DK0702696T3 - Trifunktionelle antithrombin- og antiblodpladepeptider - Google Patents

Trifunktionelle antithrombin- og antiblodpladepeptider

Info

Publication number: DK0702696T3
Authority: DK; Denmark
Prior art keywords: trifunctional; antithrombin; platelet; peptides; platelet peptides
Prior art date: 1993-06-11

Application number

DK94920004T

Other languages

English (en)

Inventor

Robert J Broersma Jr

Thomas J Owen

John L Krstenansky

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-11

Filing date

1994-05-13

Publication date

2003-11-17

1994-05-13 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

2003-11-17 Application granted granted Critical

2003-11-17 Publication of DK0702696T3 publication Critical patent/DK0702696T3/da

Links

239000004019 antithrombin Substances 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
108090000190 Thrombin Proteins 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
229940127219 anticoagulant drug Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
229960004072 thrombin Drugs 0.000 abstract 1
230000001732 thrombotic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Hematology (AREA)
Tropical Medicine & Parasitology (AREA)
Toxicology (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Materials For Medical Uses (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK94920004T 1993-06-11 1994-05-13 Trifunktionelle antithrombin- og antiblodpladepeptider DK0702696T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7606693A	1993-06-11	1993-06-11
PCT/US1994/005355 WO1994029349A1 (en)	1993-06-11	1994-05-13	Trifunctional antithrombin and antiplatelet peptides

Publications (1)

Publication Number	Publication Date
DK0702696T3 true DK0702696T3 (da)	2003-11-17

Family

ID=22129739

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94920004T DK0702696T3 (da)	1993-06-11	1994-05-13	Trifunktionelle antithrombin- og antiblodpladepeptider

Country Status (20)

Country	Link
US (1)	US5681925A (da)
EP (1)	EP0702696B1 (da)
JP (1)	JP3532920B2 (da)
KR (1)	KR100330465B1 (da)
CN (1)	CN1124964A (da)
AT (1)	ATE246203T1 (da)
AU (1)	AU685470B2 (da)
CA (1)	CA2164712C (da)
DE (1)	DE69432983T2 (da)
DK (1)	DK0702696T3 (da)
ES (1)	ES2199963T3 (da)
FI (1)	FI955905A7 (da)
HU (1)	HUT73187A (da)
IL (1)	IL109931A0 (da)
NO (1)	NO954991L (da)
NZ (1)	NZ268159A (da)
PT (1)	PT702696E (da)
TW (1)	TW295590B (da)
WO (1)	WO1994029349A1 (da)
ZA (1)	ZA943958B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6235877B1 (en)	1999-08-04	2001-05-22	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
ATE480561T1 (de)	2004-10-19	2010-09-15	Lonza Ag	Verfahren zur festphasen-peptidsynthese
US9073974B2 (en) *	2009-12-21	2015-07-07	The Regents Of The University Of California	RGD-containing cyclic peptides
WO2020036987A1 (en)	2018-08-13	2020-02-20	Signablok, Inc.	Peptides and compositions for targeted treatment and imaging
CN117143194B (zh) *	2023-11-01	2024-02-06	北京大学第一医院	抗血小板聚集多肽、其制备方法及应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4792525A (en) *	1982-08-04	1988-12-20	La Jolla Cancer Research Foundation	Tetrapeptide
DE3438296A1 (de) *	1984-04-18	1985-11-07	Hoechst Ag, 6230 Frankfurt	Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3445532A1 (de) *	1984-12-13	1986-06-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
CA1341032C (en) *	1987-01-23	2000-06-20	John L. Krstenansky	Anticoagulant peptides
EP0333356A3 (en) *	1988-03-04	1990-12-19	Biogen, Inc.	Hirudin peptides
FR2628429B1 (fr) *	1988-03-08	1990-12-28	Transgene Sa	Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir
NZ228995A (en) *	1988-05-10	1992-03-26	Merrell Dow Pharma	Hirudin peptide derivatives and pharmaceutical compositions
ES2052062T3 (es) *	1988-06-11	1994-07-01	Ciba Geigy Ag	Nuevos polipeptidos con actividad anticoagulante.
FI904329A0 (fi) *	1988-12-05	1990-09-03	Biogen Inc	Foerfaranden och kompositioner foer inhibering av tronbocytaggregation.
ZA899247B (en) *	1988-12-07	1990-09-26	Merrell Dow Pharma	Anticoagulant peptides
US5182260A (en) *	1989-01-27	1993-01-26	Biogen, Inc.	Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
EP0382451A3 (en) *	1989-02-07	1991-05-29	Merck & Co. Inc.	Viper venom polypeptides and variants
WO1990015072A1 (en) *	1989-06-07	1990-12-13	Genentech, Inc.	Platelet aggregation inhibitors and related molecules
US5196404B1 (en) *	1989-08-18	1996-09-10	Biogen Inc	Inhibitors of thrombin
ZA907742B (en) *	1989-10-03	1991-07-31	Merrell Dow Pharma	Anticoagulant peptides
ZA907743B (en) *	1989-10-03	1991-07-31	Merrell Dow Pharma	Radiolabeled anticoagulant peptides
WO1991011458A1 (en) *	1990-02-02	1991-08-08	Genentech, Inc.	CYCLIC PEPTIDES CONTAINING Arg-Gly-Asp FLANKED BY PROLINE
FI925696L (fi) *	1990-06-15	1992-12-15	Ca Nat Research Council	Pao hirudinets aminosyrasekvens baserade trombininhibitorer
IT1243358B (it) *	1990-07-23	1994-06-10	Iketon Farmaceutici Srl	Composizioni farmaceutiche per la somministrazione orale di irudina
US5118790A (en) *	1990-07-24	1992-06-02	Sri International	Analogs of hirudin
AU640502B2 (en) *	1990-07-24	1993-08-26	Merrell Dow Pharmaceuticals Inc.	Analogs of hirudin having antiplatelet activity
GB9023149D0 (en) *	1990-10-24	1990-12-05	British Bio Technology	Proteins and nucleic acids
US5242810A (en) *	1990-12-07	1993-09-07	Biogen, Inc.	Bifunctional inhibitors of thrombin and platelet activation

1994
- 1994-05-13 NZ NZ268159A patent/NZ268159A/en unknown
- 1994-05-13 DE DE69432983T patent/DE69432983T2/de not_active Expired - Fee Related
- 1994-05-13 WO PCT/US1994/005355 patent/WO1994029349A1/en not_active Ceased
- 1994-05-13 HU HU9503530A patent/HUT73187A/hu unknown
- 1994-05-13 KR KR1019950705595A patent/KR100330465B1/ko not_active Expired - Fee Related
- 1994-05-13 AT AT94920004T patent/ATE246203T1/de not_active IP Right Cessation
- 1994-05-13 ES ES94920004T patent/ES2199963T3/es not_active Expired - Lifetime
- 1994-05-13 PT PT94920004T patent/PT702696E/pt unknown
- 1994-05-13 EP EP94920004A patent/EP0702696B1/en not_active Expired - Lifetime
- 1994-05-13 JP JP50179095A patent/JP3532920B2/ja not_active Expired - Fee Related
- 1994-05-13 AU AU70938/94A patent/AU685470B2/en not_active Ceased
- 1994-05-13 CA CA002164712A patent/CA2164712C/en not_active Expired - Fee Related
- 1994-05-13 DK DK94920004T patent/DK0702696T3/da active
- 1994-05-13 CN CN94192393A patent/CN1124964A/zh active Pending
- 1994-06-06 ZA ZA943958A patent/ZA943958B/xx unknown
- 1994-06-07 TW TW083105188A patent/TW295590B/zh active
- 1994-06-08 IL IL10993194A patent/IL109931A0/xx unknown
1995
- 1995-07-17 US US08/502,989 patent/US5681925A/en not_active Expired - Lifetime
- 1995-12-08 NO NO954991A patent/NO954991L/no unknown
- 1995-12-08 FI FI955905A patent/FI955905A7/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU7093894A (en)	1995-01-03
JP3532920B2 (ja)	2004-05-31
NZ268159A (en)	1997-03-24
JPH08511518A (ja)	1996-12-03
KR100330465B1 (ko)	2002-11-23
PT702696E (pt)	2003-12-31
NO954991L (no)	1996-02-15
EP0702696A1 (en)	1996-03-27
ATE246203T1 (de)	2003-08-15
WO1994029349A1 (en)	1994-12-22
ES2199963T3 (es)	2004-03-01
DE69432983D1 (de)	2003-09-04
FI955905A0 (fi)	1995-12-08
NO954991D0 (no)	1995-12-08
CA2164712A1 (en)	1994-12-22
CN1124964A (zh)	1996-06-19
DE69432983T2 (de)	2004-04-29
HUT73187A (en)	1996-06-28
EP0702696B1 (en)	2003-07-30
US5681925A (en)	1997-10-28
AU685470B2 (en)	1998-01-22
TW295590B (da)	1997-01-11
CA2164712C (en)	2000-03-28
ZA943958B (en)	1995-02-22
FI955905A7 (fi)	1995-12-08
IL109931A0 (en)	1994-10-07
HU9503530D0 (en)	1996-02-28

Publication	Publication Date	Title
NO984928D0 (no)	1998-10-22	Pyrazinontrombininhibitorer
ATE148130T1 (de)	1997-02-15	Typ-iv-dipeptidyl-aminopeptidase-inhibitoren
SE9301270D0 (sv)	1993-04-17	Biosensor
DE69411477D1 (de)	1998-08-13	Videosynchronisiering von mehrfachquellen.
FI955149A0 (fi)	1995-10-27	Oksasmodifioituja oleellisten lineaaristen eteenipolymeerien ja muiden kestomuovipolymeerien seoksia
DK640088A (da)	1989-05-18	Plasma-deriveret aktiveret protein c til inhibering af thromboemboli
DK0925319T3 (da)	2002-04-02	Triazinpolymerer og deres anvendelse i elektroluminescerende arrangementer
DE3873793D1 (de)	1992-09-24	Erzeugung von brennbarem gas.
ATE120206T1 (de)	1995-04-15	Peptide, die die bindung des von-willebrand- faktors inhibieren.
DE59109048D1 (de)	1998-10-15	Inhibitoren zur antikoagulierenden Vorbehandung von Blutproben
DE69418387D1 (de)	1999-06-17	Neo-Diol Phosphite als Polymer-Stabilisatoren
DE69520056D1 (de)	2001-03-15	Verbindungen zur Hemmung von Thrombin
FI953916A0 (fi)	1995-08-21	Fibrinogeenireseptoriantagonisteja
EP0627684A3 (en)	1997-03-26	Specifying contexts in callback style programming.
ATE246203T1 (de)	2003-08-15	Trifunktionelle antithrombin-und antiplättchenpeptide
DE69001697D1 (de)	1993-07-01	Einwickeln von laenglichen gegenstaenden.
IT8505221A0 (it)	1985-09-06	Perfezionamenti ai dispositivi di giunzione per vincolare i tessuti sovrapposti di indumenti o articoli con essi confezionati.
FI925696A7 (fi)	1992-12-15	Hirudiinin aminohapposekvenssiin perustuvia trombiininestäjiä
DK258283D0 (da)	1983-06-07	Fremgangsmade til fremstilling af et heparinfragment med en molekylvaegt pa 20000 til 5500 og kovalent bundet til antithrombin iii
DK0556906T3 (da)	1996-09-02	Kalibrator og dens anvendelse til en immunanalyse
DK213589D0 (da)	1989-05-02	Antistoffer mod fibrin og immunogen til brug ved fremstilling deraf
DK0846166T3 (da)	2008-02-04	Fremgangsmåde til thrombinfremstilling
SE8602020L (sv)	1986-10-31	Lopytebelag for skidor, speciellt langdistansskidor
ATA231493A (de)	1994-08-15	Holzentrindungsmaschine
ATA261387A (de)	1994-11-15	Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung