RU94045902A - Производные ациламиноиндола в качестве 5-hti агонистов, фармацевтическая композиция и способ лечения - Google Patents

Производные ациламиноиндола в качестве 5-hti агонистов, фармацевтическая композиция и способ лечения

Info

Publication number
RU94045902A
RU94045902A RU94045902/04A RU94045902A RU94045902A RU 94045902 A RU94045902 A RU 94045902A RU 94045902/04 A RU94045902/04 A RU 94045902/04A RU 94045902 A RU94045902 A RU 94045902A RU 94045902 A RU94045902 A RU 94045902A
Authority
RU
Russia
Prior art keywords
compounds
diseases
agonists
acylaminoindole
hti
Prior art date
Application number
RU94045902/04A
Other languages
English (en)
Other versions
RU2110516C1 (ru
Inventor
И.Мэйкор Джон
Us]
Original Assignee
Пфайзер Инк. (US)
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. (US), Пфайзер Инк. filed Critical Пфайзер Инк. (US)
Publication of RU94045902A publication Critical patent/RU94045902A/ru
Application granted granted Critical
Publication of RU2110516C1 publication Critical patent/RU2110516C1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Soft Magnetic Materials (AREA)
  • Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Предлагаются соединения общей формулы, указанной в описании, Эти соединения могут быть использованы в качестве психотерапевтических средств и потенциальных агонистов композиции для лечения заболеваний, таких, как депрессия, тревога, расстройства процесса приема пищи, ожирения, злоупотребления лекарствами, "гистаминовая" головная боль, мигрень, боль и хронические пароксизмальные гемикрания и головная боль, сопутствующие сосудистым заболеваниям, и других заболеваний, возникающих из-за недостаточной нейротрансмиссии серотонина. Эти соединения также могут быть использованы в качестве центрально действующих антигипретензивных средств и сосудорасширяющих средств.

Claims (1)

  1. Предлагаются соединения общей формулы, указанной в описании, Эти соединения могут быть использованы в качестве психотерапевтических средств и потенциальных агонистов композиции для лечения заболеваний, таких, как депрессия, тревога, расстройства процесса приема пищи, ожирения, злоупотребления лекарствами, "гистаминовая" головная боль, мигрень, боль и хронические пароксизмальные гемикрания и головная боль, сопутствующие сосудистым заболеваниям, и других заболеваний, возникающих из-за недостаточной нейротрансмиссии серотонина. Эти соединения также могут быть использованы в качестве центрально действующих антигипретензивных средств и сосудорасширяющих средств.
RU94045902/04A 1992-04-10 1993-03-04 Производные ациламиноиндола и производные аминоиндола RU2110516C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86638292A 1992-04-10 1992-04-10
US866382 1992-04-10
PCT/US1993/001807 WO1993021180A1 (en) 1992-04-10 1993-03-04 Acylaminoindole derivatives as 5-ht1 agonists

Publications (2)

Publication Number Publication Date
RU94045902A true RU94045902A (ru) 1996-08-27
RU2110516C1 RU2110516C1 (ru) 1998-05-10

Family

ID=25347493

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94045902/04A RU2110516C1 (ru) 1992-04-10 1993-03-04 Производные ациламиноиндола и производные аминоиндола

Country Status (31)

Country Link
US (1) US5498626A (ru)
EP (1) EP0635015B1 (ru)
JP (1) JP2544704B2 (ru)
KR (1) KR0179074B1 (ru)
CN (1) CN1038506C (ru)
AT (1) ATE148465T1 (ru)
AU (1) AU670270B2 (ru)
BR (1) BR9306221A (ru)
CA (1) CA2132706C (ru)
CZ (1) CZ282653B6 (ru)
DE (1) DE69307875T2 (ru)
DK (1) DK0635015T3 (ru)
EG (1) EG20466A (ru)
ES (1) ES2097496T3 (ru)
FI (2) FI111256B (ru)
GR (1) GR3022767T3 (ru)
HR (1) HRP930753B1 (ru)
HU (1) HUT64060A (ru)
IL (1) IL105309A0 (ru)
MX (1) MX9301996A (ru)
MY (1) MY115278A (ru)
NO (1) NO309860B1 (ru)
NZ (1) NZ251047A (ru)
PL (1) PL172232B1 (ru)
RU (1) RU2110516C1 (ru)
SK (1) SK278182B6 (ru)
TW (1) TW394769B (ru)
UA (1) UA34452C2 (ru)
WO (1) WO1993021180A1 (ru)
YU (1) YU48916B (ru)
ZA (1) ZA932536B (ru)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
PL172405B1 (en) 1992-04-07 1997-09-30 Pfizer Derivatives of indole
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
CA2169179C (en) * 1993-08-31 2000-02-29 John E. Macor 5-arylindole derivatives
GB9402011D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
GB9402016D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
AU3162695A (en) * 1994-08-03 1996-03-04 Asta Medica Aktiengesellschaft Indol, indazol, pyridopyrrol and pyridopyrazol derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effects
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420503D0 (en) * 1994-10-11 1994-11-23 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
AU3170099A (en) * 1998-04-16 1999-11-08 Yamanouchi Pharmaceutical Co., Ltd. Remedies for obesity
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
EP1594490A4 (en) * 2003-01-22 2006-03-22 Gtx Inc TREATMENT OF WOMEN ANDROGEN DISEASE ASSOCIATED DISORDERS (ADIF) USING ANDROGENIC RECEPTOR MODULATORS (SARM)
RU2451016C2 (ru) * 2007-12-07 2012-05-20 Пфайзер Инк. Тозилатная соль транс-n-изобутил-3-фтор-3-[3-фтор-4-(пирролидин-1-илметил)фенил]циклобутанкарбоксамида
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN103408535B (zh) * 2013-08-13 2016-03-02 张家港威胜生物医药有限公司 一种依来曲普坦中间体-5-溴-3-(n-甲基吡咯啉-2-基甲基)-1h-吲哚合成工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
IT1171450B (it) * 1980-08-12 1987-06-10 Glaxo Group Ltd Composti eterociclici indolici, procedimento per produrli e composizioni farmaceutiche che li contengono
BE889931A (fr) * 1980-08-12 1982-02-11 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
KR100215627B1 (ko) * 1990-06-07 1999-08-16 레슬리 제인 에드워즈 치료용 헤테로사이클 화합물
CA2091562C (en) * 1990-10-15 2001-03-27 John Eugene Macor Indole derivatives useful in psychotherapeutics
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SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
DE69230803T2 (de) * 1991-11-25 2000-12-07 Pfizer Inc., New York 5-(hetero- oder carbocyclylamino)-indol derivate, deren herstellung und deren verwendung als 5-ht1 agonisten

Also Published As

Publication number Publication date
SK278182B6 (en) 1996-03-06
EP0635015A1 (en) 1995-01-25
CN1038506C (zh) 1998-05-27
FI931613L (fi) 1993-10-11
FI931613A0 (fi) 1993-04-08
IL105309A0 (en) 1993-08-18
NO943803L (no) 1994-10-07
YU25593A (sh) 1996-10-09
AU3782193A (en) 1993-11-18
PL172232B1 (pl) 1997-08-29
FI20010214L (fi) 2001-02-05
NO309860B1 (no) 2001-04-09
CA2132706C (en) 1998-08-04
BR9306221A (pt) 1998-06-30
US5498626A (en) 1996-03-12
EP0635015B1 (en) 1997-01-29
JPH07501831A (ja) 1995-02-23
HU9301048D0 (en) 1993-06-28
FI111256B (fi) 2003-06-30
CA2132706A1 (en) 1993-10-28
KR0179074B1 (ko) 1999-03-20
ES2097496T3 (es) 1997-04-01
YU48916B (sh) 2002-11-15
UA34452C2 (ru) 2001-03-15
JP2544704B2 (ja) 1996-10-16
WO1993021180A1 (en) 1993-10-28
KR950700903A (ko) 1995-02-20
AU670270B2 (en) 1996-07-11
NO943803D0 (no) 1994-10-07
DK0635015T3 (da) 1997-03-17
RU2110516C1 (ru) 1998-05-10
FI20010214A7 (fi) 2001-02-05
HRP930753B1 (en) 2000-10-31
HUT64060A (en) 1993-11-29
GR3022767T3 (en) 1997-06-30
ZA932536B (en) 1994-10-08
HRP930753A2 (en) 1994-10-31
SK120794A3 (en) 1995-05-10
MY115278A (en) 2003-05-31
CZ282653B6 (cs) 1997-08-13
CN1080288A (zh) 1994-01-05
TW394769B (en) 2000-06-21
DE69307875D1 (de) 1997-03-13
MX9301996A (es) 1994-03-31
NZ251047A (en) 1996-09-25
CZ247794A3 (en) 1995-07-12
EG20466A (en) 1999-05-31
ATE148465T1 (de) 1997-02-15
DE69307875T2 (de) 1997-05-22

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Effective date: 20040305