DK0632053T3 - Cykliske adhæsionsinhibitorer - Google Patents

Cykliske adhæsionsinhibitorer

Info

Publication number: DK0632053T3
Authority: DK; Denmark
Prior art keywords: lys; alanine; asp; atoms; prodn
Prior art date: 1993-04-01

Application number

DK94104396T

Other languages

English (en)

Inventor

Guenter Dr Hoelzemann

Brunhilde Dr Felding-Habermann

Friedrich Dr Rippmann

Beate Diefenbach

Horst Prof Dr Kessler

Roland Haubner

Jochen Wermuth

Alfred Dr Jonczyk

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-01

Filing date

1994-03-21

Publication date

2000-03-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6484433&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0632053(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-03-21 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2000-03-13 Application granted granted Critical

2000-03-13 Publication of DK0632053T3 publication Critical patent/DK0632053T3/da

Links

125000004122 cyclic group Chemical group 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 3
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
PDRJLZDUOULRHE-ZETCQYMHSA-N (2s)-2-amino-3-pyridin-2-ylpropanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=N1 PDRJLZDUOULRHE-ZETCQYMHSA-N 0.000 abstract 1
WTOFYLAWDLQMBZ-UHFFFAOYSA-N 2-azaniumyl-3-thiophen-2-ylpropanoate Chemical compound OC(=O)C(N)CC1=CC=CS1 WTOFYLAWDLQMBZ-UHFFFAOYSA-N 0.000 abstract 1
102000001189 Cyclic Peptides Human genes 0.000 abstract 1
108010069514 Cyclic Peptides Proteins 0.000 abstract 1
AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
ZGUNAGUHMKGQNY-ZETCQYMHSA-N L-alpha-phenylglycine zwitterion Chemical compound OC(=O)[C@@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-ZETCQYMHSA-N 0.000 abstract 1
125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 abstract 1
LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 abstract 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
DTERQYGMUDWYAZ-UHFFFAOYSA-N N-acetyl-N-thioacetyl-Lysine Natural products CC(=O)NCCCCC(N)C(O)=O DTERQYGMUDWYAZ-UHFFFAOYSA-N 0.000 abstract 1
AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 1
UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 1
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
229960003104 ornithine Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 1
JPZXHKDZASGCLU-LBPRGKRZSA-N β-(2-naphthyl)-alanine Chemical compound C1=CC=CC2=CC(C[C@H](N)C(O)=O)=CC=C21 JPZXHKDZASGCLU-LBPRGKRZSA-N 0.000 abstract 1
ORQXBVXKBGUSBA-QMMMGPOBSA-N β-cyclohexyl-alanine Chemical compound OC(=O)[C@@H](N)CC1CCCCC1 ORQXBVXKBGUSBA-QMMMGPOBSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Zoology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Toxicology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyrane Compounds (AREA)
Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)

DK94104396T 1993-04-01 1994-03-21 Cykliske adhæsionsinhibitorer DK0632053T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4310643A DE4310643A1 (de)	1993-04-01	1993-04-01	Cyclische Adhäsionsinhibitoren

Publications (1)

Publication Number	Publication Date
DK0632053T3 true DK0632053T3 (da)	2000-03-13

Family

ID=6484433

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94104396T DK0632053T3 (da)	1993-04-01	1994-03-21	Cykliske adhæsionsinhibitorer

Country Status (20)

Country	Link
US (2)	US5849692A (da)
EP (1)	EP0632053B1 (da)
JP (1)	JP3694332B2 (da)
KR (1)	KR100304201B1 (da)
CN (1)	CN1056851C (da)
AT (1)	ATE184288T1 (da)
AU (1)	AU684489B2 (da)
CA (1)	CA2120303C (da)
CZ (1)	CZ286768B6 (da)
DE (2)	DE4310643A1 (da)
DK (1)	DK0632053T3 (da)
ES (1)	ES2138632T3 (da)
GR (1)	GR3032074T3 (da)
HU (1)	HUT69726A (da)
NO (1)	NO313756B1 (da)
PL (1)	PL178791B1 (da)
RU (1)	RU2130030C1 (da)
SK (1)	SK281828B6 (da)
TW (1)	TW343198B (da)
UA (1)	UA34436C2 (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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US5753230A (en)	1994-03-18	1998-05-19	The Scripps Research Institute	Methods and compositions useful for inhibition of angiogenesis
DE4415310A1 (de) *	1994-04-30	1995-11-02	Merck Patent Gmbh	Cyclopeptide
US7053041B1 (en)	1996-05-31	2006-05-30	The Scripps Research Institute	Methods and compositions useful for inhibition of αvβ5mediated angiogenesis
DE19534016A1 (de) *	1995-09-14	1997-03-20	Merck Patent Gmbh	Biotinderivate
DE19534177A1 (de) *	1995-09-15	1997-03-20	Merck Patent Gmbh	Cyclische Adhäsionsinhibitoren
DE19538741A1 (de) *	1995-10-18	1997-04-24	Merck Patent Gmbh	Cyclopeptidderivate
DE19613933A1 (de) *	1996-04-06	1997-10-09	Merck Patent Gmbh	Cyclische Adhäsionsinhibitoren
PT951295E (pt)	1996-05-31	2010-07-29	Scripps Research Inst	COMPOSIÃES PARA UTILIZAÃO NA INIBIÃO DE ANGIOGéNESE MEDIADA POR ALFA-V-BETA3
DE19736772A1 (de) *	1997-08-23	1999-02-25	Merck Patent Gmbh	Cyclopeptidderivate
DE19842415A1 (de) *	1998-09-16	2000-03-23	Merck Patent Gmbh	Pharmazeutische Zubereitung
CN1398189A (zh)	1998-12-23	2003-02-19	G.D.西尔公司	用于治疗肿瘤形成的放疗与cox－2抑制剂的联合治疗
UA71608C2 (en) *	1999-03-11	2004-12-15	Merck Patent Gmbh	A method for producing the cyclic pentapeptide
DE19933173A1 (de)	1999-07-15	2001-01-18	Merck Patent Gmbh	Cyclische Peptidderivate als Inhibitoren des Integrins alpha¶v¶beta¶6¶
US6359015B1 (en)	2000-02-28	2002-03-19	The United States Of America As Represented By The Department Of Veterans Affairs	Method for antagonizing inhibition effects of alcohol on cell adhesion
US6624187B1 (en) *	2000-06-12	2003-09-23	Health Research, Inc.	Long wave length absorbing bacteriochlorin alkyl ether analogs
DE10040105A1 (de)	2000-08-17	2002-02-28	Merck Patent Gmbh	Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften
FR2814744B1 (fr) *	2000-10-04	2002-11-29	Commissariat Energie Atomique	Cyclopeptides, leur procede de preparation et leur utilisation comme inhibiteur ou activateur de l'angiogenese
AU2002306651B2 (en) *	2001-03-02	2007-12-13	Medimmune, Llc	Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav Beta3 antagonists
US7879267B2 (en) *	2001-08-02	2011-02-01	J&J Vision Care, Inc.	Method for coating articles by mold transfer
RU2214416C2 (ru) *	2001-12-10	2003-10-20	Государственный научный центр вирусологии и биотехнологии "Вектор"	Rgd-содержащие пептиды
JP2005525368A (ja) *	2002-03-04	2005-08-25	メディミューン，インコーポレーテッド	インテグリンαｖβ３アンタゴニストをＨＭＧ−ＣｏＡ還元酵素阻害剤またはビスフォスフォネートと併用投与する障害の予防または治療方法
CA2478239A1 (en) *	2002-03-04	2003-09-18	Medimmune, Inc.	The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents
JP2005535572A (ja) *	2002-04-12	2005-11-24	メディミューン，インコーポレーテッド	組換え抗インターロイキン−９抗体
GB0217017D0 (en) *	2002-07-23	2002-08-28	Bioacta Ltd	Peptide 2
ITRM20020402A1 (it) *	2002-07-29	2004-01-29	Sigma Tau Ind Farmaceuti	Derivati fluoro-alchil-ciclopeptidi ad attivita' anti-integrine.
US6977272B2 (en) *	2002-10-16	2005-12-20	President And Fellows Of Harvard College	Method for antagonizing inhibition effects of alcohol on cell adhesion
WO2004066956A2 (en) *	2003-01-30	2004-08-12	Medimmune, Inc.	Uses of integrin alphavbeta3 antagonists
KR20110094361A (ko) *	2003-04-11	2011-08-23	메디뮨 엘엘씨	재조합 ｉｌ９ 항체 및 그의 용도
US7351739B2 (en) *	2004-04-30	2008-04-01	Wellgen, Inc.	Bioactive compounds and methods of uses thereof
ITRM20040239A1 (it) *	2004-05-13	2004-08-13	Sigma Tau Ind Farmaceuti	Derivati ciclopeptidici ad attivita' antintegrine.
WO2006047639A2 (en)	2004-10-27	2006-05-04	Medimmune, Inc.	Modulation of antibody specificity by tailoring the affinity to cognate antigens
CA2657581A1 (en)	2006-07-11	2008-01-17	Roy C. Levitt	Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors
US8940683B2 (en)	2006-08-10	2015-01-27	Roy C. Levitt	Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors
US7713937B2 (en)	2006-11-10	2010-05-11	Cara Therapeutics, Inc.	Synthetic peptide amides and dimeric forms thereof
PL2064228T3 (pl)	2006-11-10	2013-01-31	Cara Therapeutics Inc	Syntetyczne amidy peptydowe
US7842662B2 (en)	2006-11-10	2010-11-30	Cara Therapeutics, Inc.	Synthetic peptide amide dimers
US8236766B2 (en)	2006-11-10	2012-08-07	Cara Therapeutics, Inc.	Uses of synthetic peptide amides
US8906859B2 (en)	2006-11-10	2014-12-09	Cera Therapeutics, Inc.	Uses of kappa opioid synthetic peptide amides
CN101990425B (zh)	2008-04-08	2016-01-20	默克专利股份有限公司	包含环肽的组合物和使用方法
CN102264756B (zh)	2008-10-23	2014-08-06	斯特巴生物技术有限公司	含rgd的拟肽和其用途
CN101906141B (zh) *	2009-06-02	2013-04-17	首都医科大学	一类肽链与双脂肪醇链的偶联物及其制备方法和应用
CN101906144B (zh) *	2009-06-03	2013-06-19	首都医科大学	一根Arg-Gly-Asp-Val链通过Asp与两根脂肪醇链的偶联物、它们的合成及在医学中的应用
RU2655763C2 (ru) *	2016-10-24	2018-05-29	Общество С Ограниченной Ответственностью "Айвикс"	Фармацевтическая композиция и способ лечения женских сексуальных дисфункций
RU2626002C1 (ru)	2016-10-24	2017-07-21	Общество С Ограниченной Ответственностью "Айвикс"	Новая группа пептидов для лечения женской сексуальной дисфункции
US10494403B2 (en)	2018-03-06	2019-12-03	Ciphore Biomed Technology Limited Company	Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4328214A (en) *	1979-07-04	1982-05-04	Ciba-Geigy Corporation	Cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture
US4472305A (en) *	1983-05-17	1984-09-18	Sterling Drug Inc.	Hexapeptide amides
GB8903804D0 (en) *	1989-02-20	1989-04-05	Sandoz Ltd	Improvements in or relating to organic compounds
DE68903907T2 (de) *	1988-09-05	1993-06-09	Sankyo Co	Cyclisches peptid, seine herstellung und seine verwendung zur behandlung von cardiovasculaeren stoerungen.
JP2945680B2 (ja) *	1988-09-09	1999-09-06	旭硝子株式会社	ペプチド誘導体およびその用途
US5192746A (en) *	1990-07-09	1993-03-09	Tanabe Seiyaku Co., Ltd.	Cyclic cell adhesion modulation compounds
HUT63609A (en) *	1992-03-10	1993-09-28	Sandoz Ag	Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds
UA43823C2 (uk) *	1992-07-06	2002-01-15	Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг	ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН
DE4237456A1 (de) *	1992-11-06	1994-05-11	Merck Patent Gmbh	Cyclopeptide
US5753230A (en) *	1994-03-18	1998-05-19	The Scripps Research Institute	Methods and compositions useful for inhibition of angiogenesis

1993
- 1993-04-01 DE DE4310643A patent/DE4310643A1/de not_active Withdrawn
1994
- 1994-03-02 UA UA94005107A patent/UA34436C2/uk unknown
- 1994-03-21 EP EP94104396A patent/EP0632053B1/de not_active Expired - Lifetime
- 1994-03-21 DK DK94104396T patent/DK0632053T3/da active
- 1994-03-21 AT AT94104396T patent/ATE184288T1/de active
- 1994-03-21 ES ES94104396T patent/ES2138632T3/es not_active Expired - Lifetime
- 1994-03-21 DE DE59408715T patent/DE59408715D1/de not_active Expired - Lifetime
- 1994-03-25 CZ CZ1994704A patent/CZ286768B6/cs not_active IP Right Cessation
- 1994-03-29 NO NO19941152A patent/NO313756B1/no not_active IP Right Cessation
- 1994-03-30 AU AU59185/94A patent/AU684489B2/en not_active Expired
- 1994-03-30 CA CA002120303A patent/CA2120303C/en not_active Expired - Lifetime
- 1994-03-30 CN CN94103298A patent/CN1056851C/zh not_active Expired - Lifetime
- 1994-03-30 TW TW083102761A patent/TW343198B/zh active
- 1994-03-31 RU RU94011276A patent/RU2130030C1/ru active
- 1994-03-31 JP JP09682994A patent/JP3694332B2/ja not_active Expired - Lifetime
- 1994-03-31 HU HU9400937A patent/HUT69726A/hu unknown
- 1994-03-31 PL PL94302854A patent/PL178791B1/pl unknown
- 1994-03-31 SK SK383-94A patent/SK281828B6/sk unknown
- 1994-03-31 KR KR1019940006639A patent/KR100304201B1/ko not_active Expired - Lifetime
1996
- 1996-03-15 US US08/616,770 patent/US5849692A/en not_active Expired - Lifetime
1998
- 1998-10-01 US US09/164,585 patent/US6169072B1/en not_active Expired - Lifetime
1999
- 1999-12-08 GR GR990403165T patent/GR3032074T3/el unknown

Also Published As

Publication number	Publication date
HUT69726A (en)	1995-09-28
EP0632053A2 (de)	1995-01-04
HU9400937D0 (en)	1994-06-28
GR3032074T3 (en)	2000-03-31
TW343198B (en)	1998-10-21
PL178791B1 (pl)	2000-06-30
EP0632053A3 (de)	1995-02-15
KR100304201B1 (ko)	2001-11-30
RU2130030C1 (ru)	1999-05-10
DE59408715D1 (de)	1999-10-14
DE4310643A1 (de)	1994-10-06
US5849692A (en)	1998-12-15
CN1099760A (zh)	1995-03-08
SK38394A3 (en)	1995-02-08
NO941152D0 (no)	1994-03-29
CA2120303A1 (en)	1994-10-02
JPH06329698A (ja)	1994-11-29
AU5918594A (en)	1994-10-06
CZ70494A3 (en)	1995-01-18
CZ286768B6 (en)	2000-07-12
ES2138632T3 (es)	2000-01-16
EP0632053B1 (de)	1999-09-08
NO313756B1 (no)	2002-11-25
JP3694332B2 (ja)	2005-09-14
ATE184288T1 (de)	1999-09-15
CN1056851C (zh)	2000-09-27
UA34436C2 (uk)	2001-03-15
SK281828B6 (sk)	2001-08-06
NO941152L (no)	1994-10-03
AU684489B2 (en)	1997-12-18
US6169072B1 (en)	2001-01-02
CA2120303C (en)	2007-05-01

Publication	Publication Date	Title
ATE184288T1 (de)	1999-09-15	Cyclische adhäsionsinhibitoren
US5023233A (en)	1991-06-11	Fibrinogen receptor antagonists
DE69434538D1 (de)	2005-12-15	Vaskularer endothelialer wachstumsfaktor 2
ES2144179T3 (es)	2000-06-01	Inhibidores de adhesion ciclicos.
EP0410540A1 (en)	1991-01-30	Fibrinogen receptor antagonists
NO920051D0 (no)	1992-01-03	Farmasoeytisk sammensetning for slanking
CA2027315A1 (en)	1991-04-14	Fibrinogen receptor antagonists
RU94011276A (ru)	1997-11-10	Циклопептиды, способ их получения, содержащие их фармацевтические композиции и способ их получения
TR199802534T2 (xx)	1999-03-22	Leptin (OB Protein) fragmanlar�
FR2767833B1 (fr)	2001-03-02	Polypeptide isole de l'epiderme et son utilisation
EP0410539A1 (en)	1991-01-30	Fibrinogen receptor antagonists
DK0585397T3 (da)	1997-08-25	Bombesinanaloger
AU5362190A (en)	1990-10-18	Novel peptides, and antidementia agents containing the same
NO941151L (no)	1994-10-03	Lineære adhesjonsinhibitorer
NO983177L (no)	1998-07-10	Anvendelse av 1-enantiomeren av centkroman til fremstilling av et farmasaytisk preparat for behandling eller profylakse av brystkreft
DK1309613T3 (da)	2008-08-11	Farmaceutisk præparat omfattende et analgetisk peptid
EP0796867A4 (en)	1999-10-20	Peptide, bronchodilator and blood flow ameliorant
NO975565L (no)	1998-01-19	Benstimulerende faktor
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