DK0626853T3 - Anvendelse af substituerede adeninderivater til behandling af multipel sclerose - Google Patents
Anvendelse af substituerede adeninderivater til behandling af multipel scleroseInfo
- Publication number
- DK0626853T3 DK0626853T3 DK93906071T DK93906071T DK0626853T3 DK 0626853 T3 DK0626853 T3 DK 0626853T3 DK 93906071 T DK93906071 T DK 93906071T DK 93906071 T DK93906071 T DK 93906071T DK 0626853 T3 DK0626853 T3 DK 0626853T3
- Authority
- DK
- Denmark
- Prior art keywords
- multiple sclerosis
- treatment
- adenine derivatives
- substituted adenine
- formula
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/838,546 US5310732A (en) | 1986-02-03 | 1992-02-19 | 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis |
| PCT/US1993/001467 WO1993016706A1 (en) | 1992-02-19 | 1993-02-18 | Use of substituted adenine derivatives for treating multiple sclerosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0626853T3 true DK0626853T3 (da) | 2000-08-07 |
Family
ID=25277387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93906071T DK0626853T3 (da) | 1992-02-19 | 1993-02-18 | Anvendelse af substituerede adeninderivater til behandling af multipel sclerose |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US5310732A (de) |
| EP (1) | EP0626853B1 (de) |
| JP (1) | JP2688113B2 (de) |
| AT (1) | ATE192045T1 (de) |
| AU (1) | AU682818B2 (de) |
| BR (1) | BR9305907A (de) |
| CA (1) | CA2130275C (de) |
| CH (1) | CH684310A5 (de) |
| DE (1) | DE69328474T2 (de) |
| DK (1) | DK0626853T3 (de) |
| FI (1) | FI943805L (de) |
| HU (1) | HU218656B (de) |
| NO (2) | NO309025B1 (de) |
| RU (1) | RU2130308C1 (de) |
| WO (1) | WO1993016706A1 (de) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5310732A (en) * | 1986-02-03 | 1994-05-10 | The Scripps Research Institute | 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis |
| US5624913A (en) * | 1991-04-05 | 1997-04-29 | Wisconsin Alumni Research Foundation | Method reducing TNF-alpha in mammals with cerebral malaria |
| EP0642347A4 (de) * | 1992-05-19 | 1997-06-18 | Scripps Research Inst | Verwendung von 2-halo-adeninderivaten als therapeutische wirkstoffe gegen chronisch-myeloische leukämie. |
| US5424296A (en) * | 1993-04-15 | 1995-06-13 | The Scripps Research Institute | 2-Halo-2'-deoxyadenosines as therapeutic agents against malignant astrocytoma |
| US5672622A (en) * | 1994-04-21 | 1997-09-30 | Berlex Laboratories, Inc. | Treatment of multiple sclerosis |
| US7094597B1 (en) | 1994-05-20 | 2006-08-22 | The Regents Of The University Of California | Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis |
| US5773570A (en) * | 1994-05-20 | 1998-06-30 | The Regents Of The University Of California | Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis |
| AU7470794A (en) * | 1994-05-26 | 1995-12-21 | Scripps Research Institute, The | 2-halo-2'-deoxyadenosine treatement for inflammatory bowel disease |
| US6060501A (en) * | 1994-06-02 | 2000-05-09 | Schering Aktiengesellschaft | Combined treatment of multiple sclerosis |
| US5817641A (en) * | 1994-07-21 | 1998-10-06 | Thomas Jefferson University | Treatment of enterotoxigenic diarrhea with 2-substituted adenosine derivatives |
| US5510336A (en) * | 1994-09-06 | 1996-04-23 | Saven; Alan | 2-halo-2'-deoxyadenosine treatment for histiocytosis |
| US5641757A (en) * | 1994-12-21 | 1997-06-24 | Ortho Pharmaceutical Corporation | Stable 2-chloro-2'-deoxyadenosine formulations |
| ES2182920T3 (es) * | 1994-12-22 | 2003-03-16 | Ortho Pharma Corp | Formulaciones solubles de 2-cloro02'-deoxiadenosina. |
| AU762821B2 (en) * | 1994-12-22 | 2003-07-03 | Ortho-Mcneil Pharmaceutical, Inc. | 'Soluble 2-chloro-2'-deoxyadenosine formulations' |
| SK283821B6 (sk) * | 1995-02-10 | 2004-02-03 | Schering Aktiengesellschaft | Farmaceutické preparáty na inhibíciu tumornekrózafaktora |
| US5811073A (en) * | 1995-06-19 | 1998-09-22 | President And Fellows Of Harvard College | Method for radioisotopic detection and localization of inflammation in a host |
| US6096310A (en) * | 1997-04-15 | 2000-08-01 | Bier; Milan | Oral immunotherapy of bacterial overgrowth |
| US6617171B2 (en) | 1998-02-27 | 2003-09-09 | The General Hospital Corporation | Methods for diagnosing and treating autoimmune disease |
| US6174873B1 (en) | 1998-11-04 | 2001-01-16 | Supergen, Inc. | Oral administration of adenosine analogs |
| AU6234000A (en) * | 1999-07-22 | 2001-02-13 | Supergen, Inc. | Methods for treating autoimmune diseases |
| US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| US6358939B1 (en) | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| SE516067C2 (sv) * | 2000-02-18 | 2001-11-12 | Lundblad Leif J I | Användning av en förening för framställning av ett läkemedel |
| ATE332910T1 (de) * | 2000-02-18 | 2006-08-15 | Southern Res Inst | Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin |
| US7608683B2 (en) * | 2000-08-09 | 2009-10-27 | The Regents Of The University Of California | Stress proteins and peptides and methods of use thereof |
| US6989146B2 (en) * | 2000-08-09 | 2006-01-24 | The Regents Of The University Of California | Stress proteins and peptides and methods of use thereof |
| EA005821B1 (ru) | 2000-11-01 | 2005-06-30 | Дзе Реджентс Оф Дзе Юниверсити Оф Калифорния | Иммуномодулирующие пептиды, полученные из белков теплового шока, и их применение |
| WO2002078446A1 (en) * | 2001-03-29 | 2002-10-10 | Bioenergy Inc. | Composition to reduce exercise-induced swelling of joints |
| US7528247B2 (en) * | 2001-08-02 | 2009-05-05 | Genzyme Corporation | Process for preparing purine nucleosides |
| US7368423B1 (en) * | 2001-12-05 | 2008-05-06 | The Scripps Research Institute | Composition and method for treating chronic allograft rejection |
| EP1549141A4 (de) * | 2002-09-27 | 2008-06-25 | Bioenvision Inc | Verfahren und zusammensetzungen für die behandlung von autoimmunerkrankungen unter verwendung von clofarabin |
| EP1551386A4 (de) * | 2002-09-27 | 2009-03-25 | Bioenvision Inc | Verfahren und zusammensetzungen zur behandlung von lupus mit clofarabin |
| US20040087527A1 (en) * | 2002-10-31 | 2004-05-06 | Day Brian J. | Methods for treatment of thiol-containing compound deficient conditions |
| US7790762B2 (en) * | 2002-10-31 | 2010-09-07 | National Jewish Health | Compounds and methods for thiol-containing compound efflux and cancer treatment |
| US20080221029A1 (en) * | 2002-10-31 | 2008-09-11 | Regents Of The University Of Colorado | Methods for treatment of thiol-containing compound deficient conditions |
| GB0228723D0 (en) * | 2002-12-09 | 2003-01-15 | Cambridge Biotechnology Ltd | Treatment of pain |
| GB0305153D0 (en) * | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Identification of therapeutic compounds |
| ES2409884T3 (es) * | 2003-03-28 | 2013-06-28 | Ares Trading S.A. | Formulaciones orales de cladribina |
| HRP20050924A2 (en) * | 2003-03-28 | 2006-08-31 | Ivax Corporation | Cladribine formulations for improved oral and transmucosal delivery |
| UA81305C2 (en) | 2003-07-02 | 2007-12-25 | Ares Trading Sa | Formulation of cladribine (variants), cladribine-cyclodextrin complex, use of cladribine-cyclodextrin complex, mixture |
| WO2005009971A1 (ja) * | 2003-07-24 | 2005-02-03 | Astellas Pharma Inc. | キノロン誘導体又はその塩 |
| US20070167353A1 (en) * | 2003-10-24 | 2007-07-19 | John Hilfinger | Prodrug composition |
| DE602004006895T2 (de) * | 2003-12-29 | 2008-01-31 | Can-Fite Biopharma Ltd. | Verfahren zur behandlung von multipler sklerose |
| CA2552788C (en) | 2004-01-12 | 2013-09-24 | Applied Molecular Evolution, Inc. | Fc region variants |
| US20050277615A1 (en) * | 2004-05-17 | 2005-12-15 | Can-Fite Biopharma Ltd. | Pharmaceutical compositions having anti-inflammatory activity |
| EP3332789B1 (de) * | 2004-12-22 | 2022-04-06 | Merck Serono SA | Cladribinkur zur behandlung von multipler sklerose |
| JP2008524310A (ja) * | 2004-12-22 | 2008-07-10 | ラボラトワール セローノ ソシエテ アノニム | 多発性硬化症の組み合せ治療 |
| CA2595126A1 (en) * | 2005-01-14 | 2006-07-20 | The Regents Of The University Of California | Methods and compositions for preventing and treating a disease related to glycan dysregulation |
| RU2393866C2 (ru) * | 2005-03-17 | 2010-07-10 | Проекто Де Биомедисина Сима, С.Л. | Применение 5'-метилтиоаденозина (мта) для предотвращения и/или лечения аутоиммунных заболеваний и/или отторжения трансплантата |
| AU2007253254B2 (en) | 2006-05-24 | 2013-01-17 | Merck Serono Sa | Cladribine regimen for treating multiple sclerosis |
| US8126690B2 (en) * | 2007-05-18 | 2012-02-28 | The Regents Of The University Of Michigan | Algorithms to predict clinical response, adherence, and shunting with thiopurines |
| EP2030615A3 (de) * | 2007-08-13 | 2009-12-02 | ELFORD, Howard L. | Ribonukleotidreduktase-Inhibitoren zur Verwendung für die Behandlung oder Vorbeugung von Nervenentzündung- oder Autoimmunerkrankungen |
| US8845627B2 (en) | 2008-08-22 | 2014-09-30 | Boston Scientific Scimed, Inc. | Regulating pressure to lower temperature in a cryotherapy balloon catheter |
| WO2010042933A2 (en) | 2008-10-10 | 2010-04-15 | Northwestern University | Inhibition and treatment of prostate cancer metastasis |
| EP2343074A1 (de) | 2009-12-23 | 2011-07-13 | Merck Serono S.A. | Verwendung von Purinanaloga zur Behandlung von Atemwegserkrankungen |
| WO2012022740A1 (en) | 2010-08-18 | 2012-02-23 | Merck Serono S.A. | Combination treatment of multiple sclerosis |
| US12590955B2 (en) | 2013-03-15 | 2026-03-31 | Zeon Corporation | Methods and systems for processing particles |
| EP3608022A1 (de) | 2013-03-15 | 2020-02-12 | The Trustees of Princeton University | Verfahren und vorrichtungen für reinigung mit hohem durchsatz |
| EP3569313A1 (de) | 2013-03-15 | 2019-11-20 | GPB Scientific, LLC | Mikrofluidische on-chip-verarbeitung von partikeln |
| US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
| GB201401465D0 (en) * | 2014-01-29 | 2014-03-12 | Roach Arthur H | Use of cladribine for treating autoimmune inflammatory disease |
| JP2017534627A (ja) | 2014-11-06 | 2017-11-24 | ノースウエスタン ユニバーシティNorthwestern University | 癌細胞運動性の阻害 |
| US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
| HK1250543A1 (zh) * | 2015-08-24 | 2018-12-21 | 日本瑞翁株式会社 | 用於多步骤细胞纯化和浓缩的方法和装置 |
| GB2564717A (en) | 2017-07-21 | 2019-01-23 | Chord Therapeutics S A R L | Use of cladribine for treating autoimmune neuromuscular disease |
| EP3713582A1 (de) | 2017-11-24 | 2020-09-30 | Merck Patent GmbH | Cladribin-dosierungsplan zur verwendung bei der behandlung progressiver formen von multipler sklerose |
| CA3194812A1 (en) | 2020-09-10 | 2022-03-17 | Merck Patent Gmbh | Novel treatment regimen for the treatment of autoimmune disorders |
| GB2601786A (en) | 2020-12-10 | 2022-06-15 | Chord Therapeutics S A R L | Use of cladribine for treating immune brain disease |
| US20240077481A1 (en) | 2021-03-03 | 2024-03-07 | Ares Trading S.A. | Improved treatment methods using dmds for the treatment of autoimmune diseases, and biomarker for predicting and/or optimising said treatment methods |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1572070C3 (de) * | 1966-03-12 | 1979-03-22 | Hoechst Ag, 6000 Frankfurt | Lichtempfindliches Kopiermaterial |
| US3472838A (en) * | 1967-12-01 | 1969-10-14 | Parke Davis & Co | 9 - (beta - d - arabinofuranosyl) - 6 - (amidino) purine compounds and methods for their production |
| US4826823A (en) * | 1985-02-05 | 1989-05-02 | Warner-Lambert Company | Methods of using 2-chloro-2'-deoxyadenosine-5'-phosphate and its salts |
| US4751221A (en) * | 1985-10-18 | 1988-06-14 | Sloan-Kettering Institute For Cancer Research | 2-fluoro-arabinofuranosyl purine nucleosides |
| US5310732A (en) * | 1986-02-03 | 1994-05-10 | The Scripps Research Institute | 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis |
| US5106837A (en) * | 1988-03-16 | 1992-04-21 | The Scripps Research Institute | Adenosine derivatives with therapeutic activity |
| GB8708050D0 (en) * | 1987-04-03 | 1987-05-07 | Wellcome Found | Therapeutic nucleosides |
| EP0314011A3 (de) * | 1987-10-30 | 1990-04-11 | F. Hoffmann-La Roche Ag | Purinderivate |
| GB8725466D0 (en) | 1987-10-30 | 1987-12-02 | Hoffmann La Roche | Purine derivatives |
| JP3090456B2 (ja) * | 1988-03-16 | 2000-09-18 | スクリップス クリニック アンド リサーチ ファウンデーション | 治療剤として有用な置換アデニン誘導体 |
| US4968702A (en) * | 1989-01-17 | 1990-11-06 | American Cyanamid Company | Substituted quinolinecarboxylic acids |
-
1992
- 1992-02-19 US US07/838,546 patent/US5310732A/en not_active Expired - Lifetime
-
1993
- 1993-02-18 US US08/256,931 patent/US5506214A/en not_active Expired - Lifetime
- 1993-02-18 AT AT93906071T patent/ATE192045T1/de not_active IP Right Cessation
- 1993-02-18 DE DE69328474T patent/DE69328474T2/de not_active Expired - Lifetime
- 1993-02-18 AU AU37249/93A patent/AU682818B2/en not_active Expired
- 1993-02-18 FI FI943805A patent/FI943805L/fi not_active Application Discontinuation
- 1993-02-18 CH CH3143/93A patent/CH684310A5/de not_active IP Right Cessation
- 1993-02-18 CA CA002130275A patent/CA2130275C/en not_active Expired - Lifetime
- 1993-02-18 EP EP93906071A patent/EP0626853B1/de not_active Expired - Lifetime
- 1993-02-18 WO PCT/US1993/001467 patent/WO1993016706A1/en not_active Ceased
- 1993-02-18 HU HU9402392A patent/HU218656B/hu unknown
- 1993-02-18 JP JP5514960A patent/JP2688113B2/ja not_active Expired - Lifetime
- 1993-02-18 BR BR9305907A patent/BR9305907A/pt not_active Application Discontinuation
- 1993-02-18 DK DK93906071T patent/DK0626853T3/da active
- 1993-02-18 RU RU94038043A patent/RU2130308C1/ru active
-
1994
- 1994-04-26 US US08/233,056 patent/US5541164A/en not_active Expired - Lifetime
- 1994-05-19 US US08/246,328 patent/US5506213A/en not_active Expired - Lifetime
- 1994-07-25 NO NO942765A patent/NO309025B1/no not_active IP Right Cessation
-
2000
- 2000-02-16 NO NO20000762A patent/NO322328B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69328474T2 (de) | 2000-09-28 |
| EP0626853A1 (de) | 1994-12-07 |
| ATE192045T1 (de) | 2000-05-15 |
| HU218656B (hu) | 2000-10-28 |
| NO322328B1 (no) | 2006-09-18 |
| US5310732A (en) | 1994-05-10 |
| JPH07507540A (ja) | 1995-08-24 |
| JP2688113B2 (ja) | 1997-12-08 |
| CH684310A5 (de) | 1994-08-31 |
| US5506214A (en) | 1996-04-09 |
| US5506213A (en) | 1996-04-09 |
| US5541164A (en) | 1996-07-30 |
| WO1993016706A1 (en) | 1993-09-02 |
| CA2130275C (en) | 1999-06-29 |
| EP0626853B1 (de) | 2000-04-26 |
| AU3724993A (en) | 1993-09-13 |
| RU2130308C1 (ru) | 1999-05-20 |
| HUT68030A (en) | 1995-05-29 |
| NO20000762D0 (no) | 2000-02-16 |
| BR9305907A (pt) | 1997-10-21 |
| NO20000762L (no) | 1994-09-13 |
| AU682818B2 (en) | 1997-10-23 |
| NO942765L (no) | 1994-09-13 |
| NO942765D0 (no) | 1994-07-25 |
| FI943805A7 (fi) | 1994-10-19 |
| FI943805L (fi) | 1994-10-19 |
| FI943805A0 (fi) | 1994-08-18 |
| HU9402392D0 (en) | 1994-10-28 |
| RU94038043A (ru) | 1996-11-20 |
| NO309025B1 (no) | 2000-12-04 |
| DE69328474D1 (de) | 2000-05-31 |
| CA2130275A1 (en) | 1993-09-02 |
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