DK0522013T3 - Nye D-vitaminanaloger - Google Patents

Nye D-vitaminanaloger

Info

Publication number: DK0522013T3
Authority: DK; Denmark
Prior art keywords: pct; hydrogen; formula; hydrocarbyl; sec
Prior art date: 1990-03-30

Application number

DK91907179.5T

Other languages

English (en)

Inventor

Ernst Torndal Binderup

Martin John Calverley

Gunnar Grue-Soerensen

Original Assignee

Leo Pharm Prod Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-30

Filing date

1991-03-22

Publication date

1995-01-30

1991-03-22 Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd

1995-01-30 Application granted granted Critical

1995-01-30 Publication of DK0522013T3 publication Critical patent/DK0522013T3/da

Links

229930003316 Vitamin D Natural products 0.000 title 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title 1
235000019166 vitamin D Nutrition 0.000 title 1
239000011710 vitamin D Substances 0.000 title 1
150000003710 vitamin D derivatives Chemical class 0.000 title 1
229940046008 vitamin d Drugs 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000024245 cell differentiation Effects 0.000 abstract 1
229910052805 deuterium Inorganic materials 0.000 abstract 1
125000004431 deuterium atom Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
210000004927 skin cell Anatomy 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK91907179.5T 1990-03-30 1991-03-22 Nye D-vitaminanaloger DK0522013T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909007236A GB9007236D0 (en)	1990-03-30	1990-03-30	Chemical compounds

Publications (1)

Publication Number	Publication Date
DK0522013T3 true DK0522013T3 (da)	1995-01-30

Family

ID=10673606

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91907179.5T DK0522013T3 (da)	1990-03-30	1991-03-22	Nye D-vitaminanaloger

Country Status (15)

Country	Link
US (1)	US5374629A (da)
EP (1)	EP0522013B1 (da)
JP (1)	JP3246913B2 (da)
KR (1)	KR100209179B1 (da)
AT (1)	ATE114302T1 (da)
AU (1)	AU630804B2 (da)
CA (1)	CA2073983C (da)
DE (1)	DE69105267T2 (da)
DK (1)	DK0522013T3 (da)
ES (1)	ES2066434T3 (da)
GB (1)	GB9007236D0 (da)
GR (1)	GR3015127T3 (da)
IE (1)	IE65283B1 (da)
NZ (1)	NZ237607A (da)
WO (1)	WO1991015475A1 (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4101953A1 (de) *	1991-01-19	1992-07-23	Schering Ag	23-oxa-derivate in der vitamin-d-reihe, verfahren zu ihrer herstellung diese derivate enthaltende pharmazeutische praeparate sowie deren verwendung als arzneimittel
GB9223061D0 (en) *	1992-11-04	1992-12-16	Leo Pharm Prod Ltd	Chemical compounds
US5449668A (en) *	1993-06-04	1995-09-12	Duphar International Research B.V.	Vitamin D compounds and method of preparing these compounds
US20040167106A1 (en) *	1993-06-04	2004-08-26	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of a Vitamin D compound
US6407082B1 (en)	1996-09-13	2002-06-18	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a vitamin D compound
GB9314400D0 (en) *	1993-07-12	1993-08-25	Leo Pharm Prod Ltd	Produktionsaktieselskab) chemical compounds
WO1995027697A1 (en) *	1994-04-11	1995-10-19	Chugai Seiyaku Kabushiki Kaisha	22-thiavitamin d3 derivative
US6242434B1 (en)	1997-08-08	2001-06-05	Bone Care International, Inc.	24-hydroxyvitamin D, analogs and uses thereof
US20040043971A1 (en) *	1995-04-03	2004-03-04	Bone Care International, Inc.	Method of treating and preventing hyperparathyroidism with active vitamin D analogs
IL118156A (en) *	1995-05-09	2001-08-26	Duphar Int Res	Vitamin d compounds, their preparation and pharmaceutical compositions containing them
DE19519273A1 (de) *	1995-05-22	1996-11-28	Schering Ag	Topisch applizierbare Mittel zur Behandlung und Prophylaxe der Alopezie
WO1997013518A1 (en) *	1995-10-10	1997-04-17	Marilyn Strube	Treatment of pruritus with vitamin d and analogs thereof
US5738745A (en) *	1995-11-27	1998-04-14	Kimberly-Clark Worldwide, Inc.	Method of improving the photostability of polypropylene compositions
NO971934L (no) *	1996-05-23	1997-11-24	Hoffmann La Roche	Flourinerte vitamin D3 -analoger
US6028064A (en)	1996-09-13	2000-02-22	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of progestin products
US6511970B1 (en)	1996-09-13	2003-01-28	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en)	2000-03-21	2004-07-20	Gustavo Rodriguez	Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6034074A (en)	1996-09-13	2000-03-07	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a Vitamin D compound
CA2275382A1 (en) *	1996-12-20	1998-07-02	Chugai Seiyaku Kabushiki Kaisha	16-ene-vitamin d derivatives
MA26481A1 (fr) *	1997-04-21	2004-12-20	Hoffmann La Roche	Derives d'arylsecocholadiene
WO1998052574A1 (en)	1997-05-22	1998-11-26	Cephalon, Inc.	Vitamin d analogues and their neuronal effects
EP0998290B1 (en) *	1997-06-06	2004-09-15	Wisconsin Alumni Research Foundation	Use of vitamin d compounds to prevent transplant rejection
JP2002509888A (ja)	1998-03-27	2002-04-02	オレゴンヘルスサイエンシーズユニバーシティー	腫瘍および他の過増殖性疾患の治療におけるビタミンｄおよびその類似体
US5972917A (en) *	1998-05-29	1999-10-26	Bone Care Int Inc	1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
ES2274785T3 (es) *	1999-04-01	2007-06-01	Johns Hopkins University	Analogos de 1-alfa,25-dihidroxi vitamina d3 no calcemicos, antiproliferativos, transcripcionalmente activos que contienen azufre.
JP2002543062A (ja)	1999-04-23	2002-12-17	レオ・ファーマ・アクティーゼルスカブ	ビタミンｄ類似体およびその薬学的使用
WO2006120681A2 (en)	2005-05-10	2006-11-16	Dermipsor Ltd.	Compositions and methods for skin care
WO2001056982A1 (en) *	2000-01-31	2001-08-09	Leo Pharma A/S	Vitamin d-derivatives and their use in treating osteoporosis and related bone disorders
MXPA02007339A (es) *	2000-01-31	2004-08-11	Leo Pharma As	Uso de derivados de la vitamina d en el tratamiento de la osteoporosis y trastornos oseos relacionados, asi como tambien derivados de la vitamina d3 novedosos.
US20010044431A1 (en) *	2000-03-21	2001-11-22	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
ATE428692T1 (de) *	2001-08-22	2009-05-15	Univ Johns Hopkins	24-schwefel-substituierte 1-alpha-25-dihydroxy- vitamin-d3-analogen
US7101865B2 (en)	2002-06-13	2006-09-05	Cytochroma Inc.	24-sulfoximine vitamin D3 compounds
CA2510228C (en)	2002-12-18	2012-10-30	Johns Hopkins University	25-so2-substituted analogs of 1.alpha.,25-dihydroxyvitamin d3
US7094775B2 (en)	2004-06-30	2006-08-22	Bone Care International, Llc	Method of treating breast cancer using a combination of vitamin D analogues and other agents
CA2586679A1 (en)	2004-11-12	2006-05-18	Bioxell Spa	Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
JP2008540514A (ja) *	2005-05-10	2008-11-20	ダーミプソルリミテッド	過剰増殖表皮疾患の治療用組成物及び方法
WO2008131267A2 (en) *	2007-04-18	2008-10-30	Johns Hopkins University	Low calcemic, highly antiproliferative, analogs of calcitriol
US8377913B2 (en) *	2007-11-20	2013-02-19	Abbvie Inc.	Vitamin D receptor activators and methods of making
SG173119A1 (en)	2009-01-27	2011-08-29	Berg Biosystems Llc	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
MX366076B (es)	2009-08-14	2019-06-27	Berg Llc	Vitamina d3 y analogos de la misma para tratar alopecia.
SG10201709894RA (en)	2013-05-29	2018-01-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d
US20190183908A1 (en)	2016-05-13	2019-06-20	Case Western Reserve University	Autophagy activators for treating or preventing skin injury

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL67153A (en) *	1981-11-02	1986-12-31	Res Inst Medicine Chem	Intermediates in the production of vitamin d analogues and method for their production
IL77668A (en) *	1986-01-21	1989-03-31	Teva Pharma	Production of cholecalciferol derivatives and novel intermediates used therefor
EP0296800B1 (en) *	1987-06-23	1991-10-16	Yamanouchi Pharmaceutical Co. Ltd.	Vitamin d3 derivatives
US4927815A (en) *	1988-04-29	1990-05-22	Wisconsin Alumni Research Foundation	Compounds effective in inducing cell differentiation and process for preparing same
WO1990000560A1 (en) *	1988-07-05	1990-01-25	Kuraray Co., Ltd.	Steroid compounds
JPH0667898B2 (ja) *	1989-02-15	1994-08-31	大同ほくさん株式会社	２２，２３―セコビタミンｄ若しくはその活性型またはそれらの誘導体の製造方法

1990
- 1990-03-30 GB GB909007236A patent/GB9007236D0/en active Pending
1991
- 1991-03-22 WO PCT/DK1991/000091 patent/WO1991015475A1/en not_active Ceased
- 1991-03-22 DE DE69105267T patent/DE69105267T2/de not_active Expired - Fee Related
- 1991-03-22 IE IE97091A patent/IE65283B1/en not_active IP Right Cessation
- 1991-03-22 AT AT91907179T patent/ATE114302T1/de not_active IP Right Cessation
- 1991-03-22 DK DK91907179.5T patent/DK0522013T3/da active
- 1991-03-22 ES ES91907179T patent/ES2066434T3/es not_active Expired - Lifetime
- 1991-03-22 CA CA002073983A patent/CA2073983C/en not_active Expired - Fee Related
- 1991-03-22 EP EP91907179A patent/EP0522013B1/en not_active Expired - Lifetime
- 1991-03-22 US US07/910,025 patent/US5374629A/en not_active Expired - Fee Related
- 1991-03-22 JP JP50676491A patent/JP3246913B2/ja not_active Expired - Fee Related
- 1991-03-22 AU AU75892/91A patent/AU630804B2/en not_active Ceased
- 1991-03-27 NZ NZ237607A patent/NZ237607A/xx unknown
1992
- 1992-07-15 KR KR1019920701665A patent/KR100209179B1/ko not_active Expired - Fee Related
1995
- 1995-02-22 GR GR940404069T patent/GR3015127T3/el unknown

Also Published As

Publication number	Publication date
EP0522013A1 (en)	1993-01-13
AU7589291A (en)	1991-10-30
IE65283B1 (en)	1995-10-18
KR100209179B1 (ko)	1999-07-15
ATE114302T1 (de)	1994-12-15
JP3246913B2 (ja)	2002-01-15
WO1991015475A1 (en)	1991-10-17
AU630804B2 (en)	1992-11-05
GR3015127T3 (en)	1995-05-31
US5374629A (en)	1994-12-20
CA2073983A1 (en)	1991-10-01
IE910970A1 (en)	1991-10-09
GB9007236D0 (en)	1990-05-30
KR920703527A (ko)	1992-12-18
ES2066434T3 (es)	1995-03-01
JPH05505613A (ja)	1993-08-19
DE69105267D1 (de)	1995-01-05
DE69105267T2 (de)	1995-04-27
CA2073983C (en)	2002-08-20
NZ237607A (en)	1993-05-26
EP0522013B1 (en)	1994-11-23

Publication	Publication Date	Title
ES2066434T3 (es)	1995-03-01	Nuevos analogos de vitamina d.
DK0633878T3 (da)	1997-04-21	Nye D-vitaminanaloger
DK0648207T3 (da)	1997-06-23	D-vitaminanaloger
DK0820481T3 (da)	2000-05-29	Nye organiske siliconeforbindelser med en funktionel carboxylgruppe samt fremgangsmåde til fremstilling deraf
DE68903212D1 (de)	1992-11-19	4-mercapto-butyramide-n-mono- oder n,n-disubstituiert durch ein mono- oder polyhydroxyalkyl-radikal und ihre verwendung als reduktionsmittel zur dauernden verformung von haaren.
FI956108A0 (fi)	1995-12-19	Uudet D-vitamiinianalogit
DE69011872D1 (de)	1994-09-29	Neue vitamin-d-derivate.
PT906276E (pt)	2002-12-31	Novos analogos da vitamina d
ES462040A1 (es)	1978-12-01	Procedimiento para la obtencion de derivados de perhidro- aza-heterociclos.
KR950702529A (ko)	1995-07-29	신규한 비타민 D 동족체(Novel vitamin D analogues)
DK0662953T3 (da)	1997-10-13	Nye D-vitaminanaloger
ES8702358A1 (es)	1987-01-01	Procedimiento para la obtencion de derivados de la 3-nitrodihidropiridina