES (1) ES2090713T3 (fr)
FI (1) FI942504A7 (fr)
GR (1) GR3021546T3 (fr)
HK (1) HK62297A (fr)
HR (1) HRP921322B1 (fr)
HU (1) HU215390B (fr)
IL (1) IL103778A (fr)
IS (1) IS1645B (fr)
LV (1) LV11949B (fr)
MA (1) MA22716A1 (fr)
MX (1) MX9206851A (fr)
MY (1) MY110523A (fr)
NO (1) NO301325B1 (fr)
NZ (1) NZ245077A (fr)
PL (2) PL170787B1 (fr)
RU (1) RU2135468C1 (fr)
SE (1) SE9103572D0 (fr)
SG (1) SG73962A1 (fr)
SI (1) SI9200351A (fr)
SK (1) SK281697B6 (fr)
TN (1) TNSN92108A1 (fr)
WO (1) WO1993011104A1 (fr)
YU (1) YU48594B (fr)
ZA (1) ZA928739B (fr)

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US5747459A (en) * 1991-02-04 1998-05-05 Nestec, Ltd. Method for insuring adequate intracellular glutathione in tissue
US5430045A (en) * 1992-04-23 1995-07-04 Free Radical Sciences, Inc. Method of reducing or preventing bone marrow hypoplasia
US5447712A (en) * 1993-12-09 1995-09-05 Free Radical Sciences Method of reducing cyclophosphamide induced hemorrhagic cystitis
SE9500897D0 (sv) * 1995-03-14 1995-03-14 Astra Ab The pharmacological use of certain cystine derivatives
SE9602262D0 (sv) * 1996-06-06 1996-06-06 Astra Ab New use of derivatives of cystine
AR007398A1 (es) * 1996-06-18 1999-10-27 Astrazeneca Ab Proceso para preparar sales inorganicas de n-n'-diacetilcistina
US6017959A (en) * 1996-06-18 2000-01-25 Astra Aktiebolag Forms of organic salts of N,N'-diacetylcystine
SE9602416D0 (sv) * 1996-06-18 1996-06-18 Astra Ab New forms of an organic salt of N'N-diacetylcystine
CN1059907C (zh) * 1997-05-23 2000-12-27 中国石油化工集团公司巴陵石化岳阳石油化工总厂 一种含共轭二烯轻聚合物的选择氢化方法
US20030203006A1 (en) * 1997-10-29 2003-10-30 Ajinomoto Co. Inc. Immunomodulator
US6197749B1 (en) * 1997-10-29 2001-03-06 Ajinomoto Co., Inc. Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes
SE9800932D0 (sv) * 1998-03-20 1998-03-20 Astra Ab New compunds
EP1004302A3 (fr) * 1998-10-29 2003-06-04 Ajinomoto Co., Inc. Immunomodulateur
SE9900438D0 (sv) * 1999-02-10 1999-02-10 Astra Ab The pharmacological use of certian cystine derivatives
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
NO20003591L (no) * 2000-07-13 2002-01-14 Thia Medica As Fettsyreanaloger for behandling av kreft
SE518784C2 (sv) * 2000-12-27 2002-11-19 Nactilus Ab "N-Acetyl-L-cystein med kompositioner för behandling av neoplasier"
EP1374831A4 (fr) * 2001-03-13 2007-07-11 Ajinomoto Kk Produits cosmetiques ou preparations a usage externe pour la peau
RU2317299C2 (ru) * 2001-08-10 2008-02-20 Кабусики Кайся Хаясибара Сеибуцу Кагаку Ассоциат, содержащий трегалозу и хлорид кальция, в форме кристаллического моногидрата или безводного кристалла
US6923175B2 (en) 2002-03-20 2005-08-02 Mannkind Corporation Inhalation apparatus
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ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
KR20130066695A (ko) 2004-08-23 2013-06-20 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
MX373000B (es) 2005-09-14 2020-05-21 Mannkind Corp Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
EP1986679B1 (fr) 2006-02-22 2017-10-25 MannKind Corporation Procédé pour améliorer les propriétés pharmaceutiques de microparticules comprenant de la dicétopipérazine et un agent actif
US8438729B2 (en) * 2006-03-09 2013-05-14 Canon Kabushiki Kaisha Method of producing liquid discharge head
CN101827626B (zh) 2008-06-13 2015-03-18 曼金德公司 干粉吸入器和用于药物输送的系统
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2421385T3 (es) * 2008-06-20 2013-09-02 Mannkind Corp Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
DK2405963T3 (da) 2009-03-11 2013-12-16 Mannkind Corp Apparat, system og fremgangsmåde til at måle modstand i en inhalator
KR102584844B1 (ko) 2009-06-12 2023-10-04 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
CA2778698A1 (fr) 2009-11-03 2011-05-12 Mannkind Corporation Appareil et methode de simulation d'efforts d'inhalation
CN102985125A (zh) 2010-06-21 2013-03-20 曼金德公司 干粉药物输送系统和方法
SG194034A1 (en) 2011-04-01 2013-11-29 Mannkind Corp Blister package for pharmaceutical cartridges
WO2012174472A1 (fr) 2011-06-17 2012-12-20 Mannkind Corporation Microparticules de dicétopipérazine de capacité élevée
MX2014004983A (es) 2011-10-24 2014-09-22 Mannkid Corp Metodos y composiciones para tratar dolor.
CN102491926B (zh) * 2011-12-15 2013-09-25 青岛市药品检验所 一种硫普罗宁二硫化物的制备和纯化方法
KR102264177B1 (ko) 2012-07-12 2021-06-11 맨카인드 코포레이션 건조 분말 약물 전달 시스템 및 방법
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EP3587404B1 (fr) 2013-03-15 2022-07-13 MannKind Corporation Compositions de dicétopipérazine microcristallines, procédés de préparation et leur utilisation
MX375448B (es) 2013-07-18 2025-03-06 Mannkind Corp Composiciones farmacéuticas en polvo seco estables al calor y métodos.
EP3030294B1 (fr) 2013-08-05 2020-10-07 MannKind Corporation Appareil d'insufflation
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
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FR2503151A1 (fr) * 1981-04-02 1982-10-08 Morelle Jean Butyryminoacides soufres. mode de preparation. emploi comme element keratogenique chez l'homme et l'animal et comme agent de fertilisation chez les vegetaux
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US4827016A (en) * 1985-09-16 1989-05-02 Morgan Lee R Method and compounds for reducing dermal inflammations
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US4724239A (en) * 1985-09-16 1988-02-09 Morgan Lee R Method of treating chemical ulcers with N,N'-diacetylcystine, N-acetyl homocysteine and N-acetyl cysteine
JPH0660157B2 (ja) * 1985-11-20 1994-08-10 三井東圧化学株式会社 システインからシスチンを製造する方法
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Also Published As

Publication number Publication date
SI9200351A (en) 1993-06-30
HU215390B (hu) 1998-12-28
CA2123516A1 (fr) 1993-06-10
LV11949B (en) 1998-07-20
CZ282085B6 (cs) 1997-05-14
MY110523A (en) 1998-07-31
FI942504A0 (fi) 1994-05-27
IL103778A0 (en) 1993-04-04
MX9206851A (es) 1993-05-01
LV11949A (lv) 1998-01-20
HRP921322B1 (en) 1998-12-31
KR100256185B1 (ko) 2000-05-15
IS1645B (is) 1997-03-25
HU9401473D0 (en) 1994-08-29
NO301325B1 (no) 1997-10-13
PL170787B1 (en) 1997-01-31
SK63294A3 (en) 1995-02-08
CN1039586C (zh) 1998-08-26
US5824681A (en) 1998-10-20
MA22716A1 (fr) 1993-07-01
ES2090713T3 (es) 1996-10-16
SE9103572D0 (sv) 1991-11-29
YU99092A (sh) 1995-12-04
NO941968D0 (no) 1994-05-26
HRP921322A2 (en) 1996-10-31
ZA928739B (en) 1993-06-09
HK62297A (en) 1997-05-16
DE69213256T2 (de) 1997-01-23
SK281697B6 (sk) 2001-06-11
DZ1637A1 (fr) 2002-02-17
CN1073683A (zh) 1993-06-30
US5385904A (en) 1995-01-31
PL171336B1 (en) 1997-04-30
DK0621862T3 (da) 1996-09-16
AU3099692A (en) 1993-06-28
US5804582A (en) 1998-09-08
RU2135468C1 (ru) 1999-08-27
WO1993011104A1 (fr) 1993-06-10
AP9200448A0 (en) 1993-01-31
DE69213256D1 (de) 1996-10-02
FI942504L (fi) 1994-05-27
US5650538A (en) 1997-07-22
GR3021546T3 (en) 1997-02-28
FI942504A7 (fi) 1994-05-27
EP0621862B1 (fr) 1996-08-28
JP3302018B2 (ja) 2002-07-15
IS3949A (is) 1993-05-30
HUT70851A (en) 1995-11-28
AP350A (en) 1994-08-09
EE03025B1 (et) 1997-08-15
JPH07501539A (ja) 1995-02-16
NZ245077A (en) 1995-04-27
AU657827B2 (en) 1995-03-23
SG73962A1 (en) 2000-07-18
ATE141913T1 (de) 1996-09-15
TNSN92108A1 (fr) 1993-06-08
NO941968L (no) 1994-05-26
CZ129794A3 (en) 1995-01-18
US5693858A (en) 1997-12-02
EP0621862A1 (fr) 1994-11-02
YU48594B (sh) 1998-12-23

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Legal Events

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