ES2105684T3 - Derivados insaturados de fosfonato de purinas y pirimidinas. - Google Patents

Derivados insaturados de fosfonato de purinas y pirimidinas.

Info

Publication number
ES2105684T3
ES2105684T3 ES94912742T ES94912742T ES2105684T3 ES 2105684 T3 ES2105684 T3 ES 2105684T3 ES 94912742 T ES94912742 T ES 94912742T ES 94912742 T ES94912742 T ES 94912742T ES 2105684 T3 ES2105684 T3 ES 2105684T3
Authority
ES
Spain
Prior art keywords
phosphonate
purine
pirimidine
unsaturated derivatives
antiviral agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94912742T
Other languages
English (en)
Inventor
Patrick Casara
Jean-Francoise Nave
Serge Halazy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2105684T3 publication Critical patent/ES2105684T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE EXPONEN DERIVADOS DE FOSFONATO INSATURADO NOVEDOSOS DE CIERTAS PURINAS O PIRIMIDINAS UTILES COMO AGENTES ANTIVIRALES; METODOS UTILES PARA SU PREPARACION Y EL USO DE ESTOS COMPUESTOS COMO AGENTES ANTIVIRALES EFICACES CONTRA LOS VIRUS DEL DNA, RETROVIRUS, Y LOS VIRUS INVOLUCRADOS EN LA FORMACION DE TUMORES.
ES94912742T 1993-04-01 1994-02-25 Derivados insaturados de fosfonato de purinas y pirimidinas. Expired - Lifetime ES2105684T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93400842A EP0618214A1 (en) 1993-04-01 1993-04-01 Unsaturated phosphonate derivatives of purines and pyrimidines

Publications (1)

Publication Number Publication Date
ES2105684T3 true ES2105684T3 (es) 1997-10-16

Family

ID=8214695

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94912742T Expired - Lifetime ES2105684T3 (es) 1993-04-01 1994-02-25 Derivados insaturados de fosfonato de purinas y pirimidinas.

Country Status (17)

Country Link
EP (2) EP0618214A1 (es)
JP (1) JPH08508481A (es)
CN (2) CN1046288C (es)
AT (1) ATE154605T1 (es)
AU (1) AU681395B2 (es)
CA (1) CA2159451C (es)
DE (1) DE69403910T2 (es)
DK (1) DK0701562T3 (es)
ES (1) ES2105684T3 (es)
FI (1) FI113539B (es)
GR (1) GR3024788T3 (es)
HU (1) HUT72459A (es)
IL (1) IL109152A0 (es)
NO (1) NO953878L (es)
NZ (1) NZ263904A (es)
WO (1) WO1994022882A1 (es)
ZA (1) ZA942092B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
TW369536B (en) * 1996-01-18 1999-09-11 Mitsubishi Chem Corp Phosphonate nucleotide compounds
FR2781229B1 (fr) * 1998-07-17 2001-11-30 Univ Nice Sophia Antipolis Nouveaux composes analogues des nucleotides, leurs procedes de preparation et leurs applications
GB9821058D0 (en) 1998-09-28 1998-11-18 Univ Cardiff Chemical compound
BRPI0210746B8 (pt) 2001-06-29 2021-05-25 Inst Of Organic Chemistry And Biochemistry Ascr derivados de 6-'2-(fosfonometóxi)alcóxi-pirimidina e seu método de preparação
JP2005508924A (ja) * 2001-08-30 2005-04-07 三菱ウェルファーマ株式会社 抗ウイルス剤
NZ543864A (en) 2003-06-16 2009-10-30 Leuven K U Res & Dev Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
US20060252729A1 (en) 2003-07-30 2006-11-09 Krawczyk Steven H Nucleobase phosphonate analogs for antiviral treatment
JP5242375B2 (ja) * 2005-04-01 2013-07-24 ザ レゲントス オブ ザ ユニバーシティ オブ カリフォルニア ホスホノ−ペント−２−エン−１−イルヌクレオシド及び類似体
EP1879657A2 (en) * 2005-04-25 2008-01-23 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of compounds to enhance processivity of telomerase
CN100352823C (zh) * 2005-08-19 2007-12-05 浙江车头制药有限公司 一种腺嘌呤衍生物的制备方法
WO2008100447A2 (en) 2007-02-09 2008-08-21 Gilead Sciences, Inc. Nucleoside analogs for antiviral treatment
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
CA2857490C (en) 2011-12-22 2020-03-31 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
HUE057052T2 (hu) 2016-02-18 2022-04-28 Invirsa Inc 5'-adenozin-difoszfát-ribóz (ADPR) gyógyászati alkalmazása
WO2019191026A2 (en) 2018-03-27 2019-10-03 Invirsa, Inc. Methods for the use of 5'-adenosine diphosphate ribose (adpr)
CN108383872B (zh) * 2018-04-18 2019-07-12 南京师范大学 一种-1,1-二氟-3-磺酰基-2,4-戊二烯膦酸酯类化合物及其合成方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2017054C (en) * 1990-05-16 1999-08-10 Jack S. Wilson Automatic storage and retrieval system
JPH05509307A (ja) * 1990-07-19 1993-12-22 ビーチャム・グループ・パブリック・リミテッド・カンパニー プリンの抗ウイルス性ホスホノ―アルケン誘導体
EP0531597A1 (en) * 1991-09-12 1993-03-17 Merrell Dow Pharmaceuticals Inc. Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine
EP0630381B1 (en) * 1991-10-11 1997-04-09 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives

Also Published As

Publication number Publication date
ZA942092B (en) 1994-10-24
EP0701562A1 (en) 1996-03-20
NO953878L (no) 1995-12-01
ATE154605T1 (de) 1997-07-15
JPH08508481A (ja) 1996-09-10
NZ263904A (en) 1996-11-26
HUT72459A (en) 1996-04-29
FI954615L (fi) 1995-09-28
CN1046288C (zh) 1999-11-10
CN1120338A (zh) 1996-04-10
HU9502854D0 (en) 1995-11-28
AU6516294A (en) 1994-10-24
EP0618214A1 (en) 1994-10-05
WO1994022882A1 (en) 1994-10-13
GR3024788T3 (en) 1998-01-30
CA2159451C (en) 1999-04-13
DK0701562T3 (da) 1997-07-07
CA2159451A1 (en) 1994-10-13
FI113539B (fi) 2004-05-14
AU681395B2 (en) 1997-08-28
FI954615A0 (fi) 1995-09-28
CN1229084A (zh) 1999-09-22
IL109152A0 (en) 1994-06-24
NO953878D0 (no) 1995-09-29
DE69403910T2 (de) 1998-01-29
EP0701562B1 (en) 1997-06-18
DE69403910D1 (de) 1997-07-24

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