ATE295363T1 - Beta-laktame zur herstellung von taxanen mit furyl oder thienyl substituierter seitenkette - Google Patents

Beta-laktame zur herstellung von taxanen mit furyl oder thienyl substituierter seitenkette

Info

Publication number: ATE295363T1
Authority: AT; Austria
Prior art keywords: furyl; side chain; lactames; taxanes; beta
Prior art date: 1993-03-22

Application number

AT02009840T

Other languages

English (en)

Inventor

Robert A Holton

Hossain Nadizadeh

Ronald J Biediger

Kasthuri Rengan

Yukio Suzuki

Ki-Byung Chai

Hamid Idmoumaz

Original Assignee

Univ Florida State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-22

Filing date

1994-03-21

Publication date

2005-05-15

1994-03-21 Application filed by Univ Florida State filed Critical Univ Florida State

2005-05-15 Application granted granted Critical

2005-05-15 Publication of ATE295363T1 publication Critical patent/ATE295363T1/de

Links

229940123237 Taxane Drugs 0.000 title 1
239000002671 adjuvant Substances 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)
Orthopedics, Nursing, And Contraception (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Pyrrole Compounds (AREA)

AT02009840T 1993-03-22 1994-03-21 Beta-laktame zur herstellung von taxanen mit furyl oder thienyl substituierter seitenkette ATE295363T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3485293A	1993-03-22	1993-03-22
US9471793A	1993-07-20	1993-07-20

Publications (1)

Publication Number	Publication Date
ATE295363T1 true ATE295363T1 (de)	2005-05-15

Family

ID=26711460

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
AT02019282T ATE295164T1 (de)	1993-03-22	1994-03-21	Taxane mit furyl oder thienyl enthaltender substituierter seitenkette
AT02009840T ATE295363T1 (de)	1993-03-22	1994-03-21	Beta-laktame zur herstellung von taxanen mit furyl oder thienyl substituierter seitenkette
AT02009839T ATE284689T1 (de)	1993-03-22	1994-03-21	Pharmazeutische zusammenstellungen enthaltende eine furyl oder thienyl substituierte seitenkette
AT94911675T ATE232871T1 (de)	1993-03-22	1994-03-21	Taxane mit furyl-oder thienyl substituierten seitenketten
AT94910982T ATE254914T1 (de)	1993-03-22	1994-03-21	Taxane ohne die c-9 oxo gruppe und diese enthaltende pharmazeutische präparate

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT02019282T ATE295164T1 (de)	1993-03-22	1994-03-21	Taxane mit furyl oder thienyl enthaltender substituierter seitenkette

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
AT02009839T ATE284689T1 (de)	1993-03-22	1994-03-21	Pharmazeutische zusammenstellungen enthaltende eine furyl oder thienyl substituierte seitenkette
AT94911675T ATE232871T1 (de)	1993-03-22	1994-03-21	Taxane mit furyl-oder thienyl substituierten seitenketten
AT94910982T ATE254914T1 (de)	1993-03-22	1994-03-21	Taxane ohne die c-9 oxo gruppe und diese enthaltende pharmazeutische präparate

Country Status (12)

Country	Link
EP (6)	EP1227093B1 (de)
JP (2)	JPH08508469A (de)
AT (5)	ATE295164T1 (de)
AU (3)	AU6367994A (de)
CA (2)	CA2158454C (de)
DE (5)	DE69434190T2 (de)
DK (5)	DK1260223T3 (de)
ES (5)	ES2193155T3 (de)
IL (4)	IL109050A0 (de)
PT (5)	PT1228759E (de)
SG (3)	SG68049A1 (de)
WO (2)	WO1994021250A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2712289B1 (fr) *	1993-11-08	1996-01-05	Rhone Poulenc Rorer Sa	Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5677470A (en) *	1994-06-28	1997-10-14	Tanabe Seiyaku Co., Ltd.	Baccatin derivatives and processes for preparing the same
AU4133096A (en) *	1994-10-28	1996-05-23	Research Foundation Of The State University Of New York, The	Taxoid derivatives, their preparation and their use as antitumor agents
US6500858B2 (en)	1994-10-28	2002-12-31	The Research Foundation Of The State University Of New York	Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6458976B1 (en)	1994-10-28	2002-10-01	The Research Foundation Of State University Of New York	Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods
CA2162759A1 (en) *	1994-11-17	1996-05-18	Kenji Tsujihara	Baccatin derivatives and processes for preparing the same
JP2964475B2 (ja)	1994-11-17	1999-10-18	田辺製薬株式会社	バッカチン誘導体及びその製法
PT826688E (pt)	1995-04-28	2002-02-28	Daiichi Seiyaku Co	Composto pentaciclico
JP2001524067A (ja) *	1995-09-13	2001-11-27	フロリダ・ステイト・ユニバーシティ	放射線感作性タキサン類およびその医薬製剤
FR2745814B1 (fr) *	1996-03-06	1998-04-03	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2746797B1 (fr) *	1996-03-27	1998-06-19	Centre Nat Rech Scient	Nouveaux derives du 10-acetyldocetaxel et leur procede de preparation
EP0927175A4 (de) *	1996-05-06	2002-05-22	Univ Florida State	1-deoxybaccatin iii, 1-deoxytaxol und 1-deoxytaxol-analoge und verfahren zu ihrer herstellung
WO1998017656A1 (en) *	1996-10-24	1998-04-30	Institute Armand-Frappier	A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
DE60136430D1 (de) *	2000-02-02	2008-12-18	Univ Florida State Res Found	Heterosubstituierte c7-taxanacetate als antitumormittel
CA2368274C (en) *	2000-02-02	2009-10-13	Florida State University Research Foundation, Inc.	C10 ester substituted taxanes as antitumor agents
CO5280224A1 (es) *	2000-02-02	2003-05-30	Univ Florida State Res Found	Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
EP1810968A3 (de) *	2003-09-25	2007-08-08	Tapestry Pharmaceuticals, Inc.	9, 10-a, a-OH-Taxan-Analoge und Herstellungsverfahren dafür
PT1664033E (pt) *	2003-09-25	2008-01-17	Tapestry Pharmaceuticals Inc	Análogos de 9,1o-a,a-oh-taxanos e processos para sua produção
EP1737444A4 (de) *	2004-03-05	2008-05-21	Univ Florida State Res Found	C7-lactyloxa-substituierte taxane
AU2006258079A1 (en) *	2005-06-10	2006-12-21	Florida State University Research Foundation, Inc.	Resolution of enantiomeric mixtures of beta-lactams
US11786504B2 (en)	2006-09-28	2023-10-17	Tapestry Pharmaceuticals, Inc.	Taxane analogs for the treatment of brain cancer
WO2008106621A1 (en)	2007-02-28	2008-09-04	Tapestry Pharmaceuticals, Inc	Taxane analogs for the treatment of brain cancer
WO2008121476A1 (en)	2007-03-28	2008-10-09	Tapestry Pharmaceuticals, Inc.	Biologically active taxane analogs and methods of treatment by oral administration
US11873308B2 (en)	2006-11-06	2024-01-16	Tapestry Pharmaceuticals, Inc.	Biologically active taxane analogs and methods of treatment by oral administration

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6075458A (ja) *	1983-06-17	1985-04-27	Osaka Soda Co Ltd	３，４−ジフエニル−１−（４−置換）アリ−ルメチルアゼチジン−２−オンの製法
US4751299A (en) *	1983-11-18	1988-06-14	Takeda Chemical Industries, Ltd.	Optically active β-lactams and method of their production
JPS61243079A (ja) *	1985-04-01	1986-10-29	Mect Corp	１−（アルコキシカルボニルアルキル）−４−（２−フリル）−３−置換−２−アゼチジノン及びその製造方法
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5006650A (en) *	1987-02-11	1991-04-09	The Upjohn Company	Novel N-1 substituted beta-lactams as antibiotics
US4942184A (en) *	1988-03-07	1990-07-17	The United States Of America As Represented By The Department Of Health And Human Services	Water soluble, antineoplastic derivatives of taxol
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
AU637109B2 (en) *	1989-06-22	1993-05-20	Rijksuniversiteit Utrecht	Improved synthesis of beta-lactams using a metal compound
US5136060A (en) *	1989-11-14	1992-08-04	Florida State University	Method for preparation of taxol using an oxazinone
US5250683A (en) *	1991-09-23	1993-10-05	Florida State University	Certain substituted taxanes and pharmaceutical compositions containing them
HU225474B1 (en) *	1991-09-23	2006-12-28	Univ Florida State	New 10-desacetoxytaxol derivatives, pharmaceutical derivatives containing them and procedure for preparing them
EP0884314B1 (de) *	1991-09-23	2004-01-21	Florida State University	Metallalkoxide
US5229526A (en) *	1991-09-23	1993-07-20	Florida State University	Metal alkoxides
US5227400A (en) *	1991-09-23	1993-07-13	Florida State University	Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5243045A (en) *	1991-09-23	1993-09-07	Florida State University	Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5284864A (en) *	1991-09-23	1994-02-08	Florida State University	Butenyl substituted taxanes and pharmaceutical compositions containing them
US5283253A (en) *	1991-09-23	1994-02-01	Florida State University	Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
FR2688518B1 (fr) *	1992-03-13	1994-05-06	Rhone Poulenc Rorer Sa	Procede de preparation de derives du taxane.
JPH07505887A (ja) *	1992-04-17	1995-06-29	アボツト・ラボラトリーズ	タキソール誘導体
FR2696460B1 (fr) *	1992-10-05	1994-11-25	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.

1994
- 1994-03-21 DE DE69434190T patent/DE69434190T2/de not_active Expired - Fee Related
- 1994-03-21 AT AT02019282T patent/ATE295164T1/de not_active IP Right Cessation
- 1994-03-21 ES ES94911675T patent/ES2193155T3/es not_active Expired - Lifetime
- 1994-03-21 ES ES02019282T patent/ES2242807T3/es not_active Expired - Lifetime
- 1994-03-21 WO PCT/US1994/003053 patent/WO1994021250A1/en not_active Ceased
- 1994-03-21 JP JP6521307A patent/JPH08508469A/ja active Pending
- 1994-03-21 CA CA002158454A patent/CA2158454C/en not_active Expired - Fee Related
- 1994-03-21 DE DE69434373T patent/DE69434373T2/de not_active Expired - Fee Related
- 1994-03-21 EP EP02009840A patent/EP1227093B1/de not_active Expired - Lifetime
- 1994-03-21 PT PT02009839T patent/PT1228759E/pt unknown
- 1994-03-21 PT PT94911675T patent/PT690867E/pt unknown
- 1994-03-21 AT AT02009840T patent/ATE295363T1/de not_active IP Right Cessation
- 1994-03-21 AU AU63679/94A patent/AU6367994A/en not_active Abandoned
- 1994-03-21 SG SG9801036A patent/SG68049A1/en unknown
- 1994-03-21 SG SG9904638A patent/SG89298A1/en unknown
- 1994-03-21 EP EP94910982A patent/EP0689436B1/de not_active Expired - Lifetime
- 1994-03-21 DE DE69432141T patent/DE69432141T2/de not_active Expired - Fee Related
- 1994-03-21 DE DE69433355T patent/DE69433355T2/de not_active Expired - Fee Related
- 1994-03-21 DK DK02019282T patent/DK1260223T3/da active
- 1994-03-21 EP EP02019282A patent/EP1260223B1/de not_active Expired - Lifetime
- 1994-03-21 SG SG1996006328A patent/SG73401A1/en unknown
- 1994-03-21 ES ES02009839T patent/ES2232694T3/es not_active Expired - Lifetime
- 1994-03-21 PT PT02009840T patent/PT1227093E/pt unknown
- 1994-03-21 DK DK94911675T patent/DK0690867T3/da active
- 1994-03-21 DK DK02009840T patent/DK1227093T3/da active
- 1994-03-21 JP JP6521330A patent/JPH08508255A/ja active Pending
- 1994-03-21 AU AU64138/94A patent/AU691804B2/en not_active Ceased
- 1994-03-21 EP EP94911675A patent/EP0690867B1/de not_active Expired - Lifetime
- 1994-03-21 PT PT02019282T patent/PT1260223E/pt unknown
- 1994-03-21 DE DE69434374T patent/DE69434374T2/de not_active Expired - Fee Related
- 1994-03-21 CA CA002158862A patent/CA2158862C/en not_active Expired - Fee Related
- 1994-03-21 PT PT94910982T patent/PT689436E/pt unknown
- 1994-03-21 DK DK02009839T patent/DK1228759T3/da active
- 1994-03-21 ES ES94910982T patent/ES2211879T3/es not_active Expired - Lifetime
- 1994-03-21 ES ES02009840T patent/ES2241923T3/es not_active Expired - Lifetime
- 1994-03-21 AT AT02009839T patent/ATE284689T1/de not_active IP Right Cessation
- 1994-03-21 IL IL10905094A patent/IL109050A0/xx unknown
- 1994-03-21 IL IL109052A patent/IL109052A/en not_active IP Right Cessation
- 1994-03-21 AT AT94911675T patent/ATE232871T1/de not_active IP Right Cessation
- 1994-03-21 AT AT94910982T patent/ATE254914T1/de not_active IP Right Cessation
- 1994-03-21 EP EP03027078A patent/EP1398028A3/de not_active Withdrawn
- 1994-03-21 IL IL180090A patent/IL180090A0/en unknown
- 1994-03-21 EP EP02009839A patent/EP1228759B1/de not_active Expired - Lifetime
- 1994-03-21 WO PCT/US1994/003097 patent/WO1994021651A1/en not_active Ceased
- 1994-03-21 DK DK94910982T patent/DK0689436T3/da active
1998
- 1998-08-03 AU AU78636/98A patent/AU714180B2/en not_active Ceased
2008
- 2008-04-17 IL IL190945A patent/IL190945A0/en unknown

Also Published As

Publication number	Publication date
PT1260223E (pt)	2005-09-30
EP0689436A1 (de)	1996-01-03
IL180090A0 (en)	2007-05-15
DE69434190T2 (de)	2005-05-25
DE69433355T2 (de)	2004-05-27
IL109052A0 (en)	1994-06-24
DE69434374D1 (de)	2005-06-16
PT1228759E (pt)	2005-04-29
CA2158862C (en)	2006-10-10
PT690867E (pt)	2003-06-30
DK1260223T3 (da)	2005-09-05
SG89298A1 (en)	2002-06-18
AU6413894A (en)	1994-10-11
DE69433355D1 (de)	2004-01-08
EP1227093B1 (de)	2005-05-11
EP0689436B1 (de)	2003-11-26
EP0690867B1 (de)	2003-02-19
WO1994021651A1 (en)	1994-09-29
ES2193155T3 (es)	2003-11-01
SG68049A1 (en)	2001-08-21
EP0690867A4 (de)	1996-03-20
EP1398028A3 (de)	2004-03-24
PT1227093E (pt)	2005-09-30
AU7863698A (en)	1998-10-01
EP1228759A2 (de)	2002-08-07
EP1260223B1 (de)	2005-05-11
EP0690867A1 (de)	1996-01-10
DK0690867T3 (da)	2003-06-10
DE69434374T2 (de)	2005-11-24
AU691804B2 (en)	1998-05-28
ES2211879T3 (es)	2004-07-16
DK1227093T3 (da)	2005-08-29
ATE232871T1 (de)	2003-03-15
ATE284689T1 (de)	2005-01-15
ATE254914T1 (de)	2003-12-15
CA2158862A1 (en)	1994-09-29
DE69432141T2 (de)	2003-07-31
AU714180B2 (en)	1999-12-23
DK1228759T3 (da)	2005-04-18
DK0689436T3 (da)	2004-03-29
EP1228759B1 (de)	2004-12-15
PT689436E (pt)	2004-04-30
EP1228759A3 (de)	2002-09-25
WO1994021250A1 (en)	1994-09-29
CA2158454C (en)	2006-05-23
ES2241923T3 (es)	2005-11-01
IL190945A0 (en)	2009-02-11
DE69434190D1 (de)	2005-01-20
AU6367994A (en)	1994-10-11
CA2158454A1 (en)	1994-09-29
EP0689436A4 (de)	1996-02-07
IL109052A (en)	2009-07-20
JPH08508469A (ja)	1996-09-10
ES2242807T3 (es)	2005-11-16
ATE295164T1 (de)	2005-05-15
DE69432141D1 (de)	2003-03-27
DE69434373T2 (de)	2006-03-09
JPH08508255A (ja)	1996-09-03
DE69434373D1 (de)	2005-06-16
EP1398028A2 (de)	2004-03-17
IL109050A0 (en)	1994-06-24
EP1227093A2 (de)	2002-07-31
ES2232694T3 (es)	2005-06-01
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