DK0701562T3 - Umættede phosphonatderivater af puriner og pyrimidiner - Google Patents

Umættede phosphonatderivater af puriner og pyrimidiner

Info

Publication number
DK0701562T3
DK0701562T3 DK94912742.7T DK94912742T DK0701562T3 DK 0701562 T3 DK0701562 T3 DK 0701562T3 DK 94912742 T DK94912742 T DK 94912742T DK 0701562 T3 DK0701562 T3 DK 0701562T3
Authority
DK
Denmark
Prior art keywords
pyrimidines
purines
phosphonate derivatives
unsaturated phosphonate
antiviral agents
Prior art date
Application number
DK94912742.7T
Other languages
English (en)
Inventor
Serge Halazy
Patrick Casara
Jean-Francoise Nave
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0701562T3 publication Critical patent/DK0701562T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Saccharide Compounds (AREA)
DK94912742.7T 1993-04-01 1994-02-25 Umættede phosphonatderivater af puriner og pyrimidiner DK0701562T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93400842A EP0618214A1 (en) 1993-04-01 1993-04-01 Unsaturated phosphonate derivatives of purines and pyrimidines
PCT/US1994/001837 WO1994022882A1 (en) 1993-04-01 1994-02-25 Unsaturated phosphonates derivatives of purines and pyrimidines

Publications (1)

Publication Number Publication Date
DK0701562T3 true DK0701562T3 (da) 1997-07-07

Family

ID=8214695

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94912742.7T DK0701562T3 (da) 1993-04-01 1994-02-25 Umættede phosphonatderivater af puriner og pyrimidiner

Country Status (17)

Country Link
EP (2) EP0618214A1 (da)
JP (1) JPH08508481A (da)
CN (2) CN1046288C (da)
AT (1) ATE154605T1 (da)
AU (1) AU681395B2 (da)
CA (1) CA2159451C (da)
DE (1) DE69403910T2 (da)
DK (1) DK0701562T3 (da)
ES (1) ES2105684T3 (da)
FI (1) FI113539B (da)
GR (1) GR3024788T3 (da)
HU (1) HUT72459A (da)
IL (1) IL109152A0 (da)
NO (1) NO953878L (da)
NZ (1) NZ263904A (da)
WO (1) WO1994022882A1 (da)
ZA (1) ZA942092B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
CA2195262C (en) * 1996-01-18 2005-08-09 Masaru Ubasawa Phosphonate nucleotide compounds
FR2781229B1 (fr) * 1998-07-17 2001-11-30 Univ Nice Sophia Antipolis Nouveaux composes analogues des nucleotides, leurs procedes de preparation et leurs applications
GB9821058D0 (en) 1998-09-28 1998-11-18 Univ Cardiff Chemical compound
WO2003002580A1 (en) * 2001-06-29 2003-01-09 Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic 6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity
WO2003028737A1 (en) * 2001-08-30 2003-04-10 Mitsubishi Pharma Corporation Anti-viral agents and in-vitro method for the identification of candidates able to inhibit binding of polymerase to epsilon
DE602004031115D1 (de) 2003-06-16 2011-03-03 Acad Of Science Czech Republic Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
AU2004260789B2 (en) 2003-07-30 2011-06-30 Gilead Sciences, Inc. Nucleobase phosphonate analogs for antiviral treatment
EP1866319B1 (en) * 2005-04-01 2011-11-23 The Regents of The University of California Phosphono-pent-2-en-1-yl nucleosides and analogs
WO2006114064A2 (en) * 2005-04-25 2006-11-02 Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic Use of compounds to enhance processivity of telomerase
CN100352823C (zh) * 2005-08-19 2007-12-05 浙江车头制药有限公司 一种腺嘌呤衍生物的制备方法
WO2008100447A2 (en) 2007-02-09 2008-08-21 Gilead Sciences, Inc. Nucleoside analogs for antiviral treatment
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
ES2874774T3 (es) 2011-12-22 2021-11-05 Geron Corp Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros
KR102622656B1 (ko) 2016-02-18 2024-01-10 인버사, 인크. 5'-아데노신 디포스페이트 리보오스 (adpr)의 사용 방법
WO2019191026A2 (en) 2018-03-27 2019-10-03 Invirsa, Inc. Methods for the use of 5'-adenosine diphosphate ribose (adpr)
CN108383872B (zh) * 2018-04-18 2019-07-12 南京师范大学 一种-1,1-二氟-3-磺酰基-2,4-戊二烯膦酸酯类化合物及其合成方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2017054C (en) * 1990-05-16 1999-08-10 Jack S. Wilson Automatic storage and retrieval system
US5356886A (en) * 1990-07-19 1994-10-18 Beecham Group P.L.C. Antiviral phosphono-alken derivatives of purines
EP0531597A1 (en) * 1991-09-12 1993-03-17 Merrell Dow Pharmaceuticals Inc. Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine
CZ287745B6 (cs) * 1991-10-11 2001-01-17 Ústav organické chemie a biochemie AV ČR Acyklické fosfonomethoxyalkylsubstituované alkenylové a alkinylové deriváty purinu a pyrimidinu

Also Published As

Publication number Publication date
ATE154605T1 (de) 1997-07-15
FI954615A0 (fi) 1995-09-28
HU9502854D0 (en) 1995-11-28
NO953878D0 (no) 1995-09-29
ZA942092B (en) 1994-10-24
GR3024788T3 (en) 1998-01-30
DE69403910T2 (de) 1998-01-29
FI954615L (fi) 1995-09-28
CA2159451C (en) 1999-04-13
EP0701562B1 (en) 1997-06-18
IL109152A0 (en) 1994-06-24
EP0618214A1 (en) 1994-10-05
NZ263904A (en) 1996-11-26
JPH08508481A (ja) 1996-09-10
DE69403910D1 (de) 1997-07-24
HUT72459A (en) 1996-04-29
FI113539B (fi) 2004-05-14
NO953878L (no) 1995-12-01
ES2105684T3 (es) 1997-10-16
AU681395B2 (en) 1997-08-28
CA2159451A1 (en) 1994-10-13
EP0701562A1 (en) 1996-03-20
AU6516294A (en) 1994-10-24
WO1994022882A1 (en) 1994-10-13
CN1229084A (zh) 1999-09-22
CN1046288C (zh) 1999-11-10
CN1120338A (zh) 1996-04-10

Similar Documents

Publication Publication Date Title
DK0701562T3 (da) Umættede phosphonatderivater af puriner og pyrimidiner
PA8483101A1 (es) Compuestos quimicos
DK0626853T3 (da) Anvendelse af substituerede adeninderivater til behandling af multipel sclerose
DK0628044T3 (da) Terapeutiske nucleosider
ATE133678T1 (de) 9-purinyl-phosphonsäurederivate
DK0741710T3 (da) Chlorpyrimidin-mellemprodukter
ES2086376T3 (es) Nucleosidos pirimidinicos antivirales.
ES2175244T3 (es) Empleo de acido poliasparaginico y de sus sales.
DK0745852T3 (da) Anvendelse af funktionelle derivater af intercellulær adhæsion-molekylet ICAM-1 i antiviral terapi
DE69110854D1 (de) Antivirusderivate von (Phosphonmethoxy)Methoxy Purin/Pyrimidin.
ZA913033B (en) N-(3-fluoro-2-phosphonylmethoxypropyl)derivatives of purine and pyrimidine heterocyclic basis,their preparation and use
FI924424A0 (fi) Hjaertskyddande tokoferolanaloger.
DE68927651D1 (de) Derivate von Fluorphosphonat-Nukleotiden
DE69927251D1 (de) Verfahren zur herstellung von purinderivaten und dessen zwischenprodukte
ATE178335T1 (de) Therapeutische nukleoside der 2',3'-dideoxy-3'- fluor -purin reihe
DE68914809D1 (de) Antivirale Wirkstoffe.
MX23335A (es) Derivados de acido glutarico y procedimiento para su preparacion.
DE69418050D1 (de) Antivirale analoge von difluorostaton
DK0593285T3 (da) Mellemprodukter og fremgangsmåder dertil til fremstilling af 5,6-dihydropyrrolo-(2,3-d)pyrimidiner
DK0412941T3 (da) Phospholipider til behandling af dissemineret sklerose