DK0635015T3 - Acylaminoindolderivater som 5-Htl agonister - Google Patents

Acylaminoindolderivater som 5-Htl agonister

Info

Publication number
DK0635015T3
DK0635015T3 DK93907096.7T DK93907096T DK0635015T3 DK 0635015 T3 DK0635015 T3 DK 0635015T3 DK 93907096 T DK93907096 T DK 93907096T DK 0635015 T3 DK0635015 T3 DK 0635015T3
Authority
DK
Denmark
Prior art keywords
aryl
alkyl
alkylaryl
hydrogen
pct
Prior art date
Application number
DK93907096.7T
Other languages
English (en)
Inventor
John E Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0635015T3 publication Critical patent/DK0635015T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
  • Materials For Photolithography (AREA)
  • Soft Magnetic Materials (AREA)
  • Pyrrole Compounds (AREA)
DK93907096.7T 1992-04-10 1993-03-04 Acylaminoindolderivater som 5-Htl agonister DK0635015T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86638292A 1992-04-10 1992-04-10

Publications (1)

Publication Number Publication Date
DK0635015T3 true DK0635015T3 (da) 1997-03-17

Family

ID=25347493

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93907096.7T DK0635015T3 (da) 1992-04-10 1993-03-04 Acylaminoindolderivater som 5-Htl agonister

Country Status (31)

Country Link
US (1) US5498626A (da)
EP (1) EP0635015B1 (da)
JP (1) JP2544704B2 (da)
KR (1) KR0179074B1 (da)
CN (1) CN1038506C (da)
AT (1) ATE148465T1 (da)
AU (1) AU670270B2 (da)
BR (1) BR9306221A (da)
CA (1) CA2132706C (da)
CZ (1) CZ282653B6 (da)
DE (1) DE69307875T2 (da)
DK (1) DK0635015T3 (da)
EG (1) EG20466A (da)
ES (1) ES2097496T3 (da)
FI (2) FI111256B (da)
GR (1) GR3022767T3 (da)
HR (1) HRP930753B1 (da)
HU (1) HUT64060A (da)
IL (1) IL105309A0 (da)
MX (1) MX9301996A (da)
MY (1) MY115278A (da)
NO (1) NO309860B1 (da)
NZ (1) NZ251047A (da)
PL (1) PL172232B1 (da)
RU (1) RU2110516C1 (da)
SK (1) SK278182B6 (da)
TW (1) TW394769B (da)
UA (1) UA34452C2 (da)
WO (1) WO1993021180A1 (da)
YU (1) YU48916B (da)
ZA (1) ZA932536B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
AU670579B2 (en) 1992-04-07 1996-07-25 Pfizer Inc. Indole derivatives as 5-HT1 agonists
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
AU686654B2 (en) * 1993-08-31 1998-02-12 Pfizer Inc. 5-arylindole derivatives
GB9402011D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
GB9402016D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
CA2195850A1 (en) * 1994-08-03 1996-02-15 Asta Medica Aktiengesellschaft Substituted indoles
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420503D0 (en) * 1994-10-11 1994-11-23 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
WO1999053956A1 (en) * 1998-04-16 1999-10-28 Yamanouchi Pharmaceutical Co., Ltd. Remedies for obesity
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
EP1594490A4 (en) * 2003-01-22 2006-03-22 Gtx Inc TREATMENT OF WOMEN ANDROGEN DISEASE ASSOCIATED DISORDERS (ADIF) USING ANDROGENIC RECEPTOR MODULATORS (SARM)
CA2708043C (en) * 2007-12-07 2012-11-13 Pfizer Inc. Tosylate salt of trans-n-isobutyl-3-fluoro-3- [3-fluoro-4- (pyrrolidin-1-yl-methyl) -phenyl] cyclobut anecarboxamide
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN103408535B (zh) * 2013-08-13 2016-03-02 张家港威胜生物医药有限公司 一种依来曲普坦中间体-5-溴-3-(n-甲基吡咯啉-2-基甲基)-1h-吲哚合成工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
DK157995C (da) * 1980-08-12 1990-08-06 Glaxo Group Ltd Analogifremgangsmaade til fremstilling af indolderivater
ZA815541B (en) * 1980-08-12 1983-03-30 Glaxo Group Ltd Heterocyclic compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
CZ288351B6 (en) * 1990-06-07 2001-05-16 Astrazeneca Ab Nitrogenous heterocyclic compound, process of its preparation and use as well as a medicament containing thereof
HU225055B1 (en) * 1990-10-15 2006-05-29 Pfizer Indole derivatives, their intermediates, process for production them and pharmaceutical compositions containing the compounds
US5208248A (en) * 1991-01-11 1993-05-04 Merck Sharpe & Dohme, Ltd. Indazole-substituted five-membered heteroaromatic compounds
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
CA2124206C (en) * 1991-11-25 2001-02-27 John Eugene Macor Indole derivatives

Also Published As

Publication number Publication date
TW394769B (en) 2000-06-21
JPH07501831A (ja) 1995-02-23
CA2132706C (en) 1998-08-04
CA2132706A1 (en) 1993-10-28
NO943803D0 (no) 1994-10-07
IL105309A0 (en) 1993-08-18
ATE148465T1 (de) 1997-02-15
EG20466A (en) 1999-05-31
YU25593A (sh) 1996-10-09
DE69307875T2 (de) 1997-05-22
CZ282653B6 (cs) 1997-08-13
SK278182B6 (en) 1996-03-06
US5498626A (en) 1996-03-12
UA34452C2 (uk) 2001-03-15
CN1038506C (zh) 1998-05-27
EP0635015B1 (en) 1997-01-29
CN1080288A (zh) 1994-01-05
RU2110516C1 (ru) 1998-05-10
FI20010214L (fi) 2001-02-05
FI20010214A7 (fi) 2001-02-05
NZ251047A (en) 1996-09-25
ES2097496T3 (es) 1997-04-01
HRP930753A2 (en) 1994-10-31
PL172232B1 (pl) 1997-08-29
MY115278A (en) 2003-05-31
YU48916B (sh) 2002-11-15
RU94045902A (ru) 1996-08-27
GR3022767T3 (en) 1997-06-30
EP0635015A1 (en) 1995-01-25
FI111256B (fi) 2003-06-30
NO309860B1 (no) 2001-04-09
KR950700903A (ko) 1995-02-20
CZ247794A3 (en) 1995-07-12
NO943803L (no) 1994-10-07
FI931613A0 (fi) 1993-04-08
KR0179074B1 (ko) 1999-03-20
JP2544704B2 (ja) 1996-10-16
DE69307875D1 (de) 1997-03-13
ZA932536B (en) 1994-10-08
HUT64060A (en) 1993-11-29
HU9301048D0 (en) 1993-06-28
AU3782193A (en) 1993-11-18
AU670270B2 (en) 1996-07-11
FI931613L (fi) 1993-10-11
SK120794A3 (en) 1995-05-10
BR9306221A (pt) 1998-06-30
MX9301996A (es) 1994-03-31
HRP930753B1 (en) 2000-10-31
WO1993021180A1 (en) 1993-10-28

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