DK0522013T3 - Nye D-vitaminanaloger - Google Patents

Nye D-vitaminanaloger

Info

Publication number: DK0522013T3
Authority: DK; Denmark
Prior art keywords: pct; hydrogen; formula; hydrocarbyl; sec
Prior art date: 1990-03-30

Application number

DK91907179.5T

Other languages

English (en)

Inventor

Ernst Torndal Binderup

Martin John Calverley

Gunnar Grue-Soerensen

Original Assignee

Leo Pharm Prod Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-30

Filing date

1991-03-22

Publication date

1995-01-30

1991-03-22 Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd

1995-01-30 Application granted granted Critical

1995-01-30 Publication of DK0522013T3 publication Critical patent/DK0522013T3/da

Links

229930003316 Vitamin D Natural products 0.000 title 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title 1
235000019166 vitamin D Nutrition 0.000 title 1
239000011710 vitamin D Substances 0.000 title 1
150000003710 vitamin D derivatives Chemical class 0.000 title 1
229940046008 vitamin d Drugs 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000024245 cell differentiation Effects 0.000 abstract 1
229910052805 deuterium Inorganic materials 0.000 abstract 1
125000004431 deuterium atom Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000000743 hydrocarbylene group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
210000004927 skin cell Anatomy 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Immunology (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK91907179.5T 1990-03-30 1991-03-22 Nye D-vitaminanaloger DK0522013T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909007236A GB9007236D0 (en)	1990-03-30	1990-03-30	Chemical compounds

Publications (1)

Publication Number	Publication Date
DK0522013T3 true DK0522013T3 (da)	1995-01-30

Family

ID=10673606

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91907179.5T DK0522013T3 (da)	1990-03-30	1991-03-22	Nye D-vitaminanaloger

Country Status (15)

Country	Link
US (1)	US5374629A (da)
EP (1)	EP0522013B1 (da)
JP (1)	JP3246913B2 (da)
KR (1)	KR100209179B1 (da)
AT (1)	ATE114302T1 (da)
AU (1)	AU630804B2 (da)
CA (1)	CA2073983C (da)
DE (1)	DE69105267T2 (da)
DK (1)	DK0522013T3 (da)
ES (1)	ES2066434T3 (da)
GB (1)	GB9007236D0 (da)
GR (1)	GR3015127T3 (da)
IE (1)	IE65283B1 (da)
NZ (1)	NZ237607A (da)
WO (1)	WO1991015475A1 (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4101953A1 (de) *	1991-01-19	1992-07-23	Schering Ag	23-oxa-derivate in der vitamin-d-reihe, verfahren zu ihrer herstellung diese derivate enthaltende pharmazeutische praeparate sowie deren verwendung als arzneimittel
GB9223061D0 (en) *	1992-11-04	1992-12-16	Leo Pharm Prod Ltd	Chemical compounds
US20040167106A1 (en) *	1993-06-04	2004-08-26	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of a Vitamin D compound
US6407082B1 (en)	1996-09-13	2002-06-18	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a vitamin D compound
US5449668A (en) *	1993-06-04	1995-09-12	Duphar International Research B.V.	Vitamin D compounds and method of preparing these compounds
GB9314400D0 (en) *	1993-07-12	1993-08-25	Leo Pharm Prod Ltd	Produktionsaktieselskab) chemical compounds
ATE195513T1 (de) *	1994-04-11	2000-09-15	Chugai Pharmaceutical Co Ltd	22-thiavitamin-d3-derivate
US20040043971A1 (en) *	1995-04-03	2004-03-04	Bone Care International, Inc.	Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US6242434B1 (en)	1997-08-08	2001-06-05	Bone Care International, Inc.	24-hydroxyvitamin D, analogs and uses thereof
CA2175881A1 (en) *	1995-05-09	1996-11-10	Andrzej Kutner	Vitamin d compounds and methods of preparing these compounds
DE19519273A1 (de) *	1995-05-22	1996-11-28	Schering Ag	Topisch applizierbare Mittel zur Behandlung und Prophylaxe der Alopezie
AU7364896A (en) *	1995-10-10	1997-04-30	Marilyn Strube	Treatment of pruritus with vitamin d and analogs thereof
US5738745A (en) *	1995-11-27	1998-04-14	Kimberly-Clark Worldwide, Inc.	Method of improving the photostability of polypropylene compositions
NO971934L (no) *	1996-05-23	1997-11-24	Hoffmann La Roche	Flourinerte vitamin D3 -analoger
US6511970B1 (en)	1996-09-13	2003-01-28	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en)	2000-03-21	2004-07-20	Gustavo Rodriguez	Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6034074A (en) *	1996-09-13	2000-03-07	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en)	1996-09-13	2000-02-22	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of progestin products
DK0947504T3 (da) *	1996-12-20	2003-11-24	Chugai Pharmaceutical Co Ltd	16-en-vitamin D-derivater
MA26481A1 (fr) *	1997-04-21	2004-12-20	Hoffmann La Roche	Derives d'arylsecocholadiene
US6207656B1 (en)	1997-05-22	2001-03-27	Cephalon, Inc.	Vitamin D analogues and their neuronal effects
JP2002510304A (ja) *	1997-06-06	2002-04-02	ウイスコンシンアラムナイリサーチフオンデーシヨン	移植体拒絶反応を防ぐためのビタミンｄ化合物の使用
ES2368824T3 (es)	1998-03-27	2011-11-22	Oregon Health & Science University	Vitamina d y sus análogos en el tratamiento de tumores y otros desórdenes hiperproliferativos.
US5972917A (en) *	1998-05-29	1999-10-26	Bone Care Int Inc	1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
EP1745787B1 (en) *	1999-04-01	2016-11-09	Johns Hopkins University	NON-CALCEMIC, ANTIPROLIFERATIVE, TRANSCRIPTIONALLY ACTIVE SULFUR-CONTAINING ANALOGS OF 1-alpha 25-DIHYDROXY VITAMIN D3
HUP0200812A3 (en) *	1999-04-23	2003-07-28	Leo Pharm Prod Ltd	Vitamin d analogues and their pharmaceutical use
WO2006120681A2 (en)	2005-05-10	2006-11-16	Dermipsor Ltd.	Compositions and methods for skin care
AU776755B2 (en) *	2000-01-31	2004-09-23	Leo Pharma A/S	Use of vitamin D-derivatives in the treatment of osteoporosis and related bone disorders, as well as novel vitamin D3-derivatives
AU2001228330A1 (en) *	2000-01-31	2001-08-14	Leo Pharma A/S	Vitamin d-derivatives and their use in treating osteoporosis and related bone disorders
US20010044431A1 (en) *	2000-03-21	2001-11-22	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
WO2003018545A1 (en) *	2001-08-22	2003-03-06	Johns Hopkins University	24-sulfur-substituted analogs of 1α,25-dihydroxy vitamin d¿3?
US7101865B2 (en)	2002-06-13	2006-09-05	Cytochroma Inc.	24-sulfoximine vitamin D3 compounds
US8106035B2 (en)	2002-12-18	2012-01-31	Cytochroma Inc.	25-SO2-substituted analogs of 1μ,25-dihydroxyvitamin D3
US7094775B2 (en)	2004-06-30	2006-08-22	Bone Care International, Llc	Method of treating breast cancer using a combination of vitamin D analogues and other agents
CA2586679A1 (en)	2004-11-12	2006-05-18	Bioxell Spa	Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
US9173835B2 (en)	2005-05-10	2015-11-03	Dermipsor Ltd.	Compositions and methods for treating hyperproliferative epidermal diseases
EP2144872A2 (en) *	2007-04-18	2010-01-20	Johns Hopkins University	Low calcemic, highly antiproliferative, analogs of calcitriol
US8377913B2 (en) *	2007-11-20	2013-02-19	Abbvie Inc.	Vitamin D receptor activators and methods of making
CA2981549A1 (en)	2009-01-27	2010-08-05	Berg Llc	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CN106265695B (zh)	2009-08-14	2021-05-07	博格有限责任公司	用于治疗脱发的维生素d3及其类似物
CN112156097A (zh)	2013-05-29	2021-01-01	博格有限责任公司	使用维生素d预防或减轻化疗诱发的脱发
US20190183908A1 (en)	2016-05-13	2019-06-20	Case Western Reserve University	Autophagy activators for treating or preventing skin injury

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0078704B1 (en) *	1981-11-02	1987-04-29	Research Institute For Medicine And Chemistry Inc.	Intermediates in the synthesis of vitamin d derivatives
IL77668A (en) *	1986-01-21	1989-03-31	Teva Pharma	Production of cholecalciferol derivatives and novel intermediates used therefor
EP0296800B1 (en) *	1987-06-23	1991-10-16	Yamanouchi Pharmaceutical Co. Ltd.	Vitamin d3 derivatives
US4927815A (en) *	1988-04-29	1990-05-22	Wisconsin Alumni Research Foundation	Compounds effective in inducing cell differentiation and process for preparing same
WO1990000560A1 (en) *	1988-07-05	1990-01-25	Kuraray Co., Ltd.	Steroid compounds
JPH0667898B2 (ja) *	1989-02-15	1994-08-31	大同ほくさん株式会社	２２，２３―セコビタミンｄ若しくはその活性型またはそれらの誘導体の製造方法

1990
- 1990-03-30 GB GB909007236A patent/GB9007236D0/en active Pending
1991
- 1991-03-22 AU AU75892/91A patent/AU630804B2/en not_active Ceased
- 1991-03-22 IE IE97091A patent/IE65283B1/en not_active IP Right Cessation
- 1991-03-22 ES ES91907179T patent/ES2066434T3/es not_active Expired - Lifetime
- 1991-03-22 JP JP50676491A patent/JP3246913B2/ja not_active Expired - Fee Related
- 1991-03-22 EP EP91907179A patent/EP0522013B1/en not_active Expired - Lifetime
- 1991-03-22 DK DK91907179.5T patent/DK0522013T3/da active
- 1991-03-22 WO PCT/DK1991/000091 patent/WO1991015475A1/en not_active Ceased
- 1991-03-22 DE DE69105267T patent/DE69105267T2/de not_active Expired - Fee Related
- 1991-03-22 AT AT91907179T patent/ATE114302T1/de not_active IP Right Cessation
- 1991-03-22 CA CA002073983A patent/CA2073983C/en not_active Expired - Fee Related
- 1991-03-22 US US07/910,025 patent/US5374629A/en not_active Expired - Fee Related
- 1991-03-27 NZ NZ237607A patent/NZ237607A/xx unknown
1992
- 1992-07-15 KR KR1019920701665A patent/KR100209179B1/ko not_active Expired - Fee Related
1995
- 1995-02-22 GR GR940404069T patent/GR3015127T3/el unknown

Also Published As

Publication number	Publication date
KR920703527A (ko)	1992-12-18
NZ237607A (en)	1993-05-26
ES2066434T3 (es)	1995-03-01
CA2073983A1 (en)	1991-10-01
ATE114302T1 (de)	1994-12-15
DE69105267T2 (de)	1995-04-27
IE65283B1 (en)	1995-10-18
KR100209179B1 (ko)	1999-07-15
GB9007236D0 (en)	1990-05-30
IE910970A1 (en)	1991-10-09
EP0522013A1 (en)	1993-01-13
JP3246913B2 (ja)	2002-01-15
WO1991015475A1 (en)	1991-10-17
EP0522013B1 (en)	1994-11-23
GR3015127T3 (en)	1995-05-31
AU7589291A (en)	1991-10-30
AU630804B2 (en)	1992-11-05
DE69105267D1 (de)	1995-01-05
JPH05505613A (ja)	1993-08-19
US5374629A (en)	1994-12-20
CA2073983C (en)	2002-08-20

Publication	Publication Date	Title
DK0522013T3 (da)	1995-01-30	Nye D-vitaminanaloger
DK0633878T3 (da)	1997-04-21	Nye D-vitaminanaloger
DK0648207T3 (da)	1997-06-23	D-vitaminanaloger
ATE81504T1 (de)	1992-10-15	4-mercapto-butyramide-n-mono- oder n,ndisubstituiert durch ein mono- oder polyhydroxyalkyl-radikal und ihre verwendung als reduktionsmittel zur dauernden verformung von haaren.
DK0820481T3 (da)	2000-05-29	Nye organiske siliconeforbindelser med en funktionel carboxylgruppe samt fremgangsmåde til fremstilling deraf
FI956108A0 (fi)	1995-12-19	Uudet D-vitamiinianalogit
DE69011872D1 (de)	1994-09-29	Neue vitamin-d-derivate.
PT906276E (pt)	2002-12-31	Novos analogos da vitamina d
ES471738A1 (es)	1979-10-16	Procedimiento para la obtencion de derivados de perhidro-aza-heterociclos.
FI951422A0 (fi)	1995-03-24	Uudet D-vitamiinianalogit
ES8702358A1 (es)	1987-01-01	Procedimiento para la obtencion de derivados de la 3-nitrodihidropiridina