DK0648207T3 - D-vitaminanaloger - Google Patents

D-vitaminanaloger

Info

Publication number: DK0648207T3
Authority: DK; Denmark
Prior art keywords: pct; deuterium; sec; hydrogen; optionally substituted
Prior art date: 1992-07-03

Application number

DK93912681.9T

Other languages

English (en)

Inventor

Claus Aage Svensgaard Bretting

Original Assignee

Leo Pharm Prod Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-03

Filing date

1993-06-07

Publication date

1997-06-23

1993-06-07 Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd

1997-06-23 Application granted granted Critical

1997-06-23 Publication of DK0648207T3 publication Critical patent/DK0648207T3/da

Links

229930003316 Vitamin D Natural products 0.000 title abstract 2
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title abstract 2
235000019166 vitamin D Nutrition 0.000 title abstract 2
239000011710 vitamin D Substances 0.000 title abstract 2
229940046008 vitamin d Drugs 0.000 title abstract 2
150000003710 vitamin D derivatives Chemical class 0.000 title 1
229910052805 deuterium Inorganic materials 0.000 abstract 2
125000004431 deuterium atom Chemical group 0.000 abstract 2
125000001153 fluoro group Chemical group F* 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
-1 vitamin D compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Nutrition Science (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK93912681.9T 1992-07-03 1993-06-07 D-vitaminanaloger DK0648207T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929214202A GB9214202D0 (en)	1992-07-03	1992-07-03	Chemical compounds

Publications (1)

Publication Number	Publication Date
DK0648207T3 true DK0648207T3 (da)	1997-06-23

Family

ID=10718182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93912681.9T DK0648207T3 (da)	1992-07-03	1993-06-07	D-vitaminanaloger

Country Status (17)

Country	Link
US (1)	US5545633A (da)
EP (1)	EP0648207B1 (da)
JP (1)	JPH08504746A (da)
KR (1)	KR100285146B1 (da)
AT (1)	ATE150013T1 (da)
AU (1)	AU667378B2 (da)
CA (1)	CA2131631A1 (da)
DE (1)	DE69308852T2 (da)
DK (1)	DK0648207T3 (da)
ES (1)	ES2101319T3 (da)
FI (1)	FI106120B (da)
GB (1)	GB9214202D0 (da)
GR (1)	GR3023407T3 (da)
HU (1)	HU222775B1 (da)
NZ (1)	NZ253026A (da)
RU (1)	RU2114825C1 (da)
WO (1)	WO1994001398A1 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9226860D0 (en) *	1992-12-23	1993-02-17	Leo Pharm Prod Ltd	Novel treatment
DE4427690A1 (de) *	1994-08-04	1996-02-08	Bogdahn Ulrich Prof	Deuterium enthaltende pharmazeutische Zusammensetzung als Zytostatikum oder Tumor-Therapeutikum
ES2130522T3 (es) *	1994-12-14	1999-07-01	Duphar Int Res	Compuestos de vitamina d y metodo para preparar estos compuestos.
TW422696B (en)	1995-03-20	2001-02-21	Katsuhiko Mukai	Ophthalmic composition containing active vitamin D
GB9526208D0 (en) *	1995-12-21	1996-02-21	Res Inst Medicine Chem	Chemical compounds
GB9721156D0 (en) *	1997-10-06	1997-12-03	Leo Pharm Prod Ltd	Novel vitamin d analogues
US20030220234A1 (en) *	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
WO2003033526A2 (en)	2001-10-19	2003-04-24	Isotechnika Inc.	Synthesis of cyclosporin analogs
US8404667B2 (en) *	2006-12-29	2013-03-26	Wisconsin Alumni Research Foundation	Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
EP1812011A1 (en)	2004-11-12	2007-08-01	Bioxell S.p.a.	Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
ES2344989T3 (es) *	2004-11-22	2010-09-13	Wisconsin Alumni Research Foundation	Analogos de 17,20(e)-deshidro vitamina d y sus usos.
US8193169B2 (en) *	2006-04-06	2012-06-05	Wisconsin Alumni Research Foundation	(20R)-2α-methyl-19,26,2-trinor-vitamin D analogs
US7713953B2 (en) *	2008-07-10	2010-05-11	Wisconsin Alumni Research Foundation	2-methylene-(22E)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs
US7893043B2 (en) *	2008-07-10	2011-02-22	Wisconsin Alumni Research Foundation	2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs
US7879829B2 (en) *	2008-07-10	2011-02-01	Wisconsin Alumni Research Foundation	19-nor-vitamin D analogs with 1,2-dihydrofuran ring
US8222236B2 (en)	2008-07-10	2012-07-17	Wisconsin Alumni Research Foundation	2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs
US8193170B2 (en)	2008-07-10	2012-06-05	Wisconsin Alumni Research Foundation	2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs
US8399439B2 (en)	2008-07-10	2013-03-19	Wisconsin Alumni Research Foundation	2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs
US7888339B2 (en)	2008-07-10	2011-02-15	Wisconsin Alumni Research Foundation	2-methylene-20(21)-dehydro-19-nor-vitamin D analogs
US7648974B1 (en) *	2008-07-10	2010-01-19	Wisconsin Alumni Research Foundation	19-nor-vitamin D analogs with 3,2-dihydrofuran ring
WO2010009243A1 (en) *	2008-07-15	2010-01-21	Theracos, Inc.	Deuterated benzylbenzene derivatives and methods of use
AU2010208323B2 (en)	2009-01-27	2016-03-10	Berg Llc	Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (en)	2009-08-14	2019-05-22	Berg LLC	Vitamin d3 and analogs thereof for treating alopecia
WO2011041579A2 (en)	2009-10-02	2011-04-07	Wisconsin Alumni Research Foundation	(20S,22E)-2-METHYLENE-19-NOR-22-ENE-1α,25-DIHYDROXYVITAMIN D3 ANALOGS
WO2011041596A2 (en)	2009-10-02	2011-04-07	Wisconsin Alumni Research Foundation	19-nor-vitamin d analogs with 1,2-or 3,2-cyclopentene ring
JP6059716B2 (ja)	2011-06-03	2017-01-11	ウイスコンシンアラムニリサーチファンデーション	（２２Ｅ）−２−メチレン−２６，２７−シクロ−２２−デヒドロ−１α−ヒドロキシ−１９−ノルビタミンＤ３誘導体
WO2013003307A1 (en)	2011-06-28	2013-01-03	Wisconsin Alumni Research Foundation	2-methylene-(22e)-25-hexanoyl-24-oxo-26,27-cyclo-22-dehydro-19-nor-vitamin d analogs
US20130178449A1 (en)	2011-07-18	2013-07-11	Wisconsin Alumni Research Foundation	2-Methylene-20(21)-Dehydro-19,24,25,26,27-Pentanor-Vitamin D Analogs
US9416102B2 (en)	2013-01-23	2016-08-16	Wisconsin Alumni Research Foundation	(22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs
SG10201709894RA (en)	2013-05-29	2018-01-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d
MX363010B (es)	2014-11-25	2019-03-04	Trophea Dev Ab	Tratamiento de la atrofia de piel con una combinacion de acido triyodotiroacetico (triac) y dehidroepiandrosterona (dhea).

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4804502A (en) *	1988-01-20	1989-02-14	Hoffmann-La Roche Inc.	Vitamin D compounds
GB9017890D0 (en) *	1990-08-15	1990-09-26	Leo Pharm Prod Ltd	Chemical compounds i

1992
- 1992-07-03 GB GB929214202A patent/GB9214202D0/en active Pending
1993
- 1993-06-07 US US08/295,755 patent/US5545633A/en not_active Expired - Fee Related
- 1993-06-07 KR KR1019940703687A patent/KR100285146B1/ko not_active Expired - Fee Related
- 1993-06-07 AT AT93912681T patent/ATE150013T1/de not_active IP Right Cessation
- 1993-06-07 EP EP93912681A patent/EP0648207B1/en not_active Expired - Lifetime
- 1993-06-07 RU RU94046411A patent/RU2114825C1/ru not_active IP Right Cessation
- 1993-06-07 HU HU9402484A patent/HU222775B1/hu not_active IP Right Cessation
- 1993-06-07 CA CA002131631A patent/CA2131631A1/en not_active Abandoned
- 1993-06-07 JP JP6502829A patent/JPH08504746A/ja not_active Withdrawn
- 1993-06-07 AU AU43111/93A patent/AU667378B2/en not_active Ceased
- 1993-06-07 ES ES93912681T patent/ES2101319T3/es not_active Expired - Lifetime
- 1993-06-07 DE DE69308852T patent/DE69308852T2/de not_active Expired - Fee Related
- 1993-06-07 DK DK93912681.9T patent/DK0648207T3/da active
- 1993-06-07 WO PCT/DK1993/000196 patent/WO1994001398A1/en not_active Ceased
- 1993-06-07 NZ NZ253026A patent/NZ253026A/en unknown
1995
- 1995-01-02 FI FI950023A patent/FI106120B/fi active
1997
- 1997-05-12 GR GR970401061T patent/GR3023407T3/el unknown

Also Published As

Publication number	Publication date
EP0648207A1 (en)	1995-04-19
US5545633A (en)	1996-08-13
FI950023L (fi)	1995-01-02
AU4311193A (en)	1994-01-31
NZ253026A (en)	1997-07-27
RU2114825C1 (ru)	1998-07-10
CA2131631A1 (en)	1994-01-20
ES2101319T3 (es)	1997-07-01
FI950023A0 (fi)	1995-01-02
DE69308852T2 (de)	1997-11-27
EP0648207B1 (en)	1997-03-12
JPH08504746A (ja)	1996-05-21
WO1994001398A1 (en)	1994-01-20
ATE150013T1 (de)	1997-03-15
AU667378B2 (en)	1996-03-21
KR100285146B1 (ko)	2001-04-02
GB9214202D0 (en)	1992-08-12
FI106120B (fi)	2000-11-30
RU94046411A (ru)	1996-10-10
HU9402484D0 (en)	1994-11-28
HUT68025A (en)	1995-05-29
DE69308852D1 (de)	1997-04-17
KR950700876A (ko)	1995-02-20
HU222775B1 (hu)	2003-10-28
GR3023407T3 (en)	1997-08-29

Publication	Publication Date	Title
KR950700876A (ko)	1995-02-20	비타민 D 동족체(Vitamin D analogues)
DK0633878T3 (da)	1997-04-21	Nye D-vitaminanaloger
FI956108A0 (fi)	1995-12-19	Uudet D-vitamiinianalogit
DK0522013T3 (da)	1995-01-30	Nye D-vitaminanaloger
PT906276E (pt)	2002-12-31	Novos analogos da vitamina d
CZ135899A3 (cs)	1999-07-14	Analogy vitamínu D
KR950702529A (ko)	1995-07-29	신규한 비타민 D 동족체(Novel vitamin D analogues)
DK0662953T3 (da)	1997-10-13	Nye D-vitaminanaloger
DK0865428T3 (da)	2000-09-25	Nye vitamin D analoger